Dermatological Side Effects of Targeted Antineoplastic Therapies: A Prospective Study.
The objective of this study is to report the cutaneous side effects of EGFR inhibitors and to share treatment methods for such side effects.Materials and method: In this prospective study, 59 patients using EGFR due to breast and colorectal carcinoma at the oncology unit of Haseki Training and Research hospital were assessed. The patients for whom EGFR was initiated were examined at the beginning of the treatment at weeks 1 and 2, their demographic characteristics were recorded, and the patients who developed a skin rash were followed up from the onset of the lesion. The papulopustular side effects that developed in the pa...
Source: Cutaneous and Ocular Toxicology - October 7, 2020 Category: Toxicology Authors: A S, Ç C, Np K Tags: Cutan Ocul Toxicol Source Type: research

Ocular Toxicology: Synergism of UV Radiation and Benzalkonium Chloride.
Conclusions: This investigation determined that at relevant human exposure levels, the combination of UV radiation (280-400 nm) and BAK can cause synergistic and additive toxic effects on human corneal epithelial cells. This finding highlights the importance of considering the combined ocular toxicity of BAK and solar radiation in the risk assessment of BAK-preserved ophthalmic solutions. PMID: 33019823 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - October 4, 2020 Category: Toxicology Authors: Xu M, Sivak JG, McCanna DJ Tags: Cutan Ocul Toxicol Source Type: research

A decrease in the tear secretion volume in a mouse model with ulcerative colitis.
Conclusions: These findings suggest that a decrease in the tear volume in UC was associated with a functional decline in the inflamed lacrimal gland. This result therefore provides useful information that could contribute to the development of treatment approaches for dry eye associated with UC. PMID: 32942916 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - September 17, 2020 Category: Toxicology Authors: Sekijima H, Hiramoto K, Kozawa S Tags: Cutan Ocul Toxicol Source Type: research

APRPG modified nanoliposome loaded with miR-146a-5p inhibitor suppressed choroidal neovascularization by targeting endothelial cells.
Conclusions: ANL-miR-146a-5p inhibitor can more effectively down-regulate the expression level of VEGF through its targeting to endothelial cells, thereby more effectively inhibiting endothelial cell proliferation, migration, tube formation, and mice CNV formation. PMID: 32928013 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - September 13, 2020 Category: Toxicology Authors: Li L, Lai K, Li C, Gong Y, Xu F, Zhao H, Zhou L, Huang C, Jin C Tags: Cutan Ocul Toxicol Source Type: research

Effect of omalizumab use on glucose homeostasis in non-diabetic patients with chronic urticaria.
Conclusion: The increase in blood glucose levels may be associated with the paradoxically increase of histamine levels in the blood by omalizumab. If this increase cannot be balanced with insulin, patients may develop impaired glucose tolerance and insulin resistance. Therefore, we suggest that patients using omalizumab should be followed up for glucose homeostasis and insulin resistance. PMID: 32885684 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - September 3, 2020 Category: Toxicology Authors: Falay Gur T, Savas Erdogan S, Erdemir VA, Doğan B Tags: Cutan Ocul Toxicol Source Type: research

The Role of MicroRNAs in Corneal Neovascularization and Its Relation to VEGF.
This study aimed to investigate the changes in the level of miRNA associated with Vascular Endothelial Growth Factor (VEGF) in corneal neovascularization (CNV), to elucidate the process of CNV formation and, thus, to prepare the ground for further experimental, and clinical studies together with drug treatments. METHODS: Twelve male Wistar-Albino rats were randomly divided into two groups of six, and two corneas of each rat were used. In all groups, CNV was generated by silver nitrate sticks. At the end of the study, rats were sacrificed by cervical dislocation under ether anesthesia, and then, their corneas were remo...
Source: Cutaneous and Ocular Toxicology - August 27, 2020 Category: Toxicology Authors: Yaşar M, Çakmak H, Dündar S, Örenay Boyacıoğlu S, Çalışkan M, Ergin K Tags: Cutan Ocul Toxicol Source Type: research

