Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration
This study aimed to investigate expression patterns, regulatory mechanisms and pathological roles of neuronal NADPH oxidase in inflammation-associated neurodegeneration. The results showed persistent upregulation of NOX2 (gp91phox; the catalytic subunit of NADPH oxidase) in both microglia and neurons in a chronic mouse model of Parkinson's disease (PD) with intraperitoneal LPS injection and LPS-treated midbrain neuron-glia cultures (a cellular model of PD). Notably, NOX2 was found for the first time to exhibit a progressive and persistent upregulation in neurons during chronic neuroinflammation. While primary neurons and N...
Source: Free Radical Biology and Medicine - March 4, 2023 Category: Biology Authors: Dezhen Tu Ravikanth Velagapudi Yun Gao Jau-Shyong Hong Hui Zhou Hui-Ming Gao Source Type: research
Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling
In conclusion, YOL had a protective and therapeutic role in APAP-induced liver injury in mice by activating Nrf2 signaling pathway and autophagy.PMID:36115150 | DOI:10.1016/j.ecoenv.2022.114073 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - September 17, 2022 Category: Environmental Health Authors: Yong-Ming He Xing-Ling Shen Yan-Na Guo Shao-Shan Liang Kang-Ning Ding Meng-Han Lu Lu-Ping Tang Source Type: research
Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway
In this study, 4-phenylbutyric acid (4PBA, a chemical chaperone) and small interference RNA (siRNA) knockdown of C/EBP Homologous Protein (CHOP)/growth arrest- and DNA damage-inducible gene 153(GAD153) blocked NPC-402-mediated autophagy induction, thus confirming the role of ER stress and autophagy in melanoma cell death. NPC-402 induced oxidative stress and apoptosis in melanoma cells, which were effectively mitigated by treatment with N-acetylcysteine (NAC). In vivo studies showed that intraperitoneal (i.p.) injection of NPC-402 at 10 mg/kg (5 days in 1 week) significantly retarded angiogenesis in the Matrigel plug assay...
Source: Frontiers in Oncology - August 2, 2022 Category: Cancer & Oncology Source Type: research
Parthanatos participates in glutamate-mediated HT22 cell injury and hippocampal neuronal death in kainic acid-induced status epilepticus rats
CONCLUSION: Parthanatos participates in glutamate-induced HT22 cell injury and hippocampal neuronal damage in rats following epileptic seizures. ROS might be the initiating factor during parthanatos.PMID:35909335 | DOI:10.1111/cns.13934 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 1, 2022 Category: Neuroscience Authors: Xue Wang Wuqiong Zhang Pengfei Ge Miaomiao Yu Hongmei Meng Source Type: research
Parthanatos participates in glutamate-mediated HT22 cell injury and hippocampal neuronal death in kainic acid-induced status epilepticus rats
CONCLUSION: Parthanatos participates in glutamate-induced HT22 cell injury and hippocampal neuronal damage in rats following epileptic seizures. ROS might be the initiating factor during parthanatos.PMID:35909335 | DOI:10.1111/cns.13934 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 1, 2022 Category: Neuroscience Authors: Xue Wang Wuqiong Zhang Pengfei Ge Miaomiao Yu Hongmei Meng Source Type: research
Radioprotective effects of N-acetylcysteine on rats' brainstem following megavoltage X-irradiations
CONCLUSION: Based on the results, NAC can decrease the irradiation-induced oxidative stress and pathology damages in the rats' brainstem. It can be concluded that NAC can be an appropriate radioprotection candidate for the human brainstem.PMID:35779304 | DOI:10.1016/j.apradiso.2022.110348 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - July 2, 2022 Category: Radiology Authors: Elham Motallebzadeh Marwah Suliman Maashi Mustafa Z Mahmoud Akbar Aliasgharzedeh Zarichehr Vakili Sayyed Alireza Talaei Mehran Mohseni Source Type: research
Radioprotective effects of N-acetylcysteine on rats' brainstem following megavoltage X-irradiations
CONCLUSION: Based on the results, NAC can decrease the irradiation-induced oxidative stress and pathology damages in the rats' brainstem. It can be concluded that NAC can be an appropriate radioprotection candidate for the human brainstem.PMID:35779304 | DOI:10.1016/j.apradiso.2022.110348 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - July 2, 2022 Category: Radiology Authors: Elham Motallebzadeh Marwah Suliman Maashi Mustafa Z Mahmoud Akbar Aliasgharzedeh Zarichehr Vakili Sayyed Alireza Talaei Mehran Mohseni Source Type: research
Anti-inflammatory effects of N-Acetylcysteine and Elaeagnus angustifolia extract on acute lung injury induced by λ-carrageenan in rat
In this study, 42 rats were randomly assigned into seven groups. NAC and EA extracts were orally administered once/day for 21 continuous days. Pulmonary damage was induced by intratracheal injection of 100 μl of 2% λ-Carrageenan on day 21. Twenty-four hours post-surgery, the rats were euthanized and the samples were collected. Pretreatment with NAC and EA extracts reduced the total and differential cell accumulation as well as IL-6, and TNF-α cytokines. Antioxidant indicators demonstrate that in the groups receiving NAC and EA extract, MDA decreased while thiol and antioxidant capacity elevated. Treatment with NAC and...
