Altered spreading of fast aperiodic brain waves relates to disease duration in Amyotrophic Lateral Sclerosis

CONCLUSIONS: In this work, we provide a deeper characterization of neuronal avalanches propagation in ALS, describing their spatio-temporal trajectories and identifying the brain regions most likely to be involved in the process. This makes it possible to recognize the brain areas that take part in the pathogenic mechanisms of ALS. Furthermore, the nodal strength of the involved regions correlates directly with disease duration.SIGNIFICANCE: Our results corroborate the clinical relevance of aperiodic, fast large-scale brain activity as a biomarker of microscopic changes induced by neurophysiological processes.PMID:38663099 | DOI:10.1016/j.clinph.2024.04.003

Source: Clinical Neurophysiology - April 25, 2024 Category: Neurology Authors: Arianna Polverino Emahnuel Troisi Lopez Marianna Liparoti Roberta Minino Antonella Romano Lorenzo Cipriano Francesca Trojsi Viktor Jirsa Giuseppe Sorrentino Pierpaolo Sorrentino Source Type: research