A Hydrogen-Sulfide Derivative of Mesalamine Reduces Severity of Intestinal and Lung Injury in Necrotizing Enterocolitis via Endothelial Nitric Oxide Synthase
CONCLUSIONS: An H2S-derivative of mesalamine improves outcomes in experimental NEC. Protective effects appear to be mediated through eNOS. Further research is warranted to explore whether ATB-429 may be an effective oral therapy to combat NEC.PMID:35912999 | DOI:10.1152/ajpregu.00229.2021
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Brian D Hosfield Chelsea E Hunter Hongge Li Natalie A Drucker Anthony R Pecoraro Krishna Manohar W Christopher Shelley Troy A Markel Source Type: research