JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review
The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 6, 2020 Category: Infectious Diseases Authors: Vijay Harypursat, Yihong Zhou, Shengquan Tang and Yaokai Chen Tags: Review Source Type: research

JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review.
Abstract The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals. The spectrum of underlying reasons for the systemic immunosuppression that permits JCV infection in the central nervous system has evolved over the past 2 decades, and therapeutic immunosuppression arousing JCV infection in the brain has become increasingly prominent as a trigger for PML. Effective immune restoration subsequent to human immunodeficiency virus-related suppression is now recog...
Source: AIDS Research and Therapy - July 6, 2020 Category: Infectious Diseases Authors: Harypursat V, Zhou Y, Tang S, Chen Y Tags: AIDS Res Ther Source Type: research

Adolescents living with HIV, complex needs and resilience in Blantyre, Malawi
Adolescents living with HIV (ALHIV) in Malawi experience multiple challenges associated with their illness and various social, environmental, economic and cultural factors. In exploring their various medical c... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 22, 2020 Category: Infectious Diseases Authors: Blessings N. Kaunda-Khangamwa, Prosperina Kapwata, Kennedy Malisita, Alister Munthali, Effie Chipeta, Sam Phiri and Lenore Manderson Tags: Research Source Type: research

Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis
The link between food insecurity and depression in people living with HIV/AIDS (PLWHA) has been explored in numerous studies; however, the existing evidence is inconclusive due to inconsistent results. Therefo... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 22, 2020 Category: Infectious Diseases Authors: Getinet Ayano, Light Tsegay and Melat Solomon Tags: Review Source Type: research

Adolescents living with HIV, complex needs and resilience in Blantyre, Malawi.
CONCLUSION: ALHIV experienced self-transformation as a result of taking ART, with fewer severe episodes of illness and distressing skin conditions. Continuous engagement at the teen-club clinic transformed both productive activities and social relationships among ALHIV as they set life goals, gained a sense of empowerment, requested SRH services, and formed intimate relationships. These transformative opportunities allowed them to learn ways of minimizing risk of reinfection and violence, and of navigating health worker-caregiver-adolescent interactions. PMID: 32571375 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 22, 2020 Category: Infectious Diseases Authors: Kaunda-Khangamwa BN, Kapwata P, Malisita K, Munthali A, Chipeta E, Phiri S, Manderson L Tags: AIDS Res Ther Source Type: research

Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis.
CONCLUSION: This systematic review and meta-analysis suggest a significant association between food insecurity and increased risk of depression PLWHA. Therefore, early screening and management of food insecurity in PLWHA seem to be necessary. PMID: 32571426 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 22, 2020 Category: Infectious Diseases Authors: Ayano G, Tsegay L, Solomon M Tags: AIDS Res Ther Source Type: research

The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau.
RE group Abstract Introduction: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prevalence of HIVDR among FSW in Guinea-Bissau. Methods: A venue-based recruitment and peer-referral of FSW was used in seven cities in Guinea-Bissau from October 2014 to September 2017. We administered a questionnaire, performed discriminatory HIV-testing and collected blood specimens for CD4 count, ...
Source: AIDS Research and Therapy - June 17, 2020 Category: Infectious Diseases Authors: Lindman J, Djalo MA, Biai A, Månsson F, Esbjörnsson J, Jansson M, Medstrand P, Norrgren H, SWEGUB CORE group Tags: AIDS Res Ther Source Type: research

Determinants of long acting contraceptive utilization among HIV positive reproductive age women attending care at art clinics of public health facilities in Arba Minch town, Southern Ethiopia, 2019: a case control study
Long acting and permanent contraceptive methods by far are the most effective, very safe and convenient methods than short acting contraceptive methods. But in less developed countries, use of long acting reve... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 15, 2020 Category: Infectious Diseases Authors: Betselot Yirsaw, Feleke Gebremeskel, Gebrekiros Gebremichael and Tewoderos Shitemaw Tags: Research Source Type: research

