Increased HIV in Greater Kinshasa Urban Health Zones: Democratic Republic of Congo (2017-2018).
CONCLUSION: While this data is sub-national and reflects an urban healthcare setting, given the large population of Kinshasa and rapidly changing age demographics, the results suggest that HIV prevalence in the DRC is substantially higher than previously reported. PMID: 33225968 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 23, 2020 Category: Infectious Diseases Authors: Pour M, James L, Singh K, Mampunza S, Baer F, Scott J, Berg MG, Rodgers MA, Cloherty GA, Hackett J, McArthur CP Tags: AIDS Res Ther Source Type: research

Increased HIV in Greater Kinshasa Urban Health Zones: Democratic Republic of Congo (2017 –2018)
Diagnosis of people living with HIV (PLHIV) is the first step toward achieving the new Fast Track Strategy to end AIDS by 2030: 95-95-95. However, reaching PLHIV is especially difficult in resource-limited set... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 23, 2020 Category: Infectious Diseases Authors: Mohammad Pour, Linda James, Kamlendra Singh, Samuel Mampunza, Franklin Baer, JoAnna Scott, Michael G. Berg, Mary A. Rodgers, Gavin A. Cloherty, John Hackett Jr and Carole P. McArthur Tags: Research Source Type: research

Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.
Abstract INTRODUCTION: With increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults aged 
Source: AIDS Research and Therapy - November 12, 2020 Category: Infectious Diseases Authors: Bahemana E, Esber A, Dear N, Ganesan K, Parikh A, Reed D, Maganga L, Khamadi S, Mizinduko M, Lwilla A, Mkondoo D, Mwaisanga G, Somi N, Owouth J, Maswai J, Kiweewa F, Iroezindu M, Ake JA, Crowell TA, Valcour VG, Polyak CS, AFRICOS Study Group Tags: AIDS Res Ther Source Type: research

Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study
With increased use of antiretroviral therapy (ART), HIV mortality rates are declining and people living with HIV (PLWH) are surviving longer. We characterized CD4 recovery and viral suppression among adults ag... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 12, 2020 Category: Infectious Diseases Authors: Emmanuel Bahemana, Allahna Esber, Nicole Dear, Kavitha Ganesan, Ajay Parikh, Domonique Reed, Lucas Maganga, Samoel Khamadi, Mucho Mizinduko, Anange Lwilla, Dorothy Mkondoo, Gwamaka Mwaisanga, Nancy Somi, John Owouth, Jonah Maswai, Francis Kiweewa & hellip Tags: Research Source Type: research

Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies
Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the accepta... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 10, 2020 Category: Infectious Diseases Authors: Jillian S. Y. Lau, Miranda Z. Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R. Lewin and James H. McMahon Tags: Short Report Source Type: research

Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies.
Abstract BACKGROUND: Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the acceptability of ATI amongst people living with HIV (PLHIV) and their HIV healthcare providers (HHP) is limited. METHODS: Two online surveys for PLHIV and HHP assessed awareness and acceptability of ATI, and understanding of the prospect for HIV cure in the future. Responses were collected from July 2017-January 2018. A descriptive analysis was performed and similar questions across the two...
Source: AIDS Research and Therapy - November 10, 2020 Category: Infectious Diseases Authors: Lau JSY, Smith MZ, Allan B, Martinez C, Power J, Lewin SR, McMahon JH Tags: AIDS Res Ther Source Type: research

Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria.
kum P Abstract BACKGROUND: A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment failure informs patient monitoring practices and distribution of limited resources for second-line regimens. We determined predictors of immunologic and virologic failures in a large ART delivery program in Abuja, Nigeria. METHODS: A retrospective cohort study was conducted at the University of Abuja Teaching Hospital, a tertiary health care facility, using data from February 2005...
Source: AIDS Research and Therapy - November 3, 2020 Category: Infectious Diseases Authors: Ndembi N, Murtala-Ibrahim F, Tola M, Jumare J, Aliyu A, Alabi P, Mensah C, Abimiku A, Quiñones-Mateu ME, Crowell TA, Rhee SY, Shafer RW, Gupta R, Blattner W, Charurat ME, Dakum P Tags: AIDS Res Ther Source Type: research

Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria
A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment fai... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 3, 2020 Category: Infectious Diseases Authors: Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash ’le Abimiku, Miguel E. Quiñones-Mateu, Trevor A. Crowell, Soo-Yon Rhee, Robert W. Shafer, Ravindra Gupta, William Blattner, Manhattan E. Tags: Research Source Type: research

Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir.
CONCLUSIONS: Tb co-infection was associated with the increased surrogate marker of the HIV reservoir, while its mechanism warrants further examination. PMID: 33076959 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Xun J, Qi T, Zou L, Tang Q, Shen Y, Yang J, Xie L, Ji Y, Zhang R, Liu L, Wang J, Steinhart C, Wang Z, Tang Y, Song W, Sun J, Cheng J, Le X, Wu H, He X, Chen R, Chen J, Lu H Tags: AIDS Res Ther Source Type: research

Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala.
Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala. AIDS Res Ther. 2020 Oct 19;17(1):62 Authors: García JI, Meléndez J, Álvarez R, Mejía-Chew C, Kelley HV, Sidiki S, Castillo A, Mazariegos C, López-Téllez C, Forno D, Ayala N, Balada-Llasat JM, Mejía-Villatoro CR, Wang SH, Torrelles JB, Ikeda J Abstract BACKGROUND: Improved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppresse...
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: García JI, Meléndez J, Álvarez R, Mejía-Chew C, Kelley HV, Sidiki S, Castillo A, Mazariegos C, López-Téllez C, Forno D, Ayala N, Balada-Llasat JM, Mejía-Villatoro CR, Wang SH, Torrelles JB, Ikeda J Tags: AIDS Res Ther Source Type: research

Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala
Improved point-of-care diagnostic tests for tuberculosis (TB) in severe immune suppressed people living with HIV (PLWH) are needed to decrease morbidity and mortality outcomes. The aim of the study is to evalu... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Juan Ignacio Garc ía, Johanna Meléndez, Rosa Álvarez, Carlos Mejía-Chew, Holden V. Kelley, Sabeen Sidiki, Alejandra Castillo, Claudia Mazariegos, Cesar López-Téllez, Diana Forno, Nancy Ayala, Joan-Miquel Balada-Llasat, Carlos Rodolfo Mejía-Villator Tags: Research Source Type: research

Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir
Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 19, 2020 Category: Infectious Diseases Authors: Jingna Xun, Tangkai Qi, Lei Zou, Qi Tang, Yinzhong Shen, Junyang Yang, Luman Xie, Yongjia Ji, Renfang Zhang, Li Liu, Jiangrong Wang, Corky Steinhart, Zhenyan Wang, Yang Tang, Wei Song, Jianjun Sun & hellip; Tags: Research Source Type: research

A comparison between different anti-retroviral therapy regimes on soluble inflammation markers: a pilot study.
CONCLUSIONS: Our results seem to discourage the administration of PI as a third drug in a virologically effective antiretroviral regimen, as its use is linked to the detection of higher levels of pro-inflammatory mediators in comparison with INI and NNRTI. PMID: 33054784 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 14, 2020 Category: Infectious Diseases Authors: Maritati M, Alessandro T, Zanotta N, Comar M, Bellini T, Sighinolfi L, Contini C Tags: AIDS Res Ther Source Type: research

A comparison between different anti-retroviral therapy regimes on soluble inflammation markers: a pilot study
Although HIV-related deaths have decreased dramatically following the introduction of antiretroviral therapy (ART), HIV infection itself causes increased morbidity and mortality for both non-AIDS-related event... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 14, 2020 Category: Infectious Diseases Authors: Martina Maritati, Trentini Alessandro, Nunzia Zanotta, Manola Comar, Tiziana Bellini, Laura Sighinolfi and Carlo Contini Tags: Research Source Type: research

