Tracheal relaxation through calcium channel blockade of Achillea millefolium hexanic extract and its main bioactive compounds
Conclusionhexanic extract of A. millefollium induced a significant relaxant effect on tracheal rat rings by calcium channel blockade and NO release.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 6, 2020 Category: Drugs & Pharmacology Source Type: research
Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines
Spinal cord injury leads to sustained protein expression of p53 in paralyzed soleus muscles. This change is not associated with differences in key cytokines associated with cellular senescence. AbstractTo determine whether muscle disuse after a spinal cord injury (SCI) produces elevated markers of cellular senescence and induces markers of the senescence ‐associated secretory phenotypes (SASPs) in paralyzed skeletal muscle. Four‐month‐old male Sprague‐Dawley rats received a moderate‐severe (250 kiloDyne) T‐9 contusion SCI or Sham surgery and were monitored over 2 weeks, and 1‐, 2‐, or 3 months. Animals we...
Source: Physiological Reports - February 6, 2020 Category: Physiology Authors: Zachary A. Graham,
Abigail Goldberger,
Daniella Azulai,
Christine F. Conover,
Fan Ye,
William A. Bauman,
Christopher P. Cardozo,
Joshua F. Yarrow Tags: ORIGINAL RESEARCH Source Type: research
Nanoemulsions and acidified milk gels as a strategy for improving stability and antioxidant activity of yarrow phenolic compounds after gastrointestinal digestion
Publication date: Available online 18 December 2019Source: Food Research InternationalAuthor(s): M. Villalva, L. Jaime, E. Arranz, Z. Zhao, M. Corredig, G. Reglero, S. SantoyoAbstractThe aim of this study was to improve the stability and antioxidant activity of yarrow phenolic compounds upon an in vitro simulated gastrointestinal digestion. Therefore, two types of caseins-based delivery systems, sodium caseinate stabilized nanoemulsions (NEs) and glucono delta-lactone acidified milk gels (MGs), were formulated containing an ultrasound-assisted yarrow extract (YE) at two concentrations (1 and 2.5 mg/mL). Formulations with 1...
Source: Food Research International - December 19, 2019 Category: Food Science Source Type: research
Partial support for food availability and thermal quality as drivers of density and area used in Yarrow ’s Spiny Lizards (Sceloporus jarrovii)
Canadian Journal of Zoology, e-First Articles. Contrary to traditional models, habitat selection in ectotherms may be chiefly based on a habitat ’s thermal properties rather than its food availability, due to their physiological dependence on environmental temperature. We tested two hypotheses: that microhabitat use in ectotherms is driven by food availability and that it is driven by thermoregulatory requirements. We predicted that the de nsity of lizards would increase and the mean area used would decrease with the natural arthropod (food) availability (or thermal quality) of a plot, as well as after experimentally inc...
Source: Canadian Journal of Zoology - November 25, 2019 Category: Zoology Authors: L.D. Patterson G. Blouin-Demers Source Type: research
Medicinal plants and their uses recorded in the Archives of Latvian Folklore from the 19th century
ConclusionsOne hundred and fifty-two plant taxa mentioned in the records of Latvian folk medicine are not included in the European Union herbal monographs providing scientific information on the safety and efficacy and deserve further exploration as traditional herbal medicines.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 9, 2019 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 24, Pages 4030: Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasa...
Source: Molecules - November 6, 2019 Category: Chemistry Authors: Andreia S.P. Pereira Antonio J. Banegas-Luna Jorge Pe ña-García Horacio P érez-Sánchez Zeno Apostolides Tags: Article Source Type: research
Application of multivariate regression and artificial neural network modelling for prediction of physical and chemical properties of medicinal plants aqueous extracts
The objective of this study was to evaluate the applicability of multiple linear regression, nonlinear regression, piecewise linear regression, and artificial neural network modelling for the prediction of the physical properties (total dissolved solids, extraction yield), and chemical properties (total phenolic content and antioxidant activity) of the aqueous extracts of nine medicinal plants (dandelion, camomile, lavender, lemon balm, marigold, mint, nettle, plantain, and yarrow), prepared in dynamic experiments based on the extraction conditions (time and temperature), and plant species. Results indicated that simple mu...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - October 15, 2019 Category: Complementary Medicine Source Type: research
Interleukin-10 and Interleukin-1 β Cytokines Expression in Leukocytes of Patients with Chronic Peri-Mucositis.
CONCLUSIONS Theses results suggest that the solution of PFS might offer a new potential for the development of a new therapeutic path to prevent and treat peri-implant mucositis.
PMID: 31586435 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research
Diet-induced Generalized Periodontitis in Lewis Rats.
Abstract
Periodontitis is an important public health concern worldwide. Because rodents from the genus Rattus are resistant to spontaneous periodontitis, experimental periodontitis must be initiated by mechanical procedures and interventions. Due to their exacerbated Th1 response and imbalanced Th17 regulatory T-cell responses, Lewis rats are highly susceptible to inducible inflammatory and autoimmune diseases. We hypothesized that feeding Lewis rats a diet high in sucrose and casein(HSC) would alter the oral microenvironment and induce inflammation and the development of periodontitis lesions without mech...