Determinants of long acting contraceptive utilization among HIV positive reproductive age women attending care at art clinics of public health facilities in Arba Minch town, Southern Ethiopia, 2019: a case control study.
Abstract BACKGROUND: Long acting and permanent contraceptive methods by far are the most effective, very safe and convenient methods than short acting contraceptive methods. But in less developed countries, use of long acting reversible contraceptive or permanent methods (LARCs/PMs) is very low. Therefore the aim of this study was to identify determinants of long acting contraceptive method utilization among HIV positive reproductive age women. METHODS: An institutional based case control study was conducted among random sample of 354 HIV positive reproductive age women (total of 97.8% response rate) at Anti-...
Source: AIDS Research and Therapy - June 15, 2020 Category: Infectious Diseases Authors: Yirsaw B, Gebremeskel F, Gebremichael G, Shitemaw T Tags: AIDS Res Ther Source Type: research

Assessment of two POC technologies for CD4 count in Morocco.
Conclusion: When compared to the reference method, PIMA and FACSPresto have shown good performance, for CD4 counting. The introduction of such POC technology will speed up the uptake of patients in the continuum of HIV care, in our country. PMID: 32528549 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 13, 2020 Category: Infectious Diseases Authors: Elharti E, Abbadi H, Bensghir R, Marhoum El Filali K, Elmrabet H, Oumzil H Tags: AIDS Res Ther Source Type: research

The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau
Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 12, 2020 Category: Infectious Diseases Authors: Jacob Lindman, Mamadu Aliu Djalo, Ansu Biai, Fredrik M ånsson, Joakim Esbjörnsson, Marianne Jansson, Patrik Medstrand and Hans Norrgren Tags: Research Source Type: research

Social response to the delivery of HIV self-testing in households: experiences from four Zambian HPTN 071 (PopART) urban communities
Door-to-door distribution of HIV self-testing kits (HIVST) has the potential to increase uptake of HIV testing services (HTS). However, very few studies have explored the social response to and implications of... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 11, 2020 Category: Infectious Diseases Authors: Chiti Bwalya, Musonda Simwinga, Bernadette Hensen, Lwiindi Gwanu, Able Hang ’andu, Chama Mulubwa, Mwelwa Phiri, Richard Hayes, Sarah Fidler, Alwyn Mwinga, Helen Ayles and Virginia Bond Tags: Research Source Type: research

Social response to the delivery of HIV self-testing in households: experiences from four Zambian HPTN 071 (PopART) urban communities.
CONCLUSION: Door-to-door distribution of HIVST as a choice for how to HIV test is appreciated at community level and provides an important testing option in the sub-Saharan context. However, it should be accompanied by counselling to manage social harms and by supporting those testing HIV-positive to link to care. PMID: 32527261 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 11, 2020 Category: Infectious Diseases Authors: Bwalya C, Simwinga M, Hensen B, Gwanu L, Hang'andu A, Mulubwa C, Phiri M, Hayes R, Fidler S, Mwinga A, Ayles H, Bond V, HPTN 071 (PopART) study team Tags: AIDS Res Ther Source Type: research

Assessment of two POC technologies for CD4 count in Morocco
In the era of “test and treat strategy”, CD4 testing remains an important tool for monitoring HIV-infected individuals. Since conventional methods of CD4 count measurement are costly and cumbersome, POC CD4 co... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 10, 2020 Category: Infectious Diseases Authors: Elmir Elharti, Halima Abbadi, Rajae Bensghir, Kamal Marhoum El Filali, Hajar Elmrabet and Hicham Oumzil Tags: Research Source Type: research

Assessment of two POC technologies for CD4 count in Morocco.
CONCLUSION: When compared to the reference method, PIMA and FACSPresto have shown good performance, for CD4 counting. The introduction of such POC technology will speed up the uptake of patients in the continuum of HIV care, in our country. PMID: 32522235 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 10, 2020 Category: Infectious Diseases Authors: Elharti E, Abbadi H, Bensghir R, Marhoum El Filali K, Elmrabet H, Oumzil H Tags: AIDS Res Ther Source Type: research

Habit formation in support of antiretroviral medication adherence in clinic-enrolled HIV-infected adults: a qualitative assessment using free-listing and unstructured interviewing in Kampala, Uganda
Despite initial high motivation, individuals receiving antiretroviral therapy (ART) for several years may experience incomplete adherence over time, increasing their risk of HIV-related morbidity and mortality... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 8, 2020 Category: Infectious Diseases Authors: Larissa Jennings Mayo-Wilson, Bianca Devoto, Jessica Coleman, Barbara Mukasa, Angela Shelton, Sarah MacCarthy, Uzaib Saya, Harriet Chemusto and Sebastian Linnemayr Tags: Research Source Type: research

