Genetic factors control regenerative properties of blood-forming stem cells, UCLA studies show

FINDINGSResearchers from the UCLA Department of Medicine, Division of Hematology Oncology and the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have published two studies that define how key genetic factors affect blood-forming stem cells by either accelerating or hindering the cells ’ regenerative properties. The findings could one day lead to improved treatments for people undergoing common therapies for cancer such as chemotherapy and radiation. BACKGROUNDBlood-forming stem cells, or hematopoietic stem cells, are found in the bone marrow. These cells have two unique properties: They can self-renew and, through a process called differentiation, they can form any type of blood cell. A healthy immune system depends on the regenerative abilities of hematopoietic stem cells.Common cancer therapies such as chemotherapy and radiation can eliminate cancer by killing cancer cells. But these treatments also damage hematopoietic stem cells, which can impede the cells ’ ability to regenerate blood, slowing the immune system and resulting in a longer, more complicated recovery for people with cancer. Previous research indicated that certain genes may alter hematopoietic stem cells’ regenerative capacity by either accelerating or hindering the cells’ ability to restore the immune system, but more research was needed to pinpoint the specific genetic activity and effects.METHODOne of the new studies focused on a gene...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Allergy,Volume 73, Issue 8, Page 1750-1751, August 2018.
Source: Allergy - Category: Allergy & Immunology Authors: Source Type: research
Conclusion: Since free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured. PMID: 29984208 [PubMed]
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
Publication date: June 2018Source: Molecular and Cellular Probes, Volume 39Author(s): Jie Yang, Yi Chen, Zhi Yu, Hui Ding, Zhongfu MaAbstractLong-term exposure to traffic-related pollutants can lead to a variety of respiratory diseases, including inflammation, asthma, and lung cancer; however, the underlying biological mechanisms are not fully understood. We focused on the effects of exposure to different air pollutants on the expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer. In order to understand the cellular responses induced by exposure to different traff...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: August 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 4Author(s): Parvaze Ahmad Wani, Javid Ahmad Wani, Shazia WahidAbstractChromium has different oxidation states which ranges between −2 to +6. Among all these oxidation states, Cr (VI) and Cr (III) are stable but vary in biological, geochemical and toxicological properties. Cr (VI) is more toxic than Cr (III), causes allergies, irritation and respiratory disorders. When Cr (VI) is taken up by the cell, its interaction with DNA-protein complex results in the formation of DNA-DNA cross links, and thus ultimately may cause ...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF‑1α pathway. Int J Oncol. 2018 Jul 11;: Authors: Kim A, Ma JY Abstract Rhaponticin (RA; 3'5-dihydroxy-4'-methoxystilbene 3-O-β-D‑glucopyranoside) is a component isolated from various medicinal herbs including Rheum undulatum L. RA has been reported to be an effective treatment for allergy, diabetes, thrombosis, liver steatosis, lung fibrosis and colitis. In addition, RA effectively inhibits tumor growth and induces apoptosis; however, the effects of RA, at non-cytotoxic doses, on the ...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
Publication date: 10 September 2018Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 159Author(s): Xixiao Wang, Jie Ren, Shixing Zhu, Guoqing Ren, Lei Wang, Xiaoyan Chen, Zhixia Qiu, Chaofeng ZhangAbstractEupatilin, a major pharmacologically active ingredient in StillenTM, has been known to possess anti-peptic, anti-cancer and anti-allergy activities. A rapid, simple, sensitive and specific high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the simultaneous determination of eupatilin and its main metabolite (eupatilin-7β-O-glucuronide, E-7-G) in rat plasma and tissu...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 April 2018Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Hong-Mei Yin, Su-Nan Wang, Shao-Ping Nie, Ming-Yong XieAbstractCoix (Coix lachryma-jobi L.), commonly known as adlay or Job's tears, is a minor cereal grown in most areas of Asia. It has been used in the traditional Chinese medicine for thousands of years, used as a stomachic, diuretic, analgesic, antispasmodic, and anti-inflammatory agent. It contains a range of bioactive components including polysaccharides, lipids, polyphenols, phytosterols, carotenoids, spiroenone and lactams. The bioactive constituents contribut...
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research
Conclusion: Awareness about protective spectrum of sunscreens, their correct method of application, and misconceptions need to be focused on. Better product development keeping in mind the Indian conditions would help in increasing the usage of sunscreens.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Publication date: August 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 4Author(s): Parvaze Ahmad Wani, Javid Ahmad Wani, Shazia WahidAbstractChromium has different oxidation states which ranges between −2 to +6. Among all these oxidation states, Cr (VI) and Cr (III) are stable but vary in biological, geochemical and toxicological properties. Cr (VI) is more toxic than Cr (III), causes allergies, irritation and respiratory disorders. When Cr (VI) is taken up by the cell, its interaction with DNA-protein complex results in the formation of DNA-DNA cross links, and thus ultimately may cause ...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: 10 September 2018Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 159Author(s): Xixiao Wang, Jie Ren, Shixing Zhu, Guoqing Ren, Lei Wang, Xiaoyan Chen, Zhixia Qiu, Chaofeng ZhangAbstractEupatilin, a major pharmacologically active ingredient in StillenTM, has been known to possess anti-peptic, anti-cancer and anti-allergy activities. A rapid, simple, sensitive and specific high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the simultaneous determination of eupatilin and its main metabolite (eupatilin-7β-O-glucuronide, E-7-G) in rat plasma and tissu...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
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