Understanding the impact of risankizumab on keratinocyte-derived IL-23A in a novel organotypic 3D skin model containing IL-23A responsive and IL-17A producing γδ-T-cells

CONCLUSIONS: Our results showed that blockade of IL-23A has inhibitory effects on the IL-36γ/IL-23A feedforward loop. Our newly developed 3D skin model containing IL-23A responsive and IL-17A producing γδ-T-cells enables molecular analysis of targeted therapies aimed at the IL-36γ/IL-23A/IL-17A signalling cascade in psoriasis.PMID:38284163 | DOI:10.1080/15569527.2024.2310243

Source: Cutaneous and Ocular Toxicology - January 29, 2024 Category: Toxicology Authors: Laura Huth Philipp M Amann Yvonne Marquardt Manuela Jansen Jens Malte Baron Sebastian Huth Source Type: research