Reasons for first line ART modification over the years during the ART scale up in Uganda
During the initial scale up of ART in sub-Saharan Africa, prescribed regimens included drugs with high potential for toxicity (particularly stavudine). More recently a growing number of patients requires secon... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 9, 2019 Category: Infectious Diseases Authors: B. Castelnuovo, F. Mubiru, I. Kalule and A. Kiragga Tags: Research Source Type: research

Reasons for first line ART modification over the years during the ART scale up in Uganda.
We described the reasons for treatment modification categorized in (1) toxicity (2) treatment failure (3) other reason (new TB treatment, new pregnancy). We used Cox proportional hazard to identify factors associated with treatment modification due to toxicity. RESULTS: We included 14,261 patients; 9114 (63.9%), were female, the median age was 34 years (IQR: 29-40), 60.8% were in WHO stage 3 and 4. The median BMI and CD4 count were 21.9 (IQR: 19.6-24.8) and 188 cell/µL (IQR: 65-353) respectively; 27.5% were started on stavudine, 46% on zidovudine, and 26.5% on a tenofovir containing regimens. We observed 62...
Source: AIDS Research and Therapy - October 9, 2019 Category: Infectious Diseases Authors: Castelnuovo B, Mubiru F, Kalule I, Kiragga A Tags: AIDS Res Ther Source Type: research

Predictors of loss to follow-up in art experienced patients in Nigeria: a 13 year review (2004 –2017)
Expanded access to antiretroviral therapy (ART) leads to improved HIV/AIDS treatment outcomes in Nigeria, however, increasing rates of loss to follow-up among those on ART is threatening optimal standard achie... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 8, 2019 Category: Infectious Diseases Authors: Ahmad Aliyu, Babatunde Adelekan, Nifarta Andrew, Eunice Ekong, Stephen Dapiap, Fati Murtala-Ibrahim, Iboro Nta, Nicaise Ndembi, Charles Mensah and Patrick Dakum Tags: Research Source Type: research

Predictors of loss to follow-up in art experienced patients in Nigeria: a 13  year review (2004-2017).
CONCLUSION: Despite increasing access to anti-retroviral therapy, loss to follow-up is still a challenge in the HIV program in Nigeria. Differentiated care approaches that will focus on males, non-pregnant females and paediatrics is encouraged. Reducing months of Anti-retroviral drug refill to less than 3 months is advocated for increased patient adherence. PMID: 31594539 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 8, 2019 Category: Infectious Diseases Authors: Aliyu A, Adelekan B, Andrew N, Ekong E, Dapiap S, Murtala-Ibrahim F, Nta I, Ndembi N, Mensah C, Dakum P Tags: AIDS Res Ther Source Type: research

Performance and trend for quality of service in a large HIV/AIDS treatment program in Nigeria
As antiretroviral therapy (ART) programs expand access, there is an increase in burden to a healthcare system. These results are reduced provider-patient contact time and poor programmatic and patient outcomes... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 1, 2019 Category: Infectious Diseases Authors: Ahmad Aliyu, Samer El-Kamary, Jessica Brown, Bruce Agins, Nicaise Ndembi, Gambo Aliyu, Jibreel Jumare, Babatunde Adelekan, Patrick Dakum, Alash ’le Abimiku and Manhattan Charurat Tags: Review Source Type: research

Performance and trend for quality of service in a large HIV/AIDS treatment program in Nigeria.
This study aimed to determine the trend of performance on HIV/AIDS quality management indicators of health facilities providing ART over a period of 5 years. METHODS: The annual performance scores of quality of care (QoC) indicators of 31 health facilities providing ART was extracted from a database covering a period of 5 years (from October 2008 to September 2012). The data are percentages that indicate scores of each health facility assessed based on compliance to National ART guidelines categorized into several indicator domains. A Chi square statistic for the trend, as well as test for departure from the...
Source: AIDS Research and Therapy - October 1, 2019 Category: Infectious Diseases Authors: Aliyu A, El-Kamary S, Brown J, Agins B, Ndembi N, Aliyu G, Jumare J, Adelekan B, Dakum P, Abimiku A, Charurat M Tags: AIDS Res Ther Source Type: research

Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda: a cross-sectional survey
In this study, we aimed to assess the f... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 18, 2019 Category: Infectious Diseases Authors: Richard Muhindo, Barbara Castelnuovo, Andrew Mujugira, Rosalind Parkes-Ratanshi, Nelson K. Sewankambo, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba Tags: Research Source Type: research

Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda: a cross-sectional survey.
CONCLUSION: Compared to HIV, uptake of repeated syphilis testing was very low. Correlates of HIV testing include; perceived self-efficacy amidst barriers and perceived confidence for HIV and low attitudes and accepting norms for syphilis. Health campaigns should emphasize overcoming barriers to HIV testing while promoting attitudes and norms including integration of serological syphilis testing and other STIs into HIV services. PMID: 31533749 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 18, 2019 Category: Infectious Diseases Authors: Muhindo R, Castelnuovo B, Mujugira A, Parkes-Ratanshi R, Sewankambo NK, Kiguli J, Tumwesigye NM, Nakku-Joloba E Tags: AIDS Res Ther Source Type: research

Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria
A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 14, 2019 Category: Infectious Diseases Authors: Patrick Dakum, Monday Tola, Nta Iboro, Chukwuemeka A. Okolo, Olachi Anuforom, Christopher Chime, Sam Peters, Jibreel Jumare, Obinna Ogbanufe, Aliyu Ahmad and Nicaise Ndembi Tags: Research Source Type: research

Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria.
Abstract BACKGROUND: A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babies which improves treatment outcomes. OBJECTIVES: We explored factors associated with EID outcomes among HEI in North-Central Nigeria. METHOD: This is a cross-sectional study using EID data of PMTCT-enrollees matched with results of HEI's dried blood samples (DBS), processed for D...
Source: AIDS Research and Therapy - September 14, 2019 Category: Infectious Diseases Authors: Dakum P, Tola M, Iboro N, Okolo CA, Anuforom O, Chime C, Peters S, Jumare J, Ogbanufe O, Ahmad A, Ndembi N Tags: AIDS Res Ther Source Type: research

Repeat HIV testing of individuals with discrepant HIV self-test results in Central Uganda
According to the user instructions from the manufacturer of OraQuick HIV self-test (HIVST) kits, individuals whose kits show one red band should be considered to be HIV-negative, no matter how weak the band is... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 12, 2019 Category: Infectious Diseases Authors: Rose Kisa, Joseph K. B. Matovu, Esther Buregyeya, William Musoke, Caroline J. Vrana-Diaz, Jeffrey E. Korte and Rhoda K. Wanyenze Tags: Short Report Source Type: research

Repeat HIV testing of individuals with discrepant HIV self-test results in Central Uganda.
CONCLUSIONS: Nearly all initially HIV-negative individuals whose HIVST kits developed a second weak band while in storage or were interpreted as HIV-positive by interviewers were found to be HIV-negative after confirmatory DNA/PCR HIV testing. These findings suggest a need for HIV-negative individuals whose HIVST results change to false positive while under storage or under other sub-optimal conditions to be provided with an option for repeat testing to determine their true HIV status. PMID: 31514745 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 12, 2019 Category: Infectious Diseases Authors: Kisa R, Matovu JKB, Buregyeya E, Musoke W, Vrana-Diaz CJ, Korte JE, Wanyenze RK Tags: AIDS Res Ther Source Type: research

Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research
Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 6, 2019 Category: Infectious Diseases Authors: Camilla Muccini, Trevor A. Crowell, Eug ène Kroon, Carlo Sacdalan, Reshmie Ramautarsing, Pich Seekaew, Praphan Phanuphak, Jintanat Ananworanich, Donn J. Colby and Nittaya Phanuphak Tags: Review Source Type: research

Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research.
Abstract Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over the last two decades. Building upon this remarkable history, Thailand has set an ambitious goal to stop the AIDS epidemic in the country by 2030. A key component of the strategy to achieve this goal includes scale-up of HIV screening programs to facilitate early HIV diagnosis and investment in mechanisms to support immediate initiation of antiretroviral therapy (ART). Initiation of ART during early ...
Source: AIDS Research and Therapy - September 6, 2019 Category: Infectious Diseases Authors: Muccini C, Crowell TA, Kroon E, Sacdalan C, Ramautarsing R, Seekaew P, Phanuphak P, Ananworanich J, Colby DJ, Phanuphak N Tags: AIDS Res Ther Source Type: research

HIV-2 as a model to identify a functional HIV cure
Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 5, 2019 Category: Infectious Diseases Authors: Joakim Esbj örnsson, Marianne Jansson, Sanne Jespersen, Fredrik Månsson, Bo L. Hønge, Jacob Lindman, Candida Medina, Zacarias J. da Silva, Hans Norrgren, Patrik Medstrand, Sarah L. Rowland-Jones and Christian Wejse Tags: Review Source Type: research

HIV-2 as a model to identify a functional HIV cure.
es SL, Wejse C Abstract Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, there is still no cure or vaccine against HIV. Consequently, the concepts of functional vaccines and cures that aim to limit HIV disease progression and spread by persistent control of viral replication without life-long treatment have been suggested as more feasible options to control the HIV pandemic. To identify virus-host mechanisms that could be targeted for functional cure d...
Source: AIDS Research and Therapy - September 5, 2019 Category: Infectious Diseases Authors: Esbjörnsson J, Jansson M, Jespersen S, Månsson F, Hønge BL, Lindman J, Medina C, da Silva ZJ, Norrgren H, Medstrand P, Rowland-Jones SL, Wejse C Tags: AIDS Res Ther Source Type: research

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-experienced, virologically suppressed patients with HIV-1: subgroup analyses of the phase 3 EMERALD study
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is a once-daily, single-tablet regimen for treatment of HIV-1 infection. The efficacy/safety of switching to D/C/F/TAF ver... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2019 Category: Infectious Diseases Authors: Gregory D. Huhn, Joseph J. Eron, Pierre-Marie Girard, Chloe Orkin, Jean-Michel Molina, Edwin DeJesus, Romana Petrovic, Donghan Luo, Erika Van Landuyt, Erkki Lathouwers, Richard E. Nettles, Kimberley Brown and Eric Y. Wong Tags: Research Source Type: research

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-experienced, virologically suppressed patients with HIV-1: subgroup analyses of the phase 3 EMERALD study.
CONCLUSIONS: For treatment-experienced, virologically suppressed patients, switching to D/C/F/TAF was highly effective and safe, regardless of demographic characteristics, prior treatment experience, or pre-switch bPI. Trial registration ClinicalTrials.gov Identifier: NCT02269917. Registered 21 October 2014. https://clinicaltrials.gov/ct2/show/NCT02269917. PMID: 31464642 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2019 Category: Infectious Diseases Authors: Huhn GD, Eron JJ, Girard PM, Orkin C, Molina JM, DeJesus E, Petrovic R, Luo D, Van Landuyt E, Lathouwers E, Nettles RE, Brown K, Wong EY Tags: AIDS Res Ther Source Type: research

Adherence to antiretroviral therapy and the associated factors among people living with HIV/AIDS in Northern Peru: a cross-sectional study
There are approximately 72,000 people living with HIV/AIDS (PLHIV) in Peru. Non-adherence to antiretroviral therapy (ART) is the most important factor for therapeutic failure and the development of resistance.... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 28, 2019 Category: Infectious Diseases Authors: Juan M. Leyva-Moral, Blanca K. Loayza-Enriquez, Patrick A. Palmieri, Genesis M. Guevara-Vasquez, Ursula E. Elias-Bravo, Joan E. Edwards, Mar ía Feijoo-Cid, Lucy Y. Davila-Olano, Juan R. Rodriguez-Llanos and Franco E. Leon-Jimenez Tags: Research Source Type: research