Habit formation in support of antiretroviral medication adherence in clinic-enrolled HIV-infected adults: a qualitative assessment using free-listing and unstructured interviewing in Kampala, Uganda.
CONCLUSION: While habit-forming interventions have the potential to improve ART adherence, targeting treatment-mature clients' existing routines may be crucial in this population. PMID: 32513192 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 8, 2020 Category: Infectious Diseases Authors: Jennings Mayo-Wilson L, Devoto B, Coleman J, Mukasa B, Shelton A, MacCarthy S, Saya U, Chemusto H, Linnemayr S Tags: AIDS Res Ther Source Type: research

Retention in care in aging adults with a dual diagnosis of HIV infection and type 2 diabetes mellitus: a longitudinal retrospective cross-sectional study
This study aimed to investigate the measures of retention in care (RIC) in persons living with HIV (PLWH) and type 2 diabetes mellitus (T2DM) by age group (younger vs. older adults). (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 29, 2020 Category: Infectious Diseases Authors: Julie Ann Zuniga, Alexandra A. Garc ía, Junse Lee and Jungmin Park Tags: Research Source Type: research

Retention in care in aging adults with a dual diagnosis of HIV infection and type 2 diabetes mellitus: a longitudinal retrospective cross-sectional study.
This study aimed to investigate the measures of retention in care (RIC) in persons living with HIV (PLWH) and type 2 diabetes mellitus (T2DM) by age group (younger vs. older adults). METHODS: This was a longitudinal retrospective cross-sectional study that used secondary data from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS). We examined RIC in 798 adult PLWH + T2DM who visited a CNICS clinic at least once in 2015. Six measures of RIC were examined: missed visits [measured as a continuous variable (total number of missed visits) and dichotomous variable (0 = n...
Source: AIDS Research and Therapy - May 29, 2020 Category: Infectious Diseases Authors: Zuniga JA, García AA, Lee J, Park J Tags: AIDS Res Ther Source Type: research

A prospective cohort study of outcomes for isoniazid prevention therapy: a nested study from a national QI collaborative in Uganda
Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy disease and major public health problem throughout the world. The risk of developing active ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 27, 2020 Category: Infectious Diseases Authors: Simon Sensalire, Esther Karungi Karamagi Nkolo, Juliana Nabwire, Anna Lawino, Dithan Kiragga, Martin Muhire, Herbert Kadama, Cordelia Katureebe, Proscovia Namuwenge, Joshua Musinguzi, Jacqueline Calnan and Dejene Seyoum Tags: Research Source Type: research

Views among Malawian women about joining HIV prevention clinical trials when pregnant
The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women ’s views regarding participation in such trials and initiating PrEP while pregnant ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 27, 2020 Category: Infectious Diseases Authors: Kristen Sullivan, Tiwonge Mtande, Elana Jaffe, Nora Rosenberg, Chifundo Zimba, Irving Hoffman, Maggie Little, Ruth Faden and Anne Drapkin Lyerly Tags: Research Source Type: research

A prospective cohort study of outcomes for isoniazid prevention therapy: a nested study from a national QI collaborative in Uganda.
Abstract BACKGROUND: Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy disease and major public health problem throughout the world. The risk of developing active TB in people living with HIV (PLHIV) is 21 times higher than the rest of the world population. The overlap of latent TB infection and HIV infection has resulted in marked increases in TB incidence in countries with dual epidemics. Although antiretroviral therapy (ART) is the single most significant way to reduce incident TB in PLHIV, besides early ART initiation, isoniazid preventive ther...
Source: AIDS Research and Therapy - May 27, 2020 Category: Infectious Diseases Authors: Sensalire S, Karungi Karamagi Nkolo E, Nabwire J, Lawino A, Kiragga D, Muhire M, Kadama H, Katureebe C, Namuwenge P, Musinguzi J, Calnan J, Seyoum D Tags: AIDS Res Ther Source Type: research

Views among Malawian women about joining HIV prevention clinical trials when pregnant.
CONCLUSIONS: The majority of participants conveyed strong interest in participating in biomedical HIV prevention research during pregnancy, largely motivated by a desire to protect themselves and their offspring. Our results are consistent with other studies that found high acceptance of HIV prevention products during pregnancy, and support the current direction of HIV research policies and practices that are increasingly aimed at protecting the health of pregnant women and their offspring through responsible research, rather than defaulting to their exclusion. PMID: 32460804 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 27, 2020 Category: Infectious Diseases Authors: Sullivan K, Mtande T, Jaffe E, Rosenberg N, Zimba C, Hoffman I, Little M, Faden R, Lyerly AD Tags: AIDS Res Ther Source Type: research

AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China
The clinical and laboratory characteristics of AIDS-associated Talaromyces marneffei infection, a rare but a fatal mycosis disease of the central nervous system, remain unclear. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 26, 2020 Category: Infectious Diseases Authors: Yu-Ye Li, Rong-Jing Dong, Samip Shrestha, Pratishtha Upadhyay, Hui-Qin Li, Yi-Qun Kuang, Xin-Ping Yang and Yun-Gui Zhang Tags: Case Report Source Type: research

AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China.
CONCLUSIONS: The common clinical symptoms of T. marneffei central nervous system infection are associated with high intracranial pressure and intracranial infectious lesions. Earlier recognition and diagnosis and a prolonged course of amphotericin B treatment followed by itraconazole combined with early ART might reduce the mortality rate. PMID: 32456686 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 26, 2020 Category: Infectious Diseases Authors: Li YY, Dong RJ, Shrestha S, Upadhyay P, Li HQ, Kuang YQ, Yang XP, Zhang YG Tags: AIDS Res Ther Source Type: research

Drug use and antiretroviral therapy (ART) interactions: a qualitative study to explore the knowledge, beliefs, adherence, and quality of life of people living with HIV taking ART and illicit drugs
To explore the use of illicit drugs by people living with HIV (PLHIV) taking antiretroviral therapy (ART) and their relationship with variables relevant to the management of HIV infection, such as knowledge an... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 24, 2020 Category: Infectious Diseases Authors: Mar ía José Fuster-RuizdeApodaca, Vanessa Castro-Granell, Ana Laguía, Ángeles Jaén, Santiago Cenoz and María José Galindo Tags: Research Source Type: research

Prediabetes among HIV-infected individuals receiving antiretroviral therapy: prevalence, diagnostic tests, and associated factors
This study aimed to determine the prevalence, ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 24, 2020 Category: Infectious Diseases Authors: Angsana Phuphuakrat, Hataikarn Nimitphong, Sirimon Reutrakul and Somnuek Sungkanuparph Tags: Research Source Type: research

Drug use and antiretroviral therapy (ART) interactions: a qualitative study to explore the knowledge, beliefs, adherence, and quality of life of people living with HIV taking ART and illicit drugs.
CONCLUSIONS: Adequate information about DDIs and clues about how to manage ART when PLHIV are using illicit drugs could reduce the negative effects of such interactions and improve ART adherence and QoL. PMID: 32448214 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 24, 2020 Category: Infectious Diseases Authors: Fuster-RuizdeApodaca MJ, Castro-Granell V, Laguía A, Jaén Á, Cenoz S, Galindo MJ Tags: AIDS Res Ther Source Type: research

Prediabetes among HIV-infected individuals receiving antiretroviral therapy: prevalence, diagnostic tests, and associated factors.
CONCLUSIONS: Prediabetes among HIV-infected individuals receiving ART is common. The agreements of glycemia estimation methods are minimal to weak. HbA1c may underestimate prediabetes prevalence. Using FPG together with HbA1c increases the detection rate to approximately three-quarters of prediabetes patients. HIV-infected individuals who had hypertension and hypertriglyceridemia should be regularly assessed for prediabetes. Trial registration ClinicalTrial.gov, NCT03545217. Registered 1 June 2018-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03545217. PMID: 32448349 [PubMed - in process] (Source:...
Source: AIDS Research and Therapy - May 24, 2020 Category: Infectious Diseases Authors: Phuphuakrat A, Nimitphong H, Reutrakul S, Sungkanuparph S Tags: AIDS Res Ther Source Type: research

Efficacy and safety of abacavir/lamivudine plus rilpivirine as a first-line regimen in treatment-na ïve HIV-1 infected adults
The anti-retroviral combination of abacavir/lamivudine plus rilpivirine (ABC/3TC/RPV) is not recommended by international guidelines as the first-line regimen. However, it is potent, well-tolerated, and afford... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 21, 2020 Category: Infectious Diseases Authors: Sharlene Ho, Joshua Guoxian Wong, Oon Tek Ng, Cheng Chuan Lee, Yee Sin Leo, David Chien Boon Lye and Chen Seong Wong Tags: Research Source Type: research

