'Hibernation protein' could help repair dementia damage

Conclusion The researchers have shown how cooling is protective against the loss of synapses in the early stages of rodent forms of Alzheimer's disease and a form of prion disease. Cooling also increased how long prion-infected mice survived. But cooling was not protective in the later stages of the diseases. The researchers found this may in part be because of the protein RBM3, which is stimulated during cooling. They found levels of RBM3 increased in the early stages of the diseases when the mice were cooled, but did not in the later stages. Stimulating this protein without cooling the mice also slowed down the loss of synapses and improved survival in mice with a prion infection. The results also showed the disease processes sped up when RBM3 levels were reduced. The researchers say this indicates RBM3 is likely to be involved in the maintenance of synapse connections under normal conditions, not just during hibernation. It is already known from other studies that similar increases in RBM3 occur when humans are given therapeutic hypothermia, where the body temperature is reduced to 34C as a protective treatment – for instance, after a heart attack. It may be the case that if this pathway is stimulated in humans, it could be a new avenue of research for the treatment of neurodegenerative disorders such as Alzheimer's disease. This is intriguing research, but still very much in its early stages. There is much we don't know about Alzheimer's disease and other rela...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Source Type: news

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Three medical stories that we didn't cover, explained.Medscape
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractAdults with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in adults with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other phase 3 cl...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionA significant association between hearing handicap and dementia was found. The mechanism of this association requires further research and may involve higher order central processing disorder.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
ConclusionsOn the basis of these findings, AEBPS could serve as a potential therapeutic target for the management of mast cell-mediated allergic inflammation and as a regulator of mast cell activation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
(CNN/CBS) — At least 1,300 people have died from the flu so far this season, according to a preliminary estimate released Friday by the US Centers for Disease Control and Prevention. There have been at least 2.6 million flu illnesses and 23,000 flu-related hospitalizations, according to the analysis. So far this season, the CDC has received reports of 10 children who have died from the flu, four more than the week before. Experts have warned that flu is hitting the United States early this year, and there are concerns that this early season could mean a particularly severe season overall. Flu spread significantly in ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Flu Source Type: news
Publication date: Available online 13 December 2019Source: EXPLOREAuthor(s): Vera Lucia Pereira dos Santos, João Luiz Coelho Ribas, Cristina Peitz de Lima, Ranieri Campos, Amanda Carvalho Garcia, Jane Manfron Budel, Iara José Messias-ReasonABSTRACTDiabetes patients present a complex healing process due to several factors directly linked to their pathology. The use of medicinal plants that aid in tissue repair can bring great benefits to such individuals. This case report describes how the topical application of the aqueous extract produced from the leaves of Piper amalago L. was used to aid the healing of a l...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
In this study, 37.0% (n=452) of the population were admitted directly to Hospital de Braga and 63.0% (n=770) were transferred from other hospitals. Although timings (in min) until reperfusion were longer in interhospital transfer patients (symptom onset-first medical contact (median 76.5, IQR 40.3–150 vs. 91.0, IQR 50–180, p=0.002), first medical contact-reperfusion (median 87.5, IQR 69.0–114 vs. 145, IQR 115–199, p
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 12 December 2019Source: Revista Española de Cardiología (English Edition)Author(s): Emad Abu-Assi, José L. Bernal, Sergio Raposeiras-Roubin, Francisco J. Elola, Cristina Fernández Pérez, Andrés Íñiguez-RomoAbstractIntroduction and objectivesThere are few data on the safety of length of stay in uncomplicated ST-segment elevation myocardial infarction. We studied trends in hospital stay and the safety of short (≤ 3 days) vs long hospital stay in Spain.MethodsUsing data from the Minimum Basic Data Set, we identified patients with unc...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Conclusion: The term neonates with RD have an increase in plasma NT-pro BNP. NT-pro BNP is a very good useful test for identification of CHD in neonates with RD, in comparison to PD. Therefore, plasma NT- pro BNP can be used to differentiate between cardiac and pulmonary cause of RD.
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
Publication date: Available online 12 December 2019Source: IJC Heart &VasculatureAuthor(s): Anke C. Fender, Dobromir Dobrev
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
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