Guillain –Barré Syndrome Associated With Zika Virus Infection: A Prospective Case Series From Mexico

Conclusion: Our results are similar to those reported from the state of Veracruz, Mexico, in which out of 33 samples of urine of patients with GBS two had a positive RT-PCR for ZIKV. Simultaneous processing of serum, CSF, urine, and saliva by RT-PCR may increase the success of diagnosis of GBS associated to ZIKV. Introduction In April 2016, a report of Epidemiological Surveillance for Zika virus (ZIKV) disease in Mexico reported 93 autochthonous laboratory-confirmed cases, collected between November 2015 and February 2016, and distributed amongst eight states of the country (1). In these patients, clinical manifestations were fever (96.6%), rash (93.3%), non-purulent conjunctivitis (88.8%), headache (85.4%), and myalgia (84.3%). No neurological manifestations were found among them. In 2015–2016, ZIKV infected individuals in South America, first in Northeast Brazil, rapidly disseminating to other South American, Caribbean and Central America countries, and reached North America by the end of 2016, with a parallel increase in cases of Guillain–Barré Syndrome (GBS) (2). Neurological disorders associated to ZIKV disease include now GBS, meningoencephalitis, myelitis, ophthalmic manifestations, and acute transient polyneuritis (3). Methods A joint study was implemented between the National Institute of Neurology and Neurosurgery of Mexico City, and the Epidemiology Department of the Ministry of Health, with the aim of prospectively identifying ZIKV inf...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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CONCLUSIONS: Despite the slight increases in the 10-year observation period a stable trend cannot be assumed. However, this study might be useful as baseline for other studies on SDM implementation. PMID: 31629688 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
RESUMO Objetivo Avaliar o efeito do internato em sa úde mental nas atitudes dos alunos de medicina quanto ao portador de transtorno mental (PTM). Métodos Atitudes foram avaliadas por questionário antes e depois do internato, por meio dos fatores: “ aceita ção social de PTM ” (F1), “ n ão acreditar em causas sobrenaturais para doença mental ” (F2), “ pap éis sociais comuns para PTM ” (F3), “ acreditar em causas psicossociais para doen ça mental ” (F4), “ intimidade ” (F5). Diferen ças foram avali...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
This study demonstrated a maximum 2.91 log reduction of Salmonella cocktail in wheat flour treated with 395 nm pulsed LED for 60 min in a semi-closed system. Oxidation occurred in wheat flour after 30 and 60 min exposure to the 395 nm LED, which subsequently led to bleaching, and polymerization of gluten components through disulphide linkage. The water holding capacity of gluten was reduced by oxidation, and the contents of secondary structures were altered significantly after pulsed LED treatment, but the rheological properties were not deteriorated. The disulfide bond formation naturally happens during dough form...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 20 October 2019Source: BiologicalsAuthor(s): Suresh Beri, Darshan Gandhi, Neil RavenscroftAbstractThe native structure of the bacterial polysaccharide is the key immunogenic component of conjugate vaccines and antibodies raised against the polysaccharide structure are responsible for providing protection against the corresponding pathogen. The manufacturing process of conjugate vaccines is very complex and has various biological and chemical steps. It is important to monitor the process to ensure that the structural identity of the polysaccharide is maintained throughout the process. NMR ...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 20 October 2019Source: Protein Expression and PurificationAuthor(s): Lei Jing, Juanjuan Liu, Dongxu Cui, Yuyin Li, Zhenxing Liu, Li Tao, Qing Zhao, Aipo DiaoAbstractAn affibody is a 58 amino acids peptide derived from the Z domain of staphylococcal protein A and generally applied in areas such as imaging diagnosis, clinical therapeutics and biotechnology research. To screen for an affibody targeting the immune checkpoint PD-L1, a combinatorial affibody library was generated in yeast using degenerate overlap PCR primers and In-fusion technology. Z-j1 and Z-j2 affibodies targeting the Ig-li...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 20 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Tomasz Janek, Lígia R. Rodrigues, Eduardo J. Gudiña, Joanna BurgerAbstractThe interactions between two types of quaternary ammonium surfactants (N,N,N-trimethyl-2-(dodecanoyloxy)ethaneammonium bromide (DMM-11) and N,N,N-trimethyl-2-(dodecanoyloxy)propaneammonium bromide (DMPM-11)) and hen egg white lysozyme were studied through several techniques, including isothermal titration calorimetry (ITC), circular dichroism (CD) and fluorescence spectroscopy, and surface tension measurement. The average number of...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
The present overview describes the formation of deoxyribonucleic acid (DNA) adducts from endogenous and exogenous aldehydes, such as acetaldehyde, acrolein, crotonaldehyde, malonaldehyde, 4-hydroxy-2-nonenal and 2,4-decadienal. Malonaldehyde reacts with 2 ’ -deoxyguanosine, 2 ’ -deoxyadenosine, and 2 ’ -deoxycytidine, yielding cyclic pyrimidopurinone and acyclic adducts. The direct addition of ɑ , β -unsaturated aldehydes to DNA bases yields cyclic substituted propano adducts, such as 1,N2-propano-2 ’ -deoxyguanosine. Alternatively, ɑ , β -unsaturated aldehydes can be oxidized to reactiv...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applica...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Aspergillus niger is a phytopathogenic fungus responsible for the plant disease called “ black mold ” , and it is considered the most versatile microorganism for producing acids, proteins, and enzymes of industrial value, besides a variety of compounds of pharmacological interest. This review presents a century of contribution of A. niger in the natural products chemistry under two different perspectives: (i) an overview of the structural diversity of secondary metabolites produced by A. niger from different habitats and their biological activities; (ii) a general discussion of the enzymatic potential of A. nig...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
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