Accurate Eye-Tracking and AI to Detect Neurological Diseases: Interview with Co-Founders of C. Light

Being diagnosed with any number of neurological diseases can be scary, not only due to the progressive nature of many of these conditions, but also because they often cannot be detected until their later stages of progression. Following the failu...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Ophthalmology Source Type: blogs

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Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model. Mol Med Rep. 2020 May 18;: Authors: Cui W, Sun C, Ma Y, Wang S, Wang X, Zhang Y Abstract Cognitive impairment and neuro‑inflammatory responses are the distinctive characteristics of Alzheimer's disease (AD). Tormentic acid (TA) is one of the major active components of Potentilla chinensis and has been demonstrated to have anti‑inflammatory properties. However, the potential effects of TA on neuro‑inflammatory responses and memory impairment in AD remain unknown. ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
LncRNA GAS5 suppresses ER stress‑induced apoptosis and inflammation by regulating SERCA2b in HG‑treated retinal epithelial cell. Mol Med Rep. 2020 May 20;: Authors: Jiang L, Wang C, Shen X Abstract Hyperglycemia impairs the retinal functions in patients with diabetic retinopathy (DR). Downregulation of long non‑coding RNA growth arrest‑specific transcript 5 (lncRNA GAS5) expression in diabetes affects glucose intake and insulin signaling. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) mediates the regulation of endoplasmic reticulum (ER) stress and apoptosis in high glucose (HG)‑tr...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Wang Z, Shen L, Wang Y, Huang S Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease, which is considered the most common type of dementia worldwide. The aim of the present study was to identify key microRNAs (miRNAs/miRs) and mRNAs affecting the pathogenesis of AD, which may be developed as promising biomarkers for the early diagnosis or targeted therapy of patients with AD. Integrative analysis was performed on 12 representative miRNA datasets and three mRNA datasets of the blood from patients with AD, in order to identify differentially expressed (DE)miRNAs and DEmRNAs. Subsequen...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSIONS: These results indicate that the CAIDE dementia risk score is associated with cortical thickness and cognitive function at midlife in a low-risk population. These data provide insight into subclinical structural and functional changes occurring during midlife associated with future risk for the development of dementia. PMID: 32467426 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Gandhi P, Klatt BN, Agrawal Y Abstract People with Alzheimer disease (AD) are at increased risk of falls and disproportionately burdened with vestibular impairment compared with healthy older adults. Although physical therapy (PT) and vestibular physical therapy (VPT) are effective rehabilitation interventions in improving balance and fall risk, referral patterns for these services in the AD population are understudied. A retrospective chart review was conducted of patients seen for primary AD care at a tertiary AD referral center to investigate the frequency of rehabilitation referrals. Of the 801 people ...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Publication date: Available online 29 May 2020Source: SeizureAuthor(s): Monika Mochol, Erik Taubøll, Pål Aukrust, Thor Ueland, Ole A. Andreassen, Sigrid Svalheim
Source: Seizure - Category: Neurology Source Type: research
Publication date: September 2020Source: Epilepsy &Behavior, Volume 110Author(s): Isabelle Sylvén, Ingrid Olsson, Tove Hallböök, Bertil Rydenhag, Colin Reilly
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: September 2020Source: Epilepsy &Behavior, Volume 110Author(s): Yan Jiang, Yi Yang, Fei Feng, Ying Zhang, Xiao-Hang Wang, Fei-Lin Ni, Qun Hou, Li-Ping Zhang
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 30 May 2020Source: Epilepsy &BehaviorAuthor(s): Naoto Kuroda
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionUnderstanding these common links and central topologies under the perspective of systems biology and network theory and greater insights are provided to uncover the complex neurodegeneration processes. PMID: 32468556 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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