European Journal of Gastroenterology and Hepatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial
Objective Although several experimental models have suggested promising pharmacological effects of naringenin in the management of obesity and its related disorders, the effects of naringenin supplementation on cardiovascular disorders as one of the main complications of nonalcoholic fatty liver disease (NAFLD) are yet to be examined in humans. Methods In this double-blind, placebo-controlled, randomized clinical trial, 44 overweight/obese patients with NAFLD were equally allocated into either naringenin or placebo group for 4 weeks. Cardiovascular risk factors including atherogenic factors, hematological indice...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Controversial risk factors for cholangiocarcinoma
Introduction Cholangiocarcinoma is a rare malignancy accounting for 3% of gastrointestinal cancers in the USA. While multiple risk factors for cholangiocarcinoma are established, other potential risk factors are still controversial. Herein, we used a large national database to investigate possible risk factors and associations. Method We used the National Inpatient Sample database to review all admissions between 2011 and 2015. We grouped patients based on the presence and absence of cholangiocarcinoma. Using multivariate logistic regression analysis, we assessed the association between obesity, alcohol abuse, s...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Prediction of high-risk esophageal varices in patients with compensated cirrhosis using albumin-bilirubin-platelet score
Background Despite the fact that endoscopy is the gold standard for screening of high-risk varices (HRVs) in patients with compensated cirrhosis, it is invasive, costly and not necessary for all patients. So, noninvasive tests can replace endoscopy. We aimed at evaluating the albumin-bilirubin-platelet (ALBL-PLT) score as a noninvasive test in predicting HRVs in compensated cirrhotic patients versus Baveno VI and extended Baveno VI criteria. Methods patients with compensated cirrhosis (n = 204) were included. Laboratory parameters, esophagogastroduodenoscopy (EGD) and liver stiffness measurement by transient ela...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Nonalcoholic fatty liver disease is associated with a higher incidence of coeliac disease
Background Recently the incidence of nonalcoholic fatty liver disease (NAFLD) has risen to become the most frequent liver disease worldwide. NAFLD is not a disease limited to the liver, but rather represents a systemic inflammatory disease involving multiple organ systems. Previous studies have suggested an association between NAFLD and coeliac disease, another disease related to inflammation. As the available clinical data is scarce and at least partially contradictory, we aimed at investigating a potential association between NAFLD and celiac disease in outpatients in Germany. Methods Using the Disease Analyze...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis
Aim Chronic hepatitis B is associated with important morbidity and mortality. Inflammation has a pivotal role in hepatic fibrosis of this population. Hemogram-derived inflammatory predictors, such as mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR), are supposed as inflammatory markers in various diseases. We aimed to compare MPV and PLR of the patients with chronic hepatitis B to those of healthy controls and to observe possible correlation between these markers and fibrosis. Methods Chronic hepatitis B patients that visited our outpatient gastroenterology clinics were enrolled in the study. He...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Association between aspartate aminotransferase-to-alanine aminotransferase ratio and insulin resistance among US adults
Objective To determine whether a low aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT ratio) is associated with insulin resistance among those without liver dysfunction. Methods In this cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) 2011–2016, we included 2747 (1434 male and 1313 nonpregnant female) adults ≥20 years without evidence of liver dysfunction (ALT (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Fibrosis scores that can be used in follow-up of after direct-acting antiviral treatment: APRI, FIB-4, King score and GUCI
Introduction Sustained virologic response in the treatment of chronic hepatitis C can be achieved with direct-acting antivirals (DAA) in recent years. Monitoring virologic and histologic response to treatment is essential and noninvasive methods are preferred. In our study, we aimed to determine the regression of fibrosis following DAA treatment with serum fibrosis indices constituting a noninvasive method. Method Patients with chronic hepatitis C to whom DAA treatment is started between January 2016 and January 2018 in our clinic are evaluated retrospectively. The fibrosis scores [fibrosis 4 index (FIB-4), amin...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research

