Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Real-World Treatment Patterns and Healthcare Resource Use for Ulcerative Colitis and Crohn's Disease in Italy
CONCLUSION: This analysis, carried-out in an Italian clinical setting, may help to optimise therapy for patients with UC and CD and provide relevant clinical practice data to inform decision-makers.PMID:38619721 | DOI:10.1007/s12325-024-02840-x (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Melania Dovizio Susanne Hartz Carlotta Buzzoni Isabel Redondo Marijana Nedeljkovic Protic Domenico Birra Valentina Perrone Chiara Veronesi Luca Degli Esposti Alessandro Armuzzi Source Type: research
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study
CONCLUSIONS: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.PMID:38616667 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Kassem Sharif Adi Lahat Yonatan Shneor Patt Niv Ben-Shabat Mahmud Omar Abdulla Watad Howard Amital Omer Gendelman Source Type: research
Real-World Treatment Patterns and Healthcare Resource Use for Ulcerative Colitis and Crohn ’s Disease in Italy
ConclusionThis analysis, carried-out in an Italian clinical setting, may help to optimise therapy for patients with UC and CD and provide relevant clinical practice data to inform decision-makers. (Source: Advances in Therapy)
Source: Advances in Therapy - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
In conclusion, our study elucidated that abnormal immune response could be the common pathogenesis of UC and CeD, and REG4 might be a key potential biomarker and therapeutic target for the comorbidity of these two diseases.PMID:38615385 | DOI:10.1016/j.intimp.2024.112059 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Changshan Wan Tao Ji Liwei Wang Qiuyan Wu Qiuyu Chen Yali Wang Yaqian Li Fengming He Wentian Liu Weilong Zhong Bangmao Wang Source Type: research
Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation
CONCLUSION: We concluded that CSD alleviated DSS-induced UC by inhibiting cGAS, thus regulating macrophage polarization.PMID:38613801 | DOI:10.18632/aging.205734 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Fei Gao Shuangjiao Deng Yujin Liu Pengcheng Wu Lifen Huang Feng Zhu Chunzhu Wei Yuyi Yuan Yang Gui Yushi Tian Heng Fan Hui Wu Source Type: research
Cohabiting with ulcerative colitis patients decreases differences of gut microbiome between healthy individuals and the patients
Conclusion: Our study revealed that cohabitation with UC patients decreased differences in the gut microbiome between healthy individuals and patients. Not only was the composition and diversity of the microbiota diminished, but active pathways also showed some decline. Furthermore, Firmicutes, Faecalibacterium, and the four related pathways may be associated with the pathological state of the host rather than with human behavior.PMID:38614128 | DOI:10.1080/07853890.2024.2337712 (Source: Annals of Medicine)
Source: Annals of Medicine - April 13, 2024 Category: Internal Medicine Authors: Chen Li Xiaoyan Guo Yan He Jing Wang Jianyu Hao Xinjuan Liu Source Type: research
First ‐trimester exposure to tofacitinib in ulcerative colitis: A case report of a healthy newborn and literature review
We present a patient with ulcerative colitis on tofacitinib who had an unplanned pregnancy. Tofacitinib was ceased, switched to vedolizumab, and she gave birth to a healthy newborn at term. Case reports of reassuring outcomes provide real-world data that assists decision-making for future patients. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 13, 2024 Category: General Medicine Authors: Arteen Arzivian,
Eva Zhang,
Robyn Laube,
Rupert Leong Tags: CASE REPORT Source Type: research
Tofacitinib and Peficitinib inhibitors of Janus kinase for autoimmune diseases treatments: A Quantum Biochemistry Description
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D3CP06332A, PaperJackson Lima Amaral, Naiara Lucredi, Victor L. B. Fran ça, Samuel J. M. Santos, Francisco F. Maia, Pablo A. Morais, Pedro F. N. Souza, Jurandir F. Comar, Valder N. Freire Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis are associated with uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. The therapy is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 12, 2024 Category: Chemistry Authors: Jackson Lima Amaral Source Type: research
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota
In conclusion, TP and its derivative peptides ameliorated DSS-induced ulcerative colitis by inhibiting the expression of inflammatory factors and modulating the composition of the intestinal microbiota; this study provides a theoretical basis for the application of TP and its derivative peptides for their anti-inflammatory activity.PMID:38608475 | DOI:10.1016/j.intimp.2024.112024 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Hai-Xiang Guo Bing-Bing Wang Hong-Yu Wu Hao-Yuan Feng Hong-Yi Zhang Wei Gao Bao Yuan Source Type: research
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota
In conclusion, TP and its derivative peptides ameliorated DSS-induced ulcerative colitis by inhibiting the expression of inflammatory factors and modulating the composition of the intestinal microbiota; this study provides a theoretical basis for the application of TP and its derivative peptides for their anti-inflammatory activity.PMID:38608475 | DOI:10.1016/j.intimp.2024.112024 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Hai-Xiang Guo Bing-Bing Wang Hong-Yu Wu Hao-Yuan Feng Hong-Yi Zhang Wei Gao Bao Yuan Source Type: research
Association of Inflammatory Bowel Disease with Incident Immunoglobulin A Nephropathy
CONCLUSIONS: We demonstrated the potential association of inflammatory bowel disease with higher risk of developing IgA nephropathy in a general population.PMID:38600627 | DOI:10.2215/CJN.0000000000000457 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 11, 2024 Category: Urology & Nephrology Authors: Takashin Nakayama Hidehiro Kaneko Akira Okada Yuta Suzuki Katsuhito Fujiu Norifumi Takeda Hiroyuki Morita Norihiko Takeda Akira Fukui Takashi Yokoo Hideo Yasunaga Masaomi Nangaku Kaori Hayashi Source Type: research
NSQIP 5-factor modified frailty index and complications after ileal anal pouch anastomosis for ulcerative colitis
CONCLUSION: IPAA for CUC is associated with high postoperative morbidity, however, the mFI-5 alone has limited utility in determining which patients are at a higher risk of complications due to frailty. These observations suggest there is a need for more relevant instruments to measure frailty in this patient cohort.PMID:38601734 | PMC:PMC11004715 | DOI:10.1016/j.sopen.2024.03.011 (Source: Anal Sci)
Source: Anal Sci - April 11, 2024 Category: Chemistry Authors: Dakota T Thompson Ethan G Breyfogle Catherine G Tran Mohammed O Suraju Aditi Mishra Hussain A Lanewalla Paolo Goffredo Imran Hassan Source Type: research
