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Diabetes is not genetic

She was a beautiful woman. A patient who was easy for me to relate to. When she started to weep, I understood. I’ve heard stories like hers hundreds of times since the beginning of my career, back in Lake Worth in 1992. Let me tell you why I think this is important for you. She said, “My doctor told me I have diabetes, and it’s incurable.” So I told her, you’re not broken. There is no gene for type 2 diabetes. The things we’ve been telling people about diabetes being genetic is just dead wrong. Research has shown that genetic predispositions for most chronic diseases explain very little about disease.1 That’s because it’s environmental. The message this woman’s doctor sent her was that there was something broken inside of her. The truth is, we’ve been doing this to her with the abnormal environment we’ve created. This environmental shift started when our ancestors went from hunting for food, to farming. I always say that when you solve one problem, you create another. This transformation from a meat- and berry-based diet — what I call primal — to a grain-based diet has left us weak and diseased. Here’s an example of how much our food has changed… Wild wheat contained 14 chromosomes. Soon after humans started to grow domesticated crops, hybrid varieties of wheat evolved to have 28 chromosomes. Today’s genetically modified version — what I call a Frankenfood — has an ama...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Natural Cures Nutrition Chronic diseases diabetes diet Glycemic glycemic index GMO grains high Glycemic foods low-glycemic food Syndrome Zero Source Type: news

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CONCLUSION: The T2DM scenario shows exponential growth from 2000 to 2030. Risk factors according to the weight they represent in occurrence of the disease were: population aged 45-49 years, inhabited private dwellings that have television, and urban population. PMID: 29466528 [PubMed - in process]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Authors: Scheen AJ Abstract INTRODUCTION: Dipeptidyl peptidase-4 inhibitors (DPP-4is) are generally considered as glucose-lowering agents with a safe profile in type 2 diabetes. Areas covered: An updated review of recent safety data from randomised controlled trials, observational studies, meta-analyses, pharmacovigilance reports regarding alogliptin, linagliptin, saxagliptin, sitagliptin, and vildagliptin, with a special focus on risks of hypoglycaemia, pancreatitis and pancreatic cancer, major cardiovascular events, hospitalisation for heart failure and other new safety issues, such as bone fractures and arthralg...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
In conclusion, we found no significant correlation between the control group and patients with T2DM, with regard to the different genetic models of the 3673G / A and 9041G / A variants. These data suggest that these VKORC1 gene variants may not be linked to T2DM. PMID: 29469681 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Authors: Kataoka H, Miyatake N, Murao S, Tanaka S Abstract Resistance training is effective against type 2 diabetes (T2DM), but the effect of resistance training on toe pinch force (TPF) is unknown. Here we investigated the effect of short-term toe resistance training on TPF in patients with T2DM, in a prospective, parallel-group, single-blind, randomized controlled trial. Twelve patients with T2DM who were hospitalized to improve glycemic control were enrolled. The patients were randomly allocated to the intervention (n=6) and control (n=6) groups. The intervention group performed traditional aerobic exercise and ...
Source: Acta Medica Okayama - Category: General Medicine Tags: Acta Med Okayama Source Type: research
AbstractPurpose of reviewObesity contributes to an estimated forty-percent, or 630,000 cases, of malignant neoplasms diagnosed in the United States, and higher body mass index (BMI) has been associated with at least seventeen types of solid tumors, including 9% of all breast cancer cases. In this review, we discuss the impact of obesity and consequences of obesity, including the metabolic syndrome and type 2 diabetes mellitus, on breast cancer risk and recurrence.Recent findingsRecent work has identified multiple molecular mechanisms that may underlie the association between obesity and breast cancer. In particular, insuli...
Source: Current Surgery Reports - Category: Surgery Source Type: research
In conclusion, 2-nitro-benzenesulfonamide derivative of metformin presents highly beneficial anticoagulant properties. This compound is therefore promising candidate for further in vitro and in vivo studies. Graphical abstract
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 23 February 2018 Source:Journal of Molecular Biology Author(s): Ting Yuan, Blaz Lupse, Kathrin Maedler, Amin Ardestani The mechanistic target of rapamycin (mTOR) signaling pathway is an evolutionary conserved pathway that senses signals from nutrients and growth factors to regulate cell growth, metabolism and survival. mTOR acts in two biochemically and functionally distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), which differ in terms of regulatory mechanisms, substrate specificity and functional outputs. While mTORC1 signaling has been extensively studied in islet/ β-ce...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
This study is registered with ClinicalTrials.gov, number NCT02597049. Findings Between Dec 7, 2015, and Feb 3, 2017, 424 patients were randomly assigned to dulaglutide 1·5 mg (n=142), dulaglutide 0·75 mg (n=142), and placebo (n=140). One patient in the dulaglutide 0·75 mg group was excluded from the analysis because they did not receive any dose of the study drug. The reduction in HbA1c concentration at 24 weeks was larger in patients receiving dulaglutide (least squares mean [LSM] for dulaglutide 1·5 mg −1·34% [SE 0·06] or −14·7 mmol/mol [0·6]; dulaglutid...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Purpose: To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients. Methods: This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion after phacoemulsification, and intraocular lens implantation were enrolled. Best-corrected visual acuity and central retinal thickness (CRT) measured by spectral-domain optical coherence tomography were recorded at 1 week preope...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
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