Rate of Recurrence Following Treatment of Lentigo Maligna with Carbon Dioxide Laser Alone or in Combination with Imiquimod: Results of a Long-term Study
Lentigo maligna (LM) is most seen in middle-aged and elderly patients. 1,2 It can be treated with surgical excision however, comorbidities, age of patient, anatomical location and size of lesions can make surgical intervention or even radiotherapy challenging and difficult to tolerate. The following is a study of patients who underwent CO2 laser therapy alone and in combination with 5% imiquimod for LM lesions. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - July 2, 2023 Category: Cosmetic Surgery Authors: Anjana Kaur, Muhammad Umair Javed, Barabarra Venables, Maxwell Murison, Jeremy Yarrow Source Type: research
Molecules, Vol. 28, Pages 4791: Phytochemical Profiling, Antioxidant and Tyrosinase Regulatory Activities of Extracts from Herb, Leaf and In Vitro Culture of Achillea millefolium (Yarrow)
mierz Głowniak
Achillea millefolium L. is one of the most known medicinal plants with a broad spectrum of applications in the treatment of inflammation, pain, microbial infections and gastrointestinal disorders. In recent years, the extracts from A. millefolium have also been applied in cosmetics with cleansing, moisturizing, shooting, conditioning and skin-lightening properties. The growing demand for naturally derived active substances, worsening environmental pollution and excessive use of natural resources are causing increased interest in the development of alternative methods for the production of plant-based in...
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Karolina Czech Katarzyna Gawe ł-Bęben Agnieszka Szopa Wirginia Kukula-Koch Thomas Jakschitz G ünther Bonn Shah Hussain Pawe ł Kubica Halina Ekiert Kazimierz G łowniak Tags: Article Source Type: research
On why we lack confidence in some signal-detection-based analyses of confidence
Conscious Cogn. 2023 Jun 7;113:103532. doi: 10.1016/j.concog.2023.103532. Online ahead of print.ABSTRACTSignal-detection theory (SDT) is one of the most popular frameworks for analyzing data from studies of human behavior - including investigations of confidence. SDT-based analyses of confidence deliver both standard estimates of sensitivity (d'), and a second estimate informed by high-confidence decisions - meta d'. The extent to which meta d' estimates fall short of d' estimates is regarded as a measure of metacognitive inefficiency, quantifying the contamination of confidence by additional noise. These analyses rely on ...
Source: Consciousness and Cognition - June 9, 2023 Category: Neurology Authors: Derek H Arnold Alan Johnston Joshua Adie Kielan Yarrow Source Type: research
On why we lack confidence in some signal-detection-based analyses of confidence
Conscious Cogn. 2023 Jun 7;113:103532. doi: 10.1016/j.concog.2023.103532. Online ahead of print.ABSTRACTSignal-detection theory (SDT) is one of the most popular frameworks for analyzing data from studies of human behavior - including investigations of confidence. SDT-based analyses of confidence deliver both standard estimates of sensitivity (d'), and a second estimate informed by high-confidence decisions - meta d'. The extent to which meta d' estimates fall short of d' estimates is regarded as a measure of metacognitive inefficiency, quantifying the contamination of confidence by additional noise. These analyses rely on ...
