Oxidized LDL‐induced angiogenesis involves sphingosine 1‐phosphate: prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data highlight the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and demonstrate that the anti‐S1P antibody effectively blocks the angiogenic effect of oxLDL. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: RESEARCH PAPER Source Type: research
Clinical Features and Patient Management of Lujo Hemorrhagic Fever
Conclusions Lujo virus causes a clinical syndrome remarkably similar to Lassa fever. Considering the high case-fatality and significant logistical impediments to controlled treatment efficacy trials for viral hemorrhagic fever, it is both logical and ethical to explore the use of the various compounds used in the treatment of the surviving case reported here in future outbreaks. Clinical observations should be systematically recorded to facilitate objective evaluation of treatment efficacy. Due to the risk of secondary transmission, viral hemorrhagic fever precautions should be implemented for all cases of Lujo virus infec...
Source: PLoS Neglected Tropical Diseases - November 13, 2014 Category: Tropical Medicine Authors: Nivesh H. Sewlall et al. Source Type: research
N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress
Publication date: Available online 7 October 2014 Source:Reproductive BioMedicine Online Author(s): Monireh Mahmoodi , Malek Soleimani Mehranjani , Seyed Mohammad Ali Shariatzadeh , Hussein Eimani , Abdulhussein Shahverdi The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4–5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before until 7 days after transplantation. After 28 days, ovary compartments were es...
Source: Reproductive BioMedicine Online - November 11, 2014 Category: Reproduction Medicine Source Type: research
Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement
Publication date: Available online 3 November 2014 Source:Pharmacological Research Author(s): Pedro Bullón , Lourdes Román-Malo , Fabiola Marín-Aguilar , José Miguel Alvarez-Suarez , Francesca Giampieri , Maurizio Battino , Mario D. Cordero Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxyg...
Source: Pharmacological Research - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Efficacy of Preventive Interventions for Iodinated Contrast-Induced Acute Kidney Injury Evaluated by Intrarenal Oxygenation as an Early Marker
ConclusionsThis is the first study to evaluate the effects of interventions to mitigate the deleterious effects of contrast media using BOLD MRI. The rate of increase in R2* after administration of iodinated contrast is associated with acute renal injury as evaluated by NGAL. Further studies are warranted to determine the optimum dose of furosemide and NAC for mitigating the ill effects of contrast media. Because NGAL has been shown to be useful in humans to document iodinated contrast-induced acute kidney injury, the method presented in this study using BOLD MRI and NGAL measurements can be translated to humans. (Source: ...
Source: Investigative Radiology - October 1, 2014 Category: Radiology Tags: Original Articles Source Type: research
Oxidized LDL‐induced angiogenesis involves sphingosine‐1‐phosphate. Prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data emphasize the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and the efficacy of the anti‐S1P antibody in blocking the angiogenic effect of oxLDL. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - September 1, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: Research Paper Source Type: research
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
CONCLUSION: MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress, and cytoprotective agents (NAC > AMF > ASC) may alleviate MTX hepatotoxicity.
PMID: 25110444 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y Tags: World J Gastroenterol Source Type: research
Oral Presentations.
In conclusion, a novel composite polymeric film was fabricated using simple electrochemical method and applied for determination of CPM in real samples. The sensor showed a good stability and sensitivity regardless the matrix of the pharmaceutical preparation. References 1. Rubinstein I, Bard A. J. J. Am. Chem. SOC. 1980;102;6641-6842. 2. Su M, Wei W, Liu S. Analytica Chimica Acta 2011;704:16-32. 3. Zhang B, Shi S, Shi W, Sun Z, Kong X, Wei M, Duan X. Electrochimica Acta 2012;67:133-139. O0006 Experimental Evidence of the Occurrence of an Intermolecular Electron Transfer in the Catalyzed Decomposition of spiro-Alkyl-1,2-Di...
Source: Clinical Breast Cancer - June 12, 2014 Category: Cancer & Oncology Tags: Luminescence Source Type: research
Protective effects of N-acetylcysteine on triamcinolone acetonide-induced lens damage in rats.
Conclusion: These results indicate that the NAC produces a protective mechanism against IVTA-induced cataract and suggest a role of oxidative stress in pathogenesis.
PMID: 24641112 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - March 18, 2014 Category: Toxicology Authors: Tuzcu EA, Tuzcu K, Basarslan F, Motor S, Coskun M, Keskin U, Ayintap E, Ilhan O, Oksuz H Tags: Cutan Ocul Toxicol Source Type: research
Preconditioning renoprotective effect of isoflurane in a rat model of virtual renal transplant
Conclusions: We present the first study demonstrating that the administration of volatile isoflurane before induction of experimental warm–cold renal IR injury provides preconditioning renoprotective effect, which is superior to the treatment with NAC. The beneficial renoprotective effect of isoflurane is most likely mediated by attenuation of proinflammatory reaction in the injured kidney. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - February 26, 2014 Category: Surgery Authors: Min-Wen Su, Shen-Shin Chang, Chung-Hao Chen, Chien-Chi Huang, Shih-Wei Chang, Yu-Chuan Tsai, Chen-Fuh Lam Tags: Transplantation/Immunology Source Type: research
Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets.
In conclusion, these results suggest that dietary NAC supplementation alleviates LPS-induced liver injury by reducing the secretion of pro-inflammatory cytokines, increasing the antioxidative capacity and improving energy metabolism.
PMID: 23829996 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - July 8, 2013 Category: Nutrition Authors: Yi D, Hou Y, Wang L, Ding B, Yang Z, Li J, Long M, Liu Y, Wu G Tags: Br J Nutr Source Type: research
N-acetylcysteine does not prevent contrast nephropathy in patients with renal impairment undergoing emergency CT: a randomized study
Conclusions:
An ultra-high dose of intravenous N-acetylcysteine is ineffective at preventing nephrotoxicity in patients with renal impairment undergoing emergency contrast CT.Trial registration: The study was registered as Clinical trial (NCT01467154). (Source: BMC Nephrology)
Source: BMC Nephrology - June 3, 2013 Category: Urology & Nephrology Authors: Pierre-Alexandre PolettiAlexandra PlatonSophie De SeigneuxElise Dupuis-LozeronFrançois SarasinChristoph BeckerThomas PernegerPatrick SaudanPierre-Yves Martin Source Type: research
Prophylactic maternal N-acetylcysteine in rats prevents maternal inflammation–induced offspring cerebral injury shown on magnetic resonance imaging
Conclusion:
Maternal NAC treatment significantly reduced evidence of neonatal brain injury associated with maternal LPS. These studies suggest that maternal NAC therapy may be effective in human deliveries associated with maternal/fetal inflammation. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 22, 2013 Category: OBGYN Authors: Ron Beloosesky, Yuval Ginsberg, Nizar Khatib, Nir Maravi, Michael G. Ross, Joseph Itskovitz-Eldor, Zeev Weiner Tags: Obstetrics Source Type: research