Comparison of the local effects of different intracameral cefuroxime solutions on rabbit cornea.
Conclusion: Dilution of intracameral cefuroxime in BSS yielded superior results compared with dilution in normal saline owing to toxicity to the endothelial cells and decline in the endothelial cell number, resulting in intracellular and intercellular morphological changes. BSS or any other solution with proven safety should be used in clinical studies. PMID: 32854557 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - August 27, 2020 Category: Toxicology Authors: Yılmaz F, Berk AT, Yılmaz O, Lebe BK, Keskinoglu P, Bagriyanik HA Tags: Cutan Ocul Toxicol Source Type: research

Hair dye and risk of skin sensitization induction: a product survey and quantitative risk assessment for para-phenylenediamine (PPD).
Conclusions: Findings suggest that use of the evaluated permanent hair dyes, under the evaluated exposure scenarios, would not be expected to induce skin sensitization due to PPD exposure at concentrations ≤0.67%. PMID: 32722942 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 28, 2020 Category: Toxicology Authors: Towle KM, Hwang RY, Fung ES, Hollins DM, Monnot AD Tags: Cutan Ocul Toxicol Source Type: research

Effects of adenosine triphosphate on vandetanib induced skin damage in rats.
man H Abstract Purpose: Vandetanib is a wide spectrum tyrosine kinase inhibitor used for the treatment of metastatic medullary thyroid cancer (MTC) and various other cancer types. Although it is usually well-tolerated ıt has been linked to a variety of severe dermatologic reactions. Our study aimed was to investigate adenosine 5'-triphosphate (ATP) on vandetanib-induced skin damage.Materials and methods: A total number of 18 rats were divided into three equal groups as vandetanib group (VDB), vandetanib plus ATP group (VAT), and healthy group (HG); 25 mg/kg ATP was injected intraperitoneally (ip) to the VA...
Source: Cutaneous and Ocular Toxicology - July 28, 2020 Category: Toxicology Authors: Akagunduz B, Ozcicek F, Kara AV, Guven DC, Yazici GN, Çoban A, Suleyman B, Mammadov R, Suleyman H Tags: Cutan Ocul Toxicol Source Type: research

Ranibizumab versus aflibercept for diabetic macular edema: 18-month results of a comparative, prospective, randomized study and multivariate analysis of visual outcome predictors.
Conclusions: Ranibizumab and aflibercept presented similar anatomical and functional outcomes in 18-month follow-up in patients with DME. It is important to determine factors, affecting VA, so as to provide individualized treatment. PMID: 32722955 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 28, 2020 Category: Toxicology Authors: Chatzirallis A, Theodossiadis P, Droutsas K, Koutsandrea C, Ladas I, Moschos MM Tags: Cutan Ocul Toxicol Source Type: research

Isotretinoin does not alter VEGF-A and VEGF-C levels: Do retinoids behave differently in dose-dependent and/or in vivo/in vitro conditions?
Conclusions: We think that 0.5 mg/kg/day isotretinoin has no effect on blood concentrations of VEGF-A and VEGF-C in humans. Therefore, there is a need for studies using isotretinoin in different doses and durations in humans in order to better evaluate its effects. PMID: 32722957 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 28, 2020 Category: Toxicology Authors: Ayhan E, Araç E, Aslan Ö Tags: Cutan Ocul Toxicol Source Type: research

Retinal teratogenicity of pregabalin in chick embryo model.
Conclusion: The use of pregabalin during pregnancy compromises retinal development in a dose-dependent manner. The use of pregabalin in pregnancy causes the aforementioned defects in this system and it may have developmental effects that needs to be further evaluated. PMID: 32722992 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 28, 2020 Category: Toxicology Authors: Secinti IE Tags: Cutan Ocul Toxicol Source Type: research

Evaluation of the effect of fingolimod (FTY720) on macular perfusion by swept-source optical coherence tomography angiography in patients with multiple sclerosis.
CONCLUSION: Fingolimod use seems to remarkably increase VDs and VDd measurements in the early period of administration and decrease CMT over a longer period of administration in patients with RR-MS. PMID: 32657164 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 11, 2020 Category: Toxicology Authors: Karaküçük Y, Gümüş H, Eker S Tags: Cutan Ocul Toxicol Source Type: research

