The marathon of life: Catching up with Greek army lieutenant, 31 years post heart surgery
Ted Sarafis ran the Athens Marathon 30 years after life-saving surgery to close a hole in his heart Well into his teenage years, Greek army lieutenant Thodoris (Ted) Sarafis thought the scar on his chest was the result of an unfortunate tumble he took as a child. “My parents told me I had an accident, and that’s where I got my scar,” he says. Sarafis didn’t learn he’d had heart surgery as a toddler until his medical clearance exam for the Greek national karate team at age 16. Ted took the news in stride, but last year, curiosity got the better of him, and he pressed his father for more information. That’s when he found out exactly where he’d had his life-saving surgery (the Boston Children’s Hospital Heart Center) and who performed that procedure (Dr. Aldo Casteneda, who now lives and works in Guatemala). Ted then learned more about the details of his diagnosis and the extraordinary measures his parents took in 1984 to save his life. Ted was born with an atrial septal defect (ASD), a hole in the wall between the upper chambers of the heart. He needed a surgical intervention to close the hole. This kind of surgery was being perfected at Boston Children’s in the early 1980s, so Ted’s parents, Denis and Maria, decided to go to the U.S. for the procedure. A generous great uncle financed the trip. Although today ASD closure is considered one of the simpler pediatric heart operations, in 1984 it was new and complicated. Ma...
DiscussionOur starting hypothesis was confirmed for the complication rate and clinical outcomes. The benefits of dual mobility cups are emphasized. While the indications for TFR are rare, they will likely increase in the coming years.Level of evidence: IV, Retrospective cohort studyâ€¦
Publication date: Available online 24 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Brooke Liang, Sara S. Lange, L. Stewart Massad, Rebecca Dick, Kathryn A. Mills, Andrea R. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Katherine C. Fuh, David G. Mutch, Matthew A. Powell, Lindsay M. KurokiAbstractObjectiveTo assess the renal outcomes of gynecologic oncology patients who present with hydronephrosis and acute kidney injury (AKI), have
In conclusion, STH have shown a chemo-preventive action on different colon cancer cell models.Graphical abstract
Background: The circadian timing system or circadian clock plays a crucial role in many biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular health, glucose homeostasis, and body temperature regulation. Energy balance is also one of the most important cornerstones of metabolic processes, whereas energy imbalance is associated with many diseases (i.e., obesity, diabetes, cardiovascular disease). Circadian clock is the main regulator of metabolism, and this analysis provides an overview of the bidirectional effect of circadian rhythm on metabolic processes and energy balance.Summary: The circ...
In conclusion, the present study suggests that the preoperative CONUT score was associated with an increased risk of mortality and complications in GI and HPB surgical oncology. Patients with higher CONUT score as compared with those having a lower score had approximately a fivefold mortality risk and an increased risk up to 55% on major and overall complications after GI and HPB surgery. Our analysis indicates that the appropriate cutoff value of the CONUT score to predict postoperative major complications would be between 4 and 5. The preoperative evaluation of the CONUT score would be helpful for predicting the risk of ...
We report an extremely rare case of a right ventricular outflow tract mass identified to be an intracardiac MC in a 4-month-old male infant. Pathology revealed an EWS-KLF15 translocation. Treatment included gross total resection and intensive chemotherapy. Recurrent cardiac mass with brain metastasis was seen 16 months after primary diagnosis. We describe the rarity of intracardiac MC in pediatric patients and the challenges encountered in the multimodal management of this patient.
Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children’s Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radi...
Conclusions: In conclusion, we report our 3-year experience about the frequency and seasonality of respiratory viruses in children with cancer.
Conclusions: Pediatric patients with head and neck cancer can be risk-stratified based on clinical and dosimetric factors. This data, combined with parent and patient perceptions, is key to the development of rational guidelines.
We report 2 cases of intravenous immunoglobulin refractory ITP in children receiving chemotherapy for high-risk neuroblastoma. ITP was successfully treated with the thrombopoietin-receptor-agonist romiplostim, allowing safe and timely continuation of antineuroblastoma therapies in these high-risk patients.
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