Combining Brentuximab Vedotin with DHAP as Salvage Treatment in Relapsed/Refractory Hodgkin Lymphoma: The Phase II HOVON/LLPC Transplant BRaVE study

ConclusionsSalvage immunochemotherapy with 3 cycles of BV-DHAP induces a high mCR rate of 79% in patients with R/R HL, which is an optimal starting point for consolidation with BEAM and ASCT and may contribute to a higher cure rate. The toxicity of combining BV and DHAP is acceptable and mainly consists of manageable hematologic toxicity and fever/infections.Figure.DisclosuresHagenbeek: Millennium/Takeda: Consultancy, Honoraria, Research Funding. Morschhauser: Janssen: Other: Scientific Lectures; BMS: Membership on an entity's Board of Directors or advisory committees; Epizyme: Consultancy; Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees; Roche: Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees. Lugtenburg: Millennium/Takeda: Consultancy, Research Funding; Servier: Consultancy, Research Funding; Roche: Consultancy; BMS: Consultancy; Sandoz: Consultancy; Genmab: Consultancy. Gastinne: Millennium/Takeda: Honoraria. Tonino: Takeda: Consultancy, Honoraria. Kersten: Millennium/Takeda: Honoraria, Research Funding; Celgene: Honoraria, Research Funding; Roche: Honoraria, Research Funding; Gilead: Honoraria; Kite Pharma: Honoraria; Novartis: Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Hagenbeek, A., Zijlstra, J. M., Plattel, W. J., Morschhauser, F., Lugtenburg, P. J., Brice, P., Hutchings, M., Gastinne, T., Liu, R. D., Burggraaf, C. N., Nijland, M., Tonino, S. H., van Tinteren, H., Lopez Yurda, M. I., Kersten, M. J. Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Poster II Source Type: research