Alcohol 'a direct cause of seven types of cancer'

Conclusion This narrative review aimed to summarise data from published biological and epidemiological research to discuss the strength of evidence that alcohol causes cancer. The author gives their main finding as a link between alcohol consumption and cancer at seven sites, and also that the highest risks seem to be associated with heavier drinking. However, they state there's no "safe" drinking threshold and that low to moderate consumption still contributes to a significant number of cancer cases. The biggest limitation of this review is that it doesn't appear to be systematic. The author provided no methods for how they identified and appraised the research they drew on. Despite referencing a number of large studies and reviews, this study and its conclusions have to be considered largely the opinion of the author following their appraisal of the evidence. We don't know whether the review has considered all research relevant to the topic and is able to reliably quantify the risks of cancer – overall or at specific sites – associated with alcohol consumption. An additional limitation to keep in mind is that this data mainly appeared to be from observational studies. These cannot prove cause and effect. The individual studies will likely have varied considerably in the additional health and lifestyle factors they took account of when looking at the links with alcohol. For example, smoking, diet and physical activity are all factors likely to be asso...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

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Publication date: Available online 17 October 2018Source: Respiratory Medicine Case ReportsAuthor(s): Saad Habib, Lazer Ezriel Leifer, Mohammed Azam, Abdul Hasan Siddiqui, Kartikeya Rajdev, Michel ChalhoubAbstractGiant Cell Carcinoma of the lung, a subtype of Sarcomatoid lung cancer is a poorly differentiated Non-Small-Cell Lung Cancer. GCCL has exceptionally aggressive characteristics, and its prognosis is much poorer than any other NSCLCs. Herein, we present a rare case of Giant Cell Carcinoma of lung treated successfully with surgical resection and adjuvant vinorelbine and cisplatin.A 48-year-old African American man wi...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Fontana J, Zima M, Vetvicka V Abstract Numerous conditions, including cancer, diabetes, aging, and atherosclerosis, are thought to be associated with oxidative stress. Oxidative stress is defined as a persistent imbalance between oxidation and antioxidation, resulting in the damage of cellular macromolecules and is often considered to be involved in wide variety of human diseases. However, the current literature is very heterogeneous making it rather difficult to draw general conclusions. Often, different biomarkers have been used in different health problems. In addition, individual biomarkers are often m...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
In conclusion, the Vγ9Vδ2 T cells activated by cancer cell lysate showed APC characteristics, and this may greatly increase interest in investigating their therapeutic potential in hematologic malignancies. Abbreviations: CML: chronic myeloid leukemia; APC: antigen-presenting cell; TCR: T cell receptor; MHC: major histocompatibility complex; N-BPs: nitrogen-containing bisphosphonates; IPP: isopentenyl pyrophosphate; PBMC: peripheral blood mononuclear cells; NKG2D: natural killer receptor group 2, member D; TRAIL: tumor necrosis factor-related apoptosis-inducing ligand. PMID: 30321079 [PubMed - as supplied by publisher]
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: Available online 16 October 2018Source: NeuroImage: ClinicalAuthor(s): Xing Liu, Yiming Li, Zenghui Qian, Zhiyan Sun, Kaibin Xu, Kai Wang, Shuai Liu, Xing Fan, Shaowu Li, Zhong Zhang, Tao Jiang, Yinyan WangAbstractObjectiveThe aim of this study was to develop a radiomics signature for prediction of progression-free survival (PFS) in lower-grade gliomas and to investigate the genetic background behind the radiomics signature.MethodsIn this retrospective study, training (n = 216) and validation (n = 84) cohorts were collected from the Chinese Glioma Genome Atlas and the Cancer Genome Atlas, respecti...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSIONS: Findings are consistent with familial transmission of AUD-associated personality traits in COAs, presumably via influences of genetics and/or familial environment. PMID: 30321089 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Authors: Papadia A, Gasparri ML, Wang J, Radan AP, Mueller MD Abstract The risk of lymph nodal metastases in endometrial cancer varies greatly according to the characteristics of the primary tumor. Surgical staging with a systematic lymphadenectomy in endometrial cancer is debated since three decades. On one hand, it provides important pathological information on the spread of the tumor allowing for an appropriate decision making on adjuvant treatment but on the other side it is characterized by a non negligible short and long term morbidity. In the past decades, various efforts have been made in the attempt to app...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: This systematic review confirms the importance of HE4 in the diagnosis of epithelial ovarian cancer and its promising role in endometrial cancer (endometrioid hystology). PMID: 30318876 [PubMed - as supplied by publisher]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: Management of pregnant women with cancer should be performed in specialized cancer centers and all cases should be discussed with a multidisciplinary approach. In the present review, we discuss the current recommendations for the management of pregnancies complicated by cancer and neonatal outcomes. PMID: 30318875 [PubMed - as supplied by publisher]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
HOW TO live longer: Eating a healthy and balanced diet is one of the ways proven to increase life expectancy, but what exactly should you be eating? Nuts have been found to improve heart health and prevent serious conditions like type 2 diabetes and bowel cancer. So which ones should you be eating?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
HOW TO live longer: Eating a healthy and balanced diet is one of the ways proven to increase life expectancy, but what exactly should you be eating? Nuts have been found to improve heart health and prevent serious conditions like type 2 diabetes and bowel cancer. So which ones should you be eating?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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