Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review
Clin Pharmacol. 2024 Jan 4;16:1-25. doi: 10.2147/CPAA.S429064. eCollection 2024.ABSTRACTThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a betacoronavirus responsible for the COVID-19 pandemic, causing respiratory disorders, and even death in some individuals, if not appropriately treated in time. To face the pandemic, preventive measures have been taken against contagions and the application of vaccines to prevent severe disease and death cases. For the COVID-19 treatment, antiviral, antiparasitic, anticoagulant and other drugs have been reused due to limited specific medicaments for the disease. Drug r...
Source: Clinical Pharmacology: Advances and Applications - January 10, 2024 Category: Allergy & Immunology Authors: Paula Andrea Vel ásquez Juan C Hernandez Elkin Galeano Jaime Hincapi é-García Mar ía Teresa Rugeles Wildeman Zapata-Builes Source Type: research
Co-emulsified Alginate-Eudragit Nanoparticles: Potential Carriers for Localized and Time-defined Release of Tenofovir in the Female Genital Tract
AAPS PharmSciTech. 2024 Jan 10;25(1):15. doi: 10.1208/s12249-023-02723-4.ABSTRACTThis research aimed to explore the possibilities of Eudragit S100 (ES100) and sodium alginate as carriers for tenofovir disoproxil fumarate (TDF) in the female genital tract. Alginate and alginate-ES100 nanoparticles were prepared using the ionic gelation and emulsion/gelation complexation method, respectively. The nanocarriers were tested using morphological, physicochemical, in vitro drug release, and cytotoxicity analyses. In SEM and TEM images, the presence of spherical and uniformly distributed nanoparticles was revealed. The FTIR spectru...
Source: AAPS PharmSciTech - January 10, 2024 Category: Drugs & Pharmacology Authors: Funanani Takalani Pradeep Kumar Pierre P D Kondiah Yahya E Choonara Source Type: research
Effects of first-line nucleot(s)ide analogues on lipid profiles in patients with chronic hepatitis B: a network meta-analysis
ConclusionTDF was effective in lipid reduction, particularly pronounced in the older population. TAF and ETV had a neutral effect to TC, TG, LDL-C, and HDL-C. Despite a relative increase in lipids observed in patients transitioning from TDF to TAF or ETV, these changes remained within acceptable limits. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
ConclusionOur findings indicate that additional considerations are needed in CNS HIV treatment strategies for people who use cocaine, as it may limit ART efficacy through regulation of drug transport and metabolizing pathways at the BBB. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - January 10, 2024 Category: Neuroscience Source Type: research
Effects of first-line nucleot(s)ide analogues on lipid profiles in patients with chronic hepatitis B: a network meta-analysis
ConclusionTDF was effective in lipid reduction, particularly pronounced in the older population. TAF and ETV had a neutral effect to TC, TG, LDL-C, and HDL-C. Despite a relative increase in lipids observed in patients transitioning from TDF to TAF or ETV, these changes remained within acceptable limits. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
Entecavir versus tenofovir for prevention of hepatitis B virus-associated hepatocellular carcinoma after curative resection: study protocol for a randomized, open-label trial
Entecavir and tenofovir disoproxil fumarate (TDF) are standard first-line treatments to prevent viral reactivation and hepatocellular carcinoma (HCC) in individuals chronically infected with the hepatitis B vi... (Source: Trials)
Source: Trials - January 5, 2024 Category: General Medicine Authors: Li-Xin Pan, Yi-Yang Wang, Zhong-Hai Li, Jia-Xi Luo, Kun-Jun Wu, Zhen-Xiu Liu, Pei-Sheng Wu, Kang Chen, Liang Ma, Xiao-Hui Fan and Jian-Hong Zhong Tags: Study protocol Source Type: research
Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine
AIDS Res Ther. 2024 Jan 3;21(1):1. doi: 10.1186/s12981-023-00590-4.ABSTRACTWe assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4 counts in the group that switched from the dolutegravir-based regimen, but not in the tenofovir alafenamide-based regimen group. High-density lipoprotein ...
Source: AIDS Research and Therapy - January 4, 2024 Category: Infectious Diseases Authors: Eisuke Adachi Makoto Saito Amato Otani Michiko Koga Hiroshi Yotsuyanagi Source Type: research
Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine
AIDS Res Ther. 2024 Jan 3;21(1):1. doi: 10.1186/s12981-023-00590-4.ABSTRACTWe assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4 counts in the group that switched from the dolutegravir-based regimen, but not in the tenofovir alafenamide-based regimen group. High-density lipoprotein ...
