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Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae
This study demonstrates that the uncoupling of the known sensors of both branches of the pathway at the level of Ssk1 and Ste11 impairs cell growth in hyperosmotic medium. However, under these conditions, Hog1 was still phosphorylated and internalised into the nucleus, suggesting the existence of an alternative Hog1 activation mechanism. In the ssk1ste11 mutant, phosphorylated Hog1 failed to associate with chromatin and to activate transcription of canonical hyperosmolarity‐responsive genes. Accordingly, Hog1 also failed to induce glycerol production at the levels of a wild type strain. Inactivation of the Ptp2 phosphata...
Source: FEBS Journal - January 17, 2018 Category: Research Authors: Araceli V ázquez‐Ibarra, Laia Subirana, Laura Ongay‐Larios, Laura Kawasaki, Eréndira Rojas‐Ortega, Miriam Rodríguez‐González, Eulàlia de Nadal, Francesc Posas, Roberto Coria Tags: Original Article Source Type: research

Corrigendum
(Source: FEBS Journal)
Source: FEBS Journal - January 16, 2018 Category: Research Tags: Corrigendum Source Type: research

A stereospecific carboxyl esterase from Bacillus  coagulans hosting nonlipase activity within a lipase‐like fold
We report the high‐resolution crystal structure of a carboxylesterase from Bacillus coagulans with lipase‐like structural features, despite nonlipolytic‐like catalytic activities. This enzyme is of particular interest due its enantioselectivity for (S)‐1,2‐O‐isopropylidenglycerol (IPG) esters and activity at elevated temperatures; (S)‐IPG is an important building block for a number of compounds, including pharmaceuticals, implying a potential use for biocatalysis. (Source: FEBS Journal)
Source: FEBS Journal - January 11, 2018 Category: Research Authors: Valerio De Vitis, Cristina Nakhnoukh, Andrea Pinto, Martina L. Contente, Alberto Barbiroli, Mario Milani, Martino Bolognesi, Francesco Molinari, Louise J. Gourlay, Diego Romano Tags: Original Article Source Type: research

The role of Nrf2 signaling in counteracting neurodegenerative diseases
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 11, 2018 Category: Research Authors: Albena T. Dinkova ‐Kostova, Rumen V. Kostov, Aleksey G. Kazantsev Tags: Review Article Source Type: research

Pulmonary endoplasmic reticulum stress: Scars, Smoke and Suffocation
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 11, 2018 Category: Research Authors: Jennifer A. Dickens, Elke Malzer, Joseph E. Chambers, Stefan J. Marciniak Tags: Review Article Source Type: research

Crystal structure of the DNA –binding domain of the LysR–type transcriptional regulator CbnR in complex with a DNA fragment of the recognition binding site in the promoter region
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 11, 2018 Category: Research Authors: Maharani Pertiwi Koentjoro, Naruhiko Adachi, Miki Senda, Naoto Ogawa, Toshiya Senda Tags: Original Article Source Type: research

The retinamide VNLG ‐152 inhibits AR/AR‐V7 and MNK‐eIF4Esignaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 11, 2018 Category: Research Authors: Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Lalji K. Gediya, Vincent C.O. Njar Tags: Original Article Source Type: research

Table of Contents
(Source: FEBS Journal)
Source: FEBS Journal - January 8, 2018 Category: Research Tags: Table of Contents Source Type: research

De ‐RSKing ERK – regulation of ERK1/2‐RSK dissociation by phosphorylation within a disordered motif
The protein kinases ERK1/2 and RSK associate in unstimulated cells but must separate to target other substrates. In this issue, Gógl et al. show that phosphorylation of RSK by active ERK1/2 culminates in the formation of an intramolecular charge clamp between Lys729 and the phosphate group on Ser732. This promotes the dissociation of ERK1/2 from RSK allowing them to engage with other targets. (Source: FEBS Journal)
Source: FEBS Journal - January 8, 2018 Category: Research Authors: Andrew M. Kidger, Simon J. Cook Tags: Commentary Source Type: research