Effects of anatomical location on in  vivo percutaneous penetration in man.
CONCLUSIONS: Regional variability in chemical and drug absorption is of clinical and pharmacological significance. More studies determining in vivo percutaneous absorption in man are necessary to further understand the role of regional variation, the mechanisms involved, and how to derive reliable formulas for extrapolating flux from one anatomic site to the next, often required for risk assessments. PMID: 32643443 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 8, 2020 Category: Toxicology Authors: Bormann JL, Maibach HI Tags: Cutan Ocul Toxicol Source Type: research

Use of choroidal vascularity index for choroidal structural evaluation in smokers: an optical coherence tomography study.
Conclusion: The CVI was significantly decreased in smokers compared to healthy controls. The study results suggest that the CVI could be a noninvasive tool for evaluating choroidal vascular changes in smokers. PMID: 32623911 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 5, 2020 Category: Toxicology Authors: Koçak N, Subaşı M, Yeter V, Yücel ÖE, Can E Tags: Cutan Ocul Toxicol Source Type: research

Ozone Treatment for High-Dose Systemic Steroid-Induced Retinal Injury.
Conclusion: Apoptosis increases in retinal tissues due to high dose systemic steroid administration and the retina becomes thinner. With biochemical examination, oxidation parameters increased while antioxidant parameters decreased. Both histopathological and biochemical parameters improved significantly with ozone treatment. PMID: 32619116 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 2, 2020 Category: Toxicology Authors: Yıldız A, Şehitoğlu MH, Karaboğa İ, Arıkan S Tags: Cutan Ocul Toxicol Source Type: research

A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review.
Conclusion: In our group of taxane receiving patients, incidence of taxane- related CME was 0.5%. In light of our study, we believe that clinicians should be alert on the occurence of taxane -related CME and carefully scrutinize the patients whenever any suspicion is arisen. PMID: 32619362 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 2, 2020 Category: Toxicology Authors: Kaya M, Atas F, Guc ZG, Oztop I, Durak I, Saatci AO Tags: Cutan Ocul Toxicol Source Type: research

Assessment of thiol/disulphide homeostasis and ischemia modified albumin and their relationship with disease severity in children with chronic urticaria.
Abstract Background: The pathogenesis chronic urticaria (CU) hasn't been fully understood. In recent years, it has been shown that thiol-disulphide homeostasis, as an antioxidant system, plays important roles in both healthy individuals and various diseases. In different ischemia-reperfusion states high oxidative stress causes ischemia modified albumin (IMA) generation.Aim: To investigate thiol/disulphide balance and IMA level in children with CU and their association with disease severity.Methods: Thirty children with CU and 20 healthy children as controls, aged 1-18 years, were included in this cross-sectional s...
Source: Cutaneous and Ocular Toxicology - July 1, 2020 Category: Toxicology Authors: Akdag S, Ozmen S, Ercan N, Bostanci I, Neselioglu S Tags: Cutan Ocul Toxicol Source Type: research

Ephedrine causes retinal damage in SD rats associating with JAK2/STAT3 pathway.
This study was to investigate effects of ephedrine on the retina and explore the underlying mechanisms. Sprague Dawley rats were treated with ephedrine (n = 10) or saline (n = 10) by oral gavage for seven days. The retinal morphology was evaluated by Toluidine blue staining. Apoptosis-related markers were detected in the retinal lysate. Enzyme-linked immunosorbent assays were used to measure neurotransmitters and oxidative stress markers. Real-time PCR and western blot were used to measure gene and protein expression, respectively. Our results demonstrated that ephedrine induced apoptosis in the...
Source: Cutaneous and Ocular Toxicology - June 29, 2020 Category: Toxicology Authors: Yin Y, Gong D, Tang Y, Wang Z Tags: Cutan Ocul Toxicol Source Type: research

