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The prognostic value of P-wave dispersion and left atrial functions assessed with three-dimensional echocardiography in patients with cirrhosis
Conclusion The results of this study showed that patients with cirrhosis had higher left atrial volume, longer PWd and worse diastolic functions compared with the control group. Higher disease severity scores were associated with left atrial function and volume. In addition, left atrial volume measured with 3DE was a strong predictor of future adverse events, and minimal left atrial volumes had a higher prognostic value than any other left atrial function indices. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Spontaneous regression of liver hemangiomas: a single-institution analysis of 46 patients
Conclusion Spontaneous regression of liver hemangiomas is an underrecognized phenomenon. Enlargement should not be a straightforward indication for intervention because it may be followed by regression. A regressed hemangioma should be considered in the differential diagnosis of liver lesions suspicious for malignancy. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Endoscopic therapy + β-blocker vs. covered transjugular intrahepatic portosystemic shunt for prevention of variceal rebleeding in cirrhotic patients with hepatic venous pressure gradient ≥16 mmHg
Background and objective Currently, monitoring hepatic venous pressure gradient (HVPG) have been proved to be the best predictor for the risk of variceal bleeding. We performed the study to evaluate the effect of endoscopic therapy + β-blocker vs. covered transjugular intrahepatic portosystemic shunt (TIPS) for the prevention of variceal rebleeding in cirrhotic patients with HVPG ≥16 mmHg. Methods Consecutive cirrhotic patients with HVPG ≥16 mmHg treated with endoscopic therapy + β-blocker or covered TIPS for variceal bleeding were retrospectively gathered between April 2013 and December 2018. ...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

A personalized treatment program in persons with type 2 diabetes is associated with a reduction in liver steatosis
Background and aims It is unclear if improving glycemic control in persons with type 2 diabetes (T2D) also has liver-related effects. We aimed to evaluate if a personalized treatment program associates with improvement of liver-related parameters in persons with advanced T2D in a real-life setting. Methods Persons with advanced T2D underwent a 4-day personalized treatment program, with the aim of improving glycemic control by dietary advice, instructions on how to achieve optimal glucose control and individualized dosage of medications. Transient elastography was used to estimate liver steatosis and fibrosis. Pe...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Endoscopic radiofrequency ablation for the treatment of severe gastric antral vascular ectasia in patients with cirrhosis
Introduction Gastric antral vascular ectasia is a significant cause of gastrointestinal bleeding in patients with cirrhosis. Aim To assess safety/efficacy and cost/advantages of radiofrequency ablation for the treatment of gastric antral vascular ectasia in patients with cirrhosis. Materials and methods Patients with cirrhosis and severe gastric antral vascular ectasia who underwent radiofrequency ablation were enrolled. Clinical data, gastric antral vascular ectasia grade, and gastric antral vascular ectasia-related hospitalizations were collected. Primary outcome was defined as the absence of transfusio...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Treatment in disproportionately minority hospitals is associated with an increased mortality in end-stage liver disease
Background Racial and ethnic disparities are a barrier in delivery of healthcare across the USA. Care for minority patients tends to be clustered into a small number of providers at minority hospitals, which has been associated with worse clinical outcomes in several conditions. However, the outcomes of treatment in patients with end-stage liver disease (ESLD) at predominately minority hospitals are unknown. We investigated the burden of the problem. Methods We utilized the nationwide in-patient sample (NIS) to conduct a retrospective nationwide cohort analysis. All patients>18 years of age admitted with ESLD ...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

The utility of two-dimensional real-time shear wave elastography for assessing liver fibrosis in patients with chronic hepatitis C virus infection
Conclusion 2D-SWE has an excellent diagnostic accuracy equivalent to that of MRE for assessing significant (≥F2) and severe (≥F3) fibrosis. MRE demonstrated a higher AUROC than 2D-SWE, but this last one has advantages such as lower cost, fewer contraindications and greater ease of performance than MRE. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

