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Published in STI: Self-start HIV postexposure prophylaxis after sexual exposure to reduce time to first dose The efficacy of HIV post-exposure prophylaxis (PEP) increases with a shorter time to treatment initiation. This randomised, prospective, open-label study among men who have sex with men (MSM) in the UK assigned 139 participants to either a 5-day PEP starter pack of emtricitabine/tenofovir disoproxil fumarate/maraviroc, or to the standard of care (SOC) PEP access through sexual health clinics or accident and emergency units. There was a significant reduction in time from sex to first PEP dose in the starter pack arm compared with the SOC (median time 7.3 hours vs 28.5 hours), with full adherence and no serious adverse events in the starter pack arm. The findings suggest the efficacy of home starter packs in HIV prevention strategies. Fox JM, Lee MJ, Fairhead CL, et al. Self-start HIV postexposure prophylaxis (PEPSE), to reduce time...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Perspective Source Type: research