Acute facial neuralgia related to initiation of emtricitabine/tenofovir for HIV PrEP: a report of two cases in a PrEP demonstration trial
Zhuoheng Yin, Rayner Kay Jin Tan, Joseph D. Tucker, Quanmin Li, Renslow Sherer, Linghua Li, Weiming Tang - Volume 21(1) HIV PrEP is widely recommended as a crucial measure for HIV prevention. In a demonstration trial in China, this article highlights two cases where facial neuralgia emerged as an unexpected side effect of PrEP medication, not previously mentioned in official prescribing information. These findings deepen our understanding of the potential side effects of emitricitabine/tenofovir disoproxil fumarate use and provide empirical evidence to enhance PrEP implementation further and address the challenges that may...
Source: Sexual Health - January 29, 2024 Category: Sexual Medicine Authors: Zhuoheng Yin Rayner Kay Jin Tan Joseph D. Tucker Quanmin Li Renslow Sherer Linghua Li Weiming Tang Source Type: research
Bone Metabolism in Men who Live with HIV Aged 50 years and Over: Impact of Infection Duration
CONCLUSION: Compared to studies conducted on the general population, the prevalence of osteoporosis in male PLWH aged 50 years and older was two times higher. The limited effect of the duration of ART use on low BMD may be due to the patients' histories of replacement therapy. Therefore, to eliminate the negative effects of ART on BMD, it may be beneficial to start replacement therapy when necessary.PMID:38279729 | DOI:10.2174/011570162X273667231213061301 (Source: Current HIV Research)
Source: Current HIV Research - January 27, 2024 Category: Infectious Diseases Authors: Bilge Caglar Emre Durcan Ridvan Karaali Ilker Inanc Balkan Sibel Yildiz Kaya Hakan Yavuzer Dildar Konukoglu Gokhan Aygun Nese Saltoglu Iclal Nur Bulut Kerim Sonmezoglu Pinar Kadioglu Bilgul Mete Omer Fehmi Tabak Source Type: research
The Cost-Effectiveness of Dolutegravir in Combination with Tenofovir and Lamivudine for HIV Therapy: A Systematic Review
(Source: ClinicoEconomics and Outcomes Research)
Source: ClinicoEconomics and Outcomes Research - January 26, 2024 Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
Viruses, Vol. 16, Pages 194: Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV-Infected Pregnant Women in Cambodia
hun
Chantana Yay
Denis Laurent
Samsorphea Chhun
Laurence Borand
Olivier Segeral
Pregnant women identified to carry hepatitis B surface antigen (HBsAg) should be linked to care for the determination of the need for long-term antiviral therapy (LTT). We assessed the performance of simplified criteria, free from HBV DNA quantification, to select women eligible for LTT using different international guidelines as a reference. A retrospective analysis of HBV-infected pregnant women enrolled in the phase 4 ANRS TA-PROHM study was conducted in Cambodia. Sensitivity, specificity, and AUROC were computed to compare thr...
Source: Viruses - January 26, 2024 Category: Virology Authors: Jee-Seon Yang Saren Sovann Yusuke Shimakawa Sovann Nhoueng Bunnet Dim Chanlina Vong Channa Sann Julia Guillebaud Darapolin Vann Bunrith Touch Hyna Chea Wathanak Pisey Choupoan Phirum Eric Rosenthal Christelle Paul Leangchhun Khun Chantana Yay Denis Lauren Tags: Article Source Type: research
Cost-effectiveness of Cabotegravir Long-Acting for HIV Pre-exposure Prophylaxis in the United States
ConclusionsOur analysis suggests that initiating CAB –LA for PrEP is cost-effective versus generic daily oral FTC/TDF for individuals at risk of acquiring HIV-1 infection. (Source: PharmacoEconomics)
Source: PharmacoEconomics - January 24, 2024 Category: Health Management Source Type: research
Real-life data of immune recovery using bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed people living with HIV. Results at 48 –96 weeks of RETROBIC Study
ConclusionIn long-term virologically controlled PLWH, B/F/TAF achieved high efficacy rates and slightly improved immune status in women and individuals aged 60 and over after 48 and 96 of switching. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - January 24, 2024 Category: Microbiology Source Type: research
Development of tenofovir monobenzyl ester phosphonoamidate prodrugs with improved anti-hepatitis B virus activity and intrahepatic tenofovir enrichment
Bioorg Med Chem. 2024 Feb 1;99:117607. doi: 10.1016/j.bmc.2024.117607. Epub 2024 Jan 18.ABSTRACTVarious tenofovir (TFV) prodrugs have been developed by introducing masking groups to the hydroxyls of the monophosphonate group to enhance intestinal absorption efficiency and therapeutic effects. However, the reported TFV prodrugs have drawbacks such as low bioavailability, systemic toxicity caused by their breakdown in non-targeted tissues, and potential low intracellular conversion efficiency. In the present study, we developed a class of TFV monobenzyl ester phosphonoamidate prodrugs without substitutions on the benzene rin...
Source: Bioorganic and Medicinal Chemistry - January 21, 2024 Category: Chemistry Authors: Xizheng Sun Li Song Ling Lin Aizhong Ding Chunjian Wang Xiaohui Ma Shuiping Zhou Jinyong Cai Hai Tang Source Type: research
Noninferiority Outcomes of Besifovir Compared to Tenofovir Alafenamide in Treatment-Na ïve Patients with Chronic Hepatitis B
CONCLUSIONS: : BSV is noninferior to TAF in terms of VR, and their clinical outcomes are comparable to CHB.PMID:38213189 | DOI:10.5009/gnl220390 (Source: Gut and Liver)
Source: Gut and Liver - January 12, 2024 Category: Gastroenterology Authors: Tae Hyung Kim Ji Hoon Kim Hyung Joon Yim Yeon Seok Seo Sun Young Yim Young-Sun Lee Young Kul Jung Jong Eun Yeon Soon Ho Um Kwan Soo Byun Source Type: research
