Polyphenol Extracts from Ziziphus jujuba Mill. “Junzao” Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice
ConclusionPERJ probably inhibits the development of UC by suppressing the NLRP3 and MAPKs signaling pathways and regulating gut microbiota homeostasis, and can be considered as a potential resource for preventing UC. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Xiaobo Wei,
Ni Ma,
Wen Yang,
Jinhu Tian,
Huiyan Liu,
Haitian Fang Tags: Research Article Source Type: research
"Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease"
CONCLUSIONS: Dysregulation of GARP, MALAT1, and miR-142-3p likely contributes to inflammation in IBD by reducing TGF-β. MALAT1 is linked to smoking and age-related changes. These genes have potential as diagnostic markers or therapeutic targets for personalized IBD treatment.PMID:38598005 | DOI:10.1007/s11033-024-09475-9 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Mohammad Reza Lahimchi Mousa Mohammadnia-Afrouzi Rasoul Baharlou Dariush Haghmorad Seyed Hassan Abedi Delaram Arjmandi Masoomeh Hosseini Bahman Yousefi Source Type: research
Update: Addendum to S3-Guidelines Crohn disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease with regard to COVID-19 (version 2.0)
Z Gastroenterol. 2024 Apr;62(4):517-534. doi: 10.1055/a-2255-7184. Epub 2024 Apr 10.NO ABSTRACTPMID:38599579 | DOI:10.1055/a-2255-7184 (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 10, 2024 Category: Gastroenterology Authors: Carsten Schmidt Andreas Stallmach Andreas Sturm Oliver Bachmann Ulf Helwig Sibylle Koletzko Petra Lynen Elisabeth Schnoy Axel Dignass Torsten Kucharzik Irina Blumenstein Collaborators Source Type: research
Are we ready to use new endoscopic scores for ulcerative colitis?
World J Gastroenterol. 2024 Mar 14;30(10):1466-1469. doi: 10.3748/wjg.v30.i10.1466.ABSTRACTFor ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity acr...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Rodrigo Quera Paulina N úñez F Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Are we ready to use new endoscopic scores for ulcerative colitis?
World J Gastroenterol. 2024 Mar 14;30(10):1466-1469. doi: 10.3748/wjg.v30.i10.1466.ABSTRACTFor ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity acr...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Rodrigo Quera Paulina N úñez F Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Safety and Efficacy of Inpatient Infliximab Rescue Therapy for Acute Crohn's Disease Flares
CONCLUSION: Inpatient rescue infliximab is safe for treating acute Crohn's disease flare in addition to standard steroid therapy. The majority of patients hospitalized with Crohn's flare requiring rescue infliximab avoided surgery with low postoperative and medication-related complications. More research is needed to clarify the optimal rescue infliximab therapy dosage.PMID:38597300 | DOI:10.1177/00031348241246160 (Source: The American Surgeon)
Source: The American Surgeon - April 10, 2024 Category: Surgery Authors: Ashlyn E Whitlock Kevin R Arndt Iordanis Zakopoulos Daniel J Wong Sumedh Kaul Joseph Feuerstein Kristen T Crowell Evangelos Messaris Source Type: research
"Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease"
CONCLUSIONS: Dysregulation of GARP, MALAT1, and miR-142-3p likely contributes to inflammation in IBD by reducing TGF-β. MALAT1 is linked to smoking and age-related changes. These genes have potential as diagnostic markers or therapeutic targets for personalized IBD treatment.PMID:38598005 | DOI:10.1007/s11033-024-09475-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Mohammad Reza Lahimchi Mousa Mohammadnia-Afrouzi Rasoul Baharlou Dariush Haghmorad Seyed Hassan Abedi Delaram Arjmandi Masoomeh Hosseini Bahman Yousefi Source Type: research
"Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease"
CONCLUSIONS: Dysregulation of GARP, MALAT1, and miR-142-3p likely contributes to inflammation in IBD by reducing TGF-β. MALAT1 is linked to smoking and age-related changes. These genes have potential as diagnostic markers or therapeutic targets for personalized IBD treatment.PMID:38598005 | DOI:10.1007/s11033-024-09475-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 10, 2024 Category: Molecular Biology Authors: Mohammad Reza Lahimchi Mousa Mohammadnia-Afrouzi Rasoul Baharlou Dariush Haghmorad Seyed Hassan Abedi Delaram Arjmandi Masoomeh Hosseini Bahman Yousefi Source Type: research
Involvement of gut microbiota recovery and autophagy induction in Youhua Kuijie Formula's protection against experimental ulcerative colitis
Exp Anim. 2024 Apr 9. doi: 10.1538/expanim.23-0166. Online ahead of print.ABSTRACTUlcerative colitis (UC) is characterized by overactive inflammatory response, impaired intestinal mucosal barrier and disrupted gut microbiota. Youhua Kuijie formula is a classic empirical prescription based on the pathogenesis of UC. The present study was designed to verify the protective effect of Youhua Kuijie Formula on DSS-induced UC in mice and uncover the related mechanism. Youhua Kuijie Formula were orally administrated to UC mice induced by DSS dissolved in drinking water for ten days. The protective effect of Youhua Kuijie Formula w...
Source: Experimental Animals - April 10, 2024 Category: Research Authors: Tianjiao Sheng Lei Wang Simeng Yan Qiuyu Wei Xiao Geng Weiru Lan Yan Chen Yuedong Liu Na Li Source Type: research
Update: Addendum to S3-Guidelines Crohn disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease with regard to COVID-19 (version 2.0)
Z Gastroenterol. 2024 Apr;62(4):517-534. doi: 10.1055/a-2255-7184. Epub 2024 Apr 10.NO ABSTRACTPMID:38599579 | DOI:10.1055/a-2255-7184 (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - April 10, 2024 Category: Gastroenterology Authors: Carsten Schmidt Andreas Stallmach Andreas Sturm Oliver Bachmann Ulf Helwig Sibylle Koletzko Petra Lynen Elisabeth Schnoy Axel Dignass Torsten Kucharzik Irina Blumenstein Collaborators Source Type: research
Are we ready to use new endoscopic scores for ulcerative colitis?
World J Gastroenterol. 2024 Mar 14;30(10):1466-1469. doi: 10.3748/wjg.v30.i10.1466.ABSTRACTFor ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity acr...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Rodrigo Quera Paulina N úñez F Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Are we ready to use new endoscopic scores for ulcerative colitis?
World J Gastroenterol. 2024 Mar 14;30(10):1466-1469. doi: 10.3748/wjg.v30.i10.1466.ABSTRACTFor ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity acr...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Rodrigo Quera Paulina N úñez F Source Type: research