Adherence to antiretroviral therapy and the associated factors among people living with HIV/AIDS in Northern Peru: a cross-sectional study.
CONCLUSIONS: Self-reported adherence appeared to be low and the use of first-line therapy is not being prescribed homogeneously. Factors associated with nonadherence are both medical and behavioral, such as having tuberculosis, pausing ART, or experiencing discomfort with ART. The Peruvian government needs to update national technical standards, monitor medication availability, and provide education to health care professionals in alignment with evidence-based guidelines and international recommendations. Instruments to measure adherence need to be developed and evaluated for use in Latin America. PMID: 31462291 ...
Source: AIDS Research and Therapy - August 28, 2019 Category: Infectious Diseases Authors: Leyva-Moral JM, Loayza-Enriquez BK, Palmieri PA, Guevara-Vasquez GM, Elias-Bravo UE, Edwards JE, Feijoo-Cid M, Davila-Olano LY, Rodriguez-Llanos JR, Leon-Jimenez FE Tags: AIDS Res Ther Source Type: research

Positioning of darunavir/cobicistat-containing antiretroviral regimens in real life: results from a large multicentre observational prospective cohort (SCOLTA)
Study aim was to evaluate the safety and durability of darunavir/cobicistat (DRV/c) in a real life setting. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 26, 2019 Category: Infectious Diseases Authors: Lucia Taramasso, Elena Ricci, Antonio Cascio, Laura Valsecchi, Barbara Menzaghi, Nicola Squillace, Paolo Maggi, Giuseppe Vittorio De Socio, Chiara Dentone, Giordano Madeddu, Giovanni F. Pellican ò, Leonardo Calza, Goffredo Angioni, Paolo Bonfanti and Ant Tags: Research Source Type: research

Positioning of darunavir/cobicistat-containing antiretroviral regimens in real life: results from a large multicentre observational prospective cohort (SCOLTA).
CONCLUSIONS: DRV/c was safe and well tolerated. Dual therapies showed a better profile of tolerability and a longer durability compared to triple therapies. PMID: 31451115 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 26, 2019 Category: Infectious Diseases Authors: Taramasso L, Ricci E, Cascio A, Valsecchi L, Menzaghi B, Squillace N, Maggi P, De Socio GV, Dentone C, Madeddu G, Pellicanò GF, Calza L, Angioni G, Bonfanti P, Di Biagio A, CISAI Study Group Tags: AIDS Res Ther Source Type: research

Impact of HIV testing and treatment services on risky sexual behaviour in the uMgungundlovu District, KwaZulu-Natal, South Africa: a cross-sectional study
The South African public health system plays an important role in the delivery of HIV testing and treatment services. The health system is also an important conduit for targeted behaviour change communication ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 21, 2019 Category: Infectious Diseases Authors: Gavin George, Sean Beckett, Cherie Cawood, David Khanyile, Kaymarlin Govender and Ayesha B. M. Kharsany Tags: Research Source Type: research

Impact of HIV testing and treatment services on risky sexual behaviour in the uMgungundlovu District, KwaZulu-Natal, South Africa: a cross-sectional study.
CONCLUSIONS: Results indicate that HIV testing and treatment services and the assumed exposure of clients to behaviour change communication, had a limited effect in reducing risky sexual behaviour. Data suggests that the engagement between health personnel and individuals accessing HIV testing and treatment services does not necessarily translate into the adoption of safer sexual practices, with the exception of individuals testing positive for HIV and those on ARV treatment, who had adopted safer sexual practices. PMID: 31434574 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 21, 2019 Category: Infectious Diseases Authors: George G, Beckett S, Cawood C, Khanyile D, Govender K, Kharsany ABM Tags: AIDS Res Ther Source Type: research