Commonly used biomarkers do not contribute to diagnosing irritable bowel syndrome
Conclusion In our real-life cohort of adult patients under the age of 50 years fulfilling the Rome criteria for IBS without red flag symptoms, standardized blood, and fecal investigations have a very low diagnostic yield accompanied by high additional costs. Colonoscopy is not indicated in patients with Rome III positive IBS and normal FCP. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

The effect of infliximab dose escalation in inflammatory bowel disease patients with antibodies to infliximab
Conclusions A strategy of DE for selected patients receiving infliximab is associated with an increase in drug levels and reduced ATI positivity. This is associated with clinical remission in approximately 70% of patients at 6 months. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

No evidence of “weekend effect” in upper gastrointestinal bleeding in Italy: data from a nationwide prospective registry
Conclusions Data from our large, prospective multicenter registry shows that in Italy there is no significant ‘weekend effect’ for either NV- or V-AUGIB. Our results show that the Italian hospital network is efficient and able to provide adequate care and an effective therapeutic endoscopy even during the weekend. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

The elderly harbor greater proportions of advanced histology in subcentimeter adenomas: implications for screening colonoscopy approaches
Conclusion The processing strategy proposed for subcentimeter polyps in the elderly still needs to be further explored in the future. Clinicians should recognize the importance of performing a detailed scan of the entire colon. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

Significance of validated symptom assessment versus breath testing for malabsorption after lactose load in children
Background and objectives Lactose malabsorption and lactose-induced symptoms are poorly correlated, as shown by breath tests and various symptom assessment methods. Validated assessment is the key to overcome the limitations of biased symptom measurements. We characterized lactose-induced symptoms with the population-specific, validated paediatric carbohydrate perception questionnaire (pCPQ) and their correlation with the history of symptoms (HoS). Methods A total of 130 patients with functional gastrointestinal symptoms underwent a lactose hydrogen breath and tolerance test (LBTT) allowing for a diagnosis of ma...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

Effect of inflammatory bowel disease and related medications on COVID-19 incidence, disease severity, and outcome: the Israeli experience
Objectives The coronavirus disease 2019 (COVID-19) pandemic raised concerns among inflammatory bowel disease (IBD) patients fearing an increased risk of infection and poor outcomes. We aimed to evaluate the incidence of COVID-19 among IBD patients; its influence on disease severity and outcome; its relationship to medication use and how the pandemic affected IBD management. Methods An anonymous questionnaire was posted online to members of the Israel Crohn’s Disease and Ulcerative Colitis Foundation (November 2020–January 2021). The questionnaire addressed the course of IBD disease and COVID-19 infection ove...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research

Differences between sporadic hyperplastic gastric polyps and portal hypertensive gastric polyps: a review
Portal hypertension (PH) is one of the most severe complications of chronic liver diseases. It is defined as an increase in pressure in the portal venous system which results in a portosystemic gradient>5 mmHg. In the western world, cirrhosis is the most frequent cause of PH, mainly due to nonalcoholic fatty liver disease and alcoholic liver disease. Patients with PH have esophageal varices in 68–73% of cases, portal hypertensive gastropathy in 51–73% and hyperplastic polyps (HPs) in 0.9–2%. Recent studies have shown that HPs found in PH patients are different from classical HPs. They constitute a new entity called p...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Review articles Source Type: research

Optimal management of functional anorectal pain: a systematic review and network meta-analysis
Functional anorectal is idiopathic and characterised by severe and potentially intractable anorectal pain. The current review aims to appraise available evidence for the management of functional anorectal pain and synthesise reported outcomes using network meta-analysis. PubMed, CENTRAL and Web of Science databases were searched for studies investigating treatments for functional anorectal pain. The primary outcome was clinical improvement of symptoms and the secondary outcome was pain scores reported during follow-up. A Bayesian network meta-analysis of interventions was performed. A total of 1538 patients were included f...
Source: European Journal of Gastroenterology and Hepatology - February 1, 2022 Category: Gastroenterology Tags: Review articles Source Type: research