Rapid Antiretroviral Therapy (ART) Initiation at a Community-Based Clinic in Jackson, MS.
Abstract BACKGROUND: Rapid antiretroviral therapy (ART), ideally initiated within twenty-four hours of diagnosis, may be crucial in efforts to increase virologic suppression and reduce HIV transmission. Recent studies, including demonstration projects in large metropolitan areas such as Atlanta, Georgia; New Orleans, Louisiana; San Francisco, California; and Washington D.C., have demonstrated that rapid ART initiation is a novel tool for expediting viral suppression in clinical settings. Here we present an evaluation of the impact of a rapid ART initiation program in a community-based clinic in Jackson, MS. M...
Source: AIDS Research and Therapy - October 8, 2020 Category: Infectious Diseases Authors: Gomillia CES, Backus KV, Brock JB, Melvin SC, Parham JJ, Mena LA Tags: AIDS Res Ther Source Type: research

Rapid Antiretroviral Therapy (ART) Initiation at a Community-Based Clinic in Jackson, MS
Rapid antiretroviral therapy (ART), ideally initiated within twenty-four hours of diagnosis, may be crucial in efforts to increase virologic suppression and reduce HIV transmission. Recent studies, including d... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 8, 2020 Category: Infectious Diseases Authors: Courtney E. Sims Gomillia, Kandis V. Backus, James B. Brock, Sandra C. Melvin, Jason J. Parham and Leandro A. Mena Tags: Research Source Type: research

Consequences of the COVID-19 pandemic on the continuum of care in a cohort of people living with HIV followed in a single center of Northern Italy
During the COVID-19 pandemic, hospitals faced increasing pressure, where people living with HIV risked to either acquire SARS-CoV-2 and to interrupt the HIV continuum of care. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 4, 2020 Category: Infectious Diseases Authors: Eugenia Quiros-Roldan, Paola Magro, Canio Carriero, Annacarla Chiesa, Issa El Hamad, Elena Tratta, Raffaella Fazio, Beatrice Formenti and Francesco Castelli Tags: Research Source Type: research

Rapid Progression of Kaposi ’s sarcoma complicated with hemophagocytic syndrome in a severely immunosuppressed patient with HIV-infection: a case report
AIDS-related KS generally involves cutaneous lesions, that slowly progress over months to years. Neither rapidly progressing of KS nor KS complicated with hemophagocytic syndrome (HPS) has rarely been reported. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 14, 2020 Category: Infectious Diseases Authors: Pingzheng Mo, Liping Deng, Xiaoping Chen, Yong Xiong and Yongxi Zhang Tags: Case Report Source Type: research

Rapid Progression of Kaposi's sarcoma complicated with hemophagocytic syndrome in a severely immunosuppressed patient with HIV-infection: a case report.
CONCLUSIONS: The condition of the KS patient could deteriorate rapidly over a period of days and even developeded into HPS, which was life-threatening. However, chemotherapy initiated in a timely manner might improve prognosis. PMID: 32928248 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2020 Category: Infectious Diseases Authors: Mo P, Deng L, Chen X, Xiong Y, Zhang Y Tags: AIDS Res Ther Source Type: research

Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
We describe a participant in an ongoing trial who, shortly after completing trial participation, died... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 10, 2020 Category: Infectious Diseases Authors: Kennedy Michael Ngowi, Lydia Masika, Furaha Lyamuya, Eva Muro, Blandina T. Mmbaga, Mirjam A. G. Sprangers, Pythia T. Nieuwkerk, Rob E. Aarnoutse, Peter Reiss and I. Marion Sumari-de Boer Tags: Case Report Source Type: research