Source: Consciousness and Cognition - June 9, 2023 Category: Neurology Authors: Derek H Arnold Alan Johnston Joshua Adie Kielan Yarrow Source Type: research
Invited review: Adrenocortical function in avian and non-avian reptiles: Insights from dispersed adrenocortical cells
Comp Biochem Physiol A Mol Integr Physiol. 2023 Apr 18:111424. doi: 10.1016/j.cbpa.2023.111424. Online ahead of print.ABSTRACTHerein we review our work involving dispersed adrenocortical cells from several lizard species: the Eastern Fence Lizard (Sceloporus undulatus), Yarrow's Spiny Lizard (Sceloporus jarrovii), Striped Plateau Lizard (Sceloporus virgatus) and the Yucatán Banded Gecko (Coleonyx elegans). Early work demonstrated changes in steroidogenic function of adrenocortical cells derived from adult S. undulatus associated with seasonal interactions with sex. However, new information suggests that both sexes operate...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - April 18, 2023 Category: Physiology Authors: Rocco V Carsia Patrick J McIlroy Henry B John-Alder Source Type: research
Invited review: Adrenocortical function in avian and non-avian reptiles: Insights from dispersed adrenocortical cells
Comp Biochem Physiol A Mol Integr Physiol. 2023 Apr 18:111424. doi: 10.1016/j.cbpa.2023.111424. Online ahead of print.ABSTRACTHerein we review our work involving dispersed adrenocortical cells from several lizard species: the Eastern Fence Lizard (Sceloporus undulatus), Yarrow's Spiny Lizard (Sceloporus jarrovii), Striped Plateau Lizard (Sceloporus virgatus) and the Yucatán Banded Gecko (Coleonyx elegans). Early work demonstrated changes in steroidogenic function of adrenocortical cells derived from adult S. undulatus associated with seasonal interactions with sex. However, new information suggests that both sexes operate...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - April 18, 2023 Category: Physiology Authors: Rocco V Carsia Patrick J McIlroy Henry B John-Alder Source Type: research
Review of Safety Data for Adenovirus 5 as a Delivery Vector for Intratumoral Cancer Gene Therapy
Human Gene Therapy,Volume 34, Issue 7-8, Page 314-324, April 2023. (Source: Human Gene Therapy)
Source: Human Gene Therapy - April 17, 2023 Category: Genetics & Stem Cells Authors: Yarrow Sheldon Byung-Chun Yoo Eric Kmiec Nicholas Petrelli Gregory Tiesi Shelley Warner Source Type: research
A developmental investigation of group concepts in the context of social hierarchy: Can the powerful impose group membership?
Cognition. 2023 Mar 23;236:105446. doi: 10.1016/j.cognition.2023.105446. Online ahead of print.ABSTRACTGroup membership is not always voluntary and can be imposed within a social context; moreover, those with power disproportionately shape group membership. We asked if children and adults view group membership as imposed by the powerful. We undertook four studies (465 children ages 4-9, 150 adults): Studies 1-2 used novel minimal groups; Study 3 used 'cool' and 'uncool'; Study 4 used novel ethnic groups. In the first three studies, children saw groups varying in power asserting that a non-categorized individual ought to be...
Source: Cognition - March 25, 2023 Category: Neurology Authors: Alexander Noyes Emily Gerdin Marjorie Rhodes Yarrow Dunham Source Type: research
A developmental investigation of group concepts in the context of social hierarchy: Can the powerful impose group membership?
Cognition. 2023 Mar 23;236:105446. doi: 10.1016/j.cognition.2023.105446. Online ahead of print.ABSTRACTGroup membership is not always voluntary and can be imposed within a social context; moreover, those with power disproportionately shape group membership. We asked if children and adults view group membership as imposed by the powerful. We undertook four studies (465 children ages 4-9, 150 adults): Studies 1-2 used novel minimal groups; Study 3 used 'cool' and 'uncool'; Study 4 used novel ethnic groups. In the first three studies, children saw groups varying in power asserting that a non-categorized individual ought to be...
Source: Cognition - March 25, 2023 Category: Neurology Authors: Alexander Noyes Emily Gerdin Marjorie Rhodes Yarrow Dunham Source Type: research
A developmental investigation of group concepts in the context of social hierarchy: Can the powerful impose group membership?
Cognition. 2023 Mar 23;236:105446. doi: 10.1016/j.cognition.2023.105446. Online ahead of print.ABSTRACTGroup membership is not always voluntary and can be imposed within a social context; moreover, those with power disproportionately shape group membership. We asked if children and adults view group membership as imposed by the powerful. We undertook four studies (465 children ages 4-9, 150 adults): Studies 1-2 used novel minimal groups; Study 3 used 'cool' and 'uncool'; Study 4 used novel ethnic groups. In the first three studies, children saw groups varying in power asserting that a non-categorized individual ought to be...