Efficacy and safety of abacavir/lamivudine plus rilpivirine as a first-line regimen in treatment-na ïve HIV-1 infected adults.
This study evaluates the efficacy and safety of ABC/3TC/RPV as an initial regimen for treatment-naïve HIV-1 infected patients. METHODS: A retrospective study was conducted in the largest HIV care centre in Singapore, with data collected June 2011 to September 2017. All treatment-naïve HIV-1 infected adults prescribed ABC/3TC as part of their initial anti-retroviral therapy regimen were included. The third drug was a non-nucleoside reverse-transcriptase inhibitor (NNRTI) such as RPV or efavirenz (EFV), or boosted protease-inhibitor (PI). Patients were followed up for 48 weeks. The primary end-point was t...
Source: AIDS Research and Therapy - May 21, 2020 Category: Infectious Diseases Authors: Ho S, Wong JG, Ng OT, Lee CC, Leo YS, Lye DCB, Wong CS Tags: AIDS Res Ther Source Type: research

Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi
Pre-treatment drug resistance (PDR) among antiretroviral drug-na ïve people living with HIV (PLHIV) represents an important indicator for the risk of treatment failure and the spread of drug resistant HIV varia... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 20, 2020 Category: Infectious Diseases Authors: F. Neuhann, A. de Forest, E. Heger, A. Nhlema, C. Scheller, R. Kaiser, H. M. Steffen, H. Tweya, G. F ätkenheuer and S. Phiri Tags: Research Source Type: research

Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi.
CONCLUSION: The prevalence of NNRTI- PDR was above the critical level of 10% suggested by the Global Action Plan on HIV Drug Resistance. The distribution of drug resistance mutations was similar to that seen in previous studies from the region, and further supports the introduction of integrase inhibitors in first-line treatment in Malawi. Furthermore, our findings underline the need for continued PDR surveillance and pharmacovigilance in Sub-Saharan Africa. PMID: 32434561 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 20, 2020 Category: Infectious Diseases Authors: Neuhann F, de Forest A, Heger E, Nhlema A, Scheller C, Kaiser R, Steffen HM, Tweya H, Fätkenheuer G, Phiri S Tags: AIDS Res Ther Source Type: research

Diffusion tensor imaging point to ongoing functional impairment in HIV-infected children at age 5, undetectable using standard neurodevelopmental assessments
Perinatal HIV infection negatively impacts cognitive functioning of children, main domains affected are working memory, processing speed and executive function. Early ART, even when interrupted, improves neuro... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 19, 2020 Category: Infectious Diseases Authors: Christelle Ackermann, Savvas Andronikou, Muhammad G. Saleh, Martin Kidd, Mark F. Cotton, Ernesta M. Meintjes and Barbara Laughton Tags: Research Source Type: research

Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC)
People living with HIV are living longer, and can experience physical, mental and social health challenges associated with aging and multimorbidity. Rehabilitation is well positioned to address disability and ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 19, 2020 Category: Infectious Diseases Authors: Kelly K. O ’Brien, Francisco Ibáñez-Carrasco, Patricia Solomon, Richard Harding, Darren Brown, Puja Ahluwalia, Soo Chan Carusone, Larry Baxter, Charles Emlet, Gayle Restall, Alan Casey, Amrita Ahluwalia, Adria Quigley, Alex R. Terpstra and Nkem Ononiw Tags: Research Source Type: research

Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC).
CONCLUSIONS: These priorities offer a foundation for collaboration among international and multidisciplinary teams to advance the field of HIV, aging and rehabilitation in order to promote healthy aging with HIV. PMID: 32429973 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 19, 2020 Category: Infectious Diseases Authors: O'Brien KK, Ibáñez-Carrasco F, Solomon P, Harding R, Brown D, Ahluwalia P, Chan Carusone S, Baxter L, Emlet C, Restall G, Casey A, Ahluwalia A, Quigley A, Terpstra AR, Ononiwu N Tags: AIDS Res Ther Source Type: research