Source: Inflammopharmacology - June 20, 2022 Category: Drugs & Pharmacology Source Type: research
Gandan Oral Liquid Improves Exudative Pneumonia by Upregulating Bacteria Clearance via Regulating AQP5 and MUC5AC in Rats
Conclusion. GOL accelerates the water secretion of respiratory tract, inhibits the inflammatory response, induces removal of bacteria of respiratory tract via the AQPs/MUC pathway, and ultimately ameliorates EP.PMID:35518345 | PMC:PMC9064532 | DOI:10.1155/2022/3890347 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 6, 2022 Category: Complementary Medicine Authors: Yinlong Wang Jing Yan Peijia Wang Xiaoqin Xu Source Type: research
Optimal N-acetylcysteine concentration for intratympanic injection to prevent cisplatin-induced ototoxicity in guinea pigs
CONCLUSIONS AND SIGNIFICANCE: Intratympanic NAC administration is an efficient and safe means of preventing cisplatin-induced ototoxicity. In our animal model, the optimal intratympanic NAC concentration was 2%; concentrations of 4% loss of otoprotection.PMID:35287541 | DOI:10.1080/00016489.2022.2038796 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - March 15, 2022 Category: ENT & OMF Authors: Bo-Cheng Chen Lian-Jie Lin Yi-Chen Lin Chia-Fone Lee Wei-Chung Hsu Source Type: research
Optimal N-acetylcysteine concentration for intratympanic injection to prevent cisplatin-induced ototoxicity in guinea pigs
CONCLUSIONS AND SIGNIFICANCE: Intratympanic NAC administration is an efficient and safe means of preventing cisplatin-induced ototoxicity. In our animal model, the optimal intratympanic NAC concentration was 2%; concentrations of 4% loss of otoprotection.PMID:35287541 | DOI:10.1080/00016489.2022.2038796 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - March 15, 2022 Category: ENT & OMF Authors: Bo-Cheng Chen Lian-Jie Lin Yi-Chen Lin Chia-Fone Lee Wei-Chung Hsu Source Type: research
Optimal N-acetylcysteine concentration for intratympanic injection to prevent cisplatin-induced ototoxicity in guinea pigs
CONCLUSIONS AND SIGNIFICANCE: Intratympanic NAC administration is an efficient and safe means of preventing cisplatin-induced ototoxicity. In our animal model, the optimal intratympanic NAC concentration was 2%; concentrations of 4% loss of otoprotection.PMID:35287541 | DOI:10.1080/00016489.2022.2038796 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - March 15, 2022 Category: ENT & OMF Authors: Bo-Cheng Chen Lian-Jie Lin Yi-Chen Lin Chia-Fone Lee Wei-Chung Hsu Source Type: research
Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death
In this study, we aim to investigate the protective effect of Amygdalin in the APAP-induced acute liver failure mice model. We establish the ALI model via intraperitoneal APAP injection and mice were treated with Amygdalin with intraperitoneal injection. We detected liver enzyme and histological change to evaluate the liver injury. We measured oxidative damage markers and inflammatory cell infiltration of liver tissues. At last, we investigated the mechanism of Amygdalin on protecting hepatocytes. Results showed that Amygdalin reduced ALT/AST level and decreased necrotic area of liver tissue. In addition, Amygdalin reduced...
Source: Cell Research - March 8, 2022 Category: Cytology Authors: Congcong Zhang Jiacheng Lin Chao Zhen Fang Wang Xuehua Sun Xiaoni Kong Yueqiu Gao Source Type: research
