Flavouring found in e-cigarettes linked to 'popcorn lung'

ConclusionThis study shows three chemicals reportedly linked to serious lung damage are present in many flavoured e-cigarettes in the US, raising concerns about their safety. Although the study tested US brands, it's likely similar findings would be found here in the UK, where e-cigarettes are similarly unregulated.However, this issue is not black and white. The researchers' concerns have been rightly raised, and their conclusion that urgent research needs to follow this study seems logical given the apparent lack of knowledge in this area.  Still, much of the potential health risk and alarm factor of this study hangs on the strength of previous reports suggesting these chemicals can cause lung damage. But this particular study didn't address this directly. We don't yet know whether these chemicals, in their vaporised forms and inhaled at the levels typical in e-cigarettes, cause any lung damage.This study simply looked at how often the three chemicals were detected in e-cigarettes, assuming a link with potential lung damage from other studies that were not appraised here. What we really need is more information on the potential causal link between these chemicals and lung disease, particularly the doses at which any damage might occur, which may or may not be present in e-cigs. Many e-cigarette users may be asking themselves whether they should stop vaping. This study only provides indirect evidence of a risk linking chemicals in e-cigarettes to lung disease, ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Source Type: news

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CONCLUSIONS: These results indicate for the first time that advanced T stage and low miR-126 level are predictors of unfavorable prognosis and recurrence in LN-negative GC patients. These parameters should be taken into account to stratify patients for adjuvant therapy and close follow-up. PMID: 30248047 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
This study aimed to evaluate the expression of the stem cell-related proteins (CD133 and Sox2) and their prognostic value in astrocytic glioma. METHODS: The immunohistochemical expression of CD133 and Sox2 in 40 patients with an astrocytic glioma of different grades was studied. The recorded data on the overall survival (OS), progression-free survival (PFS) and the response to the therapeutic protocol were collected and lastly analyzed. RESULTS: CD133 expression was observed in 87.5% of the cases, while positive Sox2 expression was found in all the studied cases. There was a significant association of CD133 ex...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
We examined biopsy of different types of cancer cells to diagnose skin cancer at early stages by using FTIR spectroscopy. To differentiate metastases we examined two human melanoma cells of same patient but at different metastatic potential and two murine melanoma cells with common genetic background but different metastatic potential. Our findings revealed that melanoma changes the permeability of cell membrane and higher metastatic potential is related to the hydration level of cell membrane. Thus, ATR-FTIR spectroscopy is a potential technique to help in early diagnosing of skin cancer and to differentiate different met...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Authors: Meng FT, Huang M, Shao F, Huang Q Abstract BACKGROUND: Free fatty acid receptor 4 (FFAR4) is associated with the epithelial mesenchymal transition (EMT) and is involved in the progression of several types of cancer. However, the role of FFAR4 in cholangiocarcinoma (CCA) remains unclear. OBJECTIVE: The present study evaluated the diagnosis and prognosis of CCA using FFAR4 as a biomarker. METHODS: Immunohistochemistry was employed to detect expression of FFAR4 in 98 samples of CCA tissues and adjacent tissues. In addition, expression of E-cadherin, vimentin, Snail-1, CK7 and CK19 in the 98 ...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Single mother Roisin McWilliams was diagnosed with stage four Hodgkins Lymphoma last year.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Authors: Meronard K, Josowicz M, Saheb A Abstract Direct and efficient label-free voltammetric detection of Glutathione S-Transferase Pi 1 (GSTP1) hypermethylation is reported using a custom developed 16-channel Microelectrode Array chip. The microelectrode array chip is used in a dipstick configuration allowing detection of DNA hybridization in a solution volume of only 0.35 mL. Platinum microelectrode disks (n = 16) 30 µm in diameter have been modified with a polypyrrole bilayer before any contact with the oligonucleotides. The attachment of the 15-mer Probe DNA to the bilayer is random but controlled by th...
Source: Analytical Letters - Category: Chemistry Tags: Anal Lett Source Type: research
PANCREATIC cancer symptoms include unexplained weight loss, back pain, and vomiting. But, you could also be at risk of tumour signs if your wee looks like this.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aims to investigate the relationship between ERCC5 polymorphism and the breast cancer risk in the lower northeastern region women of Thailand. One hundred fifty five samples from breast cancer patients and 122 samples from healthy control group were analysed. Genomic DNA was extracted from white blood cell of all samples. The real-time polymerase chain reaction (qPCR) was used to demonstrate genetic polymorphism of ERCC5. The results showed that the ERCC5 rs751402 polymorphism variant AG was associated with an increased risk of breast cancer. The frequency of ERCC5 rs751402 in patients with breast cancer was hig...
Source: International Journal of Molecular Epidemiology and Genetics - Category: Genetics & Stem Cells Tags: Int J Mol Epidemiol Genet Source Type: research
This study evaluated how different levels of pressure under inelastic multi-layer bandages affect the reduction of secondary arm lymphedema and patient comfort throughout therapy. Ninety-six women with lymphedema after breast cancer treatment were randomized into three groups of 32 patients depending on level of applied pressure in compression therapy: group I (control) at 21-30 mmHg; study groups II A at 31-40 mmHg and group II B at 41-60 mmHg. All patients were treated with complex decongestive therapy (CDT) and intermittent pneumatic compression (IPC) before compression. Fixed points of bilateral arms were measured at t...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Authors: Debakey Y, Zaghloul A, Farag A, Mahmoud A, Elattar I Abstract Background: Undoubtedly, robotic systems have largely penetrated the surgical field. For any new operative approach to become an accepted alternative to conventional methods, it must be proved safe and result in comparable outcomes. The purpose of this study is to compare the short-term operative as well as oncologic outcomes of robotic-assisted and laparoscopic rectal cancer resections. Methods: This is a prospective randomized clinical trial conducted on patients with rectal cancer undergoing either robotic-assisted or laparoscopic surgery...
Source: Minimally Invasive Surgery - Category: Surgery Tags: Minim Invasive Surg Source Type: research
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