Preventing viral relapse with prophylactic tenofovir in hepatitis B carriers receiving chemotherapy: a phase IV randomized study in Taiwan
ConclusionsThe 24-week preventative TDF has comparable efficacy to the 48-week treatment in virologic and clinical relapse. High baseline HBsAg or HBV DNA is associated with a higher risk of HBV relapse. These findings imply a 24-week duration of TDF treatment with a close monitor for patients with a high baseline viral load.Lay summaryHepatitis B virus infection is a prominent cause of liver cancer and chronic liver disease and affected millions of people worldwide. When HBV-infected people are exposed to immunosuppressive medication or chemotherapy for cancer, the chance of HBV reactivation rises considerably. This trial...
Source: Hepatology International - February 20, 2024 Category: Infectious Diseases Source Type: research
Point-of-care testing for sexually transmitted infections and HIV pre-exposure prophylaxis among pregnant women in South Africa, 2021-2022: randomised controlled trial
Conclusions
POC STI testing was not associated with PrEP initiation or persistence relative to syndromic management. However, improving STI diagnosis by supplementing syndromic management with POC STI testing could improve PrEP initiation among PPW.
Trial registration number
NCT03902418; Clinical Trials.gov; 1 April 2019. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - February 19, 2024 Category: Sexual Medicine Authors: de Voux, A., Nyemba, D. C., Silliman, M., Mashele, N., Mvududu, R., Myer, L., Joseph Davey, D. Tags: Original research Source Type: research
Reactive HIV testing and pre-exposure prophylaxis (PrEP) use in a London sexual health clinic
We present a descriptive case note review of HIV testing outcomes from 56 Dean Street, a London sexual health clinic, from 1 January to 31 December 2021. Gender, age, sexual risk, PrEP history (using tenofovir disoproxil and emtricitabine) and HIV testing outcomes (see figure 1 for definitions) were collected. Figure 1PrEP, pre-exposure prophylaxis. 292 screening tests were reactive. Median age was 34.5 years old (IQR 28.5–39.5). 90.4% (n=264) were cis male, of whom 93.2% (n=246) were men having sex with men (MSM); 5.1% (n=15) were cis female with high-risk partners and/or sex workers, and 4.4% (n=13) were transwome...
Source: Sexually Transmitted Infections - February 19, 2024 Category: Sexual Medicine Authors: Spencer, M., Patel, S., Whitlock, G., Mavropoulos, I., Mcowan, A., Tittle, V. Tags: PostScript Source Type: research
Cancers, Vol. 16, Pages 813: Cost & ndash;Utility Analysis of Tenofovir Alafenamide and Entecavir in Chronic Hepatitis B Patients: A Markov Decision Model
Cancers, Vol. 16, Pages 813: Cost–Utility Analysis of Tenofovir Alafenamide and Entecavir in Chronic Hepatitis B Patients: A Markov Decision Model
Cancers doi: 10.3390/cancers16040813
Authors:
Chun-Huang Lai
Hon-Yi Shi
Cheng-En Tsai
Yuan-Chieh Yang
Si-Un Frank Chiu
From the perspective of health economics, the evaluation of drug-related cost effectiveness and clinical utility is crucial. We conducted a cost–utility analysis of two first-line drugs, tenofovir alafenamide (TAF) and entecavir (ETV), in the treatment of chronic hepatitis B (CHB) patients. We performed inverse probability...
Source: Cancers - February 17, 2024 Category: Cancer & Oncology Authors: Chun-Huang Lai Hon-Yi Shi Cheng-En Tsai Yuan-Chieh Yang Si-Un Frank Chiu Tags: Article Source Type: research
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention
Expert Rev Mol Diagn. 2024 Feb 14:1-7. doi: 10.1080/14737159.2024.2312122. Online ahead of print.ABSTRACTINTRODUCTION: Although effective antiretroviral and pre-exposure prophylaxis/PrEP regimens are available globally, adherence challenges persist. Objective measures of adherence can both measure adherence accurately and can be used to drive interventions. The first point-of-care pharmacologic adherence measure, urine tenofovir testing using a lateral flow assay, is now available.AREAS COVERED: This review examines the ability of pharmacologic metrics of adherence to predict HIV and PrEP clinical outcomes and the past use...
