Reported link between diet drinks and dementia and stroke is weak
Conclusion The researchers used data from a large ongoing cohort study to look for links between consumption of sugary and artificially sweetened drinks and risk of stroke or dementia. This cohort study benefits from the large overall sample size, long period of data collection, careful and valid diagnostic assessments, and adjustments for a number of confounders. However, care must be taken when interpreting these results – particularly if latching on to the maximal tripled risk figures reported in the media. There are several points to consider: Small numbers The new number of strokes and dementia in this study was small, just 3% and 5% of the cohort, respectively. The most common category for consumption of artificially sweetened drinks in the full cohort was actually zero. The paper doesn't report how many of the 97 people with stroke or 81 with dementia were in the highest consumption categories, but it's likely to be few. The numbers will get even smaller when restricting to the 82 with ischaemic stroke and 63 with Alzheimer's. Analyses with smaller numbers can be less accurate, as indicated by the rather wide confidence intervals on the tripled associations. Variable consumption measures As said above, the researchers grouped consumption categories according to the most common response. The categories for the three different drinks aren't consistent, which makes it quite difficult to compare them with one another. Overall this makes it very difficult to conclude ...
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In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
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This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke. To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
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