Scientists identify a key gene in the transmission of deadly African sleeping sickness
Life scientists from UCLA and the University of Bern have identified a key gene in the transmission of African sleeping sickness — a severe disease transmitted by the bite of infected tsetse flies, which are common in sub-Saharan Africa.The disease is fatal if untreated, as the parasite responsible moves from the bloodstream to the central nervous system. Tens of millions of people in 36 African countries are at risk. There is no vaccine, and conventional drug treatments, which include an arsenic derivative, are antiquated, not very effective and have severe side effects.The research, published in the journal Nature Communications, could lead to new approaches to treat the disease. It also provides scientists with the first detailed understanding of how the parasite moves through the fly and what genes enable it to do so.The tiny, single-celled parasite that causes African sleeping sickness in humans, and debilitating diseases in other mammals, is called Trypanosoma brucei, or T. brucei. To become infectious, the parasite must travel through tissues of the fly, from the midgut to the salivary gland — and then into the human or other animal, through a bite.In the study, Stephanie DeMarco, a UCLA graduate student in molecular biology, and Sebastian Shaw, a graduate student at Switzerland ’s University of Bern, worked with two sets of the T. brucei parasite. In one set, they made a mutation in one of the parasite’s genes, called phosphodi...
The Department of Health and Human Services outlined support for Moderna and Johnson &Johnson, as the companies work to develop coronavirus vaccines. Beefing up manufacturing capacity is a priority.(Image credit: David L. Ryan/Boston Globe via Getty Images)
AbstractNeuropathic pain (NeP) is an intractable pain caused by a lesion or disease of the somatosensory nervous system. NeP is often challenging to manage because most of the mechanisms remain to be elucidated. Recent investigations in the field of autoimmune neurology have demonstrated that specific autoantibodies against antigens in the somatosensory pathway can cause NeP. Detection of pathogenic autoantibodies in NeP adds to the understanding of the mechanism of pain, which might aid in the development of novel immunotherapies. Therefore, it is necessary to explore novel NeP ‐related autoantibodies to improve the man...
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We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on. Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines? The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing r...
ConclusionSmaller tissue transfers are less prone to infections of the recipient site and present low LOS. For an POABP regime, the combination of 2nd and 3rd generation cephalosporins presents substantial results in recipient site infections. In cases of allergy, potential pathogens show adequate susceptibility to moxifloxacin.Clinical relevanceA combination of 2nd and 3rd generation cephalosporins may be used to prevent recipient sites in head and neck surgery.
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Publication date: Available online 31 March 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Suvina Amin, Mena Soliman, Andrew McIvor, Andrew Cave, Claudia Cabrera
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