Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B

The use of tenofovir disoproxil fumarate (TDF) is associated with a reduction in bone mineral density and an increase in bone metabolism biomarkers. However, data on clinical bone fractures remain limited. We evaluated the impact of TDF compared to entecavir on the risk of fracture in elderly patients with chronic hepatitis B (CHB).

Source: Journal of Hepatology - December 13, 2023 Category: Gastroenterology Authors: Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Tsz-Fai Yam, Yee-Kit Tse, Vicki Wing-Ki Hui, Mandy Sze-Man Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong Tags: Research Article Source Type: research