The FEBS Journal in 2018 – putting a bit of color in your life, and your figures
Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He works on all aspects of cell death control and is especially interested in the links between cell death, cell stress and inflammation. He received the GlaxoSmithKline Award of The Biochemical Society (2006) and The RDS‐Irish Times Boyle Medal (2015) for his work on the role of caspases in apoptosis and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He is the Editor‐in‐Chief of The FEBS Journal since 2014. (Source: FEBS Journal)
Source: FEBS Journal - January 8, 2018 Category: Research Authors: Seamus J. Martin Tags: Editorial Source Type: research

Issue Information
Invadosomes in health and disease, by E. K. Paterson and S. A. Courtneidge (pp. 8 – 27). (Source: FEBS Journal)
Source: FEBS Journal - January 8, 2018 Category: Research Tags: Issue Cover & Information Source Type: research

Functions of autophagy in the tumor microenvironment and cancer metastasis
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 1, 2018 Category: Research Authors: Erin E. Mowers, Marina N Sharifi, Kay F. MacLeod Tags: State ‐of‐the‐Art Review Source Type: research

Post ‐translational incorporation of 3,4‐dihydroxyphenylalanine into the C‐terminus of α‐tubulin in living cells
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 1, 2018 Category: Research Authors: Yanela M. Dentesano, Yanina Ditamo, Cristian Hansen, Carlos A. Arce, C.Gast ón Bisig Tags: Original Article Source Type: research

Canonical signaling and nuclear activity of mTOR: a teamwork effort to regulate metabolism and cell growth
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 1, 2018 Category: Research Authors: Vincent Gigu ère Tags: State ‐of‐the‐Art Review Source Type: research

Inhibition of UVSSA ubiquitination suppresses transcription ‐coupled nucleotide excision repair deficiency caused by dissociation from USP7
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 1, 2018 Category: Research Authors: Mitsuru Higa, Kiyoji Tanaka, Masafumi Saijo Tags: Original Article Source Type: research

Biochemical and structural insights into a thermostable cellobiohydrolase from Myceliophthora  thermophila
In this study, we determined the 3D structure of catalytic domain using X‐ray crystallography and retrieved the full‐length enzyme envelope via small‐angle X‐ray scattering (SAXS) technique. The SAXS data reveal a tadpole‐like molecular shape with a rigid linker connecting the CD and CBM. Our biochemical studies show that MtCel7A has higher catalytic efficiency and thermostability as well as lower processivity when compared to the well‐studied TrCel7A from Trichoderma reesei. Based on a comparison of the crystallographic structures of CDs and their molecular dynamic simulations, we demonstrate that MtCel7A...
Source: FEBS Journal - January 1, 2018 Category: Research Authors: Marco A. S. Kadowaki, Paula Higasi, Mariana O. Godoy, Rolf A. Prade, Igor Polikarpov Tags: Original Article Source Type: research

Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide
We present the first crystal structure of a native fungal β‐N‐acetylhexosaminidase, isolated from Aspergillus oryzae. This chitobiose‐processing enzyme adopts a tight dimeric assembly further stabilized by a chain‐swapped propeptide. The propeptide possesses unique O‐glycosylation involved in enzyme dimerization. Loops and the propeptide of the second monomer in the dimer affect active pocket shape and enzyme specificity. (Source: FEBS Journal)
Source: FEBS Journal - December 30, 2017 Category: Research Authors: Jana Škerlová, Jan Bláha, Petr Pachl, Kateřina Hofbauerová, Zdeněk Kukačka, Petr Man, Petr Pompach, Petr Novák, Zbyszek Otwinowski, Jiří Brynda, Ondřej Vaněk, Pavlína Řezáčová Tags: Original Article Source Type: research

Challenges to DNA replication in hypoxic conditions
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 30, 2017 Category: Research Authors: Natalie Ng, Karin Purshouse, Iosifina P. Foskolou, Monica M. Olcina, Ester M. Hammond Tags: State ‐of‐the‐Art Review Source Type: research

