Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis.
In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. PMID: 32975064 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 27, 2020 Category: Universities & Medical Training Authors: Park J, Jeong D, Chung YW, Kim DH, Cheon JH, Ryu JH Tags: Yonsei Med J Source Type: research

Bullous Sweet's syndrome in a patient with ulcerative colitis: a rare case report.
We report a case of a 62-year-old female patient with acute exacerbation of ulcerative colitis associated with infiltrating purple-erythematous skin plaques, which were partly vesicular, and oral ulcerative stomatitis. Biopsy was consistent with bullous Sweet's syndrome. Treatment with betamethasone sodium phosphate, starting at 5.5 mg, followed by gradual dose tapering for 12 weeks, resulted in improvement of the ulcerative colitis and disappearance of the cutaneous lesions. Bullous Sweet's syndrome most commonly occurs in the setting of hematologic malignancies, suggesting that physicians should perform long-term screeni...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - September 27, 2020 Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research

Intramesorectal o total mesorectal excision for ulcerative colitis: what is better for the patient?
Authors: Carannante F, Mazzotta E, Mascianá G, Caricato M, Capolupo G PMID: 32975388 [PubMed - as supplied by publisher] (Source: Minerva Chirurgica)
Source: Minerva Chirurgica - September 26, 2020 Category: Surgery Tags: Minerva Chir Source Type: research

Prevalence of autoimmune disorders among bladder pain syndrome patients' relatives.
CONCLUSIONS: Our study suggests that in BPS patients' families, fibromyalgia and autoimmune diseases including asthma, and especially the non-allergic form of asthma, may be over-represented. PMID: 32964777 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - September 25, 2020 Category: Urology & Nephrology Tags: Scand J Urol Source Type: research

Control of Gut Inflammation by Modulation of Purinergic Signaling
Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often refractory to conventional immunosuppressive treatment. In both conditions, imbalance between effector and regulatory cell immune responses has been documented and is thought to contribute to disease pathogenesis. Purinergic signaling is a known modulator of systemic and local inflammation and growing evidences point to extracellular ATP/adenosine imbalance as a key determ...
Source: Frontiers in Immunology - September 25, 2020 Category: Allergy & Immunology Source Type: research

Biologic Therapy for Ulcerative Colitis
Five biologics are approved for the treatment of ulcerative colitis (UC): infliximab, adalimumab, golimumab, vedolizumab, and ustekinumab. These drugs have varying levels of efficacy and are recommended as first-line treatment of moderate to severe UC. There has been only 1 head-to-head trial comparing the efficacy of the biologics, adalimumab and vedolizumab, which has important implications for management. Therapeutic drug monitoring of biologics, especially anti-TNF alpha agents, may improve the long-term efficacy of these agents. The future of treatment may include personalization of medications, based on patient-speci...
Source: Gastroenterology Clinics of North America - September 25, 2020 Category: Gastroenterology Authors: Abhik Bhattacharya, Mark Tomislav Osterman Source Type: research

Ulcerative Colitis: Where We Are and Where We Are Not in 2020
Inflammatory bowel disease (IBD) has 2 general subclasses of disease: Crohn disease and ulcerative colitis, although I have always felt that our diagnostic abilities have been naive in that these are in reality many different diseases: gastroduodenal Crohn is fundamentally different from terminal ileal disease, which differs from isolated colonic disease, not to mention fistulizing disease, and obstructive disease. We are not as yet ready to chuck the term Crohn, perhaps out of deference to the Crohn family. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Alan L. Buchman Tags: Foreword Source Type: research

Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime?
“Patients with inflammatory bowel disease, including ulcerative colitis (UC) and Crohn disease, have altered gut microbiomes. The success of fecal microbiota transplantation (FMT) in the treatment of Clostridioides difficile infection, a disease that is also marked by dysbiosis, has spurred resear ch in applying FMT to UC. So far, 3 randomized controlled trials have demonstrated benefit in mild to moderate UC disease course after FMT. However, important questions regarding optimal stool preparation, route, and frequency of administration, as well as characteristics of the stool donor and reci pient still remain.&rdqu...
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Yao-Wen Cheng, Monika Fischer Source Type: research