Source: Comparative Medicine - September 30, 2019 Category: Zoology Authors: Messer JG, La S, Kipp DE, Castillo EJ, Yarrow JF, Jorgensen M, Wnek RD, Kimmel DB, Aguirre JI Tags: Comp Med Source Type: research
Ethnopharmacological survey of medicinal plants traded in herbal markets in the Peloponnisos, Greece
ConclusionsBased on our results, the plant taxa of Salvia spp., Aloysia citriodora, Achillea millefolium, Calendula officinalis, Juniperus communis, Malva sylvestris, Matricaria chamomilla, Origanum vulgare, Thymbra capitata, Taraxacum and Tilia spp. and Zea mays had novel medicinal uses which deserve further investigation.Graphical abstract (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - September 22, 2019 Category: Complementary Medicine Source Type: research
Hard to disrupt: Categorization and enumeration by gender and race from mixed displays
Publication date: November 2019Source: Journal of Experimental Social Psychology, Volume 85Author(s): Xin Yang, Yarrow DunhamAbstractWhile much research has focused on the ways in which stereotyping and prejudice follow from category-based perception of others, less work has examined how and when category-based perception emerges in the first place. Here we adopt a number estimation task to explore perceivers' ability to estimate the number of individuals belonging to a given social category (race or gender) from briefly presented arrays of faces. We also investigate facial features that are crucial for this ability. Acros...
Source: Journal of Experimental Social Psychology - September 11, 2019 Category: Psychiatry & Psychology Source Type: research
Predator-prey interactions and venom composition in a high elevation lizard specialist, Crotalus pricei (twin-spotted Rattlesnake).
Abstract
The Twin-spotted Rattlesnake (Crotalus pricei) is a small lizard specialist restricted to higher montane habitat in the Sky Islands of Arizona and México. Though this species is restricted to high elevations and dispersal between mountaintops is impossible, few studies have investigated venom composition or the predator-prey relationship between C. p. pricei and its primary prey source, Yarrow's Spiny Lizard (Sceloporus jarrovii). Because of current isolation of populations in disjunct mountain ranges, it is possible that populations show local adaptation to prey and/or environmental conditions, ...
Source: Toxicon - September 8, 2019 Category: Toxicology Authors: Grabowsky ER, Mackessy SP Tags: Toxicon Source Type: research
The impact of ectoparasitism on thermoregulation in Yarrow ’s Spiny Lizards (Sceloporus jarrovii)
Canadian Journal of Zoology, e-First Articles. Parasites are ubiquitous and can have large impacts on the fitness of their hosts. The effects of ectoparasites on physiology, behaviour, and immune function suggest that they could be part of the factors which impact thermoregulation. We tested the hypothesis that ectoparasites impact thermoregulation in Yarrow ’s Spiny Lizards (Sceloporus jarrovii Cope in Yarrow, 1875) living along an elevational gradient. We predicted a positive association between ectoparasite load and body temperature (Tb), and a negative association between ectoparasite load and effectiveness of thermo...
Source: Canadian Journal of Zoology - July 7, 2019 Category: Zoology Authors: N. Johnson A.H. Lymburner G. Blouin-Demers Source Type: research
The spatio-temporal expression of some genes involved in the biosynthetic pathways of terpenes/phenylpropanoids in yarrow (Achillea millefolium)
Publication date: Available online 29 June 2019Source: Plant Physiology and BiochemistryAuthor(s): Ehsan Fathi, Mohammad Majdi, Dara Dastan, Asad MaroufiAbstractYarrow (Achillea millefolium) is a medicinal plant from the Asteracea which biosynthesize different secondary metabolites especially terpenes and phenylpropanoids. To improve our understanding of the regulatory mechanisms behind the biosynthesis of these compounds we analyzed the expression of some genes associated with the biosynthesis of terpenes and phenylpropanoids in different tissues and in response to trans-cinnamic acid (tCA) as an inhibitor of PAL activity...
Source: Plant Physiology and Biochemistry - June 30, 2019 Category: Biochemistry Source Type: research
Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice
This study was not supportive of a beneficial role for recombinant human relaxin delivered either systemically or locally via collagen scaffolds applied to the lesions. AbstractBone fractures are associated with considerable morbidity and increased mortality. A major limitation to healing is lack of bone blood flow, which is impaired by physical disruption of intraskeletal and/or periosteal vasculature by the fracture. Thus, pharmacological interventions are needed to improve osseous blood flow, thereby accelerating bone fracture closure. Relaxin is secreted by the ovary and circulates in rodents and humans during pregnanc...
Source: Physiological Reports - June 1, 2019 Category: Physiology Authors: Kirk P. Conrad,
Ean G. Phillips,
Jessica Jiron,
Julie Bailes,
Biswadeep Dhar,
YanPeng Diao,
Jose Ignacio Aguirre,
Joshua F. Yarrow Tags: Original Research Source Type: research