Regulation of tumor –stroma interactions by the unfolded protein response
The unfolded protein response (UPR) is a conserved adaptive pathway that helps cells cope with the protein misfolding burden within the endoplasmic reticulum (ER). Imbalance between protein folding demand and capacity in the ER leads to a situation called ER stress that is often observed in highly proliferative and secretory tumor cells. As such, activation of the UPR signaling has emerged as a key adaptive mechanism promoting cancer progression. It is becoming widely acknowledged that, in addition to its intrinsic effect on tumor biology, the UPR can also regulate tumor microenvironment. In this review, we discuss how the...
Source: FEBS Journal - December 29, 2017 Category: Research Authors: Joanna Obacz, Tony Avril, Camila Rubio ‐Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean‐Ehrland Ricci, Eric Chevet Tags: Review Article Source Type: research

Regulation of human Nfu activity in Fe ‐S cluster delivery—characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex
Iron–sulfur cluster biogenesis is a complex, but highly regulated process that involves de novo cluster formation from iron and sulfide ions on a scaffold protein, and subsequent delivery to final targets via a series of Fe‐S cluster‐binding carrier proteins. The process of cluster release from the scaffold/carrier for transfer to the target proteins may be mediated by a dedicated Fe‐S cluster chaperone system. In human cells, the chaperones include heat shock protein HSPA9 and the J‐type chaperone Hsc20. While the role of chaperones has been somewhat clarified in yeast and bacterial systems, many questions r...
Source: FEBS Journal - December 29, 2017 Category: Research Authors: Christine Wachnowsky, Yushi Liu, Taejin Yoon, J. A. Cowan Tags: Original Article Source Type: research

Shared CaM ‐ and S100A1‐binding epitopes in the distal TRPM4 N terminus
The transient receptor potential channel of melastatin 4 (TRPM4) belongs to a group of large ion receptors that are involved in countless cell signalling cascades. This unique member is ubiquitously expressed in many human tissues, especially in cardiomyocytes, where it plays an important role in cardiovascular processes. Transient receptor potential channels (TRPs) are usually constituted by intracellular N‐ and C‐ termini, which serve as mediators affecting allosteric modulation of channels, resulting in the regulation of the channel function. The TRPs tails contain a number of conserved epitopes that specifically bi...
Source: FEBS Journal - December 29, 2017 Category: Research Authors: Kristyna Bousova, Petr Herman, Jaroslav Vecer, Lucie Bednarova, Lenka Monincova, Pavel Majer, Ladislav Vyklicky, Jiri Vondrasek, Jan Teisinger Tags: Original Article Source Type: research

Kinetic characterization of wild ‐type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms
In this study, we recombinantly produced human TGR (hTGR wild‐type) by fusing its open reading frame with a bacterial selenocysteine insertion sequence element and co‐expressing the construct in Escherichia coli together with the selA, selB, and selC genes. Additionally, the Sec→Cys mutant (hTGRU642C) of the full‐length protein, the isolated TrxR domain (hTGR151–643) and the Grx domain containing a monothiol active site (hTGR1–150) were produced and purified. All four proteins were kinetically characterized in direct comparison using Trx, DTNB, HED, or GSSG as the oxidizing substrate. Interestin...
Source: FEBS Journal - December 29, 2017 Category: Research Authors: Christina Brandstaedter, Karin Fritz ‐Wolf, Stine Weder, Marina Fischer, Beate Hecker, Stefan Rahlfs, Katja Becker Tags: Original Article Source Type: research

Structural Plasticity of Mini ‐M Conotoxins: Expression of all mini‐M subtypes by Conus regius
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 28, 2017 Category: Research Authors: Aldo Franco, Sanaz Dovell, Carolina Moller, Meghan Grandal, Evan Clark, Frank Mar í Tags: Original Article Source Type: research

