Flavouring found in e-cigarettes linked to 'popcorn lung'

ConclusionThis study shows three chemicals reportedly linked to serious lung damage are present in many flavoured e-cigarettes in the US, raising concerns about their safety. Although the study tested US brands, it's likely similar findings would be found here in the UK, where e-cigarettes are similarly unregulated.However, this issue is not black and white. The researchers' concerns have been rightly raised, and their conclusion that urgent research needs to follow this study seems logical given the apparent lack of knowledge in this area.  Still, much of the potential health risk and alarm factor of this study hangs on the strength of previous reports suggesting these chemicals can cause lung damage. But this particular study didn't address this directly. We don't yet know whether these chemicals, in their vaporised forms and inhaled at the levels typical in e-cigarettes, cause any lung damage.This study simply looked at how often the three chemicals were detected in e-cigarettes, assuming a link with potential lung damage from other studies that were not appraised here. What we really need is more information on the potential causal link between these chemicals and lung disease, particularly the doses at which any damage might occur, which may or may not be present in e-cigs. Many e-cigarette users may be asking themselves whether they should stop vaping. This study only provides indirect evidence of a risk linking chemicals in e-cigarettes to lung disease, ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Source Type: news

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A 73-year-old female presenting with haemoptysis and dyspnoea was found to have a locally advanced left thyroid mass and vocal cord palsy. A CT scan of the neck and thorax and endoscopy demonstrated invasion into the tracheal lumen. Histopathology of the intraluminal tracheal mass confirmed a papillary thyroid cancer (PTC). The tumour was deemed unresectable due to local extent and patient comorbidities. TKI therapy with lenvatinib was used for 14 months. On serial scanning, a marked reduction in tumour volume from 31 × 59 × 32 mm to 17 × 28 × 22 mm was noted. This subsequently allowed a successful ...
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Publication date: Available online 16 January 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Irida Kastrati, Svetlana Semina, Benjamin Gordon, Emily SmartAbstractEstrogen receptor (ER) is the most important factor in the pathophysiology of breast cancer. Consequently, modulation of ER activity has been exploited to develop drugs against ER + breast cancer, such as tamoxifen, referred to as endocrine therapies. With deeper understanding of ER mechanism of action, posttranslational modifications (PTMs) are increasingly recognized as important in mediating ER activity. Some ER PTMs such as phosphorylatio...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 17 January 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Heebin Son, Keumhan Noh, Changhyun Kang, MinKyun Na, Sangtaek Oh, Im-Sook Song, Wonku KangAbstractIlimaquinone, a metabolite isolated from the marine sponge Hippiospongia metachromia, has antimicrobial, cytotoxic, anti-HIV, anti-inflammatory, and anti-cancer activities. A new quantitative analytical method for determination of ilimaquinone in rat plasma using HPLC-MS/MS was developed and validated. Ascorbic acid was added to ensure the stability of ilimaquinone in plasma. After protein precipitation using a...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 January 2019Source: PhytomedicineAuthor(s): Wagner B.R. Santos, Marlange A.O. Melo, Rafael S. Alves, Renan G. de Brito, Thallita K. Rabelo, Lindaura da S. Prado, Virginia K. dos S. Silva, Daniel P. Bezerra, José E.R. de Menezes-Filho, Diego S. Souza, Carla M.L. de Vasconcelos, Luciana Scotti, Marcus Tullius Scotti, Waldecy de Lucca Júnior, Lucindo J. Quintans-Júnior, Adriana G. GuimarãesAbstractBackgroundOncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-cymene (PC) is a monoterpene found in more than 100...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionThis is the first report on the antiproliferative activity of flavipin isolated from endophytic C. globosum and also proposed that interaction of flavipin with NFкB could be a possible mechanism for this activity. Flavipin induced apoptosis at low concentrations in cancer cell lines (A549, HT-29) and exhibited itself as a potential anticancer agent.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Americans are obsessed with protein. It’s touted as the cornerstone of any healthy diet, since it helps people feel full and builds muscle. But most Americans eat too much protein every day, according to federal estimates—and they’re going especially overboard with animal proteins, namely red meat. It’s becoming clear how big a problem excessive red-meat consumption can be for health. Research has found associations between diets heavy in red and processed meats and many chronic diseases, including Type 2 diabetes, heart disease and cancer. Red meat comes with high amounts of saturated fat, and proc...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
ConclusionRadiation oncologists who were recently trained and had high treatment volume are associated with poorer outcomes among HNC patients getting IMRT treatment.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 January 2019Source: Journal of Geriatric OncologyAuthor(s): Nicolò Matteo Luca Battisti, Allison Magnuson, Mina S. Sedrak, Enrique Soto-Perez-de-Celis
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionOur results do not provide evidence for a major role of petroleum-based and oxygenated solvents in the occurrence of oral and oropharyngeal cancers in men.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionOur findings imply an increasing risk of CRC in both Western and Asian populations as their younger cohorts reach older ages. These findings are consistent with the life course argument that macro-environmental changes associated with socio-economic development have specific effects that extend over the life course. Actions that pertain to altering lifestyle-related exposures over the life course are of great importance in combating young CRC risks in the future.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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