Source: AIDS Research and Therapy - January 4, 2024 Category: Infectious Diseases Authors: Eisuke Adachi Makoto Saito Amato Otani Michiko Koga Hiroshi Yotsuyanagi Source Type: research
Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine
AIDS Res Ther. 2024 Jan 3;21(1):1. doi: 10.1186/s12981-023-00590-4.ABSTRACTWe assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4 counts in the group that switched from the dolutegravir-based regimen, but not in the tenofovir alafenamide-based regimen group. High-density lipoprotein ...
Source: AIDS Research and Therapy - January 4, 2024 Category: Infectious Diseases Authors: Eisuke Adachi Makoto Saito Amato Otani Michiko Koga Hiroshi Yotsuyanagi Source Type: research
Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice
(Source: Journal of NeuroVirology)
Source: Journal of NeuroVirology - January 4, 2024 Category: Neurology Source Type: research
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function
Biochem Pharmacol. 2023 Dec 26:116010. doi: 10.1016/j.bcp.2023.116010. Online ahead of print.ABSTRACTCombined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human immunodeficiency virus (PLWH). To gain insight into the combined effects of cART components on adipocyte dysfunction, we assessed whether and how treatment of human adipocytes with dolutegravir (DTG) and the nucleotide-analog reverse-transcriptase inhibitors (NRTIs), tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), alone and in combination, altered biologi...
Source: Biochemical Pharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: T Quesada-L ópez R Cereijo A Blasco-Roset A Mestres-Arenas P Prieto J C Domingo F Villarroya P Domingo M Giralt Source Type: research
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function
Biochem Pharmacol. 2023 Dec 26:116010. doi: 10.1016/j.bcp.2023.116010. Online ahead of print.ABSTRACTCombined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human immunodeficiency virus (PLWH). To gain insight into the combined effects of cART components on adipocyte dysfunction, we assessed whether and how treatment of human adipocytes with dolutegravir (DTG) and the nucleotide-analog reverse-transcriptase inhibitors (NRTIs), tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), alone and in combination, altered biologi...
Source: Biochemical Pharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: T Quesada-L ópez R Cereijo A Blasco-Roset A Mestres-Arenas P Prieto J C Domingo F Villarroya P Domingo M Giralt Source Type: research
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function
Biochem Pharmacol. 2023 Dec 26:116010. doi: 10.1016/j.bcp.2023.116010. Online ahead of print.ABSTRACTCombined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human immunodeficiency virus (PLWH). To gain insight into the combined effects of cART components on adipocyte dysfunction, we assessed whether and how treatment of human adipocytes with dolutegravir (DTG) and the nucleotide-analog reverse-transcriptase inhibitors (NRTIs), tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), alone and in combination, altered biologi...
Source: Biochemical Pharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: T Quesada-L ópez R Cereijo A Blasco-Roset A Mestres-Arenas P Prieto J C Domingo F Villarroya P Domingo M Giralt Source Type: research
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function
Biochem Pharmacol. 2023 Dec 26:116010. doi: 10.1016/j.bcp.2023.116010. Online ahead of print.ABSTRACTCombined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human immunodeficiency virus (PLWH). To gain insight into the combined effects of cART components on adipocyte dysfunction, we assessed whether and how treatment of human adipocytes with dolutegravir (DTG) and the nucleotide-analog reverse-transcriptase inhibitors (NRTIs), tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), alone and in combination, altered biologi...
Source: Biochemical Pharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: T Quesada-L ópez R Cereijo A Blasco-Roset A Mestres-Arenas P Prieto J C Domingo F Villarroya P Domingo M Giralt Source Type: research
Risk of sexually transmitted infections among U.S. military service members in the setting of HIV pre-exposure prophylaxis use
ConclusionsThe data suggest entry into PrEP care reduced the overall risk of STIs following adjustment for anatomical site of STI and treatment. Service members engaged in PrEP services also receive more STI prevention counseling, which might contribute to decreases in STI risk while on PrEP. (Source: PLoS One)
Source: PLoS One - December 28, 2023 Category: Biomedical Science Authors: Jason M. Blaylock Source Type: research