Diffusion tensor imaging point to ongoing functional impairment in HIV-infected children at age 5, undetectable using standard neurodevelopmental assessments.
CONCLUSION: Even directed neurodevelopmental tests will underestimate the degree of microstructural white matter damage detected by DTI. The visual perception deficit detected in the entire study population should be further examined in a larger study. PMID: 32430069 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 19, 2020 Category: Infectious Diseases Authors: Ackermann C, Andronikou S, Saleh MG, Kidd M, Cotton MF, Meintjes EM, Laughton B Tags: AIDS Res Ther Source Type: research

The effect of “universal test and treat” program on HIV treatment outcomes and patient survival among a cohort of adults taking antiretroviral treatment (ART) in low income settings of Gurage zone, South Ethiopia
Through universal “test and treat approach” (UTT) it is believed that HIV new infection and AIDS related death will be reduced at community level and through time HIV can be eliminated. With this assumption th... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 18, 2020 Category: Infectious Diseases Authors: Tadele Girum, Fedila Yasin, Abebaw Wasie, Teha Shumbej, Fitsum Bekele and Bereket Zeleke Tags: Research Source Type: research

The effect of "universal test and treat" program on HIV treatment outcomes and patient survival among a cohort of adults taking antiretroviral treatment (ART) in low income settings of Gurage zone, South Ethiopia.
CONCLUSION: Mortality was significantly reduced after UTT. Therefore, intervention to further reduce deaths has to focus on early initiation of treatment and strengthening UTT programs. PMID: 32423457 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 18, 2020 Category: Infectious Diseases Authors: Girum T, Yasin F, Wasie A, Shumbej T, Bekele F, Zeleke B Tags: AIDS Res Ther Source Type: research

Survival of people aged 50 years and older by HIV and HIV treatment status: findings from three waves of the SAGE-Wellbeing of Older People Study (SAGE-WOPS) in Uganda
The objective of this study was to determine the survival status of people aged 50 years and olde... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 14, 2020 Category: Infectious Diseases Authors: Joseph Mugisha Okello, Stephen Nash, Paul Kowal, Nirmala Naidoo, Somnath Chatterji, Ties Boerma and Janet Seeley Tags: Research Source Type: research

Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia
About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with lim... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 14, 2020 Category: Infectious Diseases Authors: Tendai Munthali, Charles Michelo, Paul Mee, Crispin Moyo, Andrew Kashoka, Liswaniso Liswaniso, Innocent Chiboma and Jim Todd Tags: Research Source Type: research

Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia.
We examined trends in HIV testing and ART initiation in Zambia. METHODS: We conducted a retrospective cohort study using routinely collected patient level data from 496 health facilities across Zambia. We used Poisson regression to derive incident rate ratios and 95% confidence intervals (95% CI) for background characteristics and used a Cuzick non-parametric test for trends to test the 13-year trends. Median time from testing to ART initiation in days and incidence rates were derived using life tables in survival analysis. We used multi-level random effects Poisson regression model to determine variations in time fro...
Source: AIDS Research and Therapy - May 14, 2020 Category: Infectious Diseases Authors: Munthali T, Michelo C, Mee P, Moyo C, Kashoka A, Liswaniso L, Chiboma I, Todd J Tags: AIDS Res Ther Source Type: research

Survival of people aged 50  years and older by HIV and HIV treatment status: findings from three waves of the SAGE-Wellbeing of Older People Study (SAGE-WOPS) in Uganda.
CONCLUSION: Older adults living with HIV on ART had a risk of mortality that was nearly twice as high as HIV-negative adults. Further analyses of longitudinal data should be done to understand factors that affect the survival of older adults on ART. PMID: 32410634 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 14, 2020 Category: Infectious Diseases Authors: Mugisha Okello J, Nash S, Kowal P, Naidoo N, Chatterji S, Boerma T, Seeley J Tags: AIDS Res Ther Source Type: research

Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: an open-label, randomized, single center study in south Florida
People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adhere... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 13, 2020 Category: Infectious Diseases Authors: Elizabeth M. Sherman, Jianli Niu, Shara Elrod, Kevin A. Clauson, Fadi Alkhateeb and Paula Eckardt Tags: Research Source Type: research

Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: an open-label, randomized, single center study in south Florida.
Abstract BACKGROUND: People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS: ART-naïve PHIV receiving care through the clinic's Ryan White HIV/AIDS Program were enrolled and randomly assigned to the intervention or control groups with a 1:1 ratio. The intervention group received a 1-way text message daily and the control group received standard care without rec...
Source: AIDS Research and Therapy - May 13, 2020 Category: Infectious Diseases Authors: Sherman EM, Niu J, Elrod S, Clauson KA, Alkhateeb F, Eckardt P Tags: AIDS Res Ther Source Type: research

