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CHCHD10 < sup > S59L/+ < /sup > mouse model: Behavioral and neuropathological features of frontotemporal dementia
Neurobiol Dis. 2024 Apr 5:106498. doi: 10.1016/j.nbd.2024.106498. Online ahead of print.ABSTRACTCHCHD10-related disease causes a spectrum of clinical presentations including mitochondrial myopathy, cardiomyopathy, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We generated a knock-in mouse model bearing the p.Ser59Leu (S59L) CHCHD10 variant. Chchd10S59L/+ mice have been shown to phenotypically replicate the disorders observed in patients: myopathy with mtDNA instability, cardiomyopathy and typical ALS features (protein aggregation, neuromuscular junction degeneration and spinal motor neuron loss). H...
Source: Neurobiology of Disease - April 7, 2024 Category: Neurology Authors: Emmanuelle C Genin Pauline Pozzo di Borgo Thomas Lorivel Sandrine Hugues M élissa Farinelli Alessandra Mauri-Crouzet Fran çoise Lespinasse Lucas Godin V éronique Paquis-Flucklinger Agn ès Petit-Paitel Source Type: research

Sensors, Vol. 24, Pages 2355: Analysis of Heart Rate Variability in Individuals Affected by Amyotrophic Lateral Sclerosis
Conclusion: The Polar H7 Bluetooth&reg; device is effective in determining heart rate variability alterations in ALS, being a promising prognostic tool for the disease. (Source: Sensors)
Source: Sensors - April 7, 2024 Category: Biotechnology Authors: Rosa Maset-Roig Jordi Caplliure-Llopis Nieves de Bernardo Jes ús Privado Jorge Alarc ón-Jiménez Julio Mart ín-Ruiz Marta Botella-Navas Carlos Villar ón-Casales David Sancho-Cantus Jos é Enrique de la Rubia Ortí Tags: Article Source Type: research

Regulated cell death and its role in Alzheimer ’s disease and amyotrophic lateral sclerosis
AbstractDespite considerable research efforts, it is still not clear which mechanisms underlie neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple pathways have been identified that can execute regulated cell death (RCD). Among these RCD pathways, apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy-related cell death, and lysosome-dependent cell death have been intensively investigated. Although RCD consists of numerou s individual pathways, multiple common proteins have been identified that allow shifting from one cell death pathway to another. Another layer of complexity is adde...
Source: Acta Neuropathologica - April 7, 2024 Category: Neurology Source Type: research

Effectiveness of atropine in managing sialorrhea: A systematic review and meta-analysis
CONCLUSION: Atropine is efficacious in managing sialorrhea in most disease states. Sublingual administration of atropine is superior to other routes of administration in reducing salivary flow in patients with sialorrhea.PMID:38577753 | DOI:10.5414/CP204538 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Venkata K Yellepeddi Jonathan A Race Mary M McFarland Jonathan E Constance Elika Fanaeian Nancy A Murphy Source Type: research

Effectiveness of atropine in managing sialorrhea: A systematic review and meta-analysis
CONCLUSION: Atropine is efficacious in managing sialorrhea in most disease states. Sublingual administration of atropine is superior to other routes of administration in reducing salivary flow in patients with sialorrhea.PMID:38577753 | DOI:10.5414/CP204538 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Venkata K Yellepeddi Jonathan A Race Mary M McFarland Jonathan E Constance Elika Fanaeian Nancy A Murphy Source Type: research

KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
Cell Stem Cell. 2024 Apr 4;31(4):519-536.e8. doi: 10.1016/j.stem.2024.03.004.ABSTRACTTraumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it remains unclear which neurodegenerative mechanisms are intrinsic to the brain and which strategies most potently mitigate these processes. We developed a high-intensity ultrasound platform to inflict mechanical injury to induced pluripotent stem cell (iPSC)-derived cortical organoids. Mechanically injured organoids elicit classic hallmarks of TBI, including neuronal death, tau phosphorylation, and TDP-43 nuclear egress. We found that deep-layer neu...
Source: Cell Stem Cell - April 5, 2024 Category: Stem Cells Authors: Jesse D Lai Joshua E Berlind Gabriella Fricklas Cecilia Lie Jean-Paul Urenda Kelsey Lam Naomi Sta Maria Russell Jacobs Violeta Yu Zhen Zhao Justin K Ichida Source Type: research

Effectiveness of atropine in managing sialorrhea: A systematic review and meta-analysis
CONCLUSION: Atropine is efficacious in managing sialorrhea in most disease states. Sublingual administration of atropine is superior to other routes of administration in reducing salivary flow in patients with sialorrhea.PMID:38577753 | DOI:10.5414/CP204538 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Venkata K Yellepeddi Jonathan A Race Mary M McFarland Jonathan E Constance Elika Fanaeian Nancy A Murphy Source Type: research