03:00 PM Abstract No. 393 A phase I/II study of direct injection of Bromelain and Acetylcysteine in patients with inoperable mucinous peritoneal tumours
Many patients with mucinous peritoneal tumours achieve long-term recurrence free and overall survival from cytoreductive surgery and intraperitoneal chemotherapy, however recurrence is frequently seen. Repeat surgical interventions have a negative impact on quality of life, risks may outweigh any potential benefits and repeated admissions have a considerable impact on healthcare systems. The deconditioned patient is eventually deemed inoperable with no treatment option for their disease. In an attempt to modify these outcomes, we discovered remarkable synergy in extensive preclinical studies between Bromelain (Br) and Acet...
Source: Journal of Vascular and Interventional Radiology : JVIR - February 23, 2019 Category: Radiology Authors: S. Valle, J. Akhter, D. Glenn, M. Power, S. Lodh, W. Liauw Tags: Scientific Session 41: Other Nonvascular Interventions Source Type: research
Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss
The underlying molecular mechanisms of age-related hearing loss (ARHL) in humans and many strains of mice have not been fully characterized. This common age-related disorder is assumed to be closely associated with oxidative stress. Here, we demonstrate that mTORC1 signaling is highly and specifically activated in the cochlear neurosensory epithelium (NSE) in aging mice, and rapamycin injection prevents ARHL. To further examine the specific role of mTORC1 signaling in ARHL, we generated murine models with NSE-specific deletions of Raptor or Tsc1, regulators of mTORC1 signaling. Raptor-cKO mice developed hearing loss consid...
Source: Journal of Clinical Investigation - November 2, 2018 Category: Biomedical Science Authors: Xiaolong Fu, Xiaoyang Sun, Linqing Zhang, Yecheng Jin, Renjie Chai, Lili Yang, Aizhen Zhang, Xiangguo Liu, Xiaochun Bai, Jianfeng Li, Haibo Wang, Jiangang Gao Source Type: research
Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy
ConclusionCisplatin ototoxicity can be detected by auditory brain stem responses and otoacoustic emissions testing in rats. N-acetylcysteine may protect the cochlear cells from histopathological changes. We concluded that N-acetylcysteine given 4 h after cisplatin injection has a potential otoprotective effect against cisplatin ototoxicity. which suggests it could be used in clinical trials.ResumoIntroduçãoA ototoxicidade é um problema de saúde que surge após certos tipos de tratamentos para condições graves de saúde. Às vezes é inevitável quando o tratamento da doença é necessário. A cisplatina é um ag...
Source: Brazilian Journal of Otorhinolaryngology - September 15, 2018 Category: ENT & OMF Source Type: research
Oxidative stress mediated mitochondrial damage plays roles in pathogenesis of diabetic nephropathy rat.
CONCLUSIONS: Oxidative stress-mediated mitochondrial damage is an important part of the pathogenesis of DN. Inhibition of ROS production can be a potential target for DN treatment.
PMID: 30178848 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Peroxiredoxin I maintains luteal function by regulating unfolded protein response.
CONCLUSION: These observations provide the first evidence regarding the basic mechanisms connecting PRDX1 and progesterone production in the functional stage of CL.
PMID: 30111318 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - August 15, 2018 Category: Reproduction Medicine Authors: Park HJ, Lee DG, Seong JB, Lee HS, Kwon OS, Kang BS, Park JW, Lee SR, Lee DS Tags: Reprod Biol Endocrinol Source Type: research
A comparison of the effects of thymoquinone, silymarin and N-acetylcysteine in an experimental hepatotoxicity
This study investigated the effects of thymoquinone, silymarin, and N-acetylcysteine in a rat model with carbon tetrachloride (CCl4)-induced hepatotoxicity. Although numerous similar studies are available, we aimed to compare the efficacy of these agents by considering N-acetylcysteine as a reference compound. A total of 50 male Wistar albino rats were randomly designated as 5 groups: Group I, CCl4; group II, thymoquinone and CCl4; group III, silymarin and CCl4; group IV, N-acetylcysteine and CCl4; group V, control group. CCl4 was administered intraperitoneally at a dose of 1.5 mL/kg (a mixture of CCl4: olive oil, 1:2)...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research
Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives [Basic Sciences]
Conclusions—The results indicate that detoxification of acrolein by NAC derivatives is caused through glutathione conjugation with acrolein catalyzed by glutathione S-transferases, which can be stabilized by NAC derivatives. This is a new concept of acrolein detoxification by NAC derivatives. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Takeshi Uemura, Kenta Watanabe, Kenta Ko, Kyohei Higashi, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Koichi Takao, Yoshiaki Sugita, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi Tags: Animal Models of Human Disease, Ischemia, Oxidant Stress, Ischemic Stroke Original Contributions Source Type: research
Fast and reliable BIA/amperometric quantification of acetylcysteine using a nanostructured double hydroxide sensor.
This study reports the preparation and characterization of nickel/lead hydroxide nanoparticles used to construct electrochemical sensors, which were investigated for amperometric quantification of N-acetylcysteine (NAC). The newly synthesised material presents good uniformity, with the lead (II) ions homogenously incorporated into the alpha nickel hydroxide crystal structure, confirmed by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy analyses. Films of nanoparticles (3 nm in size) were prepared on conductive fluorine-doped tin oxide-coated glass slides and used connected to a sp...
Source: Talanta - May 24, 2018 Category: Chemistry Authors: Correa AL, Gonçalves JM, Rossini PO, Bernardes JS, Neves CA, Araki K, Angnes L Tags: Talanta Source Type: research
Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice.