Antiretroviral treatment, government policy and economy of HIV/AIDS in Brazil: is it time for HIV cure in the country?
Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal m... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 14, 2019 Category: Infectious Diseases Authors: Adele S. Benzaken, Gerson F. M. Pereira, Lendel Costa, Amilcar Tanuri, Andr é F. Santos and Marcelo A. Soares Tags: Review Source Type: research

Antiretroviral treatment, government policy and economy of HIV/AIDS in Brazil: is it time for HIV cure in the country?
Abstract Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal measures. These included an early response to the epidemic, the development of a universal and free public health system, incisive discussions with pharmaceutical companies to reduce antiretroviral (ARV) drug prices, investments towards the development of generic drugs and compulsory licensing of ARVs. Through such measures, Brazil is among the leading LMIC towards achieving the 90-90-90 UNAIDS goals ...
Source: AIDS Research and Therapy - August 14, 2019 Category: Infectious Diseases Authors: Benzaken AS, Pereira GFM, Costa L, Tanuri A, Santos AF, Soares MA Tags: AIDS Res Ther Source Type: research

Social barriers in accessing care by clients who returned to HIV care after transient loss to follow-up
People living with HIV (PLHIV) constantly need to address social issues such as the cost of accessing care, stigma, and lack of social support which impacts on their level of adherence to clinic visits or anti... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 12, 2019 Category: Infectious Diseases Authors: Babatunde Adelekan, Nifarta Andrew, Iboro Nta, Asabe Gomwalk, Nicaise Ndembi, Charles Mensah, Patrick Dakum and Ahmad Aliyu Tags: Research Source Type: research

Differences in HIV testing and receipt of results between adolescent and non-adolescent women in Uganda
This study assesses differences in HIV testing and re... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 12, 2019 Category: Infectious Diseases Authors: Stephen Ediru, Robert Wamala and Betty Kwagala Tags: Research Source Type: research

Differences in HIV testing and receipt of results between adolescent and non-adolescent women in Uganda.
This study assesses differences in HIV testing and receipt of results (HTR) between adolescent and non-adolescent women in Uganda. The differences were decomposed into components attributed to variation in characteristics and variation in effects of characteristics in the two groups. The assessment was based on data sourced from 2011 Uganda Demographic Health Survey. Statistical analysis was done using a Non-linear Oaxaca' Blinder Multivariate Decomposition of the logistic regression. In the results, the difference in HIV testing and receipt of result between adolescent and non-adolescent women was significantly (P 
Source: AIDS Research and Therapy - August 12, 2019 Category: Infectious Diseases Authors: Ediru S, Wamala R, Kwagala B Tags: AIDS Res Ther Source Type: research

Social barriers in accessing care by clients who returned to HIV care after transient loss to follow-up.
CONCLUSION: Stigma, lack of support and prior loss to follow-up event are essential factors affecting retention in care. Social constructs such as home-based visits, community-based care services, transportation subsidies, and robust strong social systems should be built into HIV service delivery models to improve retention in care of people on HIV treatment. The authors advocate for further studies on how differentiated care models impact on retention of patients in care. PMID: 31405386 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 12, 2019 Category: Infectious Diseases Authors: Adelekan B, Andrew N, Nta I, Gomwalk A, Ndembi N, Mensah C, Dakum P, Aliyu A Tags: AIDS Res Ther Source Type: research

Primary cutaneous actinomycosis: a diagnosis consideration in people living with HIV/AIDS
Owing to similar clinical presentations, as of cutaneous disease of different etiologies, and extreme rarity in the global incidence; primary cutaneous actinomycosis often remains as diagnostic challenges. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 30, 2019 Category: Infectious Diseases Authors: Priyatam Khadka and Soniya Koirala Tags: Case Report Source Type: research

Primary cutaneous actinomycosis: a diagnosis consideration in people living with HIV/AIDS.
CONCLUSION: The case underscores cutaneous actinomycosis requires a diagnosis consideration, especially in People Living with HIV/AIDS (PLHA), where myriad of opportunistic cutaneous infections are common. PMID: 31362755 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 30, 2019 Category: Infectious Diseases Authors: Khadka P, Koirala S Tags: AIDS Res Ther Source Type: research

Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
Human herpes virus 8 (HHV8) is the causative agent of Kaposi ’s sarcoma and has been associated with an increasing number of hematologic diseases such as primary effusion lymphoma (PEL) (both classic and extrac... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 27, 2019 Category: Infectious Diseases Authors: Laura Campogiani, Carlotta Cerva, Gaetano Maffongelli, Elisabetta Teti, Livio Pupo, Sara Vaccarini, Maria Cantonetti, Alfredo Pennica, Massimo Andreoni and Loredana Sarmati Tags: Case Report Source Type: research

Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.
We present a case of extracavitary PEL in an HIV-infected patient, regressed after ART initiation. CASE PRESENTATION: A 42-year-old male was admitted to the emergency room because of several months of malaise, fever and progressive deterioration of the general conditions. On physical examination soft non-painful subcutaneous masses were palpable at retronuchal, retroauricolar and thoracic regions. HIV serology resulted positive: HIV plasma viremia was 782,270 copies/mL, CD4 103 cells/mL. The excision of one of the masses, metabolically active at a positron emission tomography (PET-CT) scan, revealed an HHV8-related ex...
Source: AIDS Research and Therapy - July 27, 2019 Category: Infectious Diseases Authors: Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L Tags: AIDS Res Ther Source Type: research

Spatiotemporal analysis and epidemiological characterization of the human immunodeficiency virus (HIV) in Libya within a twenty five year period: 1993 –2017
Infection with the human immunodeficiency virus (HIV) is an alarming problem in North African countries, but few studies have analyzed the geographical distribution of the epidemic. Libya, the second largest c... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 25, 2019 Category: Infectious Diseases Authors: Mohamed A. Daw, Amina M. Daw, Nadia E. M. Sifennasr, Aisha M. Draha, Ahmed A. Daw, Ali A. Daw, Mohamed O. Ahmed, Ebtisam S. Mokhtar, Abdallah Hu. El-Bouzedi, Ibrahem M. Daw, Samia I. Adam and Saed Warrag Tags: Research Source Type: research

Spatiotemporal analysis and epidemiological characterization of the human immunodeficiency virus (HIV) in Libya within a twenty five year   period: 1993-2017.
The objective of this study was to assess HIV infection clustering and trends in Libya. METHODS: Information on all recorded HIV/AIDS cases during 1993-2017 were extracted from the National Reporting System. A total of 8015 newly diagnosed HIV cases with address information were included. Spatial autocorrelation and spatial-temporal analysis were used to identify HIV clusters. Spatial correlations between cases and socio-demographic factors were determined using spatial regression. RESULTS: HIV cases steadily increased within the Libyan population, particularly among those aged 
Source: AIDS Research and Therapy - June 25, 2019 Category: Infectious Diseases Authors: Daw MA, Daw AM, Sifennasr NEM, Draha AM, Daw AA, Daw AA, Ahmed MO, Mokhtar ES, El-Bouzedi AH, Daw IM, Adam SI, Warrag S, In association with Libyan Study Group of Hepatitis & HIV Tags: AIDS Res Ther Source Type: research

HIV risk, risk perception and uptake of HIV testing and counseling among youth men who have sex with men attending a gay sauna
Men who have sex with men (MSM) are amongst populations at-risk for HIV acquisition in Thailand. In youth MSM (aged 15 –24 years), the incidence of HIV infection has substantially increased. However, data on HI... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 12, 2019 Category: Infectious Diseases Authors: Thana Khawcharoenporn, Suteera Mongkolkaewsub, Chanon Naijitra, Worawoot Khonphiern, Anucha Apisarnthanarak and Nittaya Phanuphak Tags: Research Source Type: research

