Microbiome: The first 1,000 days

In the United States and other developed countries, we have seen a shift over the past several decades in the types of illness people struggle with. Public health campaigns around vaccination, sanitation, and judicious use of antibiotics have largely eradicated many infectious illnesses. As the nature of disease has shifted to inflammatory conditions, we’ve seen a striking increase in allergy and autoimmune conditions such as diabetes, obesity, inflammatory bowel disease, celiac disease, and multiple sclerosis. The microbiome — the varied and teeming colonies of gut bacteria inside of us — may be helping to drive this shift. What is the microbiome? Colonization occurs within the first two years of life. It passes through stages: some exposure in utero occurs with bacteria from the mother’s intestine passing through the placenta into amniotic fluid. Major colonization begins with delivery, when the fetus either passes through the birth canal or is born by cesarean section. Each mode of delivery produces a different colonization pattern. Colonization is further affected by diet (breast milk vs. formula) and weaning to solid foods. Maternal illness during pregnancy and infant illness with the use of antibiotics can disrupt the process. With complete colonization at two years of life, each individual has a unique signature of billions of organisms residing principally in their colon. The nature of colonizing bacteria differs based on geographic location in...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Family Planning and Pregnancy Inflammation Probiotics Source Type: blogs

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Conclusions: Nutrition counseling was rarely documented in a large sample of electronic medical record (EMR) data from pediatric wellness visits in South Carolina-a state heavily burdened by childhood obesity. Children's BMIs were infrequently recorded, which may be a barrier to tracking BMI over time. Sociodemographic and geographic differences in nutrition counseling may exacerbate disparities in childhood obesity. PMID: 32960095 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Publication date: Available online 21 September 2020Source: European Journal of RadiologyAuthor(s): Ana I. Garcia Diez, David Fuster, Laura Morata, Ferran Torres, Ruben Garcia, Daniel Poggio, Santiago Sotes, Montserrat Del Amo, Jaime Isern-Kebschull, Jaume Pomes, Alex Soriano, Laura Brugnara, Xavier Tomas
Source: European Journal of Radiology - Category: Radiology Source Type: research
Resumo Os fitoter ápicos podem atuar como dispositivo terapêutico micropolítico para o campo da saúde mental. Este relato de experiência apresenta o percurso de uma horta comunitária em uma Unidade de Saúde da Família (USF) no sul da Bahia, com objetivo de resgatar os saberes locais para produzir um campo de visibilidade. Trabalhou-se com o referencial teórico-metodológico da cartografia para analisar os efeitos do dispositivo horta na saúde dos participantes e na construção do vínculo dos trabalhadores de saúde com usu&a...
Source: Psicologia e Sociedade - Category: Psychiatry & Psychology Source Type: research
US drugmaker Johnson&Johnson says the vaccine could be available for use by early 2021 if proven safe, effective. In the next phase J&J will enroll up to 60,000 volunteers across three continents and study safety and efficacy of a single vaccine dose.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Johnson&Johnson has advanced its one-shot COVID-19 vaccine into phase 3 testing. The National Institute of Allergy and Infectious Diseases describes this as the fourth candidate to reach this stage.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Infectious Diseases News Source Type: news
Abstract Even though bariatric surgery is one of the most effective treatment option of obesity, post-surgical weight loss is not always ensured, especially in the long term, when many patients experience weight regain. Bariatric procedures are largely based on surgeon's expertise and intra-operative decisions, while an integrated in-silico approach could support surgical activity. The effects of bariatric surgery on gastric distension, which activates the neural circuitry promoting satiety, can be considered one of the main factors in the operation success. This aspect can be investigated trough computational mod...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract In this work, surface modification of nano silver-loaded zirconium phosphate (6S-NP3) were obtained from simultaneous silanization of γ-methacryloxypropyltrimethoxysilane (MPS) and grafting reaction of methyl methacrylate (MMA), and then mixed with denture base resin (E-Denture) to prepare denture base composites using 3D printer printing. FT-IR spectra confirmed that surface silanization and grafting reaction had occurred and MPS and MMA were successfully anchored on the surface of 6S-NP3. XRD results demonstrated that surface modification had occurred on the surface of hexagonal lattice. The avera...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
This article demonstrates our efforts in developing and evaluating all-ceramic, biodegradable composites of calcium phosphate cements (CPCs) reinforced with silver (Ag)-doped magnesium phosphate (MgP) crystals. Two primary goals of this study were to 1) enhance CPC's poor mechanical properties with micro-platelet reinforcement, and 2) impart antibacterial functionalities in composites with the aim to inhibit surgical site infections (SSI). The work embodies three novel features. First, as opposed to well-known reinforcements with whisker or fiber-like morphology, we explored micro-platelets for the first time as the streng...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Publication date: Available online 21 September 2020Source: Pregnancy HypertensionAuthor(s): Kim J.C. Verschueren, Rubinah R. Paidin, Annabel Broekhuis, Olivier S.S. Ramkhelawan, Lachmi R. Kodan, Humphrey H.H. Kanhai, Joyce L. Browne, Kitty W.M. Bloemenkamp, Marcus J. Rijken
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: Available online 22 September 2020Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Emily W. Duffy, Marissa G. Hall, Francesca R. Dillman Carpentier, Aviva A. Musicus, Michele L. Meyer, Eric Rimm, Lindsey Smith Taillie
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
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