In this study, we investigated the protective effect of kaempferol on propacetamol-induced ALI and its underlying mechanism in mice. Kaempferol pretreatment (125 mg/Kg) before propacetamol injection significantly decreased propacetamol-induced serum ALT and AST activities, and DNA fragmentation. Kaempferol administration also reduced propacetamol-induced oxidative stress by inhibiting thiobarbituric acid reactive substances (TBARS) and 3-nitrotyrosine (3-NT) formation partly through downregulation of cytochrome P450 2E1 (CYP2E1) expression, upregulation of UDP glucuronosyltransferase family 1 member A1 (UGT1A1) expressio...
Source: Toxicology Letters - March 21, 2018 Category: Toxicology Authors: Tsai MS, Wang YH, Lai YY, Tsou HK, Liou GG, Ko JL, Wang SH Tags: Toxicol Lett Source Type: research
Endocrine disrupting chemicals, 4 ‐nonylphenol, bisphenol A and butyl benzyl phthalate, impair metabolism of estradiol in male and female rats as assessed by levels of 15α‐hydroxyestrogens and catechol estrogens in urine
Abstract
Bisphenol A (BPA), 4‐nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine‐disrupting chemicals, are known to mimic estrogen activity. The effects of these chemicals on 17β‐estradiol (E2) metabolism in vivo in rats were examined. Male and female rats were given NP (250 mg kg–1 day–1), BPA (250 μg kg–1 day–1) or BBP (500 mg kg–1 day–1) by gavage for 14 days, followed by a single intraperitoneal injection of E2 (5 mg kg–1) on the final day. The urinary excretion over 72 hours of 2‐hydroxyestrone 1‐N‐acetylcysteine thioether, 2‐hydroxyestrone 4‐N‐acetylcysteine...
Source: Journal of Applied Toxicology - December 18, 2017 Category: Toxicology Authors: Madoka Nakagomi, Emako Suzuki, Yoshiaki Saito, Tetsuji Nagao Tags: RESEARCH ARTICLE Source Type: research
N-acetylcysteine ameliorates contrast ‑induced kidney injury in rats with unilateral hydronephrosis.
N-acetylcysteine ameliorates contrast‑induced kidney injury in rats with unilateral hydronephrosis.
Mol Med Rep. 2017 Nov 21;:
Authors: Xia Q, Liu C, Zheng X
Abstract
The aim of the present study was to investigate the protective effects of N‑acetylcysteine (NAC) on contrast‑induced acute kidney injury in rats with unilateral hyronephrosis. Eighty‑two male Sprague Dawley rats were randomized to undergo sham operation (n=14) or unilateral ureteral obstruction (UUO) (n=68). After 3 weeks, the UUO animals were randomized to three groups: NAC gastric perfusion, UUO+iohexol+NA...
Source: Molecular Medicine Reports - December 6, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Inhibition of Advanced Glycation Endproduct (AGE) Rescues against Streptozotocin-Induced Diabetic Cardiomyopathy: Role of Autophagy and ER Stress.
This study was designed to assess the role of inhibition of advanced glycation endproducts (AGE) in streptozotocin (STZ)-induced diabetic cardiac dysfunction. Cardiac contractile function was assessed in normal C57BL/6 and STZ (200mg/kg, single injection and maintained for 2 wks)-induced diabetic mice treated with or without the AGE inhibitor aminoguanidine (50mg/kg/d in drinking water) for 2 weeks using echocardiography and IonOptix MyoCam techniques. Diabetes compromised cardiac contractile function shown as reduced fractional shortening and ejection fraction, enlarged left ventricular end systolic/diastolic diameters, d...
Source: Toxicology Letters - November 22, 2017 Category: Toxicology Authors: Pei Z, Deng Q, Babcock SA, He EY, Ren J, Zhang Y Tags: Toxicol Lett Source Type: research
Effects of particulate matter from straw burning on lung fibrosis in mice
Conclusion Exposure of mice with BLM-induced IPF to PM2.5 from straw burning exacerbated lung inflammation and fibrosis and increased mortality; NAC increased the mouse survival, indicating protective effects. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 8, 2017 Category: Environmental Health Source Type: research
Mitigation of Acute Aluminum Toxicity by Sodium Selenite and N-Acetylcysteine in Adult Male Rats.
The objective of this study is to investigate the toxic effects of aluminum and the potential alleviation of selenite and N-acetylcysteine (NAC) on this toxicity. Acute aluminum toxicity was induced by intraperitoneal (i.p.) injection of AlCl3 (30 mg Al(3+)/kg) for four consecutive days. Al(3+) damaged the synthetic capability and regeneration power of liver cells and induced inflammation. It also damaged the kidney and disturbed the lipid profile enhancing the total cholesterol level and LDL-cholesterol level increasing the risks of atherosclerosis. Al(3+) reduced the cellular antioxidant milieu typified by the decrease ...
Source: Biological Trace Element Research - August 17, 2017 Category: Biology Authors: Nour-Eldein NH, Hassanin EA, El-Sayed WM Tags: Biol Trace Elem Res Source Type: research
The Role of Oxidative Stress in Acute Renal Injury of Newborn Rats Exposed to Hypoxia and Endotoxin
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - July 17, 2017 Category: Research Authors: Egor Y. Plotnikov, Tatiana A. Pavlenko, Irina B. Pevzner, Ljubava D. Zorova, Vasily N. Manskikh, Denis N. Silachev, Gennady T. Sukhikh, Dmitry B. Zorov Tags: Original Article Source Type: research