Risk of Colon Cancer and Recommended Surveillance Strategies in Patients with Ulcerative Colitis
This article summarizes key strategies for colonoscopic surveillance, the most widely used and evidence-based method of CRC prevention. As currently constituted and practiced, surveillance examinations every 1 to 3 years with lesion detection and removal using high-definition endoscopic systems with or without pancolonic spray-dye chromoendoscopy is the best method for mitigating the development of CRC morbidity and mortality. For patients with primary sclerosing cholangitis with UC, surveillance should begin at the time of diagnosis and colonoscopy should be performed annually. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Wendy Rabbenou, Thomas A. Ullman Source Type: research

Treatment of Ulcerative Colitis with Steroids (in Whom, How Long, What Dose, What Form)
Corticosteroids are a nonspecific immune modulator used in the treatment of ulcerative colitis. Topical and systemic forms of corticosteroids have been shown to be effective in induction of clinical remission and remain first-line therapy for acute severe ulcerative colitis. A large proportion of patients experience adverse effects, however, including some serious adverse effects, including infection and increased mortality. Newer formulations of gut selective corticosteroids have reduced adverse effects associated with steroids. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Lauren A. George, Raymond K. Cross Source Type: research

Epidemiology and Pathogenesis of Ulcerative Colitis
Ulcerative colitis (UC) is a complex chronic, immune-mediated inflammatory disorder of the colon. Factors associated with increased risk of UC include diet, particularly Western diet influences in newly industrialized nations, medications, and lifestyle factors that may influence the host ’s microbiome or immune response to antigens. Although much evidence identifying potential genetic and host-related factors is currently available, there are still many unanswered questions. As the global UC incidence and prevalence continues to increase, there are multiple opportunities for conti nued investigation to clarify our u...
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Lillian Du, Christina Ha Source Type: research

Mesalamine in the Initial Therapy of Ulcerative Colitis
Inflammatory bowel disease is a chronic disorder of intestinal inflammation and includes Crohn ’s disease and ulcerative colitis. The goal of therapy is to induce and maintain remission, which is achieved with conventional therapies. Mesalamine is considered a first-line therapy for ulcerative colitis. Clinical trials have confirmed its efficacy and safety in patients with mild to moderate ulcerative colitis. Doses of more than 2.4 g/d achieve significantly higher rates of clinical and endoscopic remission, with a decreased risk of relapse. Serious adverse effects are rare, but nonadherence is common. Mesalamine...
Source: Gastroenterology Clinics of North America - September 24, 2020 Category: Gastroenterology Authors: Richa Chibbar, Alan C. Moss Source Type: research

CME Exam 2: Incremental Benefit of Achieving Endoscopic and Histologic Remission in Patients With Ulcerative Colitis: A Systematic Review and Meta-Analysis
(Source: Gastroenterology)
Source: Gastroenterology - September 24, 2020 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

Cutaneous Polyarteritis Nodosa in a Patient with Ulcerative Colitis
Publication date: Available online 22 September 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): T. Hiraiwa, T. Yamamoto (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 23, 2020 Category: Dermatology Source Type: research