Returning of antiretroviral medication dispensed over a period of 8  months suggests non-adherence despite full adherence according to real time medication monitoring.
We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months' dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV c...
Source: AIDS Research and Therapy - September 9, 2020 Category: Infectious Diseases Authors: Ngowi KM, Masika L, Lyamuya F, Muro E, Mmbaga BT, Sprangers MAG, Nieuwkerk PT, Aarnoutse RE, Reiss P, Sumari-de Boer IM Tags: AIDS Res Ther Source Type: research

Level of knowledge, acceptability, and willingness to use oral fluid HIV self-testing among medical students in Kilimanjaro region, Tanzania: a descriptive cross-sectional study
HIV Self-Testing (HIVST) is universally accepted as an innovative strategy complimenting existing HIV testing services to archive the UNAIDS, 95-95-95 goals by 2030. However, the adoption of HIVST is lagging i... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 9, 2020 Category: Infectious Diseases Authors: Proches Arobogast Vara, Luyeye Sostenes Buhulula, Fatma Aziz Mohammed and Bernard Njau Tags: Research Source Type: research

Level of knowledge, acceptability, and willingness to use oral fluid HIV self-testing among medical students in Kilimanjaro region, Tanzania: a descriptive cross-sectional study.
CONCLUSIONS: The high level of knowledge on oral fluid HIV self-testing, acceptability and willingness to buy self-test kit if available for public use among sexually active medical students underscores the importance of introducing HIVST as a complementary approach for existing HIV testing services in this setting. To make HIVST effective, interventionist should address concerns associated with self-testing, such as lack of pre and post-test counseling, suicidal risks after receiving HIV positive results, perceived risks of inaccurate HIVST test results, lack of linkage to care of individuals receiving HIV positive result...
Source: AIDS Research and Therapy - September 8, 2020 Category: Infectious Diseases Authors: Vara PA, Buhulula LS, Mohammed FA, Njau B Tags: AIDS Res Ther Source Type: research

“They have this not care – don’t care attitude:” A Mixed Methods Study Evaluating Community Readiness for Oral PrEP in Adolescent Girls and Young Women in a Rural Area of South Africa
Adolescent girls and young women (AGYW) remain disproportionately affected by HIV. In a rural area of South Africa with an annual incidence (2011 –2015) of 5 and 7% per annum for 15–19 and 20–24-year olds respe... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 7, 2020 Category: Infectious Diseases Authors: Sarah E Nakasone, Natsayi Chimbindi, Nondumiso Mthiyane, Busisiwe Nkosi, Thembelihle Zuma, Kathy Baisley, Jaco Dreyer, Deenan Pillay, Sian Floyd, Isolde Birdthistle, Janet Seeley and Maryam Shahmanesh Tags: Research Source Type: research

"They have this not care - don't care attitude:" A Mixed Methods Study Evaluating Community Readiness for Oral PrEP in Adolescent Girls and Young Women in a Rural Area of South Africa.
CONCLUSIONS: The health system in this poor, high-HIV incidence area had multiple barriers to a PrEP rollout to AGYW. Norms around adolescent sexuality and gatekeeper concerns that PrEP could divert health resources from treatment to prevention could create barriers to PrEP roll-out in this setting. Alternate modes of delivery, particularly those which are youth-led and demedicalize PrEP, must be explored. PMID: 32894138 [PubMed - as supplied by publisher] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 6, 2020 Category: Infectious Diseases Authors: Nakasone SE, Chimbindi N, Mthiyane N, Nkosi B, Zuma T, Baisley K, Dreyer J, Pillay D, Floyd S, Birdthistle I, Seeley J, Shahmanesh M Tags: AIDS Res Ther Source Type: research

Programmed death-1 expression and regulatory T cells increase in the Intestinal mucosa of cytomegalovirus colitis in patients with HIV/AIDS
Cytomegalovirus (CMV) is among the most common opportunistic infections identified in patients with HIV/AIDS. CMV often targets the colon in such patients. However, the role of regulatory T cells (Tregs) and Prog... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 5, 2020 Category: Infectious Diseases Authors: Lei Sun, Kun Yang, Liang Zhang, Li-ming Qi, Jia-min Chen, Ping Li, Jiang Xiao, Hong-xin Zhao and Peng Wang Tags: Research Source Type: research

