Predicting hotspots for future flu outbreaks

This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.   "Using surveillance of influenza cases in humans and birds, we've come up with a technique to predict sites where these viruses could mix and generate a future pandemic," said lead author Trevon Fuller, a UCLA postdoctoral research fellow at the Institute of the Environment and Sustainability's Center for Tropical Research.   The researchers' models revealed that coastal and central China and Egypt's Nile Delta are danger zones where bird flu could combine with human flu to create a virulent kind of super-flu. Governments can prioritize these zones — and use the researchers' models to identify other hotspots — for increased monitoring of flu in humans, livestock, poultry and wild birds. That could help detect a novel flu virus before it spreads worldwide, the researchers said.   The research paper, "Predicting Hotspots for Influenza Virus Reassortment," was published March 13 in the peer-reviewed public health journal Emerging Infectious Diseases.   Previous pandemics, such as the 1957 and 1968 influenzas that each killed more than a million people or the 2009 H1N1 swine flu outbreak that killed 280,000 worldwide, developed when viruses from humans and a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

This report highlights the risk posed by the importation of dogs inadequately vaccinated against rabies from high-risk countries and the difficulty in verifying health status of these animals.Morbidity &Mortality Weekly Report
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Over 15% of pediatric solid organ transplant recipients are hospitalized for a vaccine-preventable infection in the first five years after transplant, according to new findings in JAMA Pediatrics.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Authors: Blot M, Chavanet P, Piroth L Abstract Lower respiratory infections remain the deadliest communicable disease in the world. Influenza infections are particularly involved, whether intrinsically, or more frequently, by promoting bacterial infections and superinfections. The flu is also responsible for the decompensation of many comorbidities and could lead to some myocardial infarction and stroke. The effect of antiviral therapies is limited but preventives measures, such as vaccination, remain a major public health issue. The flu is a major challenge at all levels and all times, from vaccine prevention, to ...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
ConclusionsThe rate of nosocomial cases was high despite established precaution measures.RSV was associated with morbidity and mortality comparable to influenza. Pneumonia remains the main complication of acute viral respiratory infections, and antimicrobial treatment should include both antiviral as well as antibacterial agents.
Source: Infection - Category: Infectious Diseases Source Type: research
TUESDAY, Jan. 15, 2019 -- There have been 600 confirmed cases of Ebola and 347 confirmed deaths since early August in the Democratic Republic of the Congo, making this outbreak of the disease the second largest and second deadliest in history. Since...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 15 January 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Chunhui Duan, Dandan Hu, Xinming Tang, Jingxia Suo, Si wang, Sixin Zhang, Geru Tao, Chao Li, Chaoyue Wang, Xiaolong Gu, Xiaoli Tang, Guangping Huang, Biqi Xiang, Shaoqiang Wu, Choukri Ben Mamoun, Xun Suo, Xianyong LiuAbstractEimeria spp., the causative agents of coccidiosis, are the most common protozoan pathogens of chickens. Infection with these parasites can result in poor development or death of animals leading to a devastating economic impact on poultry production. The establishment of transfection protocols for ...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Adriana E Kajon, Daryl M Lamson, Kirsten St. GeorgeHuman adenoviruses (HAdVs) are prevalent causes of acute respiratory disease (ARD) in military and civilian communities. Over the last 20 years, collaborative efforts between US public health, military and academic laboratories have gathered comprehensive data documenting the emergence and re-emergence of specific HAdV types in association with outbreaks and unrelated cases of ARD, which have attracted national attention. New or reemerging HAdVs have included genomic variants of HAdV-B1...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Nigel James Maclachlan, Stephan Zientara, William C Wilson, Juergen A Richt, Giovanni SaviniBluetongue (BT) and epizootic hemorrhagic disease (EHD) are globally re-emerging diseases of domestic and wild ruminants, respectively caused by BT virus (BTV) and EHD virus. Both viruses are transmitted by hematophagous midges; however, newly recognized BTV serotypes may be transmitted horizontally without requirement for any biological vector. The global range of these viruses and/or their associated diseases have changed remarkably in recent y...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Qiuhong Wang, Anastasia N Vlasova, Scott P Kenney, Linda J SaifPorcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV) are emerging/reemerging coronaviruses (CoVs). They cause acute gastroenteritis in neonatal piglets. Sequence analyses suggest that PEDV and SADS-CoV may have originated from bat CoVs and PDCoV from a sparrow CoV, reaffirming the interspecies transmission of CoVs. The clinical signs and pathogenesis of the three viruses are similar. Necrosis of in...
Source: Current Opinion in Virology - Category: Virology Source Type: research
In this study, we identified three polyoxometales (POMs), the Anderson-Evans type [TeW6O24]6- (TeW6), and the Keggin-type [TiW11CoO40]8-_ (TiW11Co), and [Ti2PW10O40]7- (Ti2PW10), that inhibit ZIKV infection with EC50s in the low micromolar range. Ti2PW10, the POM with the greater selectivity index (SI), was selected and the step of ZIKV replicative cycle putatively inhibited was investigated by specific antiviral assays. We demonstrated that Ti2PW10 targets the entry process of ZIKV infection and it is able to significantly reduce ZIKV progeny production. These results suggest that the polyanion Ti2PW10 could be a good sta...
Source: Antiviral Therapy - Category: Virology Source Type: research
More News: African Health | Biology | Bird Flu | Bird Flu (H5N1 Avian Influenza) Vaccine | Economics | Education | Environmental Health | Flu Pandemic | Genetics | Grants | H1N1 | H3N2 | H5N1 | Health | Infectious Diseases | Influenza | Influenza Vaccine | International Medicine & Public Health | Laboratory Medicine | National Institutes of Health (NIH) | Outbreaks | Pandemics | Science | Study | Swine Flu | Swine Flu (H1N1) Vaccine | United Nations | Universities & Medical Training | Vaccines | WHO