Germacrane-Type Sesquiterpene Lactones from Achillea millefolium L. and Their Anti-inflammatory Activity

Chem Biodivers. 2023 Mar 13:e202300079. doi: 10.1002/cbdv.202300079. Online ahead of print.ABSTRACTSix undescribed germacrane-type sesquiterpene lactones (1-6) and two known analogues (7-8) were isolated from the ethyl acetate fraction of the whole plant of Achillea millefolium L. growing in Xinjiang, China. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS, UV spectral data analyses and comparison with literatures. The absolute configurations of compounds 1-6 were confirmed by experimental and calculated electronic circular dichroism (ECD) data. Compounds 1-8 displayed the approximate tendency to inhibit the NO release in LPS-induced BV2 cells.PMID:36914847 | DOI:10.1002/cbdv.202300079
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research