Programme quality indicators of HIV drug resistance among adolescents in urban versus rural settings of the centre region of Cameroon
The high rate of mortality among HIV-vertically infected adolescents might be favoured by HIV drug resistance (HIVDR) emergence, which calls for timeous actions in this underserved population. We thus sought t... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 12, 2020 Category: Infectious Diseases Authors: Joseph Fokam, Armanda Nangmo, Carlson Wandum, Desire Takou, Maria Mercedes Santoro, Anne-Esther Njom Nlend, Francis Ndongo Ateba, Paul Koki Ndombo, Nelly Kamgaing, Cedric Kamta, Andre Essiane, Virginie Lambo, Charles Fokunang, Dora Mbanya, Vittorio Colizz Tags: Research Source Type: research

Daily variations of gut microbial translocation markers in ART-treated HIV-infected people
Increased intestinal barrier permeability and subsequent gut microbial translocation are significant contributors to inflammatory non-AIDS comorbidities in people living with HIV (PLWH). Evidence in animal mod... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - May 12, 2020 Category: Infectious Diseases Authors: Jing Ouyang, St éphane Isnard, John Lin, Brandon Fombuena, Debashree Chatterjee, Tomas Raul Wiche Salinas, Delphine Planas, Amélie Cattin, Augustine Fert, Etiene Moreira Gabriel, Laurence Raymond Marchand, Yonglong Zhang, Malcolm Finkelman, Yaokai Chen, Tags: Short Report Source Type: research

Daily variations of gut microbial translocation markers in ART-treated HIV-infected people.
Abstract BACKGROUND: Increased intestinal barrier permeability and subsequent gut microbial translocation are significant contributors to inflammatory non-AIDS comorbidities in people living with HIV (PLWH). Evidence in animal models have shown that markers of intestinal permeability and microbial translocation vary over the course of the day and are affected by food intake and circadian rhythms. However, daily variations of these markers are not characterized yet in PLWH. Herein, we assessed the variation of these markers over 24 h in PLWH receiving antiretroviral therapy (ART) in a well-controlled environme...
Source: AIDS Research and Therapy - May 12, 2020 Category: Infectious Diseases Authors: Ouyang J, Isnard S, Lin J, Fombuena B, Chatterjee D, Wiche Salinas TR, Planas D, Cattin A, Fert A, Moreira Gabriel E, Raymond Marchand L, Zhang Y, Finkelman M, Chen Y, Kaufmann DE, Cermakian N, Ancuta P, Routy JP Tags: AIDS Res Ther Source Type: research

Programme quality indicators of HIV drug resistance among adolescents in urban versus rural settings of the centre region of Cameroon.
Abstract BACKGROUND: The high rate of mortality among HIV-vertically infected adolescents might be favoured by HIV drug resistance (HIVDR) emergence, which calls for timeous actions in this underserved population. We thus sought to evaluate program quality indicators (PQIs) of HIVDR among HIV-vertically infected adolescents on antiretroviral therapy (ART). METHODS: A study was conducted in the Centre region of Cameroon among adolescents (10-19 years) receiving ART in two urban (The Mother-Child Centre of the Chantal BIYA Foundation, the National Social Welfare Hospital) and three rural (Mfou District Hos...
Source: AIDS Research and Therapy - May 12, 2020 Category: Infectious Diseases Authors: Fokam J, Nangmo A, Wandum C, Takou D, Santoro MM, Nlend AN, Ateba FN, Ndombo PK, Kamgaing N, Kamta C, Essiane A, Lambo V, Fokunang C, Mbanya D, Colizzi V, Perno CF, Ndjolo A Tags: AIDS Res Ther Source Type: research

Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection
The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4+:CD8+ ratio normalisation in people living with HIV (PLWH) on effective antir... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 15, 2020 Category: Infectious Diseases Authors: In ês T. Freitas, Willard Tinago, Hirofumi Sawa, Julie McAndrews, Brenda Doak, Charlotte Prior-Fuller, Gerard Sheehan, John S. Lambert, Eavan Muldoon, Aoife G. Cotter, William W. Hall, Patrick W. G. Mallon and Michael J. Carr Tags: Research Source Type: research