Interplay between myotubularins and Ca < sup > 2+ < /sup > homeostasis
Biochim Biophys Acta Mol Cell Res. 2024 May 4:119739. doi: 10.1016/j.bbamcr.2024.119739. Online ahead of print.ABSTRACTThe myotubularin family, encompassing myotubularin 1 (MTM1) and 14 myotubularin-related proteins (MTMRs), represents a conserved group of phosphatases featuring a protein tyrosine phosphatase domain. Nine members are characterized by an active phosphatase domain C(X)5R, dephosphorylating the D3 position of PtdIns(3)P and PtdIns(3,5)P2. Mutations in myotubularin genes result in human pathologies myopathies, and several neuropathies including X-linked myotubular myopathy and Charcot-Marie-Tooth type 4B. MTM1...
Source: Biochimica et Biophysica Acta - May 6, 2024 Category: Biochemistry Authors: Ning Dai Jody Groenendyk Marek Michalak Source Type: research
E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
Biochim Biophys Acta Mol Cell Res. 2024 May 3:119743. doi: 10.1016/j.bbamcr.2024.119743. Online ahead of print.ABSTRACTHuman DNA polymerase ι (Polι) belongs to the Y-family of specialized DNA polymerases engaged in the DNA damage tolerance pathway of translesion DNA synthesis that is crucial to the maintenance of genome integrity. The extreme infidelity of Polι and the fact that both its up- and down-regulation correlate with various cancers indicate that Polι expression and access to the replication fork should be strictly controlled. Here, we identify RNF2, an E3 ubiquitin ligase, as a new interacting partner of PolÎ...
Source: Biochimica et Biophysica Acta - May 5, 2024 Category: Biochemistry Authors: Mikolaj Fedorowicz Agnieszka Halas Matylda Macias Ewa Sledziewska-Gojska Roger Woodgate Justyna McIntyre Source Type: research
E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
Biochim Biophys Acta Mol Cell Res. 2024 May 3:119743. doi: 10.1016/j.bbamcr.2024.119743. Online ahead of print.ABSTRACTHuman DNA polymerase ι (Polι) belongs to the Y-family of specialized DNA polymerases engaged in the DNA damage tolerance pathway of translesion DNA synthesis that is crucial to the maintenance of genome integrity. The extreme infidelity of Polι and the fact that both its up- and down-regulation correlate with various cancers indicate that Polι expression and access to the replication fork should be strictly controlled. Here, we identify RNF2, an E3 ubiquitin ligase, as a new interacting partner of PolÎ...
Source: Biochimica et Biophysica Acta - May 5, 2024 Category: Biochemistry Authors: Mikolaj Fedorowicz Agnieszka Halas Matylda Macias Ewa Sledziewska-Gojska Roger Woodgate Justyna McIntyre Source Type: research
Notable enhancement of Amphotericin B channel activity by applied pressures in the range of MS channel activation
Biochim Biophys Acta Biomembr. 2024 May 3;1866(5):184326. doi: 10.1016/j.bbamem.2024.184326. Online ahead of print.ABSTRACTThe mechanism of Amphotericin B at the membrane is still subject of debate, with the prevailing hypothesis being the formation of pores. The activity of these pores is influenced by various factors. Recently aggregation in solution and insertion in the membrane had been highlighted as crucial for action of the drug Here we investigated the effect of applied pressure on the activity of Amphotericin B. Our findings demonstrate that applied pressure of 50 mmHg is sufficient to enhance the activity. We int...
Source: Biochimica et Biophysica Acta - May 4, 2024 Category: Biochemistry Authors: Tammy Haro-Reyes Iv án Ortega-Blake Source Type: research
A complete biosynthetic pathway of the long-chain polyunsaturated fatty acids in an amphidromous fish, ayu sweetfish Plecoglossus altivelis (Stomiati; Osmeriformes)
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 3;1869(6):159498. doi: 10.1016/j.bbalip.2024.159498. Online ahead of print.ABSTRACTThe biosynthetic capability of the long-chain polyunsaturated fatty acids (LC-PUFA) in teleosts are highly diversified due to evolutionary events such as gene loss and subsequent neo- and/or sub-functionalisation of enzymes encoded by existing genes. In the present study, we have comprehensively characterised genes potentially involved in LC-PUFA biosynthesis, namely one front-end desaturase (fads2) and eight fatty acid elongases (elovl1a, elovl1b, elovl4a, elovl4b, elovl5, elovl7, elovl8a ...
Source: Biochimica et Biophysica Acta - May 4, 2024 Category: Biochemistry Authors: Bo Zhao Yingying Peng Yuki Itakura Myriam Lizanda Yutaka Haga Shuichi Satoh Juan C Navarro Óscar Monroig Naoki Kabeya Source Type: research
Ketogenesis attenuated KLF5 disrupts iron homeostasis via LIF to confer oxaliplatin vulnerability in colorectal cancer
This study aimed to determine whether the consumption of a KD increases the sensitivity of CRC cells to oxaliplatin via the inhibition of a classical stem cell marker, Krupple-like factor 5 (KLF5). KLF5 functions as a transcription factor for the leukemia inhibitory factor (LIF) and directly binds to its promoter region. LIF upregulation induces dephosphorylation of metal regulatory transcription factor 1 (MTF1), which is recruited to the promoter area of Ferroportin (FPN1), the only cellular iron exporter. FPN1 upregulation reduces the labile iron pool (LIP) and ferroptosis in CRC cells. KLF5 knockdown inhibits the LIF/MT...
