Viruses, Vol. 16, Pages 194: Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV-Infected Pregnant Women in Cambodia

Viruses, Vol. 16, Pages 194: Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV-Infected Pregnant Women in Cambodia Viruses doi: 10.3390/v16020194 Authors: Jee-Seon Yang Saren Sovann Yusuke Shimakawa Sovann Nhoueng Bunnet Dim Chanlina Vong Channa Sann Julia Guillebaud Darapolin Vann Bunrith Touch Hyna Chea Wathanak Pisey Choupoan Phirum Eric Rosenthal Christelle Paul Leangchhun Khun Chantana Yay Denis Laurent Samsorphea Chhun Laurence Borand Olivier Segeral Pregnant women identified to carry hepatitis B surface antigen (HBsAg) should be linked to care for the determination of the need for long-term antiviral therapy (LTT). We assessed the performance of simplified criteria, free from HBV DNA quantification, to select women eligible for LTT using different international guidelines as a reference. A retrospective analysis of HBV-infected pregnant women enrolled in the phase 4 ANRS TA-PROHM study was conducted in Cambodia. Sensitivity, specificity, and AUROC were computed to compare three simplified criteria (TREAT-B, HBcrAg/ALT, and TA-PROHM) with the American (AASLD) and European (EASL) guidelines as a reference. An additional assessment was performed at 6 months postpartum. Of 651 HBsAg-positive women, 209 (32%) received peripartum antiviral prophylaxis using tenofovir disoproxil fumarate (TDF). During pregnancy, 9% and 12% of women were eligible for LTT according to AASLD and EASL guidelines, re...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research