Construction of green fluorescence protein mutant to monitor STT3B ‐dependent N‐glycosylation
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 28, 2017 Category: Research Authors: Toshihiko Kitajima, Wei Xue, Yi ‐Shi Liu, Chun‐Di Wang, Si‐Si Liu, Morihisa Fujita, Xiao‐Dong Gao Tags: Original Article Source Type: research

Protection of macrophages from intracellular pathogens by miR ‐182‐5p mimic—a gene expression meta‐analysis approach
We describe an approach for using public gene expression datasets to identify gene modules that are regulated by related stimuli. We used this approach to identify macrophage genes involved in the response to diverse intracellular pathogens. This module contained more miR‐182‐5p (miR‐182) targets than expected. We therefore delivered miR‐182 to macrophages and found it enhanced resistance to intracellular bacteria. (Source: FEBS Journal)
Source: FEBS Journal - December 26, 2017 Category: Research Authors: David J. Gregory, Igor Kramnik, Lester Kobzik Tags: Original Article Source Type: research

Functional role of the core gap in the middle part of tropomyosin
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 26, 2017 Category: Research Authors: Alexander M. Matyushenko, Daniil V. Shchepkin, Galina V. Kopylova, Sergey Y. Bershitsky, Natalia A. Koubassova, Andrey K. Tsaturyan, Dmitrii I. Levitsky Tags: Original Article Source Type: research

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses
This article details three aspects that we believe intertwine, and therefore should be considered together in wound healing within the GIT during postsurgical recovery: the microbiome, the host genetic make‐up and their relationship to the perioperative inflammatory status. Each of these, alone or in combination, has been linked with various states of health and disease, and in combining these three aspects in the case of postoperative recovery from bowel resection, we may be nearer an answer to preventing anastomotic leaks than might have been thought just a few years ago. Gastrointestinal resections often involve an a...
Source: FEBS Journal - December 22, 2017 Category: Research Authors: Jou A. Lee, Timothy J. A. Chico, Stephen A. Renshaw Tags: Viewpoint Source Type: research

Table of Contents
(Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Tags: Table of Contents Source Type: research

Macrophage p38 kinase inhibition for liver regeneration
In this issue, Ying et al. show that p38α kinase (MAPK14) controls macrophage polarization following acute liver injury. Myeloid cell‐specific depletion of p38α promotes polarization to anti‐inflammatory M2 macrophages and prevents pro‐inflammatory cytokine secretion that ameliorate acute liver injury and promotes hepatocyte proliferation. Therapeutic targeting of macrophage p38α is an attractive strategy not only to suppress inflammation, but also to support liver regeneration. (Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Authors: Klaus Schulze ‐Osthoff, Heike Bantel Tags: Commentary Source Type: research

Research Highlights
As part of our 50th anniversary celebration, the Research Highlights in this issue cover some of the notable papers published within our own pages in the past few years. We hope you enjoy the selection of research papers and reviews on topics from A(utophagy) to Z(ebrafish). (Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Tags: Research Highlights Source Type: research

Announcing the winners of our 50th Anniversary Science Communication Competition
The FEBS Journal is pleased to announce the three winners of its 50th Anniversary Science Communication Competition. Read on to see their prize‐winning entries! (Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Authors: Emily J. Chenette Tags: Editorial Source Type: research

50  years of The FEBS Journal: looking back as well as ahead
In this last issue of 2017, we're celebrating the 50th anniversary of The FEBS Journal. This Editorial considers how the journal has grown and changed from volume 1, issue 1 and outlines our exciting plans for the future. (Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Authors: Emily J. Chenette, Seamus J. Martin Tags: Editorial Source Type: research

Issue Information
This issue celebrates the 50th anniversary of The FEBS Journal. Cover illustration by Matthew McClements, Blink Studio Ltd, http://www.blink.biz. (Source: FEBS Journal)
Source: FEBS Journal - December 18, 2017 Category: Research Tags: Issue Cover & Information Source Type: research

