The marathon of life: Catching up with Greek army lieutenant, 31 years post heart surgery
Ted Sarafis ran the Athens Marathon 30 years after life-saving surgery to close a hole in his heart Well into his teenage years, Greek army lieutenant Thodoris (Ted) Sarafis thought the scar on his chest was the result of an unfortunate tumble he took as a child. “My parents told me I had an accident, and that’s where I got my scar,” he says. Sarafis didn’t learn he’d had heart surgery as a toddler until his medical clearance exam for the Greek national karate team at age 16. Ted took the news in stride, but last year, curiosity got the better of him, and he pressed his father for more information. That’s when he found out exactly where he’d had his life-saving surgery (the Boston Children’s Hospital Heart Center) and who performed that procedure (Dr. Aldo Casteneda, who now lives and works in Guatemala). Ted then learned more about the details of his diagnosis and the extraordinary measures his parents took in 1984 to save his life. Ted was born with an atrial septal defect (ASD), a hole in the wall between the upper chambers of the heart. He needed a surgical intervention to close the hole. This kind of surgery was being perfected at Boston Children’s in the early 1980s, so Ted’s parents, Denis and Maria, decided to go to the U.S. for the procedure. A generous great uncle financed the trip. Although today ASD closure is considered one of the simpler pediatric heart operations, in 1984 it was new and complicated. Ma...
CONCLUSIONS: Oncotype is a cost-effective intervention from a health system perspective since each QALY gained costs less than 25,000 euros. From a societal perspective, it is dominant since it provides greater health and is accompanied by cost savings. PMID: 30442434 [PubMed - as supplied by publisher]
Abstract Human liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Mekong countries such as Thailand, Laos, Cambodia, Vietnam, and Myanmar with over 10 million infected through consumption of fish containing infective metacercariae. With no tissue migration phase and living entirely within the larger secondary (intrahepatic) bile ducts, liver flukes are only exposed to a biliary mucosal immune response, while their excretory and secretory products also stimulate chronic inflammation of biliary epithelium. Neither mucosal nor tissue immune responses appear to cause parasi...
Abstract The availability of genome and transcriptome data of the liver fluke Opisthorchis viverrini provides the foundation for exploration of gene function and its effect on host-parasite interactions and pathogenesis of O. viverrini-associated bile duct cancer. Functional genomics approaches address the function of DNA at levels of the gene, RNA transcript and protein product using informative manipulations of the genome, epigenome, transcriptome, proteome, microbiome and metabolome. Advances in functional genomics for O. viverrini have thus far focused on RNA interference. The flukes have been transfected with...
Abstract The liver flukes Opisthorchis viverrini, O. felineus, and Clonorchis sinensis are closely related fish-borne trematodes endemic in East Asia, Eurasia, and Siberia. Following ingestion, the parasites locate to the biliary tree, where chronic infection frequently leads to cholangiocarcinoma (CCA). Infection with C. sinensis or O. viverrini is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Infection with O. felineus may also be carcinogenic. The mechanism(s) by which infection with these liver flukes culminates in CCA remain elusive, although they are likely to be mult...
Andrey A. Rosenkranz, Tatiana A. Slastnikova, Tatiana A. Karmakova, Maria S. Vorontsova, Natalia B. Morozova, Vasiliy M. Petriev, Alexey S. Abrosimov, Yuri V. Khramtsov, Tatiana N. Lupanova, Alexey V. Ulasov, Raisa I. Yakubovskaya, Georgii P. Georgiev, Alexander S. Sobolev
Gabriella Del Bene, Fabio Calabr ò, Diana Giannarelli, Elizabeth R. Plimack, Lauren C. Harshman, Evan Y. Yu, Simon J. Crabb, Sumanta Kumar Pal, Ajjai S. Alva, Thomas Powles, Ugo De Giorgi, Neeraj Agarwal, Aristotelis Bamias, Sylvain Ladoire, Andrea Necchi, Ulka N. Vaishampayan, Günter Niegisch, Joaquim Bellmunt, Jack Baniel, Matt hew D. Galsky, Cora N. Sternberg
Xu Tian, Xiao-Ling Liu, Yuan-Ping Pi, Hui Chen, Wei-Qing Chen
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