Pilot study of an elimination diet in adults with mild to moderate Crohn’s disease

Background There remains limited data supporting the efficacy of dietary therapy in adults with Crohn’s disease (CD). This was a pilot study of the McMaster Elimination diet for CD (MED-CD), which excludes several potentially detrimental ingredients commonly found in the Western diet. Methods Prospective study in adults with mild-moderately active CD [Harvey–Bradshaw Index (HBI) scores 5–16] and endoscopic disease activity of>7 (or ≥4 for isolated ileal disease) as measured by the Simple Endoscopic Score for Crohn’s disease (SES-CD). Patients were treated for 2 weeks using oral enteral nutrition (EN). Those with symptomatic improvement (HBI score reduction ≥2) were transitioned to the MED-CD for 12 weeks. Outcomes of interest included satisfactory adherence (≥20 on the modified medical adherence report scale-5 questionnaire), clinical remission (CR) (HBI ≤4), clinical response (HBI reduction ≥3), endoscopic response (SES-CD reduction ≥50%), and endoscopic remission (ER) (SES-CD
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original articles: Gastroenterology Source Type: research