Influence of timolol, benzalkonium-preserved timolol, and benzalkonium-preserved brimonidine on oxidative stress biomarkers in the tear film.
Conclusions: This indicates that using BAC-preserved topical medications increases oxidative stress in the tear film and may, in the long-term, contribute to the clinical presentation of dry eye disease. PMID: 32594785 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 28, 2020 Category: Toxicology Authors: Sedlak L, Wojnar W, Zych M, Wyględowska-Promieńska D Tags: Cutan Ocul Toxicol Source Type: research

Experience with Omalizumab for the Treatment of Chronic Spontaneous Urticaria in a Tertiary Center: Real life experience.
CONCLUSIONS: Our results show that omalizumab was an effective treatment for intractable CSU and did not cause any serious adverse effects other than asthenia, vertigo, and injection site reaction in 4 patients. These findings are relevant because they reflect real-life data. PMID: 32597235 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 27, 2020 Category: Toxicology Authors: Acar A, Gerceker Turk B, Ertam Sagduyu I, Ceylan C, Ozturk G, Unal I Tags: Cutan Ocul Toxicol Source Type: research

Validation of the OptiSafe ™ Eye Irritation Test.
Conclusion: The OptiSafe test method is useful for identifying non-surfactant substances not requiring classification for ocular irritancy. OptiSafe represents a new tool for the in vitro assessment of ocular toxicity in a tiered-testing strategy where chemicals can be initially tested and identified as not requiring hazard classification. PMID: 32586141 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 24, 2020 Category: Toxicology Authors: Choksi N, Lebrun S, Nguyen M, Daniel A, DeGeorge G, Willoughby J, Layton A, Lowther D, Merrill J, Matheson J, Barroso J, Yozzo K, Casey W, Allen D Tags: Cutan Ocul Toxicol Source Type: research

Retinal ganglion cell complex and visual evoked potentials in levetiracetam treatment.
Conclusion: Central macular and GCC thicknesses; and VEP parameters in patients receiving levetiracetam treatment may differ from healthy subjects. PMID: 32543904 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 15, 2020 Category: Toxicology Authors: Hazirolan D, Duman M, Keskin Guler S, Uney G, Ornek F Tags: Cutan Ocul Toxicol Source Type: research

Assessment of Macular Choroidal Thickness, Central Macular Thickness and Retinal Nerve Fiber Layer in Patients Receiving Oral Isotretinoin Treatment.
Conclusion: After the use of oral isotretinoin for 3 months, no significant side effects have been observed in choroidal thickness, CMT, and RNFL thickness by OCT. PMID: 32543917 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 15, 2020 Category: Toxicology Authors: Karadag O, Kocamaz M, Dastan M, Ozturk Durur S Tags: Cutan Ocul Toxicol Source Type: research

Effects of adenosine triphosphate on methanol-induced experimental optic nerve damage in rats: biochemical and histopathological evaluation.
Conclusion: Intravenous ATP administration had a significant positive effect on the oxidative stress parameters and optic nerve structure in methanol-intoxicated rats. Antioxidant therapies should be considered in future studies as a possible therapy for methanol-induced toxic optic neuropathy. PMID: 32543996 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - June 15, 2020 Category: Toxicology Authors: Icel E, Suleyman H, Yazici GN, Bakan N, Sunar M Tags: Cutan Ocul Toxicol Source Type: research

Assessment of dermal safety of oil extracted from Periplaneta americana: acute dermal toxicity, irritation, and sensitization.
Conclusions: These results suggest that P. americana oil does not produce any significant acute toxic effects and is safe for use in animal models with almost no dermal irritation or sensitization. Therefore, it presents a low risk of provoking skin reactions in humans. PMID: 32406268 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - May 13, 2020 Category: Toxicology Authors: Li X, He Z, Ding W, Zhang X, Ma C, Feng Y Tags: Cutan Ocul Toxicol Source Type: research

