Genetic factors control regenerative properties of blood-forming stem cells, UCLA studies show

FINDINGSResearchers from the UCLA Department of Medicine, Division of Hematology Oncology and the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have published two studies that define how key genetic factors affect blood-forming stem cells by either accelerating or hindering the cells ’ regenerative properties. The findings could one day lead to improved treatments for people undergoing common therapies for cancer such as chemotherapy and radiation. BACKGROUNDBlood-forming stem cells, or hematopoietic stem cells, are found in the bone marrow. These cells have two unique properties: They can self-renew and, through a process called differentiation, they can form any type of blood cell. A healthy immune system depends on the regenerative abilities of hematopoietic stem cells.Common cancer therapies such as chemotherapy and radiation can eliminate cancer by killing cancer cells. But these treatments also damage hematopoietic stem cells, which can impede the cells ’ ability to regenerate blood, slowing the immune system and resulting in a longer, more complicated recovery for people with cancer. Previous research indicated that certain genes may alter hematopoietic stem cells’ regenerative capacity by either accelerating or hindering the cells’ ability to restore the immune system, but more research was needed to pinpoint the specific genetic activity and effects.METHODOne of the new studies focused on a gene...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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(International Cytokine&Interferon Society) The ICIS has chosen Chen Dong, PhD as the recipient of the 2019 BioLegend William E Paul Award for Excellence in Cytokine Research in recognition of his transformative research in immunology, including ground-breaking discoveries in the field of T cell biology and IL-17 family cytokines. Dr. Dong's research focuses on molecular mechanisms whereby immune and inflammatory responses are normally regulated, applying this to the understanding and treatment of autoimmunity, allergy disorders and cancer.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Researchers used an experimental gene therapy to develop a possible treatment for a rare and deadly immune disorder known as “bubble boy” disease, the National Institutes of Health (NIH) announced Wednesday. Because of a gene mutation, babies who are born with X-linked severe combined immunodeficiency (X-SCID) do not develop immune cells properly, leaving them highly susceptible to infections. The condition, which strikes up to one in 50,000 newborns, primarily affects boys and requires extreme measures to prevent infection. In one famous case, a boy with SCID, David Vetter, lived in a sterile plastic “bu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Ljiljana Cvetkovic1,2, Stojan Perisic2,3, Jens Titze2,4, Hans-Martin Jäck1 and Wolfgang Schuh1* 1Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany 2Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany 3Department of Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany 4Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore B lymphocytes, as a central par...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Qiancheng Deng1, Yangyang Luo1,2, Christopher Chang3, Haijing Wu1, Yan Ding4* and Rong Xiao1* 1Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China 2Department of Dermatology, Hunan Children's Hospital, Changsha, China 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United States 4Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, China Autoimmune diseases are usually complex and multifactorial, characterized by aberrant produc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, we evaluated whether the combination of focused ultrasound (FUS) and microbubbles can improve adoptively NK-92MI cell infiltration into ovarian tumors through biodistribution, immunofluorescence, and flow cytometry. The treatment effects of using this strategy twice a week were explored. The potential molecular mechanism of FUS assisting NK cell therapy was also initially explored through evaluating the expression of ICAM1 and CX3CL1 by qRT-PCR. Our results indicated that FUS and microbubbles can improve NK-92MI cells’ infiltration into tumors, and the combination of FUS and NK-92MI cells had a better ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Mariya Y. Radeva1†, Elias Walter1†, Ramona Alexandra Stach2, Amir S. Yazdi2,3, Nicolas Schlegel4, Ofer Sarig5, Eli Sprecher5,6 and Jens Waschke1* 1Department I, Institute of Anatomy and Cell Biology, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany2Department of Dermatology, University Medical Center Tübingen, Eberhard Karls University, Tübingen, Germany3Department of Dermatology, RWTH Aachen, Aachen, Germany4Department of General, Visceral, Vascular and Paediatric Surgery, Julius-Maximilians-Universität, Würzburg, Germany5Department of Dermatology, Tel-Aviv Sourask...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Ulrik Stervbo1†, Toralf Roch2†, Timm H. Westhoff1, Ludmyla Gayova3, Andrii Kurchenko3, Felix S. Seibert1‡ and Nina Babel1,2*‡ 1Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospitals of the Ruhr-University of Bochum, Herne, Germany 2Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany 3Department of Bioorganic and Biological Chemistry, Bogomolets National M...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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