Programmed death-1 expression and regulatory T cells increase in the Intestinal mucosa of cytomegalovirus colitis in patients with HIV/AIDS.
In this study, we evaluate the expression of programmed death -1 (PD-1) and its association with regulatory T cells (Tregs) in patients with HIV/AIDS having CMV colitis. METHODS: CMV was detected in the intestinal mucosal biopsy samples via nucleic acid in situ hybridization. PD-1, CD4, CD8, and Treg-specific marker as well as the winged-helix transcription factor and forkhead box P3 (FoxP3) were detected by immunohistochemical methods. RESULTS: Intestinal CMV diease was identified in 20 out of 195 patients with HIV/AIDS enrolled in our study. CMV was diagnosed microscopically by the presence of giant cell inclus...
Source: AIDS Research and Therapy - September 4, 2020 Category: Infectious Diseases Authors: Sun L, Yang K, Zhang L, Qi LM, Chen JM, Li P, Xiao J, Zhao HX, Wang P Tags: AIDS Res Ther Source Type: research

Performance of the BD FACSPresto near to patient analyzer in comparison with representative conventional CD4 instruments in Cameroon
In the context of scaling the viral load in resource limited settings, following HIV infected patient ’s adults and children with CD4+ T-lymphocyte count still very important in settings where the decentralizat... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 17, 2020 Category: Infectious Diseases Authors: Bertrand Sagnia, Fabrice Mbakop Ghomsi, Ana Gutierrez, Samuel Sosso, Rachel Kamgaing, Aubin Joseph Nanfack, Nadesh Nji, Georgia Ambada, Abel Lissom, Thibaut Flaurant Tchouangueu, Loveline Ngu Ndengkoh, Iren ée Domkam, Godwin Nchinda and Alexis Ndjolo Tags: Research Source Type: research

Performance of the BD FACSPresto near to patient analyzer in comparison with representative conventional CD4 instruments in Cameroon.
In this study, we have assessed the sensitivity, specificity and correlation between most representative flow cytometry instruments present in Cameroon with more than 5000 CD4 T cells tests per year including FACSCalibur, FACSCount, and PIMA POC from Becton-Dickinson and ALERE respectively. METHODS: 268 patients aged from 1 to 72 years old were enrolled and included in the study after inform consent. The BD FACSPresto POC CD4+ T cell technology was placed at CIRCB and operated by technician staff. HIV infected patients were from Chantal BIYA international reference Center (CIRCB), Centre de Sante Catholique de NK...
Source: AIDS Research and Therapy - August 16, 2020 Category: Infectious Diseases Authors: Sagnia B, Mbakop Ghomsi F, Gutierrez A, Sosso S, Kamgaing R, Nanfack AJ, Nji N, Ambada G, Lissom A, Tchouangueu TF, Ngu Ndengkoh L, Domkam I, Nchinda G, Ndjolo A Tags: AIDS Res Ther Source Type: research

Cytomegalovirus and disseminated histoplasmosis-related hemophagocytic lymphohistiocytosis syndrome in an HIV-patient late presenter with IRIS: a case report
We present a patie... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 14, 2020 Category: Infectious Diseases Authors: Luz A. Gonz ález-Hernández, Monserrat Alvarez-Zavala, Rodolfo I. Cabrera-Silva, Pedro Martínez-Ayala, Fernando Amador-Lara, Aída S. Ramírez-González, Ana L. Ron-Magaña, Vida V. Ruiz Herrera, Karina Sánchez-Reyes and Jaime F. Andrade-Villanueva Tags: Case Report Source Type: research