A Review of Methanol Poisoning: A Crisis Beyond Ocular Toxicology.
Abstract At first blush, methanol poisoning may be seen as an arcane problem generally associated with rapid ocular neuropathy. The emerging clinical reality is that methanol poisoning around the globe has claimed increasingly large numbers of deaths largely due to the press of poverty and the delay in suspecting and diagnosing methanol toxicity. With the onset of the COVID-19 pandemic, false beliefs about methanol's preventive potential vs viral infection of have arisen. In March of this year, more than 300 Iranians died and 1,000 became ill after consuming methanol in the hope that it would protect them against ...
Source: Cutaneous and Ocular Toxicology - May 11, 2020 Category: Toxicology Authors: Pressman P, Clemens R, Sahu S, Hayes AW Tags: Cutan Ocul Toxicol Source Type: research

Omalizumab does not lead to a distinct alteration in hematological parameters and complete blood count-derived inflammation biomarkers except for basophil count.
Conclusions: Increased basophil counts suggest that omalizumab has a crucial effect through basophils in chronic spontaneous urticaria. Further studies focusing on basophils may contribute to the literature both to elucidate the etiopathogenesis of urticaria and to improve novel treatment agents for the disease. On the other hand, our study revealed that omalizumab did not have a distinct effect on complete blood count derived inflammation biomarkers and thus inflammation. PMID: 32380865 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - May 6, 2020 Category: Toxicology Authors: Tamer F Tags: Cutan Ocul Toxicol Source Type: research

Ocular nonsteroidal inflammatory drugs. Where do we stand today?
Abstract Since their first introduction in Ophthalmology, NSAIDs (nonsteroidal anti-inflammatory drugs) use has been exponentially expanded, with numerous therapeutic applications. Despite their controversial history, they have proven their efficacy as anti-inflammatory agents in a variety of diseases. Nowadays, NSAIDs are part of surgical protocols of the most commonly performed ophthalmic operations, such as cataract or ocular surgery. They are universally implicated in the management of conjunctivitis, retinal and choroidal disease and miscellaneous inflammatory diseases. Moreover, although linked with serious ...
Source: Cutaneous and Ocular Toxicology - April 25, 2020 Category: Toxicology Authors: Kandarakis SA, Petrou P, Papakonstantinou E, Spiropoulos D, Rapanou A, Georgalas I Tags: Cutan Ocul Toxicol Source Type: research

Comparison of the effect of topical bevacizumab and sorafenib in experimental corneal neovascularization.
n N Abstract Purpose: The purpose of this study was to compare the neovascularization inhibiting the effect of topical bevacizumab and sorafenib and to determine the effective dose of sorafenib.Material and Methods: Forty-two healthy Wistar albino rats were randomly divided into six groups. The right corneas of all rats except group 1 were cauterized with silver nitrate. Group 2 received DMSO, group 3 received topical bevacizumab (5mg/dL, 3 times a day) and group 4, 5 and 6 received topical sorafenib (2.5mg/dl, 5mg/dL, 7.5mg/dL, 2 times a day respectively), between days 1 and 7. Corneal photographs were taken on d...
Source: Cutaneous and Ocular Toxicology - April 25, 2020 Category: Toxicology Authors: Yildirim H, Aydemir O, Balbaba M, Özercan İH, Ilhan N Tags: Cutan Ocul Toxicol Source Type: research

Evaluation of the acute effects of cigarette smoking on the eye of non-Smoking healthy young male subjects by optical coherence tomography angiography.
ebi S Abstract Purpose: Investigation of the acute effects of cigarette smoking on the eye using optical coherence tomography angiography (OCTA) on young healthy non-smoking male subjects.Materials and methods: The right eye of 25 healthy non-smoking male subjects were included in this study. Selected parameters of the macular and circumpapillary vasculature were measured, including macular flow indices, foveal avascular zone, vessel densities of macula and optic disc using OCTA. The measurements of the subjects were performed on the first day without smoking at 0 min, 5 min, 30 min and 60&thi...
Source: Cutaneous and Ocular Toxicology - April 23, 2020 Category: Toxicology Authors: Kaymaz A, Ulaş F, Toprak G, Uyar E, Çelebi S Tags: Cutan Ocul Toxicol Source Type: research

