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Mouse study shows spinal cord injury causes bone marrow failure syndrome
(Ohio State University Wexner Medical Center) Research conducted at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome that may contribute to chronic immune dysfunction. " We also found that it's possible to overcome certain aspects of spinal cord injury-induced bone marrow failure. This could have an immediate impact on people affected by spinal cord injury, " said lead author Phillip Popovich. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 24, 2020 Category: International Medicine & Public Health Source Type: news
When to Suspect a Bone Marrow Failure Syndrome in a Child When to Suspect a Bone Marrow Failure Syndrome in a Child
The child may be asymptomatic, the clues nonspecific. So how do pediatric providers detect a child with bone marrow failure?Medscape Pediatrics (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 13, 2017 Category: Pathology Tags: Pediatrics Expert Column Source Type: news
What Are Common Causes of Congenital Aplastic Anemia?
Discussion Aplastic anemia are disorders where there is inadequate production of erythrocytes, granulocytes and platelets caused by decreased bone marrow production leading to a peripheral blood pancytopenia. Most often it is acquired because of exposures to infections (especially viruses such as Epstein-Barr virus, rubella, herpes, etc.), drugs (e.g. chloramphenicol, chemotherapeutic agents, etc.), toxins or radiation. Learning Point The most common congenital bone marrow failure syndromes causing pancytopenia are (in this order) Fanconi anemia, Diamond-Blackfan anemia, and Shwachman-Diamond anemia. Most have a variety of...
Source: PediatricEducation.org - April 17, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Aplastic anemia or dyskeratosis congenita? Unclear diagnosis forces a difficult decision
Having a child diagnosed with a life-threatening illness is heart-wrenching for all parents, but when the diagnosis itself is uncertain, parents can face excruciatingly difficult decisions. This is what Katie and Josh Stevens of Idaho confronted after their son Riley was diagnosed in October 2012 with the blood disorder aplastic anemia, in which the body’s bone marrow produces too few oxygen-carrying red blood cells, too few infection-fighting white blood cells and too few clot-promoting platelets. He was an 11-year-old skier and runner who was tired, bruised and unable to shake a cold. When his blood was drawn, he becam...
Source: Thrive, Children's Hospital Boston - March 9, 2016 Category: Pediatrics Authors: Irene Sege Tags: Diseases & Conditions Our Patients’ Stories Akiko Shimamura Aplastic anemia Bone marrow Failure Program Dana-Farber/Boston Children's Cancer and Blood Disorders Center stem cell transplant Suneet Agarwal Source Type: news
Five years after stem cell transplant complications, he’s an active teenager
Drew at 2014 Be the Match Walk in NYC. His stem cell donor lives in Germany. “It’s eye-opening to realize how fragile life really is when you’re young.” Drew D’Auteuil certainly knows whereof he speaks. He is a 16-year-old animal-loving, skiing, rowing, volleyball-playing, honor roll student and licensed driver with braces and a shock of red hair. In April 2010, five months after receiving a stem cell transplant to treat the blood disorder severe aplastic anemia, Drew suffered rare, life-threatening complications. One day Drew was biking with a friend near his New Hampshire home, suffering little more than a mil...
Source: Thrive, Children's Hospital Boston - November 5, 2015 Category: Pediatrics Authors: Irene Sege Tags: All posts Cancer Diseases & conditions Allison O'Neill Aplastic anemia Dana-Farber/ Children's Hospital Cancer Center stem cell transplant Source Type: news
Repurposed anti-cholesterol drug could improve treatment-resistant anemias
Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome, is usually diagnosed during childhood and is typically treated with glucocorticoids that cause a host of unwanted, often dangerous side effects. Using a mouse model, a research team has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of DBA and other erythropoietin-resistant anemias. These promising results are the foundation for a clinical trial that will begin soon. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 11, 2015 Category: Science Source Type: news
Adopted from Ethiopia, his African siblings travel to Boston to save his life
By Irene Sege One morning in 2006, Aidan Barry showed his wife, Midori Kobayashi, a newspaper story on the plight of the lost boys of Sudan and children affected by the diamond war in Sierra Leone. Little did the Stratham, N.H., couple know that this moment at their breakfast table would lead them to adopt a 6-year-old boy from Ethiopia whose desperately poor parents could not support all their children. Neither could they predict that, seven years later, their adopted son would develop a life-threatening blood disorder connecting his adopted family and birth family for a stem cell transplant to offer him the best chance o...
Source: Thrive, Children's Hospital Boston - May 22, 2014 Category: Pediatrics Authors: Guest Blogger Tags: All posts Aplastic anemia Dana-Farber/Boston Children's Cancer and Blood Disorders Center our patients' stories Stem cell Stem Cell Transplant Program Source Type: news