Evaluation of Micafungin Use in Children.
[Evaluation of Micafungin Use in Children]. Mikrobiyol Bul. 2020 Jan;54(1):120-134 Authors: Yeşil E, Çelebi S, Sezgin Evim M, Özer A, Turan C, Timur D, Çakır SÇ, Bülbül B, Ener B, Güneş AM, Köksal N, Özkan H, Sevinir B, Düzcan Kilimci D, Hacımustafaoğlu M Abstract Micafungin is recommended especially in patients with liver and kidney failure and in the presence of other side effects due to antifungals apart from its known priority indications such as invasive candidiasis. The aim of this study was to evaluate the children who have received micafungin treatment. In the study, 125 children who were hospitalized in the pediatric wards and intensive care units of our hospital and had used micafungin between November 2016 and January 2019 were analyzed retrospectively. Clinical data, micafungin indication, blood values on the first and fourth days of the treatment, side effects of the drug and efficacy were evaluated. Sixty percent (75/125) of the patients were male and the mean age of all the patients were 58 ± 67 (0-215, 30) months. Approximately half of the cases (48%) had malignancy and 13% of them were premature. Sixty-two percent (n= 37) of the malignencies were hematological (27 acute lymphocytic leukemia, nine acute myeloid leukemia, one myelodysplastic syndrome) and 38% (n= 23) were oncological (six neuroblastoma, four Hodgkin lymphoma, two Non-Hodgkin's lymphoma, five sarcomas, one h...
Introduction: Emergency medical services (EMS) systems exist to provide prehospital care in diverse environments throughout the world. Advanced Life Support (ALS) services can provide advanced care including 12-lead electrocardiogram (ECG), endotracheal intubation and parenteral medication administration. Basic Life Support (BLS) can provide basic care such as splinting, wound care and cardiopulmonary resuscitation. ALS can release patients to BLS for transport to the hospital, and this is an area of high risk. Our study examines patients who were triaged and admitted to a critical care location, including an intensive car...
Schematics of the experimental protocol used to demonstrate the selective anti ‐tumor effect of the OSKM factors in vivo. Briefly, HSPCs from reprogrammable mice were isolated, infected in culture for 2 days with a retrovirus containing MLL‐AF9‐GFP and transplanted into sublethally irradiated mice. One week later the percentage of GFP+ cells in the bone marrow and bloo d was determined and animals treated with doxycycline (doxy) for 1 week to activate OSKM in the donor cells or left untreated (no doxy). The mice were then monitored for several months for the onset of leukemia and death. While untreated animals...
Publication date: June 2020Source: Nano Energy, Volume 72Author(s): Junwei Han, Chen Zhang, Debin Kong, Xinzi He, Jing Xiao, Fanqi Chen, Ying Tao, Ying Wan, Quan-Hong Yang
An ultra-high frame rate and high spatial resolution ion-sensing Lab-on-Chip platform using a 128 × 128 CMOS ISFET array is presented. Current mode operation is employed to facilitate high-speed operation, with the ISFET sensors biased in the triode region to provide a linear response. Sensing pixels include a reset switch to allow in-pixel calibration for non-idealities such as offset, trapped charge and drift by periodically resetting the floating gate of the ISFET sensor. Current mode row-parallel signal processing is applied throughout the readout pipeline including auto-zeroing circuits for the removal...
Publication date: Available online 30 March 2020Source: LWTAuthor(s): Ana Laura Mosso, Jean Guy LeBlanc, Isabel Castanheira, Pablo Ribotta, Norma Sammán
Publication date: Available online 30 March 2020Source: LWTAuthor(s): Meixia Fu, Xuyang Sun, Di Wu, Linghan Meng, Xiao Feng, Weiwei Cheng, Chengcheng Gao, Yuling Yang, Xinchun Shen, Xiaozhi Tang
Publication date: Available online 29 March 2020Source: Food PolicyAuthor(s): Joao Breda, Lea Samanta Nash Castro, Stephen Whiting, Julianne Williams, Jo Jewell, Kaia Engesveen, Kremlin Wickramasinghe
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ConclusionMonomeric catechins are efficiently converted to gut microbiota ‐derived HGVLs that are absorbed and excreted in human urine, whereas oligomeric PC are much less efficiently converted.This article is protected by copyright. All rights reserved
ConclusionsEnergy ‐rich meals induced hyperglycemia, hyperlipemia, an inflammatory response and a decrease in antioxidant markers. A meal typical for the Mediterranean diet resulted in favorable effects on glycemic, insulinemic and lipemic responses.This article is protected by copyright. All rights reserved
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