Impairment of wound healing by reactive skin decontamination lotion (RSDL ®) in a Göttingen minipig® model.
In conclusion, wound management care and clinical therapeutic intervention plans should be established to account for a prolonged duration of healing in patients with RSDL-contaminated wounds. PMID: 32321319 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - April 21, 2020 Category: Toxicology Authors: Connolly JM, Stevenson RS, Railer RF, Clark OE, Whitten KA, Lee-Stubbs RB, Anderson DR Tags: Cutan Ocul Toxicol Source Type: research

Corneal damage and its recovery after instillation of preservative-free versus preserved latanoprost eye drops.
Conclusions: Preservative-free latanoprost can be safely instilled to the corneal epithelium. Latanoprost with 0.02% BAC has an immediate deleterious impact on the corneal epithelium; however, it disappears within 24 hours after instillation. PMID: 32295438 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - April 15, 2020 Category: Toxicology Authors: Inoue D, Mohamed YH, Uematsu M, Kitaoka T Tags: Cutan Ocul Toxicol Source Type: research

Evaluation of the effect of energy drink consumption on retina and choroid: An optical coherence tomography and optical coherence tomography angiography study.
CONCLUSION: The consumption of energy drinks acutely leads to changes in retinal vascular density parameters. PMID: 32285710 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - April 13, 2020 Category: Toxicology Authors: Doğan M, Sabaner MC, Akar AT, Şenel M, Kaşikçi İ, Günal EŞ, Özbay AE, Şarman T, Gobeka HH, Cam Ö Tags: Cutan Ocul Toxicol Source Type: research

Decontamination Efficacy of Soapy Water and Water Washing Following Exposure of Toxic Chemicals on Human Skin.
s L Abstract Following exposure to toxic chemicals, skin uptake is a potential route of intoxication. Therefore, efficient methods for rapid skin decontamination to mitigate systemic effects is of utmost importance. In operational guidelines, skin decontamination is recommended to be performed by dry absorption and washing with water or soapy water. In the present study, evaluation of decontamination efficacy using water or soapy water was performed for five chemicals, three toxic industrial chemicals and two simulants for chemical warfare agents. Decontamination was initiated at time points 5, 15, 45 and 120&thin...
Source: Cutaneous and Ocular Toxicology - March 25, 2020 Category: Toxicology Authors: Forsberg E, Öberg L, Artursson E, Wigenstam E, Bucht A, Thors L Tags: Cutan Ocul Toxicol Source Type: research

Anti-inflammatory effect of Arnica montana in a UVB radiation-induced skin-burn model in mice.
Conclusion: we concluded that Arnica montana ointment is effective in alleviating the auricular inflammatory process and oxidative damage induced by acute UVB radiation, sustaining the traditional use of Arnica montana for the treatment of skin disorders. PMID: 32183539 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - March 16, 2020 Category: Toxicology Authors: Prade JDS, Bálsamo EC, Machado FR, Poetini MR, Bortolotto VC, Araújo SM, Londero L, Boeira SP, Sehn CP, de Gomes MG, Prigol M, Cattelan Souza L Tags: Cutan Ocul Toxicol Source Type: research

Comment on ''the effect of omalizumab on hematological and inflammatory parameters in patients with chronic spontaneous urticaria'': reply from authors.
, Saracoğlu ZN Abstract We read Cosansu's commentary entitled '' Effectiveness of the new inflammatory parameters in patients with chronic spontaneous urticaria'' to our study with great interest. The author remarked that a limited number patients had C-reactive Protein levels and it was not specified whether there were any other drugs used by the patients and no information was given about the severity of the disease in our study. PMID: 32183543 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - March 16, 2020 Category: Toxicology Authors: Acer E, Kaya Erdoğan H, Yüksel Çanakçı N, Saracoğlu ZN Tags: Cutan Ocul Toxicol Source Type: research