Cytomegalovirus and disseminated histoplasmosis-related hemophagocytic lymphohistiocytosis syndrome in an HIV-patient late presenter with IRIS: a case report.
CONCLUSION: The objective of this report is to highlight the importance of having multidisciplinary support, including basic medical sciences groups providing specific tests that are sometimes very difficult to get, which provides a benefit to patients in the well-aimed diagnosis as part of applied translational medicine. PMID: 32795368 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 13, 2020 Category: Infectious Diseases Authors: González-Hernández LA, Alvarez-Zavala M, Cabrera-Silva RI, Martínez-Ayala P, Amador-Lara F, Ramírez-González AS, Ron-Magaña AL, Ruiz Herrera VV, Sánchez-Reyes K, Andrade-Villanueva JF Tags: AIDS Res Ther Source Type: research

Determinants of comprehensive knowledge of HIV/AIDS among reproductive age (15 –49 years) women in Ethiopia: further analysis of 2016 Ethiopian demographic and health survey
The key cause of HIV transmission is failure to provide adequate information about HIV/AIDS which is a substantial public health issue in low and middle-income countries. While global health coverage continues... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 12, 2020 Category: Infectious Diseases Authors: Chilot Desta Agegnehu, Bisrat Misganaw Geremew, Malede Mequanent Sisay, Kindie Fentahun Muchie, Zinash Teferu Engida, Temesgen Worku Gudayu, Daniel Sisay Weldetsadik and Alemneh Mekuriaw Liyew Tags: Research Source Type: research

Determinants of comprehensive knowledge of HIV/AIDS among reproductive age (15-49  years) women in Ethiopia: further analysis of 2016 Ethiopian demographic and health survey.
CONCLUSION: Women with higher education and higher wealth quintiles, knowing the place of HIV test, watching television, a traditional contraceptive method use, having a mobile phone and being in female headed household were positively associated with comprehensive knowledge of HIV/AIDS among women of reproductive age in Ethiopia. Programs working on HIV/AIDS should target women based on the identified factors so as to scale up their comprehensive knowledge towards HIV/AIDS. In this context, the media should actively contribute to raising awareness of HIV/AIDS. PMID: 32787881 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 11, 2020 Category: Infectious Diseases Authors: Agegnehu CD, Geremew BM, Sisay MM, Muchie KF, Engida ZT, Gudayu TW, Weldetsadik DS, Liyew AM Tags: AIDS Res Ther Source Type: research

Perspectives on the utility and interest in a point-of-care urine tenofovir test for adherence to HIV pre-exposure prophylaxis and antiretroviral therapy: an exploratory qualitative assessment among U.S. clients and providers
Real-time, objective measures of adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are needed to better assess adherence levels and to expedite clinical response for those with subo... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 6, 2020 Category: Infectious Diseases Authors: Ashley R. Bardon, Jane M. Simoni, Leif M. Layman, Joanne D. Stekler and Paul K. Drain Tags: Research Source Type: research

Perspectives on the utility and interest in a point-of-care urine tenofovir test for adherence to HIV pre-exposure prophylaxis and antiretroviral therapy: an exploratory qualitative assessment among U.S. clients and providers.
CONCLUSIONS: Our findings indicate POC-TFV testing may be beneficial for routine, clinic-based adherence monitoring, particularly for individuals receiving PrEP or for PLWH with persistent viremia or following recent ART initiation. These findings should also be used to formulate a target product profile for a POC-TFV test and to guide further developments in tools for objective antiretroviral adherence monitoring. PMID: 32762713 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 5, 2020 Category: Infectious Diseases Authors: Bardon AR, Simoni JM, Layman LM, Stekler JD, Drain PK Tags: AIDS Res Ther Source Type: research

Epidemiology of survival pattern and its predictors among HIV positive patients on highly active antiretroviral therapy in Southern Ethiopia public health facilities: a retrospective cohort study
In resource poor countries like Ethiopia, little is known about the survival of patients treated with antiretroviral therapy which depends on different factors. Evidence shows that mortality has been high part... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 5, 2020 Category: Infectious Diseases Authors: Abewa Kebede, Fasil Tessema, Gadisa Bekele, Zerihun Kura and Hailu Merga Tags: Research Source Type: research