Long non-coding RNA Mirt2 interacts with long non-coding RNA IFNG-AS1 to regulate ulcerative colitis.
Authors: Li C, Cui L, Li S, Li M, Miao X Abstract Long non-coding RNAs (lncRNAs) Mirt2 and interferon-γ antisense RNA I (IFNG-AS1) play opposing roles in lipopolysaccharide (LPS)-induced inflammation, a key initiator of ulcerative colitis (UC). The present study aimed to analyze the potential interaction between Mirt2 and IFNG-AS1 in UC. Levels of IFNG-AS1 and Mirt2 in plasma samples from UC patients were measured using reverse transcription-quantitative PCR. Receiver operating characteristic curves were used to evaluate the diagnostic values of IFNG-AS1 and Mirt2 fr UC. The role of Mirt2 and IFNG-AS1 in colo...
Source: Experimental and Therapeutic Medicine - September 23, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Modified two-stage restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis: a systematic review and meta-analysis of observational research
We present a systematic review and meta-analysis comparing postoperative complication rates between modified 2-stage and traditional RPC with ileal pouch anal anastomosis.MethodsRecords were sourced from PubMed/Embase databases. Studies comparing postoperative complications following RPC for ulcerative colitis (UC) were selected according to PRISMA guidelines comparing modified 2-stage (exposure), classic 2-stage, and 3-stage approaches (comparators). The primary outcome measure was safety as measured by postoperative complication rates. We employed random effects meta-analysis.ResultsWe included ten observational studies ...
Source: International Journal of Colorectal Disease - September 23, 2020 Category: Gastroenterology Source Type: research

GSE138495 Inhibition of histone deacetylation by MS-275 alleviates colitis by activating the vitamin D receptor
CONCLUSION: We demonstrate that MS-275 inhibits histone deacetylation and alleviates colitis by ameliorating inflammation, reducing apoptosis and maintaining intestinal epithelial barrier via VDR, providing new strategies for UC treatment. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 23, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Cancers, Vol. 12, Pages 2728: Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT
In conclusion, F. nucleatum accelerates the progression of CAC by promoting EMT through the EGFR signaling pathway. (Source: Cancers)
Source: Cancers - September 23, 2020 Category: Cancer & Oncology Authors: Mi Ra Yu Hye Jung Kim Hae Ryoun Park Tags: Article Source Type: research

Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials
ConclusionEfficacy, safety, and immunogenicity of both the originator and biosimilar infliximab were comparable in CD and UC in the NOR-SWITCH main and extension trials. These explorative subgroup analyses confirm that there are no significant concerns related to switching from originator infliximab to CT-P13 in CD and UC.Trial RegistrationClinicalTrials.gov, number NCT02148640. (Source: BioDrugs)
Source: BioDrugs - September 23, 2020 Category: Drugs & Pharmacology Source Type: research

Assessing Severity of Disease in Patients with Ulcerative Colitis
This article reviews the history of severity scoring in UC and provides a concise, clinically oriented approach to assessing disease severity. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 23, 2020 Category: Gastroenterology Authors: Baldeep Singh Pabla, David Allen Schwartz Source Type: research

Ulcerative Colitis
Ulcerative colitis is an inflammatory condition of the colon. The diagnosis of ulcerative colitis is based on clinical presentation, endoscopic evaluation, and histologic parameters in the absence of demonstrable alternate etiology. The differential diagnosis remains broad, and infection in particular must be considered and excluded. Although laboratory and radiographic findings can aid in the diagnosis of ulcerative colitis, endoscopy remains the gold standard for diagnosis. A correct diagnosis and disease staging are imperative because these factors affect treatment options and prognosis. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 23, 2020 Category: Gastroenterology Authors: Tanyaporn Kaenkumchorn, Ghassan Wahbeh Source Type: research

The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis.
In this study we show a potent and significant downregulation of the dominant serotonin reuptake transporter (SERT) mRNA (SLC6A4) in active CD ileitis, CD colitis and UC colitis, compared to healthy controls. The mRNA of the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 was unregulated. Immunohistochemistry showed expression of SERT protein in both the epithelium and the lamina propria and localised the downregulation to the epithelial monolayer. Laser capture microdissection followed by RNA sequencing confirmed downregulation of SLC6A4 in the epithelial monolayer during intestinal inflammation. Pat...
Source: Am J Physiol Gastroi... - September 23, 2020 Category: Gastroenterology Authors: Jørandli JW, Thorsvik S, Skovdahl HK, Kornfeld B, Sæterstad S, Gustafsson BI, Sandvik AK, Granlund AVB Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Association between psoriasis, psoriatic arthritis and gastrointestinal disease : An exploratory nationwide inpatient sample analysis.
Abstract BACKGROUND: Psoriasis is associated with cardiovascular disease, inflammatory bowel disease (IBD), metabolic syndrome, and psychiatric disease. Furthermore, psoriasis is associated with immune dysregulation and systemic inflammation. OBJECTIVE: To determine the association of psoriasis and psoriatic arthritis with IBD and the association of the combination of psoriasis or psoriatic arthritis with IBD and other gastrointestinal illnesses. METHODS: Discharge data from the 2000-2014 Nationwide Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), which approximates a 20% stratified...
Source: Wiener Klinische Wochenschrift - September 23, 2020 Category: General Medicine Authors: Yousaf A, Raiker R, Davis SM, Gayam S, Zinn Z Tags: Wien Klin Wochenschr Source Type: research