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β peptides or phosphorylated tau proteins. Accumulating evidence suggests that alterations in the buffering capacity of the proteostasis network are a salient feature of AD. The endoplasmic reticulum (ER) is the main compartment involved in protein folding and secretion and is drastically affected in AD neurons. ER stress triggers the activation of the unfolded protein response (UPR), a signal transduction pathway that enforces adaptive programs to recove...
Source: FEBS Journal - December 15, 2017 Category: Research Authors: Yannis Gerakis, Claudio Hetz Tags: State ‐of‐the‐Art Review Source Type: research

Shared CaM and S100A1 binding epitopes in the distal TRPM4 N ‐terminus
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 14, 2017 Category: Research Authors: Kristyna Bousova, Petr Herman, Jaroslav Vecer, Lucie Bednarova, Lenka Monincova, Pavel Majer, Ladislav Vyklicky, Jiri Vondrasek, Jan Teisinger Tags: Original Article Source Type: research

ER Stress in Skeletal Muscle Remodeling and Myopathies
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 14, 2017 Category: Research Authors: Dil Afroze, Ashok Kumar Tags: Review Article Source Type: research

Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 14, 2017 Category: Research Authors: Jana Škerlová, Jan Bláha, Petr Pachl, Kateřina Hofbauerová, Zdeněk Kukačka, Petr Man, Petr Pompach, Petr Novák, Zbyszek Otwinowski, Jiří Brynda, Ondřej Vaněk, Pavlína Řezáčová Tags: Original Article Source Type: research

A wake ‐up call to quiescent cancer cells – potential use of DYRK1B inhibitors in cancer therapy
Nondividing cancer cells are relatively resistant to chemotherapeutic drugs and environmental stress factors. Promoting cell cycle re‐entry of quiescent cancer cells is a potential strategy to enhance the cytotoxicity of agents that target cycling cells. It is therefore important to elucidate the mechanisms by which these cells are maintained in the quiescent state. The protein kinase dual specificity tyrosine phosphorylation‐regulated kinase 1B (DYRK1B) is overexpressed in a subset of cancers and maintains cellular quiescence by counteracting G0/G1–S phase transition. Specifically, DYRK1B controls the S phase ch...
Source: FEBS Journal - December 12, 2017 Category: Research Authors: Walter Becker Tags: Review Article Source Type: research

PHISTc protein family members localize to different subcellular organelles and bind Plasmodium  falciparum major virulence factor PfEMP‐1
This study describes differential subcellular localization of novel PHISTc members PFD1140w and PF11_0503 in infected erythrocytes and identifies their binding partners in an attempt to comprehend their functions in parasitized red blood cells. The research adds another chapter to the basic understanding of lethal malaria. (Source: FEBS Journal)
Source: FEBS Journal - December 10, 2017 Category: Research Authors: Vikash Kumar, Jasweer Kaur, Amrit P. Singh, Vineeta Singh, Anjali Bisht, Jiban J. Panda, Prakash C. Mishra, Rachna Hora Tags: Original Article Source Type: research

Stemazole Promotes Survival and Preserves Stemness in Human Embryonic Stem Cells
In conclusion, stemazole significantly promotes survival of stem cells in single‐cell or starvation cultures without compromising stemness and pluripotency. This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 8, 2017 Category: Research Authors: Ying Sun, Xiaoyan zhang, Huajun Li, Shasha Xu, Xiaoyan zhang, Yinan Liu, Mei Han, Jinhua Wen Tags: Original Article Source Type: research

Biochemical and structural insights into a thermostable cellobiohydrolase from Myceliophthora thermophila
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 8, 2017 Category: Research Authors: Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov Tags: Original Article Source Type: research

14 ‐3‐3 proteins mediate inhibitory effects of cAMP on salt‐inducible kinases (SIKs)
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 6, 2017 Category: Research Authors: Tim Sonntag, Joan M. Vaughan, Marc Montminy Tags: Original Article Source Type: research