HIV risk, risk perception and uptake of HIV testing and counseling among youth men who have sex with men attending a gay sauna.
Abstract BACKGROUND: Men who have sex with men (MSM) are amongst populations at-risk for HIV acquisition in Thailand. In youth MSM (aged 15-24 years), the incidence of HIV infection has substantially increased. However, data on HIV risk, risk perception and HIV testing and counseling (HTC) uptake among youth MSM in hotspots are limited. METHODS: A subanalysis of a prospective study among Thai MSM attending a gay sauna was conducted. HIV risk and risk perception were assessed by an anonymous survey. The MSM were categorized as having actual "low-risk", "moderate-risk" and "high-ri...
Source: AIDS Research and Therapy - June 12, 2019 Category: Infectious Diseases Authors: Khawcharoenporn T, Mongkolkaewsub S, Naijitra C, Khonphiern W, Apisarnthanarak A, Phanuphak N Tags: AIDS Res Ther Source Type: research

Tenofovir-associated kidney disease in Africans: a systematic review
Data on chronic kidney disease development in HIV infection is important towards building a comprehensive knowledge of HIV, ageing and polypharmacy in Africa. Several previous studies on tenofovir-associated k... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 6, 2019 Category: Infectious Diseases Authors: Takudzwa J. Mtisi, Chiratidzo E. Ndhlovu, Chiedza C. Maponga and Gene D. Morse Tags: Review Source Type: research

Tenofovir-associated kidney disease in Africans: a systematic review.
CONCLUSIONS: Our review identified studies in Africans reporting statistically significant renal function decline associated with TDF use but the clinical significance of this effect was not enough to contraindicate its continued use in ART regimens. Consistent with studies in other populations, patients are at greater risk if they have pre-existing renal disease and are more advanced in age. More research is needed on paediatric populations under 16 years of age. Trial registration This review was registered on Prospero (registration number CRD42018078717). PMID: 31171021 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 6, 2019 Category: Infectious Diseases Authors: Mtisi TJ, Ndhlovu CE, Maponga CC, Morse GD Tags: AIDS Res Ther Source Type: research

Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use
As in non-infected subjects, statins and aspirin have a pivotal preventive role in reducing the cardiovascular related morbidity and mortality in HIV infected patients. The persistence of immune activation in ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 24, 2019 Category: Infectious Diseases Authors: P. Maggi, G. V. De Socio, S. Cicalini, M. D ’Abbraccio, G. Dettorre, A. Di Biagio, C. Martinelli, G. Nunnari, S. Rusconi, L. Sighinolfi, V. Spagnuolo and N. Squillace Tags: Methodology Source Type: research

Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use.
CONCLUSIONS: As demonstrated in surveys, HIV physicians are generally highly committed regarding CVD and autonomous in prescribing statins and ASA. Consequently, in the light of the previously discussed discrepancies among the different guidelines and of the incomplete indications regarding HIV-positive persons, the present suggestions could overcome the actual differences and limitations among the current ones. PMID: 31126301 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 24, 2019 Category: Infectious Diseases Authors: Maggi P, De Socio GV, Cicalini S, D'Abbraccio M, Dettorre G, Di Biagio A, Martinelli C, Nunnari G, Rusconi S, Sighinolfi L, Spagnuolo V, Squillace N Tags: AIDS Res Ther Source Type: research

Immunogenicity and safety of 4 vs. 3 standard doses of HBV vaccination in HIV-infected adults with isolated anti-HBc antibody
Presence of isolated anti-HBc antibody is common in HIV-infected patients in endemic areas and could be caused by prior HBV infection with loss of anti-HBs antibody. The role of vaccination in these patients r... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 3, 2019 Category: Infectious Diseases Authors: Nattinee Laksananun, Jutarat Praparattanapan, Wilai Kotarathititum, Khuanchai Supparatpinyo and Romanee Chaiwarith Tags: Research Source Type: research

