Nestorone (segesterone acetate) effects on neuroregeneration
Front Neuroendocrinol. 2024 Apr 25;73:101136. doi: 10.1016/j.yfrne.2024.101136. Online ahead of print.ABSTRACTNestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was f...
Source: Frontiers in Neuroendocrinology - April 26, 2024 Category: Endocrinology Authors: Regine Sitruk-Ware Heather Sussman Roberta Brinton Michael Schumacher Patrick Singer Narender Kumar Alejandro F De Nicola Martine El-Etr Rachida Guennoun Cesar V Borlongan Source Type: research
ALSUntangled #75: Portable neuromodulation stimulator therapy
. (Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration)
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - April 26, 2024 Category: Neurology Authors: Laurel OfficerCarmel ArmonPaul BarkhausMorgan BeauchampMichael BenatarTulio BertoriniRobert BowserMark BrombergAndrew BrownOlimpia Mihaela CarbunarGregory T. CarterJesse CrayleKeelie DensonEva FeldmanTimothy FullamTerry Heiman-PattersonCarlayne JacksonSar Source Type: research
Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation
In this study, we have designed two new MTLs that modulate three pharmacological targets simultaneously (tau, beta-amyloid and TAR DNA-binding protein 43). To enhance their brain penetration, we have formulated organic polymeric nanoparticles using poly(lactic-co-glycolic acid). The characterization of the formulations, evaluation of their permeability through an in vitro BBB model, and assessment of their activity on disease-representative cellular models, such as Alzheimer's disease and amyotrophic lateral sclerosis, have been conducted. The results demonstrate the potential of the new MTLs and their nanoparticle encapsu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Vanesa Nozal Paula Fern ández-Gómez Alfonso Garc ía-Rubia Loreto Mart ínez-González Eva P Cuevas Eva Carro Valle Palomo Ana Mart ínez Source Type: research
Altered spreading of fast aperiodic brain waves relates to disease duration in Amyotrophic Lateral Sclerosis
CONCLUSIONS: In this work, we provide a deeper characterization of neuronal avalanches propagation in ALS, describing their spatio-temporal trajectories and identifying the brain regions most likely to be involved in the process. This makes it possible to recognize the brain areas that take part in the pathogenic mechanisms of ALS. Furthermore, the nodal strength of the involved regions correlates directly with disease duration.SIGNIFICANCE: Our results corroborate the clinical relevance of aperiodic, fast large-scale brain activity as a biomarker of microscopic changes induced by neurophysiological processes.PMID:38663099...
Source: Clinical Neurophysiology - April 25, 2024 Category: Neurology Authors: Arianna Polverino Emahnuel Troisi Lopez Marianna Liparoti Roberta Minino Antonella Romano Lorenzo Cipriano Francesca Trojsi Viktor Jirsa Giuseppe Sorrentino Pierpaolo Sorrentino Source Type: research
Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation
In this study, we have designed two new MTLs that modulate three pharmacological targets simultaneously (tau, beta-amyloid and TAR DNA-binding protein 43). To enhance their brain penetration, we have formulated organic polymeric nanoparticles using poly(lactic-co-glycolic acid). The characterization of the formulations, evaluation of their permeability through an in vitro BBB model, and assessment of their activity on disease-representative cellular models, such as Alzheimer's disease and amyotrophic lateral sclerosis, have been conducted. The results demonstrate the potential of the new MTLs and their nanoparticle encapsu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Vanesa Nozal Paula Fern ández-Gómez Alfonso Garc ía-Rubia Loreto Mart ínez-González Eva P Cuevas Eva Carro Valle Palomo Ana Mart ínez Source Type: research
Altered spreading of fast aperiodic brain waves relates to disease duration in Amyotrophic Lateral Sclerosis
CONCLUSIONS: In this work, we provide a deeper characterization of neuronal avalanches propagation in ALS, describing their spatio-temporal trajectories and identifying the brain regions most likely to be involved in the process. This makes it possible to recognize the brain areas that take part in the pathogenic mechanisms of ALS. Furthermore, the nodal strength of the involved regions correlates directly with disease duration.SIGNIFICANCE: Our results corroborate the clinical relevance of aperiodic, fast large-scale brain activity as a biomarker of microscopic changes induced by neurophysiological processes.PMID:38663099...