Functional BKCa channel in human resident cardiac stem cells expressing W8B2
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 6, 2017 Category: Research Authors: Oualid Ayad, Christophe Magaud, St éphane Sebille, Jocelyn Bescond, Chloé Mimbimi, Christian Cognard, Jean‐Francois Faivre, Patrick Bois, Aurelien Chatelier Tags: Original Article Source Type: research

Table of Contents
(Source: FEBS Journal)
Source: FEBS Journal - December 4, 2017 Category: Research Tags: Table of Contents Source Type: research

ADP ‐ribosylation of DNA moving into focus
In this issue of The FEBS Journal, Munnur and Ahel describe the reversible mono‐ADP‐ribosylation of DNA by PARP3, a member of the poly‐ADP‐ribose‐polymerase family known to modify proteins. They demonstrate a selective ADP‐ribosylation of the 5′‐phosphate group on DNA ends and show that the modification can be reversed by several known ADP‐ribosylhydrolases including PARG. (Source: FEBS Journal)
Source: FEBS Journal - December 4, 2017 Category: Research Authors: Christian D ölle, Mathias Ziegler Tags: Commentary Source Type: research

Online tools for enhancing presentation, understanding, and retention of 3D structural data
Dr Alexander Wlodawer, an Editor for The FEBS Journal, provides an overview of three useful resources for structural biologists: Protopedia, Molstack and the Integrated Resource for Reproducibility in Macromolecular Crystallography (IRRMC). (Source: FEBS Journal)
Source: FEBS Journal - December 4, 2017 Category: Research Authors: Alexander Wlodawer Tags: Editorial Source Type: research

Issue Information
A model for nucleolar formation in human cells, by H. Mangan et al. (pp. 3977–3985). DIC images reproduced from figure 2 in Brangwynne et al. (2011) Proc Natl Acad Sci USA 108, 4334‐4339. (Source: FEBS Journal)
Source: FEBS Journal - December 4, 2017 Category: Research Tags: Issue Cover & Information Source Type: research

Protection of macrophages from intracellular pathogens by miR ‐182‐5p mimic: a gene expression meta‐analysis approach
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 2, 2017 Category: Research Authors: David J. Gregory, Igor Kramnik, Lester Kobzik Tags: Original Article Source Type: research

Structure and interaction of Corynebacterium pseudotuberculosis cold shock protein A with Y ‐box single‐stranded DNA fragment
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - December 2, 2017 Category: Research Authors: Ícaro P. Caruso, Vineet Panwalkar, Monika A. Coronado, Andrew J. Dingley, Marinônio L. Cornélio, Dieter Willbold, Raghuvir K. Arni, Raphael J. Eberle Tags: Original Article Source Type: research

A double point mutation at residues Ile14 and Val15 of Bcl ‐2 uncovers a role for the BH4 domain in both protein stability and function
B‐cell lymphoma 2 (Bcl‐2) protein is the archetype apoptosis suppressor protein. The N‐terminal Bcl‐2‐homology 4 (BH4) domain of Bcl‐2 is required for the antiapoptotic function of this protein at the mitochondria and endoplasmic reticulum (ER). The involvement of the BH4 domain in Bcl‐2′s antiapoptotic functions has been proposed based on Gly‐based substitutions of the Ile14/Val15 amino acids, two hydrophobic residues located in the center of Bcl‐2′s BH4 domain. Following this strategy, we recently showed that a BH4‐domain‐derived peptide in which Ile14 and Val15 have been replaced by Gly...
Source: FEBS Journal - December 2, 2017 Category: Research Authors: Giovanni Monaco, Rita La Rovere, Spyridoula Karamanou, Kirsten Welkenhuyzen, Hristina Ivanova, Elien Vandermarliere, Marta Di Martile, Donatella Del Bufalo, Humbert De Smedt, Jan B. Parys, Anastassios Economou, Geert Bultynck Tags: Original Article Source Type: research