Immunogenicity and safety of 4 vs. 3 standard doses of HBV vaccination in HIV-infected adults with isolated anti-HBc antibody.
Abstract BACKGROUND: Presence of isolated anti-HBc antibody is common in HIV-infected patients in endemic areas and could be caused by prior HBV infection with loss of anti-HBs antibody. The role of vaccination in these patients remains controversial and is based largely on limited and low quality data. We, therefore, conducted this study to determine immunogenicity and safety of 4 vs. 3 standard doses of HBV vaccination in HIV-infected adults with isolated anti-HBc antibody. METHODS: An open-label, randomized controlled trial was conducted among HIV-infected patients visiting HIV clinic of the Faculty of Med...
Source: AIDS Research and Therapy - May 3, 2019 Category: Infectious Diseases Authors: Laksananun N, Praparattanapan J, Kotarathititum W, Supparatpinyo K, Chaiwarith R Tags: AIDS Res Ther Source Type: research

Covalent linkage of bacterial voltage-gated sodium channels
Bacterial sodium channels are important models for understanding ion permeation and selectivity. However, their homotetrameric structure limits their use as models for understanding the more complex eukaryotic... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 27, 2019 Category: Infectious Diseases Authors: Huaping Sun, Zeyu Zheng, Olena A. Fedorenko and Stephen K. Roberts Tags: Research article Source Type: research

Development of a neurocognitive test battery for HIV-associated neurocognitive disorder (HAND) screening: suggested solutions for resource-limited clinical settings
Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neu... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 15, 2019 Category: Infectious Diseases Authors: Lai Gwen Chan, Mei Jing Ho, Yijun Carol Lin, Yining Ong and Chen Seong Wong Tags: Research Source Type: research

Development of a neurocognitive test battery for HIV-associated neurocognitive disorder (HAND) screening: suggested solutions for resource-limited clinical settings.
CONCLUSION: The 3-test combinations presented in this study appear to be promising screening options for HAND in HIV-infected patients. The addition of 2 tests to MoCA improves the overall accuracy while retaining its convenience, giving more potential for the inclusion of cognitive screening in routine clinical care. Further validation of the batteries in specific settings is warranted to determine specific screening cut-offs to a global cognitive score. PMID: 30987670 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 15, 2019 Category: Infectious Diseases Authors: Chan LG, Ho MJ, Lin YC, Ong Y, Wong CS Tags: AIDS Res Ther Source Type: research

Feasibility and yield of HIV screening among adult trauma patients presenting to an urban emergency department of a tertiary referral hospital in Tanzania
The World Health Organization and Tanzanian National Guidelines for HIV and AIDS management, recommends provider initiated testing and counseling for HIV at any point of health care contact. In Tanzania, over ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 9, 2019 Category: Infectious Diseases Authors: Juma Ramadhani, Hendry R. Sawe, Said S. Kilindimo, Juma A. Mfinanga and Ellen J. Weber Tags: Research Source Type: research

Feasibility and yield of HIV screening among adult trauma patients presenting to an urban emergency department of a tertiary referral hospital in Tanzania.
CONCLUSIONS: In our cohort of adult trauma patients presenting to ED, routine HIV screening for unrelated reason, was feasible and acceptable. The yield is sufficient to warrant an on-going program and superior to having physicians choose which patients to test. Future studies should focus on factors affecting the linkage to CTC among HIV positive patients identified at the ED. PMID: 30967145 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 9, 2019 Category: Infectious Diseases Authors: Ramadhani J, Sawe HR, Kilindimo SS, Mfinanga JA, Weber EJ Tags: AIDS Res Ther Source Type: research

Efficacy and improvement of lipid profile after switching to rilpivirine in resource limited setting: real life clinical practice
This study assessed the efficacy and safety of switching from a first-line NNRTI or boosted PI-based regimens to RPV-based reg... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 5, 2019 Category: Infectious Diseases Authors: Sivaporn Gatechompol, Anchalee Avihingsanon, Tanakorn Apornpong, Win Min Han, Stephen J. Kerr and Kiat Ruxrungtham Tags: Research Source Type: research