Vedolizumab Trough Levels in Children With Anti-Tumor Necrosis Factor Refractory Inflammatory Bowel Disease
Objectives: Inflammatory bowel disease (IBD) can be successfully treated with vedolizumab. Studies in adult IBD patients have shown that differences in response to vedolizumab may be related to variability in vedolizumab trough levels, but in children with pediatric-onset IBD data regarding vedolizumab trough levels are not available. Thus far, the role of trough levels in pediatric-onset IBD treatment remains unclear. We aimed to investigate predictors of vedolizumab trough levels in pediatric-onset IBD patients. Methods: Data from anti-tumor necrosis factor refractory pediatric-onset IBD patients who received vedoli...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Correlation of menstrual distress to severity of gastrointestinal symptoms in inflammatory bowel disease patients
AbstractInflammatory bowel diseases (IBD), namely, Crohn ’s disease (CD) and ulcerative colitis (UC) are idiopathic chronic, relapsing, inflammatory diseases of the gastrointestinal (GI) tract. Triggers for disease flares include medications, infection, acute stress, and the menstrual cycle. Varying ovarian hormone levels i.e. prostaglandins and proges terone may exaggerate GI symptoms in IBD. We aimed to determine the relationship between quality of life, endoscopic and clinical disease activity and the menstrual cycle among females with IBD through a questionnaire based cross-sectional study. The first 75 wome...
Source: Indian Journal of Gastroenterology - September 22, 2020 Category: Gastroenterology Source Type: research

Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program
A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may be used to optimize treatment algorithms. (Source: Gastroenterology)
Source: Gastroenterology - September 22, 2020 Category: Gastroenterology Authors: Esther Orlanski Meyer, Martine Aardoom, Amanda Ricciuto, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan D äbritz, Marla Dubinsky, Séamus Hussey, Peter Lewindon, Javier Martin De Carpi, Víctor Manuel Navas-López, Marina Orsi, Frank M. Ruemm Source Type: research

Modified Kudo classification can improve accuracy of virtual chromoendoscopy with FICE in endoscopic surveillance of ulcerative colitis
Conclusions Targeted biopsies of polypoid and non-polypoid lesions, using the modified Kudo classification with FICE are more accurate than WLE in UC surveillance. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - September 22, 2020 Category: Gastroenterology Authors: Cassinotti, Andrea Fociani, Paolo Duca, Piergiorgio Nebuloni, Manuela Davies, Sophia Elizabeth Campbell Sampietro, Gianluca Buffoli, Federico Corona, Alberto Maconi, Giovanni Ardizzone, Sandro Tags: Original article Source Type: research

Comprehensive analysis of key biomarkers, immune infiltration and potential therapeutic agents for ulcerative colitis
Publication date: 1 November 2020Source: Life Sciences, Volume 260Author(s): Yu Lei, Yu Chen, Zhuoying Lin, Dean Tian, Ping Han (Source: Life Sciences)
Source: Life Sciences - September 21, 2020 Category: Biology Source Type: research

