MicroRNA-124 ameliorates autophagic dysregulation in glaucoma via regulation of P2X7-mediated Akt/mTOR signaling
In this study, we investigated the role of microRNA-124 (MiR-124) in surgically induced glaucomatous neurodegeneration using a mouse model. Animals were segregated into four cohorts of 10 each: (i) sham-operated (n = 10); (ii) surgically induced glaucoma (SIG; n = 10); (iii) SIG + miR-124 mimic; (iv) SIG + miR-NC. Chronic elevation of intraocular pressure (IOP) is a critical risk factor for glaucoma. In our study, chronically elevated IOP caused anterograde axonal transport (AAT) defect, increased the autophagic activity (manifested by significantly (p
Source: Cutaneous and Ocular Toxicology - November 30, 2021 Category: Toxicology Authors: Jun Guo Haojie Liu Lin Fu Source Type: research

MicroRNA-124 ameliorates autophagic dysregulation in glaucoma via regulation of P2X7-mediated Akt/mTOR signaling
In this study, we investigated the role of microRNA-124 (MiR-124) in surgically induced glaucomatous neurodegeneration using a mouse model. Animals were segregated into four cohorts of 10 each: (i) sham-operated (n = 10); (ii) surgically induced glaucoma (SIG; n = 10); (iii) SIG + miR-124 mimic; (iv) SIG + miR-NC. Chronic elevation of intraocular pressure (IOP) is a critical risk factor for glaucoma. In our study, chronically elevated IOP caused anterograde axonal transport (AAT) defect, increased the autophagic activity (manifested by significantly (p
Source: Cutaneous and Ocular Toxicology - November 30, 2021 Category: Toxicology Authors: Jun Guo Haojie Liu Lin Fu Source Type: research

MicroRNA-124 ameliorates autophagic dysregulation in glaucoma via regulation of P2X7-mediated Akt/mTOR signaling
In this study, we investigated the role of microRNA-124 (MiR-124) in surgically induced glaucomatous neurodegeneration using a mouse model. Animals were segregated into four cohorts of 10 each: (i) sham-operated (n = 10); (ii) surgically induced glaucoma (SIG; n = 10); (iii) SIG + miR-124 mimic; (iv) SIG + miR-NC. Chronic elevation of intraocular pressure (IOP) is a critical risk factor for glaucoma. In our study, chronically elevated IOP caused anterograde axonal transport (AAT) defect, increased the autophagic activity (manifested by significantly (p
Source: Cutaneous and Ocular Toxicology - November 30, 2021 Category: Toxicology Authors: Jun Guo Haojie Liu Lin Fu Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Short-term effect of angiotensin-converting enzyme inhibitor on retinal vessel diameter in patients with systemic hypertension
This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.RESULTS: The baseline diameters of the ST...
Source: Cutaneous and Ocular Toxicology - November 16, 2021 Category: Toxicology Authors: Nazife A şıkgarip Emine Temel Kemal Örnek Ahmet K ıvrak Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A Prospective Randomized placebo controlled 1-Year Follow-up Study
Cutan Ocul Toxicol. 2021 Nov 8:1-14. doi: 10.1080/15569527.2021.2003376. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo.METHODS AND RESULTS: Fifty-one eyes of 51 patients were recruited for primary MMC (0.2mg/ml for 1 min) augmented trabeculectomy. 17 patients were randomly assigned to receive 1.25mg (0.05ml) of bevacizumab augmentation, 21 patients were assigned to receive 0.1ml of 50mg/ml 5-FU and 13 patients were assigned to a control group receiving a norma...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Stylianos Kandarakis Anastasios Kontaxakis Leonidas Doumazos Petros Petrou Konstantinos Droutsas Demetrios Papaconstantinou Ilias Georgalas Source Type: research

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects
Cutan Ocul Toxicol. 2021 Nov 8:1-25. doi: 10.1080/15569527.2021.2003377. Online ahead of print.ABSTRACTOBJECTIVE: The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model.MATERIALS AND METHODS: Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis.RESULTS: Rats of G2 exhibited clinical si...
Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

MiRNA-375 inhibits retinoblastoma progression through targeting ERBB2 and inhibiting MAPK1/MAPK3 signalling pathway
CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.PMID:34711123 | DOI:10.1080/15569527.2021.1994587 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 29, 2021 Category: Toxicology Authors: Lei Liu Chunlin Xiao Qiuyun Sun Source Type: research

Dose and Time Response Study to Develop Retinal Degenerative Model of Zebrafish with Lead Acetate
This study was designed to calculate the lowest possible dose of PbAc (lead acetate), a neurotoxicant, that can have a toxicological impact on the zebrafish retina and to minimize animal usage. Dose and time-dependent changes were observed in the zebrafish retina following PbAc exposure with zero mortality. Vision and visual behavior response are the foremost indicators that can be recorded to mark the risk assessment of any chemical. Therefore, the present study aims at dose and time response to find the lowest dose of PbAc affecting the zebrafish retina and its visual behavior. Zebrafish were treated for 3 weeks with fou...
Source: Cutaneous and Ocular Toxicology - October 28, 2021 Category: Toxicology Authors: Vincy Garg Ravneet Kaur Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Dec;40(4):350-358. doi: 10.1080/15569527.2021.1973022. Epub 2021 Sep 8.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 1...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Dec;40(4):350-358. doi: 10.1080/15569527.2021.1973022. Epub 2021 Sep 8.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 1...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Dec;40(4):350-358. doi: 10.1080/15569527.2021.1973022. Epub 2021 Sep 8.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 1...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research

Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye
Cutan Ocul Toxicol. 2021 Sep 8:1-9. doi: 10.1080/15569527.2021.1973022. Online ahead of print.ABSTRACTPURPOSE: To investigate the efficacy of topical application of 3% diquafosol sodium (DQS) and tocopherol (TCP) acetate mixtures in a mouse model of experimental dry eye (EDE).METHODS: After exposure to desiccating stress for 5 days, eye drops consisting of 3% DQS alone, 0.01% TCP alone, or 3% DQS and 0.005% or 0.01% TCP mixture were applied for the treatment of EDE. Tear volume, tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS), and tear film lipid layer grades (TFLLG) were measured at 0, 5 and 10 ...
Source: Cutaneous and Ocular Toxicology - September 9, 2021 Category: Toxicology Authors: Lan Li Rujun Jin Ying Li Hee Su Yoon Hyeon Jeong Yoon Kyung Chul Yoon Source Type: research