Source: Clinical Neurophysiology - April 25, 2024 Category: Neurology Authors: Arianna Polverino Emahnuel Troisi Lopez Marianna Liparoti Roberta Minino Antonella Romano Lorenzo Cipriano Francesca Trojsi Viktor Jirsa Giuseppe Sorrentino Pierpaolo Sorrentino Source Type: research
Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 22:167192. doi: 10.1016/j.bbadis.2024.167192. Online ahead of print.ABSTRACTSeveral mutations in the SOD1 gene encoding for the antioxidant enzyme Superoxide Dismutase 1, are associated with amyotrophic lateral sclerosis, a rare and devastating disease characterized by motor neuron degeneration and patients' death within 2-5 years from diagnosis. Motor neuron loss and related symptomatology manifest mostly in adult life and, to date, there is still a gap of knowledge on the precise cellular and molecular events preceding neurodegeneration. To deepen our awareness of the early ph...
Source: Biochimica et Biophysica Acta - April 24, 2024 Category: Biochemistry Authors: Francesco Liguori Francesca Alberti Susanna Amadio Daniela Francesca Angelini Eleonora Pilesi Giuseppe Vitale Giulia Tesoriere Giovanna Borsellino Fiammetta Vern ì Cinzia Volont é Source Type: research
Identifying the Unmet Needs of People Living With Amyotrophic Lateral Sclerosis: A National Survey to Inform Interdisciplinary Palliative Care
Discussion: Interdisciplinary palliative care teams may enhance ALS care by promoting advance care planning behaviors (particularly discussing one's wishes with healthcare providers), providing interventions to improve quality of life, and supporting pALS in navigating challenges related to physical intimacy.PMID:38657132 | DOI:10.1177/10499091241248653 (Source: The American Journal of Hospice and Palliative Care)
Source: The American Journal of Hospice and Palliative Care - April 24, 2024 Category: Palliative Care Authors: Karla T Washington Charlton A Mechling Kyle A Pitzer Samuel Maiser Ambereen K Mehta Source Type: research
Real-time ultrasound-guided sacral plexus block combined with mild sedation for hemorrhoidectomy and hemorrhoidal artery ligation in a patient with amyotrophic lateral sclerosis: a case report
ConclusionsReal-time ultrasound-guided sacral plexus block combined with mild sedation may be an effective and safe technique in patients with amyotrophic lateral sclerosis undergoing hemorrhoidectomy and hemorrhoidal artery ligation. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 24, 2024 Category: General Medicine Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
Amyotrophic lateral sclerosis stratification: unveiling patterns with virome, inflammation, and metabolism molecules
AbstractAmyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status and progression has led to investigations that extend beyond motor neurons ’ pathology, encompassing broader systemic factors such as metabolism, immunity, and the microbiome. Our study contributes to this effort by examining the potential role of microbiome-related components, including viral elements, such as torque tenovirus (TTV), and various inflammatory factors, in ALS. In our analysis of serum samples from 10...
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research
Advance Care Planning in a Multidisciplinary Amyotrophic Lateral Sclerosis Clinic
1. Discuss the aspects of advance care planning that are unique or complex in patients with ALS.2. Discuss the effectiveness of integrated palliative care and social work to increase rates of ACP completion in a multidisciplinary, urban ALS clinic. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Astrid Grouls, James Orengo, Minh B. Nguyen Source Type: research
GSE264018 Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms
Contributors : Hang Sun ; Bingwei Yang ; Qiong Li ; Yang SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the dysfunction and progressive death of cerebral and spinal motor neurons. Preliminary epidemiological research has hinted at a relationship between environmental risks and the escalation of ALS, but the underlying reasons remain mostly mysterious. Here, we show that nano-size polystyrene plastics (PS) induce ALS-like symptoms and illustrate the related molecular mechanism. When exposed to ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
