Optimal N-acetylcysteine concentration for intratympanic injection to prevent cisplatin-induced ototoxicity in guinea pigs

CONCLUSIONS AND SIGNIFICANCE: Intratympanic NAC administration is an efficient and safe means of preventing cisplatin-induced ototoxicity. In our animal model, the optimal intratympanic NAC concentration was 2%; concentrations of 4% loss of otoprotection.PMID:35287541 | DOI:10.1080/00016489.2022.2038796

Source: Acta Oto-Laryngologica - March 15, 2022 Category: ENT & OMF Authors: Bo-Cheng Chen Lian-Jie Lin Yi-Chen Lin Chia-Fone Lee Wei-Chung Hsu Source Type: research