Epidemiology of survival pattern and its predictors among HIV positive patients on highly active antiretroviral therapy in Southern Ethiopia public health facilities: a retrospective cohort study.
CONCLUSION: Patients with older age, tuberculosis infection, bedridden patients and severe anemia were predictors. Tracing poorly adhered patients and giving drug counseling as well as encouraging them for disclosure to their families is crucial to improve their survival. PMID: 32758247 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 4, 2020 Category: Infectious Diseases Authors: Kebede A, Tessema F, Bekele G, Kura Z, Merga H Tags: AIDS Res Ther Source Type: research

HIV and syphilis testing behaviors among heterosexual male and female sex workers in Uganda
In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 1, 2020 Category: Infectious Diseases Authors: Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K. Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba Tags: Research Source Type: research

HIV and syphilis testing behaviors among heterosexual male and female sex workers in Uganda.
CONCLUSIONS: Non-testing for HIV and syphilis was common among HMSW relative to FSW. Future studies should evaluate strategies to increase testing uptake for this neglected sub-population of sex workers. PMID: 32738909 [PubMed - as supplied by publisher] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 31, 2020 Category: Infectious Diseases Authors: Muhindo R, Mujugira A, Castelnuovo B, Sewankambo NK, Parkes-Ratanshi R, Kiguli J, Tumwesigye NM, Nakku-Joloba E Tags: AIDS Res Ther Source Type: research

Depression is associated with efavirenz-containing treatments in newly antiretroviral therapy initiated HIV patients in Ecuador
It is well known that people living with HIV (PLWH) is in higher risk for the development of depression and it has also been suggested that the use of efavirenz into the antiretroviral regimens increases even ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 29, 2020 Category: Infectious Diseases Authors: Alejandro Checa, Alberto Castillo, Malena Camacho, William Tapia, Isabel Hernandez and Enrique Teran Tags: Short Report Source Type: research

Depression is associated with efavirenz-containing treatments in newly antiretroviral therapy initiated HIV patients in Ecuador.
CONCLUSION: In our cohort study, depression was much higher in patients on Efavirenz-containing treatments. Therefore, assessment for depression must be essential as part of follow-up in these patients. PMID: 32727488 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 28, 2020 Category: Infectious Diseases Authors: Checa A, Castillo A, Camacho M, Tapia W, Hernandez I, Teran E Tags: AIDS Res Ther Source Type: research

Case report: one case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a normal CD4+ T cell count
The COVID-19 has been a severe pandemic all around the world. Nowadays the patient with co-infection of HIV and SARS-CoV-2 was rarely reported. Here we reported a special case with HIV and SARS-CoV-2 co-infect... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 23, 2020 Category: Infectious Diseases Authors: Wu Menghua, Zheng Xin, Liu Jianwei, Zhang Yu and Yao Qinwei Tags: Case Report Source Type: research

Case report: one case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a normal CD4+ T cell count.
CONCLUSION: The viral shedding duration may be prolonged in people living with HIV. The 14 days isolation strategy might not be long enough for them. The isolation or discharge of these patients needs further confirmation for preventing epidemics. PMID: 32703286 [PubMed - in process] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 22, 2020 Category: Infectious Diseases Authors: Menghua W, Xin Z, Jianwei L, Yu Z, Qinwei Y Tags: AIDS Res Ther Source Type: research

Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort study
The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC  + DRV) in treatment-experienced pa... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 20, 2020 Category: Infectious Diseases Authors: In és Suárez-García, Cristina Moreno, Marta Ruiz-Algueró, María Jesús Pérez-Elías, Marta Navarro, Marcos Díez Martínez, Pompeyo Viciana, Laura Pérez-Martínez, Miguel Górgolas, Concha Amador, Miguel Alberto de Zárraga and Inma Jarrín Tags: Research Source Type: research

Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort study.
arrín I, Cohort of the Spanish HIV/AIDS Research Network (CoRIS) Abstract BACKGROUND: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). METHODS: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as ten...
Source: AIDS Research and Therapy - July 19, 2020 Category: Infectious Diseases Authors: Suárez-García I, Moreno C, Ruiz-Algueró M, Pérez-Elías MJ, Navarro M, Díez Martínez M, Viciana P, Pérez-Martínez L, Górgolas M, Amador C, de Zárraga MA, Jarrín I, Cohort of the Spanish HIV/AIDS Research Network (CoRIS) Tags: AIDS Res Ther Source Type: research

Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study
To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwester... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 17, 2020 Category: Infectious Diseases Authors: Yunxuan Huang, Oulu Zhou, Zhigang Zheng, Yuexiang Xu, Yi Shao, Chunwei Qin, Fengxiang Qin, Jingzhen Lai, Huifang Liu, Rongfeng Chen, Li Ye, Hao Liang, Xionglin Qin and Junjun Jiang Tags: Research Source Type: research

Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study.
Abstract OBJECTIVE: To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwestern China. METHODS: The retrospective cohort was conducted among 6757 HIV/AIDS patients on ART (2NRTIs + 1NNRTI, 2NRTIs + 1PI and Single or two drugs) recruited in Guigang city, Guangxi, China, from January 2004 to December 2018. Participants were divided into ADE and non-ADE groups, and were followed-up every six months to observe treatment outcomes. Co...
Source: AIDS Research and Therapy - July 16, 2020 Category: Infectious Diseases Authors: Huang Y, Zhou O, Zheng Z, Xu Y, Shao Y, Qin C, Qin F, Lai J, Liu H, Chen R, Ye L, Liang H, Qin X, Jiang J Tags: AIDS Res Ther Source Type: research

Determinants of undisclosed HIV status to a community-based HIV program: findings from caregivers of orphans and vulnerable children in Tanzania
HIV status disclosure facilitates receipt of HIV prevention and treatment services. Although disclosure to sexual partners, family members or friends has been extensively studied, disclosure to community-based... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 16, 2020 Category: Infectious Diseases Authors: John Charles, Amon Exavery, Asheri Barankena, Erica Kuhlik, Godfrey M. Mubyazi, Ramadhani Abdul, Alison Koler, Levina Kikoyo and Elizabeth Jere Tags: Research Source Type: research

Possible role of plasma Galectin-9 levels as a surrogate marker of viremia in HIV infected patients on antiretroviral therapy in resource-limited settings
Early detection of viremia in HIV infected patients on anti-retroviral therapy (ART) is important to prevent disease progression as well as accumulation of drug resistance mutations. This makes HIV viral load ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - July 16, 2020 Category: Infectious Diseases Authors: Ashwini Shete, Sampada Dhayarkar, Ashwini Dhamanage, Smita Kulkarni, Manisha Ghate, Shashikala Sangle, Uttam Medhe, Vinita Verma, Shobini Rajan, Toshio Hattori and Raman Gangakhedkar Tags: Research Source Type: research

Possible role of plasma Galectin-9 levels as a surrogate marker of viremia in HIV infected patients on antiretroviral therapy in resource-limited settings.
Abstract BACKGROUND: Early detection of viremia in HIV infected patients on anti-retroviral therapy (ART) is important to prevent disease progression as well as accumulation of drug resistance mutations. This makes HIV viral load (VL) monitoring indispensable in HIV infected patients on ART. However VL, being an expensive test, results in heavy financial burden on health services. Hence, cheaper surrogate markers of viremia are desired to reduce overall cost of management of HIV infected patients. METHODS: We enrolled aviremic (n = 63, M:F = 31:32) and viremic (n = 43...
Source: AIDS Research and Therapy - July 15, 2020 Category: Infectious Diseases Authors: Shete A, Dhayarkar S, Dhamanage A, Kulkarni S, Ghate M, Sangle S, Medhe U, Verma V, Rajan S, Hattori T, Gangakhedkar R Tags: AIDS Res Ther Source Type: research