Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS
This study compared expression of these HSPs in cultured motor neurons expressing three variants linked to familial ALS: TDP-43G348C, FUSR521G or SOD1G93A. All variants were poor inducers of Hspa1a, and reduced levels of Hspa8 mRNA and protein, indicating multiple compromises in chaperoning capacity. To promote HSP expression, cultures were treated with the putative HSP co-inducer, arimoclomol, class I histone deacetylase (HDAC) inhibitors to promote active chromatin for transcription, and the combination. Treatments had variable, often different effects on expression of Hspa1a and Hspa8, depending on the ALS variant expre...
Source: Cell Stress and Chaperones - April 3, 2024 Category: Cytology Authors: Mario Fern ández Comaduran Sandra Minotti Suleima Jacob-Tomas Javeria Rizwan Nancy Larochelle Richard Robitaille Chantelle F Sephton M Vera Josephine N Nalbantoglu Heather D Durham Source Type: research
Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA-protein interactions
Cell Mol Life Sci. 2024 Apr 3;81(1):162. doi: 10.1007/s00018-024-05204-4.ABSTRACTSpatiotemporal-controlled second messengers alter molecular interactions of central signaling nodes for ensuring physiological signal transmission. One prototypical second messenger molecule which modulates kinase signal transmission is the cyclic-adenosine monophosphate (cAMP). The main proteinogenic cellular effectors of cAMP are compartmentalized protein kinase A (PKA) complexes. Their cell-type specific compositions precisely coordinate substrate phosphorylation and proper signal propagation which is indispensable for numerous cell-type sp...
Source: Cellular and Molecular Life Sciences : CMLS - April 3, 2024 Category: Cytology Authors: Andreas Feichtner Florian Enzler Valentina Kugler Katharina Hoppe Sophia Mair Leopold Kremser Herbert Lindner Roland G Huber Ulrich Stelzl Eduard Stefan Omar Torres-Quesada Source Type: research
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS
This study compared expression of these HSPs in cultured motor neurons expressing three variants linked to familial ALS: TDP-43G348C, FUSR521G or SOD1G93A. All variants were poor inducers of Hspa1a, and reduced levels of Hspa8 mRNA and protein, indicating multiple compromises in chaperoning capacity. To promote HSP expression, cultures were treated with the putative HSP co-inducer, arimoclomol, class I histone deacetylase (HDAC) inhibitors to promote active chromatin for transcription, and the combination. Treatments had variable, often different effects on expression of Hspa1a and Hspa8, depending on the ALS variant expre...
Source: Cell Stress and Chaperones - April 3, 2024 Category: Cytology Authors: Mario Fern ández Comaduran Sandra Minotti Suleima Jacob-Tomas Javeria Rizwan Nancy Larochelle Richard Robitaille Chantelle F Sephton M Vera Josephine N Nalbantoglu Heather D Durham Source Type: research
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS
This study compared expression of these HSPs in cultured motor neurons expressing three variants linked to familial ALS: TDP-43G348C, FUSR521G or SOD1G93A. All variants were poor inducers of Hspa1a, and reduced levels of Hspa8 mRNA and protein, indicating multiple compromises in chaperoning capacity. To promote HSP expression, cultures were treated with the putative HSP co-inducer, arimoclomol, class I histone deacetylase (HDAC) inhibitors to promote active chromatin for transcription, and the combination. Treatments had variable, often different effects on expression of Hspa1a and Hspa8, depending on the ALS variant expre...
Source: Cell Stress and Chaperones - April 3, 2024 Category: Cytology Authors: Mario Fern ández Comaduran Sandra Minotti Suleima Jacob-Tomas Javeria Rizwan Nancy Larochelle Richard Robitaille Chantelle F Sephton M Vera Josephine N Nalbantoglu Heather D Durham Source Type: research
Neurogenic Dysphagia
This article provides an overview of neurogenic dysphagia, describing the evaluation and management of swallowing dysfunction in various neurologic diseases. The article will focus on stroke, Parkinson ’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 3, 2024 Category: ENT & OMF Authors: Swapna K. Chandran, Manon Doucet Source Type: research
Factors Affecting Performance on a Screening Tool in Persons with Amyotrophic Lateral Sclerosis
This study examined the relationship between performance of the ALS-Cognitive Behavioral Screen (ALS-CBS) and the demographic parameters of sex, education, time post-ALS diagnosis, and severity of symptoms. Data were collected retrospectively from 69 participants seen at the Mayo Clinic. Correlations were conducted on the ALS-CBS total scores and subsection scores and the above listed parameters; t-tests were conducted between participant subgroups. No statistically significant relationships or differences occurred between the ALS-CBS or its subsections and the variables measured with exception of age and the attention sub...
Source: Seminars in Speech and Language - April 2, 2024 Category: Speech-Language Pathology Authors: Jordan Stierwalt Julie A G Stierwalt Heather Clark Angela Burda Hanna Benavidez Kiley Erica Collins Morgan Kortemeyer Elizabeth Miller Grace Peckenschneider Elizabeth Schieltz Yashvi Shah Kayleigh Simon Source Type: research
Factors Affecting Performance on a Screening Tool in Persons with Amyotrophic Lateral Sclerosis
This study examined the relationship between performance of the ALS-Cognitive Behavioral Screen (ALS-CBS) and the demographic parameters of sex, education, time post-ALS diagnosis, and severity of symptoms. Data were collected retrospectively from 69 participants seen at the Mayo Clinic. Correlations were conducted on the ALS-CBS total scores and subsection scores and the above listed parameters; t-tests were conducted between participant subgroups. No statistically significant relationships or differences occurred between the ALS-CBS or its subsections and the variables measured with exception of age and the attention sub...
