Prevalence and clinical significance of visible oral lesions in patients with Fanconi Anemia at risk for head and neck cancer.

Prevalence and clinical significance of visible oral lesions in patients with Fanconi Anemia at risk for head and neck cancer. Curr Drug Targets. 2017 May 24;: Authors: Velleuer E, Dietrich R, Frohnmayer A, Pomjanski N, Hays LE, Biesterfeld S Abstract Fanconi anemia is a genetic bone marrow failure syndrome, variably associated with congenital anomalies and a sharply increased risk for epithelial malignancies. During the past 20 years, hematopoietic stem cell transplantation (HSCT) has dramatically improved survival. However, compared to the general population, FA patients are at greatly increased risk, and at a much younger age, for squamous cell carcinomas (SCC) of the oral cavity, esophagus and the anogenital region. The relative risk and age of onset appears to negatively correlate with HSCT in FA patients. Due to the underlying defect in DNA crosslink repair, standard chemotherapy protocols cannot be used in FA patients with SCCs. Therefore, early detection of precancerous lesions is the most promising option for long-term cure and survival. Based on oral screenings of 300 patients, we report here on the prevalence of visible oral lesions as potential precursors of oral SCCs in FA patients. PMID: 28545381 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research

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There is an urgent need to share expertise and offer emergency guidance for breast radiation therapy (RT) during the COVID-19 (Coronavirus) pandemic. As per the World Health Organisation (WHO) statement, our aim and obligation should be “to stop, contain, control, delay and reduce the impact of this virus at every opportunity”. In our roles as healthcare professionals and/or breast cancer experts this translates to minimising exposure of our patients to COVID-19 without compromising oncological outcome.
Source: Clinical Oncology - Category: Radiology Authors: Tags: Editorial Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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