Evaluation of the Efficacy and Safety of Tenofovir Disoproxil Fumarate in Intercepting Mother-to-Child Transmission of Hepatitis B Virus
This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. Ther...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Dongxiang Han Jianxiu Du Wei Wang Cui Wang Source Type: research
Evaluation of the Efficacy and Safety of Tenofovir Disoproxil Fumarate in Intercepting Mother-to-Child Transmission of Hepatitis B Virus
This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. Ther...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Dongxiang Han Jianxiu Du Wei Wang Cui Wang Source Type: research
Virologic outcomes with tenofovir-lamivudine-dolutegravir in adults failing PI-based second-line ART
Conclusion: Amongst patients failing second-line PI with no PI resistance, switching to TLD was associated with higher virologic suppression, likely due to improved adherence. Virologic outcomes were similar in patients with PI resistance switched to darunavir-based regimens or TLD. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - April 26, 2024 Category: African Health Authors: Ying Zhao Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Underlying Neural Mechanisms of Cognitive Improvement in Fronto-striatal Response Inhibition in People Living with HIV Switching Off Efavirenz: A Randomized Controlled BOLD fMRI Trial
ConclusionPotential neural mechanisms underlying cognitive improvement after discontinuing EFV in PLWH were found in subcortical functioning, with our findings suggesting that EFV ’s effect on attention and processing speed is, at least partially, mediated by reactive inhibition.Trial RegistrationClinicaltrials.gov identifier [NCT02308332]. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 20, 2024 Category: Infectious Diseases Source Type: research
Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022
In this study, we isolated hepatitis B virus (HBV) DNA from 58 of 169 hepatitis B surface antigen (HBsAg)-positive blood samples from Japanese blood donors and determined the nucleotide sequence encoding the small envelope protein. DNA from six (10%) of the samples had VEMs, but no missense mutations, such as G145R, were detected. Complete HBV genome sequences were obtained from 29 of the 58 samples; the viral genotype was A1 in one (3%), A2 in three (10%), B1 in nine (31%), B2 in five (17%), B4 in one (3%), and C2 in 10 (34%) samples. Tenofovir-resistance mutations were detected in two (7%) samples. In addition, several c...
Source: Archives of Virology - April 18, 2024 Category: Virology Source Type: research
Research news in clinical context
Published in STI: Self-start HIV postexposure prophylaxis after sexual exposure to reduce time to first dose The efficacy of HIV post-exposure prophylaxis (PEP) increases with a shorter time to treatment initiation. This randomised, prospective, open-label study among men who have sex with men (MSM) in the UK assigned 139 participants to either a 5-day PEP starter pack of emtricitabine/tenofovir disoproxil fumarate/maraviroc, or to the standard of care (SOC) PEP access through sexual health clinics or accident and emergency units. There was a significant reduction in time from sex to first PEP dose in the starter pack arm ...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Tan, R. K. J., Herbert, R., Vielot, N. A. Tags: Perspective Source Type: research
Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study
Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 12, 2024 Category: Gastroenterology Authors: Hariklia Kranidioti, Konstantinos Zisimopoulos, Theodora Oikonomou, Theodoros Voulgaris, Spyros Siakavellas, Polixeni Agorastou, Melanie Deutsch, Christos Triantos, Ioannis Goulis, George Papatheodoridis and Spilios Manolakopoulos Tags: Research Source Type: research
Reply to "Cardiovascular risk of tenofovir disoproxil fumarate or tenofovir alafenamide fumarate in HBV patients"
Clin Mol Hepatol. 2024 Apr 11. doi: 10.3350/cmh.2024.0228. Online ahead of print.NO ABSTRACTPMID:38600870 | DOI:10.3350/cmh.2024.0228 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Pin-Nan Cheng Ming-Lung Yu Source Type: research
