The many adventures of Wesley: Specialty care helps toddler with heart disease reach neurodevelopmental milestones
Will and Alicia Ethridge knew their unborn son would need complex open-heart surgery soon after birth, due to a serious congenital defect that was detected in utero. Wesley suffered from a genetic form of cardiomyopathy, which meant the walls of his heart muscles were thickened, and blood flow to the left side of his body was restricted. The knowledge about their son’s disease prepared them for many things about the impending medical journey (including arranging for cardiac surgery at the Boston Children’s Hospital Heart Center, just a few hours’ drive from their home in Maine) but there were many more things about the months to come that they did not expect. Immediately after birth in October 2013, baby Wesley was transferred to the (CICU) at Boston Children’s. His case quickly became more complicated than anyone had anticipated. After Wesley’s initial surgery, he had five more, all before his second birthday. In February 2015, he fell critically ill and was listed for heart transplant. He received a new heart that May. While supporting their son through his various medical trials, Alicia and Will were simultaneously concerned about his neurological development. “There were very obvious delays right away,” says Alicia. Wesley was intubated during his first few weeks of life in the hospital, so he struggled with feeding for a while. Due to tightened muscles called contractures, he couldn’t raise his arms above his head, and...
Conclusion: Cardiac left ventricular and arterial functions are affected in psoriatic children and may be an alarming sign of atherosclerotic heart disease in the long term. Early detection of these changes may be helpful for eliminating other risk factors. PMID: 30997977 [PubMed - as supplied by publisher]
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, genetic studies have revealed several risk gene variants associated with ADHD; however, these variants could only be partly replicated and are responsible for only a fraction of the whole heritability of ADHD estimated from family and twin studies. One factor that could potentially explain the ‘missing heritability’ of ADHD is that childhood and adult or persistent ADHD could be genetically distinct subtypes, which therefore need to be analyzed separately. Another approach to identify t...
A 38-year-old man with a history of end-stage renal disease due to congenital vesicoureteral reflux underwent transplantation of a deceased donor kidney with good graft function thereafter. Alemtuzumab was used for induction immunosuppression, followed by maintenance immunosuppression consisting of mycophenolate mofetil, tacrolimus, and prednisone. Aerosolized pentamidine was used for posttransplant Pneumocystis jirovecii prophylaxis instead of the standard therapy with trimethoprim-sulfamethoxazole because of hyperkalemia associated with trimethoprim-sulfamethoxazole.
Conditions: Diabetes Mellitus; Quality of Life Intervention: Procedure: Solid Organ Pancreas Transplantation with or without Kidney Transplantation Sponsor: University of Oxford Recruiting
Condition: Fluid Response Intervention: Device: Massimo for Pleth variability index Sponsor: Ain Shams University Recruiting
Condition: Acute Myeloid Leukemia Interventions: Procedure: Biospecimen Collection; Other: Laboratory Biomarker Analysis Sponsors: University of Southern California; National Cancer Institute (NCI) Recruiting
Conditions: Hematologic Disease; Neoplams; Transplantation; Immunologic Deficiency Syndromes; Critical Illness Intervention: Sponsor: University Hospital, Strasbourg, France Recruiting
Condition: Allogeneic Hematopoietic Stem Cell Transplantation Recipient Interventions: Other: Best Practice; Drug: CBM588 Sponsors: City of Hope Medical Center; National Cancer Institute (NCI) Recruiting
ConclusionBoth conventional CT and 3D volumetric methods strongly correlate with AGW in donors of LDLT, whereas overall accuracy of estimation of graft weight improved marginally by 3D volumetry.
We describe a novel approach for bilateral lung transplantation as off-pump technique via median sternotomy which has the potential to combine the advantages of median sternotomy with less postoperative pain and better chest wall function and off-pump technique with reduced risk of primary graft dysfunction and bleeding complications.
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