Tolerability of hair cleansing conditioners: a double-blind randomized, controlled trial designed to evaluate consumer complaints to the U.S. Food and Drug Administration.
Abstract Importance: Consumers have reported skin rash/irritation and hair loss/breakage with Wen by Chaz Dean Sweet Almond Mint Cleansing Conditioner (WCDSAMCC), however epidemiologic, toxicologic and clinical hair loss studies have not provided an explanation. Contact dermatitis has been hypothesized.Objective: To assess the tolerability of six products: WCDSAMCC, three other hair cleansing conditioners, and two controls [salicylic acid shampoo (SAS) and baby shampoo (BS)].Design: Double-blind, randomized, controlled trial.Setting: Single-site study.Population: General population volunteers.Intervention: Standar...
Source: Cutaneous and Ocular Toxicology - March 1, 2020 Category: Toxicology Authors: Warshaw EM, Schlarbaum JP, Liou YL, Kimyon RS, Zhang AJ, Nikle AB, Monnot AD, Hylwa SA Tags: Cutan Ocul Toxicol Source Type: research

Can monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients?
In this study, 116 nodulocystic acne patients who received ISO treatment for at least three months were evaluated retrospectively. ISO treatment was given to patients at a dose of 0.5-1 mg/kg. Pre-treatment and post-treatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, mean platelet volume (MPV), platelet, plateletcrit, platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol and MHR were evaluated.Results: MPV and MHR values were significantly increased after 3 month treatment (p 0...
Source: Cutaneous and Ocular Toxicology - February 25, 2020 Category: Toxicology Authors: Önder S, Ozturk M Tags: Cutan Ocul Toxicol Source Type: research

Incidence of cystoid macular edema with intracameral cephalosporin or vancomycin in cataract surgery.
Conclusions: There was no statistical difference in the incidence of pseudophakic CME in subjects who received intracameral cephalosporin versus intracameral vancomycin during cataract surgery. PMID: 32100589 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - February 25, 2020 Category: Toxicology Authors: Adeli M, Mauger TF Tags: Cutan Ocul Toxicol Source Type: research

Retinal structural changes in patients receiving tamoxifen therapy by spectral-domain optical coherence tomography.
Abstract Purpose: To evaluate choroidal thickness, ganglion cell complex (GCC) and photoreceptor outer segment (PROS) length were measured in patients with breast cancer undergoing tamoxifen therapy, using spectral-domain optical coherence tomography (SD-OCT); results were compared with those for normal eyes.Materials and Methods: Forty-four patients with breast cancer, undergoing tamoxifen therapy, and 41 healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500, 1000, 1500&thinsp...
Source: Cutaneous and Ocular Toxicology - February 25, 2020 Category: Toxicology Authors: Bolukbasi S, Kandemir Gursel O, Cakir A, Erden B, Karatas M Tags: Cutan Ocul Toxicol Source Type: research

Lysergic acid diethylamide causes mouse retinal damage by up-regulating p-JAK1/p-STAT1.
This study was to investigate the acute toxicity of LSD on the retina of C57 mice and its mechanisms of action. C57 mice were treated with LSD at progressively increasing doses (0.2-1.2 mg/kg) intraperitoneally two times daily for 5 days, mice treated with saline served as negative control. Electroretinography (ERG) was used to test the function of the retina. Toluidine blue staining was used to detect the morphology of the retina. Enzyme-linked immunosorbent assay (ELISA) was used to measure the apoptosis-related factors. Real-time PCR and western blot techniques were used to measure expression changes of genes and...
Source: Cutaneous and Ocular Toxicology - February 15, 2020 Category: Toxicology Authors: Chen K, He X, Li C, Ou Y, Li Y, Lai J, Lv M, Li X, Ran P, Li Y Tags: Cutan Ocul Toxicol Source Type: research

