Predicting hotspots for future flu outbreaks

This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.   "Using surveillance of influenza cases in humans and birds, we've come up with a technique to predict sites where these viruses could mix and generate a future pandemic," said lead author Trevon Fuller, a UCLA postdoctoral research fellow at the Institute of the Environment and Sustainability's Center for Tropical Research.   The researchers' models revealed that coastal and central China and Egypt's Nile Delta are danger zones where bird flu could combine with human flu to create a virulent kind of super-flu. Governments can prioritize these zones — and use the researchers' models to identify other hotspots — for increased monitoring of flu in humans, livestock, poultry and wild birds. That could help detect a novel flu virus before it spreads worldwide, the researchers said.   The research paper, "Predicting Hotspots for Influenza Virus Reassortment," was published March 13 in the peer-reviewed public health journal Emerging Infectious Diseases.   Previous pandemics, such as the 1957 and 1968 influenzas that each killed more than a million people or the 2009 H1N1 swine flu outbreak that killed 280,000 worldwide, developed when viruses from humans and a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study, the porcine GM-CSF (pGM-CSF) and FliC protein were expressed by pSUMO in E.coli Rosetta (DE3) and purified by Ni-NTA Sepharose, respectively. The immunogenicity of PCV vaccine with pGM-CSF and FliC was firstly evaluated to identify the immunoenhancement in mice. The results indicated that mice immunized with vaccine + pGM-CSF + FliC enhanced immune responses ability significantly and quickly. Then, the immune response level of PCV vaccine with pGM-CSF and FliC was assessed in piglets. The results indicated that pigs immunized with vaccine + pGM-CSF + Fl...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 18 November 2018Source: BiologicalsAuthor(s): Gowrisankar Rajam, George Carlone, Ellie Kim, Jin Choi, Simon Paulos, SoHee Park, Amilia Jeyachandran, Yamini Gorantla, Emily Wong, Amit Sabnis, Peter Browning, Rita Desai, Conrad P. Quinn, Jarad SchifferAbstractDespite wide spread vaccination, the public health burden of pertussis remains substantial. Current acellular pertussis vaccines comprise upto five Bordetella pertussis (Bp) antigens. Performing an ELISA to quantify antibody for each antigen is laborious and challenging to apply to pediatric samples where serum volume may be limited. W...
Source: Biologicals - Category: Biology Source Type: research
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.  Click arrow to play Download TWiV 520 (70 MB .mp3, 116 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology chronic kidney disease clinical trial HA stalk vaccine immunocompromised immunosufficient influenza kidney fibrosis parvovirus peptide tubulointerstitial nephropathy universal influenza vaccine viral viruses Source Type: blogs
Health officials: No reason to skip Thanksgiving dinner because of a salmonella outbreak linked to raw turkey
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai MSc program Molecular Biology and Pathology of Viruses, Univ Colleg...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Conclusions: Similar results were obtained when applying the results of previous studies to specific diseases, and it is considered that many other diseases should be studied at the national and sub-national levels. PMID: 30443418 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
In conclusion, infants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to A. lumbricoides showed no such impairment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
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r Lal Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and endocytosis had remained elusive until now. In the present study, we observed co-localization of IAV with a lipid raft marker ganglioside, GM1, on the host surface. Further, we isolated the lipid raft micro-domains from IAV infected cells and detected IAV protein in the raft fraction. Finally, raft disruption using Methyl-β-Cyclodextrin revealed significant r...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionsHPV prevalence in the oral mucosa of the assessed FA patients was higher than reported in the general population. Additional studies with collection of sequential samples are needed to know the natural history of the presence of multiple HPV types in these individuals and its association with the development of tumors, to evaluate the implementation of preventive measures, such as vaccination, and to guide early treatment.This article is protected by copyright. All rights reserved.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: Original Report Source Type: research
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