Source: Biochimica et Biophysica Acta - May 4, 2024 Category: Biochemistry Authors: Haoran Jiang Yuan Zeng Xue Jiang Xuni Xu Lihao Zhao Xiaoye Yuan Jun Xu Mengjing Zhao Fang Wu Gang Li Source Type: research
Emerging biomarkers and molecular targets for precision medicine in cervical cancer
In conclusion, the evolving landscape of biomarkers and molecular targets presents exciting opportunities for advancing precision medicine in cervical cancer. By harnessing these insights, clinicians can optimize treatment selection, enhance patient outcomes, and ultimately transform the management of this devastating disease.PMID:38701936 | DOI:10.1016/j.bbcan.2024.189106 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Pankaj Garg Madhu Krishna Ayalur Raghu Subbalakshmi Sravani Ramisetty Atish Mohanty Prakash Kulkarni David Horne Ravi Salgia Sharad S Singhal Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
Impact of HMGB1 on cancer development and therapeutic insights focused on CNS malignancy
Biochim Biophys Acta Rev Cancer. 2024 May 1:189105. doi: 10.1016/j.bbcan.2024.189105. Online ahead of print.ABSTRACTThe present study explores the complex roles of High Mobility Group Box 1 (HMGB1) in the context of cancer development, emphasizing glioblastoma (GBM) and other central nervous system (CNS) cancers. HMGB1, primarily known for its involvement in inflammation and angiogenesis, emerges as a multifaceted player in the tumorigenesis of GBM. The overexpression of HMGB1 correlates with glioma malignancy, influencing key pathways like RAGE/MEK/ERK and RAGE/Rac1. Additionally, HMGB1 secretion is linked to the maintena...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Sucharita Patra Pritam Kumar Roy Ankita Dey Mahitosh Mandal Source Type: research
OSBPL2 compound heterozygous variants cause dyschromatosis, ichthyosis, deafness and atopic disease syndrome
CONCLUSIONS: Our study not only unveiled the association between OSBPL2 variants and the newly identified DIDA syndrome but also shed light on the underlying mechanism.PMID:38701954 | DOI:10.1016/j.bbadis.2024.167207 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yumeng Wang Anqi Zhao Naihui Zhou Xiaoxiao Wang Chaolan Pan Shengru Zhou Haisheng Huang Yijun Yang Jianqiu Yang Yifan Yang Jingwen Zhang Fuying Chen Qiaoyu Cao Jingjun Zhao Si Zhang Ming Li Min Li Source Type: research
Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer
This study aimed to evaluate circulating miRNA, cortisol and catecholamine as potential biomarkers that can predict FOLFOX-CIPN symptoms. High-throughput microRNA (miRNA) sequencing was performed on the RNA circulating in the plasma of eight patients with CRC who underwent FOLFOX chemotherapy. miRNA expression profiles were evaluated according to two groups: those who underwent ≤3 cycles and those who underwent ≥6 cycles of FOLFOX chemotherapy. The identified miRNAs were validated in 27 patients with CRC who underwent FOLFOX chemotherapy using quantitative reverse transcription polymerase chain reaction. Target genes w...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yeongdon Ju Dong Hoon Baek Go-Eun Choi Aelee Jang Source Type: research
Electroacupuncture pre-treatment exerts a protective effect on LPS-induced cardiomyopathy in mice through the delivery of miR-381 via exosomes
CONCLUSIONS: Our research findings have revealed a novel endogenous cardiac protection mechanism, wherein circulating exosomes derived from EA pre-treatment mitigate LPS-induced cardiac dysfunction via miR-381.PMID:38701956 | DOI:10.1016/j.bbadis.2024.167208 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yong Chen Shuangli Chen Jingyu Zhang Xiyou Hu Ningcen Li Zhen Liu Lihong Huang Jianbo Yu Yuan Zhang Xiaowei Lin Zhifang Xu Yuxin Fang Zelin Chen Yi Guo Bo Chen Source Type: research
AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes
In conclusion, the parallel structure of AS1411 allows it to bind to nucleolin and disrupt the exosome-miRNA-27a-mediated reciprocal activation loop between glioma cells and astrocytes. Our results may help in the development of a novel approach to therapeutic modulation of the glioma microenvironment.PMID:38701957 | DOI:10.1016/j.bbadis.2024.167211 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Xiaoming Sun Wenzi Zhang Changlong Gou Xinyu Wang Xianhui Wang Xin Shao Xiao Chen Zhuo Chen Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria
Biochim Biophys Acta Mol Cell Res. 2024 May 1:119742. doi: 10.1016/j.bbamcr.2024.119742. Online ahead of print.ABSTRACTPeroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisomal membrane fractions purified from the yeast Hansenula polymorpha by untargeted label-free quantitation mass spectrometry. As expected, several known peroxisome-associated proteins were enriched in the peroxiso...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Marc Pilegaard Pedersen Justina C Wolters Rinse de Boer Arjen M Krikken Ida J van der Klei Source Type: research