Source: Cognition - March 25, 2023 Category: Neurology Authors: Alexander Noyes Emily Gerdin Marjorie Rhodes Yarrow Dunham Source Type: research
A developmental investigation of group concepts in the context of social hierarchy: Can the powerful impose group membership?
Cognition. 2023 Mar 23;236:105446. doi: 10.1016/j.cognition.2023.105446. Online ahead of print.ABSTRACTGroup membership is not always voluntary and can be imposed within a social context; moreover, those with power disproportionately shape group membership. We asked if children and adults view group membership as imposed by the powerful. We undertook four studies (465 children ages 4-9, 150 adults): Studies 1-2 used novel minimal groups; Study 3 used 'cool' and 'uncool'; Study 4 used novel ethnic groups. In the first three studies, children saw groups varying in power asserting that a non-categorized individual ought to be...
Source: Cognition - March 25, 2023 Category: Neurology Authors: Alexander Noyes Emily Gerdin Marjorie Rhodes Yarrow Dunham Source Type: research
Germacrane-Type Sesquiterpene Lactones from Achillea millefolium L. and Their Anti-inflammatory Activity
Chem Biodivers. 2023 Mar 13:e202300079. doi: 10.1002/cbdv.202300079. Online ahead of print.ABSTRACTSix undescribed germacrane-type sesquiterpene lactones (1-6) and two known analogues (7-8) were isolated from the ethyl acetate fraction of the whole plant of Achillea millefolium L. growing in Xinjiang, China. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS, UV spectral data analyses and comparison with literatures. The absolute configurations of compounds 1-6 were confirmed by experimental and calculated electronic circular dichroism (ECD) data. Compounds 1-8 displayed the approximate...
Source: Chemistry and Biodiversity - March 14, 2023 Category: Biochemistry Authors: Hongliang Li Haji Akber Aisa Jun Li Source Type: research
Effects of Testosterone+Finasteride On Muscle After Spinal Cord Injury: A Randomized Double-Blind, Placebo-Controlled Pilot Study
To evaluate the influence of high-dose testosterone plus finasteride (T+F) on voluntary knee extensor (KE) strength and KE cross-sectional area (CSA) in men with impaired gait and low to low-normal testosterone after chronic incomplete spinal cord injury (SCI). (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - March 1, 2023 Category: Rehabilitation Authors: Dana Otzel, David Clark, Jonathan Miles, Varsini Balamurugan, Joelle Simpson, Larissa Nichols, Christine Conover, Chris Gregory, Christopher Sonntag, Anita Wokhlu, Charles Levy, Charles Plumlee, Robert Sammel, Kevin White, Joshua Yarrow Tags: Late Breaking Research Poster 2229345 Source Type: research
Effects of Testosterone+Finasteride on Bone After Spinal Cord Injury: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
To assess the influence of high-dose testosterone plus finasteride (T+F) on bone mineral density (BMD) in men with impaired gait and low to low-normal testosterone subsequent to chronic incomplete spinal cord injury (SCI). (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - March 1, 2023 Category: Rehabilitation Authors: Stephen Marangi, Dana Otzel, Larissa Nichols, Christine Conover, Chris Gregory, David Clark, Christopher Sonntag, Anita Wokhlu, Charles Levy, Charles Plumlee, Robert Sammel, Kevin White, Joshua Yarrow Tags: Late Breaking Research Poster 2229370 Source Type: research
Testosterone+Finasteride Improves Body Composition After Spinal Cord Injury: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
To assess the influence of high-dose testosterone plus finasteride (T+F) on body composition in men with impaired gait and low to low-normal testosterone after chronic incomplete spinal cord injury (SCI). (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - March 1, 2023 Category: Rehabilitation Authors: Joshua Yarrow, Jayachandra Kura, Dana Otzel, Larissa Nichols, Christine Conover, Chris Gregory, David Clark, Christopher Sonntag, Anita Wokhlu, Charles Levy, Charles Plumlee, Robert Sammel, Kevin White Tags: Late Breaking Research Poster 2229368 Source Type: research