Source: Expert Review of Molecular Diagnostics - February 14, 2024 Category: Laboratory Medicine Authors: Matthew Spinelli Monica Gandhi Source Type: research
Effectiveness and Safety of Tenofovir Alafenamide Fumarate in the Prevention of Perinatal Hepatitis B Transmission: A Meta-Analysis
ConclusionsTAF antiviral therapy during pregnancy was found to be safe for both mothers and fetuses. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 10, 2024 Category: Gastroenterology Source Type: research
Biochemical evaluation and ligand binding studies on glycerophosphodiester phosphodiesterase from Staphylococcus aureus using STD-NMR spectroscopy and molecular docking analysis
In this study, competent E. coli BL21(DE3)pLysS expression cells were used to express the GDPD enzyme from vancomycin-resistant Staphylococcus aureus (VRSA), which was then purified using size exclusion and anion exchange chromatography. The hydrolytic activity of GDPD was evaluated on the non-physiological substrate bis(p-nitrophenyl) phosphate (BpNPP), which indicated functional activity of the enzyme. 79 drugs were evaluated for their inhibitory potential against GDPD enzyme by the colorimetric assay. Out of 79 drugs, 13 drugs, including tenofovir (1), adenosine (2), clioquinol (11), bromazepam (12), lamotrigine (13), s...
Source: Bioorganic Chemistry - February 9, 2024 Category: Chemistry Authors: Uzma Salar None Atia-Tul-Wahab M Iqbal Choudhary Source Type: research
Effects of Prolonged Administration of Tenofovir Disoproxil Fumarate-Containing Antiviral Regimen on Renal Function in Low-Risk of Kidney Injury HIV Patients
This study intended to investigate the impact of long-term tenofovir fumarate (TDF) antiviral regimen on renal function in human immunodeficiency virus (HIV)-infected patients with low-risk of kidney injury. The observational study involving 100 HIV-infected patients without underlying diseases who achieved virological suppression and immunological recovery after sustained antiviral regimen of TDF+ lamivudine+ efavirenz (TLE) for 3.19 years. Renal function, including estimated glomerular filtration rate (eGFR), blood and urine β2 microglobulin, and other parameters, was assessed every 3 months over a period of 2.5 years. ...
Source: The Journal of Clinical Pharmacology - February 7, 2024 Category: Drugs & Pharmacology Authors: Yuan Yuan Shenghua He Huanxia Liu Yuanhong He Ruifeng Zhou Yuan Yao Ke Yin Chunrong Lyu Source Type: research
Cost-effectiveness of switching from tenofovir disoproxil fumarate to tenofovir alafenamide versus entecavir for chronic hepatitis B patients in Greece
Conclusion: Switching from TDF to TAF in patients living with CHB is a cost effective strategy to reduce adverse liver disease outcomes, while improving bone- and renal-related safety outcomes.PMID:38317634 | DOI:10.57264/cer-2023-0090 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 6, 2024 Category: General Medicine Authors: Emmanouil Sinakos Nandita Kachru Christos Tsoulas Sushanth Jeyakumar Nathaniel J Smith Alon Yehoshua Evangelos Cholongitas Source Type: research
Review on article of effects of tenofovir alafenamide and entecavir in chronic hepatitis B virus patients
World J Hepatol. 2024 Jan 27;16(1):109-111. doi: 10.4254/wjh.v16.i1.109.ABSTRACTThis letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published on World J Hepatol 2023 August 27. We review the related research content, topic selection, methodology, conclusions, strengths and weaknesses of this article. And evaluate it in relation to other published relevant articles.PMID:38313247 | PMC:PMC10835485 | DOI:10.4254/wjh.v16.i1.109 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - February 5, 2024 Category: Gastroenterology Authors: Yu-Tong Sun Qian-Qian Chen Source Type: research