The defining of the reference range of liver stiffness and fat attenuation parameter for healthy Chinese children
Conclusion For healthy children from 0 to 18 years in southern China, the LSM reference range was 1.5–5.9 kPa, and the FAP reference range was 159.6–217.1 dB/m. The LSM values were age-dependent in children from 3 to 18 years old, and the FAP values were age-independent in children from 0 to18 years old. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Mucocutaneous manifestations in patients with inflammatory bowel disease: a decade study from a Greek cohort
Background We sought to investigate the prevalence of mucocutaneous manifestations (MCM) and potential associations with clinical characteristics in Greek patients with IBD. Methods This was a retrospective observational single-center study. Patients with IBD diagnosis attending a tertiary referral hospital in Heraklion, Crete, from January 2010 to January 2020 were included. Data were extracted with relevant medical information from the IBD registry. Standard statistical tests, descriptive statistics tests, chi-square, Pearson correlation and multivariate analysis tests were performed, using IBM SPSS Statistics...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases
Conclusion Significant alterations in gut microbiota profile were shown in our IBD pediatric patients, in whom an abundance of species with a proinflammatory mucosal activity was clearly detected. An analysis of gut microbiota could be incorporated in designing personalized IBD treatment scenarios in future. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Malnutrition and sarcopenia are prevalent among inflammatory bowel disease patients with clinical remission
Conclusion In conclusion, our findings revealed a considerable proportion of IBD patients in clinical remission to be malnourished or at risk of malnutrition along with a high rate of sarcopenia. This emphasizes the need for concomitant screening for nutritional status and body composition analysis in patients with IBD for provision of appropriate nutritional support, even during the remission period, and prevention of sarcopenia-related surgical and poor clinical outcomes. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Prevalence, incidence and clinical features of SARS-CoV-2 infection in adult coeliac patients
Conclusion Patients with CD do not seem to carry an increased risk of COVID-19 compared to the general population and their disease course is mild. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

The effects of diabetes mellitus on clinical outcomes of hospitalized patients with acute diverticulitis
Objectives Acute diverticulitis is a common gastrointestinal illness due to diverticular inflammation and focal necrosis. Diabetes mellitus has been reported to influence the outcomes of patients with diverticular disease. Our study aimed to examine the inpatient outcomes and complications of patients with acute diverticulitis and coexisting diabetes mellitus. Methods The Nationwide Inpatient Sample was used to identify adult patients in 2014 admitted for acute diverticulitis. Primary outcomes were mortality, length of stay (LOS), and total hospitalization charges. Secondary outcomes were complications of acute ...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Preexisting opioid use disorder is associated with poor outcomes in hospitalized acute pancreatitis patients
Introduction Although opioids are widely used for pain management in acute pancreatitis, the impact of opioid use disorder (OUD) on outcomes in patients with acute pancreatitis remains unknown. In the current study, we aimed to evaluate the impact of the OUD on outcomes in patients hospitalized with acute pancreatitis and delineate the trends associated with OUD and acute pancreatitis using a nationally representative sample. Methods This is a retrospective cohort study of patients with acute pancreatitis using the combined releases of the year 2005–2014 of the National (Nationwide) Inpatient Sample (NIS) data...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Long-term cumulative incidence of metachronous advanced colorectal neoplasia after colonoscopy and a novel risk factor: a cohort study
Background and aim Long-term cumulative incidence of and risk factors for metachronous advanced colorectal neoplasia, including both advanced colorectal adenoma (≥10 mm, or with villous or high-grade dysplasia) and colorectal cancer, are critical for surveillance strategies. The aim of this study was to determine the cumulative incidence of metachronous advanced colorectal neoplasia and its risk factors. Methods A retrospective cohort study was conducted on 6720 consecutive individuals who underwent general health check-ups and colonoscopy. Colorectal adenomas at initial colonoscopy were categorized as low-ris...
Source: European Journal of Gastroenterology and Hepatology - October 7, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research