Source: Seminars in Speech and Language - April 2, 2024 Category: Speech-Language Pathology Authors: Jordan Stierwalt Julie A G Stierwalt Heather Clark Angela Burda Hanna Benavidez Kiley Erica Collins Morgan Kortemeyer Elizabeth Miller Grace Peckenschneider Elizabeth Schieltz Yashvi Shah Kayleigh Simon Source Type: research
Factors Affecting Performance on a Screening Tool in Persons with Amyotrophic Lateral Sclerosis
This study examined the relationship between performance of the ALS-Cognitive Behavioral Screen (ALS-CBS) and the demographic parameters of sex, education, time post-ALS diagnosis, and severity of symptoms. Data were collected retrospectively from 69 participants seen at the Mayo Clinic. Correlations were conducted on the ALS-CBS total scores and subsection scores and the above listed parameters; t-tests were conducted between participant subgroups. No statistically significant relationships or differences occurred between the ALS-CBS or its subsections and the variables measured with exception of age and the attention sub...
Source: Seminars in Speech and Language - April 2, 2024 Category: Speech-Language Pathology Authors: Jordan Stierwalt Julie A G Stierwalt Heather Clark Angela Burda Hanna Benavidez Kiley Erica Collins Morgan Kortemeyer Elizabeth Miller Grace Peckenschneider Elizabeth Schieltz Yashvi Shah Kayleigh Simon Source Type: research
Qualitative analysis of initial palliative care consultations in amyotrophic lateral sclerosis
This study reports the analysis of PC consult notes from a larger feasibility trial. The specific aims of this analysis were to i) identify the PC needs of patients with ALS via qualitative analysis and ii) identify characteristics of patients and caregivers that could predict specific PC needs. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 2, 2024 Category: Palliative Care Authors: Christine L. Watt, Ian C. Smith, Jill Rice, Rebekah Murphy, Ari Breiner, Maria Duff, Danica Nogo, Shirley H. Bush, Susan McNeely, Usha Buenger, Belinda Zehrt, Jocelyn Zwicker Tags: Original Article Source Type: research
Artificial intelligence for screening and diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis
. (Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration)
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - April 2, 2024 Category: Neurology Authors: Tungki Pratama UmarNityanand JainManthia PapageorgakopoulouRahma Sameh ShaheenJehad Feras AlsamhoriMuhammad MuzzamilAndrejs Kostiks1 Department of Medical Profession, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia2 Faculty of Medicine, R Source Type: research
Factors Affecting Performance on a Screening Tool in Persons with Amyotrophic Lateral Sclerosis
This study examined the relationship between performance of the ALS-Cognitive Behavioral Screen (ALS-CBS) and the demographic parameters of sex, education, time post–ALS diagnosis, and severity of symptoms. Data were collected retrospectively from 69 participants seen at the Mayo Clinic. Correlations were conducted on the ALS-CBS total scores and subsection scores and the above listed parameters; t-tests were conducted between participant subgroups. No statistically significant relationships or differences occurred between the ALS-CBS or its subsections and the variables measured with exception of age and the attention s...
Source: Seminars in Speech and Language - April 2, 2024 Category: Speech-Language Pathology Authors: Stierwalt, Jordan Stierwalt, Julie A.G. Clark, Heather Burda, Angela Benavidez Kiley, Hanna Collins, Erica Kortemeyer, Morgan Miller, Elizabeth Peckenschneider, Grace Schieltz, Elizabeth Shah, Yashvi Simon, Kayleigh Tags: Review Article Source Type: research
Analgesic Strategies in Patients With Amyotrophic Lateral Sclerosis #477
Journal of Palliative Medicine,Volume 27, Issue 4, Page 565-566, April 2024. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - April 2, 2024 Category: Palliative Care Authors: Emma E. Meyers Kate T. Brizzi Source Type: research
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Curr Protein Pept Sci. 2024 Mar 29. doi: 10.2174/0113892037275221240327042353. Online ahead of print.ABSTRACTNeurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant and growing global health challenge. Current therapies predominantly focus on symptom management rather than altering disease progression. In this review, we discuss the major therapeutic strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments are cholinesterase inhibitors and N-me...
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Kuldeep Singh Jeetendra Kumar Gupta Shivendra Kumar Urvashi Soni Source Type: research
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Curr Protein Pept Sci. 2024 Mar 29. doi: 10.2174/0113892037275221240327042353. Online ahead of print.ABSTRACTNeurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant and growing global health challenge. Current therapies predominantly focus on symptom management rather than altering disease progression. In this review, we discuss the major therapeutic strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments are cholinesterase inhibitors and N-me...
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Kuldeep Singh Jeetendra Kumar Gupta Shivendra Kumar Urvashi Soni Source Type: research
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Curr Protein Pept Sci. 2024 Mar 29. doi: 10.2174/0113892037275221240327042353. Online ahead of print.ABSTRACTNeurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant and growing global health challenge. Current therapies predominantly focus on symptom management rather than altering disease progression. In this review, we discuss the major therapeutic strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments are cholinesterase inhibitors and N-me...
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Kuldeep Singh Jeetendra Kumar Gupta Shivendra Kumar Urvashi Soni Source Type: research
