Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B
The use of tenofovir disoproxil fumarate (TDF) is associated with a reduction in bone mineral density and an increase in bone metabolism biomarkers. However, data on clinical bone fractures remain limited. We evaluated the impact of TDF compared to entecavir on the risk of fracture in elderly patients with chronic hepatitis B (CHB). (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 13, 2023 Category: Gastroenterology Authors: Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Tsz-Fai Yam, Yee-Kit Tse, Vicki Wing-Ki Hui, Mandy Sze-Man Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong Tags: Research Article Source Type: research
Membrane-permeable tenofovir-di- and monophosphate analogues
We report on the synthesis of three types of lipophilic triphosphate analogues of (R)-PMPA and dialkylated diphosphate analogues of (R)-PMPA. A highly selective release of the different nucleotide analogues ((R)-PMPA-DP, (R)-PMPA-MP, and (R)-PMPA) from these compounds was achieved. All dialkylated (R)-PMPA-prodrugs proved to be very stable in PBS as well as in CEM/0 cell extracts and human plasma. In primer extension assays, both the monoalkylated and the dialkylated (R)-PMPA-DP derivatives acted as (R)-PMPA-DP as a substrate for HIV-RT. In contrast, no incorporation events were observed using human polymerase γ. The dial...
Source: European Journal of Medicinal Chemistry - December 12, 2023 Category: Chemistry Authors: Xiao Jia Giuliano A Kullik Marianna Bufano Andrea Brancale Dominique Schols Chris Meier Source Type: research
Membrane-permeable tenofovir-di- and monophosphate analogues
We report on the synthesis of three types of lipophilic triphosphate analogues of (R)-PMPA and dialkylated diphosphate analogues of (R)-PMPA. A highly selective release of the different nucleotide analogues ((R)-PMPA-DP, (R)-PMPA-MP, and (R)-PMPA) from these compounds was achieved. All dialkylated (R)-PMPA-prodrugs proved to be very stable in PBS as well as in CEM/0 cell extracts and human plasma. In primer extension assays, both the monoalkylated and the dialkylated (R)-PMPA-DP derivatives acted as (R)-PMPA-DP as a substrate for HIV-RT. In contrast, no incorporation events were observed using human polymerase γ. The dial...
Source: European Journal of Medicinal Chemistry - December 12, 2023 Category: Chemistry Authors: Xiao Jia Giuliano A Kullik Marianna Bufano Andrea Brancale Dominique Schols Chris Meier Source Type: research
Natural course of AIDS following HIV-2 infection
AbstractIn a 21-year-old female, AIDS following infection with HIV-2 was diagnosed alongside an HIV-associated high-grade B cell lymphoma. Treatment of HIV-2 with dolutegravir, emtricitabine, and tenofovir resulted in viral suppression and slow recovery of CD4 cell counts. Treatment of lymphoma caused significant adverse effects but led to complete remission. The patient denied sexual activity and intravenous drug abuse. The patient had been born to an HIV-2-positive mother but appropriate perinatal testing based on national guidelines had remained negative. This case recapitulates the natural course of HIV-2 infection. (Source: Infection)
Source: Infection - December 12, 2023 Category: Infectious Diseases Source Type: research
On-Time Appointment Keeping and Associated Factors among Human Immunodeficiency Virus-Positive Adult Patients Accessing Antiretroviral Therapy at Health Centers in East Gojjam Zone, Northwest Ethiopia, 2019
CONCLUSION: On-time appointment keeping was low. Adherence support and appointment reminders should be strengthened.PMID:38078055 | PMC:PMC10703533 | DOI:10.1155/2023/1416187 (Source: AIDS Research and Treatment)
Source: AIDS Research and Treatment - December 11, 2023 Category: Infectious Diseases Authors: Mengistie Kassahun Tariku Abebe Habtamu Belete Daniel Tarekegn Worede Sewnet Wongiel Misikir Source Type: research
Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007-2021
AIDS Res Treat. 2023 Nov 30;2023:4423132. doi: 10.1155/2023/4423132. eCollection 2023.ABSTRACTCurrent U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles in routine HIV care. We analyzed medical record data from the HIV Outpatient Study's participants in care from 2007 to 2021. Hyperlipidemia was defined based on clinical diagnoses, treatments, and laboratory results. We calculated hyperlipidemia incidence rates and rate ratios (RRs) during initial ART and assesse...
Source: AIDS Research and Treatment - December 11, 2023 Category: Infectious Diseases Authors: Jun Li Selom Agbobli-Nuwoaty Frank J Palella Richard M Novak Ellen Tedaldi Cynthia Mayer Jonathan D Mahnken Qingjiang Hou Kimberly Carlson Angela M Thompson-Paul Marcus D Durham Kate Buchacz Source Type: research
On-Time Appointment Keeping and Associated Factors among Human Immunodeficiency Virus-Positive Adult Patients Accessing Antiretroviral Therapy at Health Centers in East Gojjam Zone, Northwest Ethiopia, 2019
CONCLUSION: On-time appointment keeping was low. Adherence support and appointment reminders should be strengthened.PMID:38078055 | PMC:PMC10703533 | DOI:10.1155/2023/1416187 (Source: AIDS Research and Treatment)
Source: AIDS Research and Treatment - December 11, 2023 Category: Infectious Diseases Authors: Mengistie Kassahun Tariku Abebe Habtamu Belete Daniel Tarekegn Worede Sewnet Wongiel Misikir Source Type: research
Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007-2021
AIDS Res Treat. 2023 Nov 30;2023:4423132. doi: 10.1155/2023/4423132. eCollection 2023.ABSTRACTCurrent U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles in routine HIV care. We analyzed medical record data from the HIV Outpatient Study's participants in care from 2007 to 2021. Hyperlipidemia was defined based on clinical diagnoses, treatments, and laboratory results. We calculated hyperlipidemia incidence rates and rate ratios (RRs) during initial ART and assesse...
Source: AIDS Research and Treatment - December 11, 2023 Category: Infectious Diseases Authors: Jun Li Selom Agbobli-Nuwoaty Frank J Palella Richard M Novak Ellen Tedaldi Cynthia Mayer Jonathan D Mahnken Qingjiang Hou Kimberly Carlson Angela M Thompson-Paul Marcus D Durham Kate Buchacz Source Type: research