Neferine inhibits epidermal growth factor-induced proliferation and migration of retinal pigment epithelial cells through downregulating p38 MAPK and PI3K/AKT signalling.
Conclusion: It can be considered that neferine may be a potential candidate molecule in the treatment of PVR by inhibiting cell proliferation and the migration of EGF-induced RPE cells through the modulation of various transcriptional activities. PMID: 32064963 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - February 15, 2020 Category: Toxicology Authors: Ozal SA, Gurlu V, Turkekul K, Guclu H, Erdogan S Tags: Cutan Ocul Toxicol Source Type: research

Methamphetamine causes acute toxicity in the retina of Balb/c mice.
This study was to investigate effects of Meth treatment on the retina. Balb/c mice were treated with Meth at progressively increasing doses (0 to 6 mg/kg) intraperitoneally 4 times per day for 5 days, mice treated with saline as negative control. Electroretinography (ERG) was used to test the function of retina after Meth treatment. Pathological changes were examined by Hematoxylin & Eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Enzyme-linked immunosorbent assay (ELISA) was used to measure the norepinephrine and tumor necrosis factor alpha (TNFα). Real-time ...
Source: Cutaneous and Ocular Toxicology - January 26, 2020 Category: Toxicology Authors: Zhang Y, Li Q, Guan S, Li H Tags: Cutan Ocul Toxicol Source Type: research

Effects of a prostaglandin F2alpha derivative glaucoma drug on EGF expression and E-cadherin expression in a corneal epithelial cell line.
Conclusions: Travoprost activates epithelial cell proliferation by up-regulating an EGF-related signal in association with the suppression of E-cadherin localization in the cell-cell contact zone. Modulation of the EGF signal may be a strategy to minimize the negative impact of this mitogen on reformation of corneal barrier function during epithelial renewal. PMID: 31986917 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - January 26, 2020 Category: Toxicology Authors: Takada Y, Yamanaka O, Okada Y, Sumioka T, Reinach PS, Saika S Tags: Cutan Ocul Toxicol Source Type: research

Comment on ''How does omalizumab affect the immunoinflammatory response in patients with chronic spontaneous urticaria?'': Reply from Author.
k M PMID: 31899976 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - January 2, 2020 Category: Toxicology Authors: Önder S, Ozturk M Tags: Cutan Ocul Toxicol Source Type: research

Optical coherence tomography findings in patients with alcohol use disorder and their relationship with clinical parameters.
Conclusions: Our study is the first study that examines the retinal GCIPL and CT with OCT in patients who are diagnosed with AUD. In our results, it was determined that there were no statistically significant differences between the participants in terms of OCT parameters. Further studies with larger sampling groups evaluating neurotransmission findings may provide wider results. PMID: 31847594 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 16, 2019 Category: Toxicology Authors: Özsoy F, Alim S Tags: Cutan Ocul Toxicol Source Type: research

Effectiveness of the new inflammatory parameters in patients with chronic spontaneous urticaria.
Abstract In recent years, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio have been studied in many dermatological diseases as various parameters indicating inflammation, and found to be associated with disease activity, prognosis and spread of disease 2,3. In the present study, authors found a significant decrease in the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and C-Reactive Protein after omalizumab treatment. However, a limited number of patients had C-Reactive Protein levels. Since no correlation analysis was performed in the study, the significance of these results remains weak. Moreov...
Source: Cutaneous and Ocular Toxicology - December 5, 2019 Category: Toxicology Authors: Cosansu NC Tags: Cutan Ocul Toxicol Source Type: research

The effect of ınflıxımab and octreotıde on cytokıne levels experımental prolıferatıve vıtreoretınopathy.
Conclusions: Intravitreal infliximab can inhibit the development of PVR and reduce levels of cytokine, which plays an essential role in the pathogenesis of PVR. The results of our study suggest that it may be possible to identify the ideal adjuvant pharmacological drugs that are effective in preventing PVR. PMID: 31809602 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2019 Category: Toxicology Authors: Savur F, Aydemir O, İlhan N Tags: Cutan Ocul Toxicol Source Type: research

Hematological parameters in patients with chronic spontaneous urticaria.
PMID: 31809603 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2019 Category: Toxicology Authors: Cosansu NC Tags: Cutan Ocul Toxicol Source Type: research