Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis

Aim Chronic hepatitis B is associated with important morbidity and mortality. Inflammation has a pivotal role in hepatic fibrosis of this population. Hemogram-derived inflammatory predictors, such as mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR), are supposed as inflammatory markers in various diseases. We aimed to compare MPV and PLR of the patients with chronic hepatitis B to those of healthy controls and to observe possible correlation between these markers and fibrosis. Methods Chronic hepatitis B patients that visited our outpatient gastroenterology clinics were enrolled in the study. Healthy volunteers were enrolled as controls. MPV, PLR and other parameters of the study groups were compared. Results Median MPV of the mild fibrosis, advanced fibrosis control groups were 8.1 (6.6–13) fL, 8.2 (6.3–14.5) fL and 7.2 (4.6–8.9) fL, respectively (P
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research