Protective effect of Gloeostereum  incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice.
Protective effect of Gloeostereum incarnatum on ulcerative colitis via modulation of Nrf2/NF‑κB signaling in C57BL/6 mice. Mol Med Rep. 2020 Aug 05;: Authors: Li X, Liu X, Zhang Y, Zhang Y, Liu S, Zhang N, Li Y, Wang D Abstract Chronic non‑specific inflammatory cell infiltration of the colon is generally considered to be the cause of ulcerative colitis (UC). Gloeostereum incarnatum (GI), a fungus rich in amino acids and fatty acids, exhibits a variety of biological functions. In the present study, GI was identified to contain 15 fatty acids, 17 amino acids and 11 metallic elements. ...
Source: Molecular Medicine Reports - September 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Cancers, Vol. 12, Pages 2700: Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study
Frederiksen An association between hematological cancers and inflammatory bowel disease (IBD) has previously been suggested, but the risk of IBD in patients with myeloproliferative neoplasms (MPNs) is unknown. We conducted a nationwide population-based cohort study using Danish registries, to estimate the risk of IBD in individuals diagnosed with essential thrombocythemia, polycythemia vera, myelofibrosis or unclassifiable MPN during 1994–2013. MPN patients were matched 1:10 with sex- and age-matched comparisons. Everyone was followed until a diagnosis of IBD, death/emigration, or 31 December 2013. The ri...
Source: Cancers - September 21, 2020 Category: Cancer & Oncology Authors: Marie Bak Tine Jess Esben Meulengracht Flachs Ann-Dorthe Zwisler Knud Juel Henrik Frederiksen Tags: Article Source Type: research

Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study.
Authors: Pettersson N, Kragsbjerg F, Hamrin A, Bergman S, Forsblad-d'Elia H, Karling P Abstract BACKGROUNDS/AIMS: Musculoskeletal symptoms are common in patients with ulcerative colitis (UC), but no study has compared the prevalence of chronic pain to controls from a general population. METHODS: Patients with UC (n = 1164) and controls (n = 3867) were sent questionnaires comprising demography, history of pain, pain localization and UC patients' Patient-Simple Clinical Colitis Activity Index. Chronic regional pain (ChRP) and chronic widespread pain (ChWP) were defined as having pain f...
Source: Scandinavian Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway.
Abstract Ulcerative colitis (UC) is a chronic and idiopathic inflammatory disease that affects the colon, resulting in immune dysregulation and the production of large amounts of pro-inflammatory cytokines. Pyroptosis and NLRP3 inflammasome are associated with various kinds of inflammatory diseases including colitis. The purpose of this study is to investigate the protective effects and regulatory mechanism of Gly-Pro-Ala (GPA) peptide on DSS-induced colitis. In vivo, we find GPA peptide could exert anti-inflammatory effects on DSS-induced mice colitis, and its anti-inflammatory effects are abolished in NLRP3-/- m...
Source: Aging - September 20, 2020 Category: Biomedical Science Authors: Deng Z, Ni J, Wu X, Wei H, Peng J Tags: Aging (Albany NY) Source Type: research

Women ’s Health and Ulcerative Colitis
This article reviews topics that affect females with ulcerative colitis, including the impact of disease on the menstrual cycle, fertility, child bearing, sexual health, and recommendations for health care maintenance. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 19, 2020 Category: Gastroenterology Authors: Kindra Clark-Snustad, Madalina Butnariu, Anita Afzali Source Type: research

Nonbiologic Immune Suppression in Ulcerative Colitis
This article reviews nonbiologic immunosuppressive agents in the induction and maintenance of remission of ulcerative colitis. Based on meta-analyses and North American guidelines, azathioprine, mercaptopurine, and methotrexate monotherapy are not recommended for induction therapy. Thiopurines are recommended in combination with infliximab. Tofacitinib has been shown to be an effective induction agent. Cyclosporine or tacrolimus are calcineurin inhibitors that can be used as induction therapy. Thiopurine monotherapy is suggested or recommended as maintenance therapy for patients who have achieved steroid-induced remission....
Source: Gastroenterology Clinics of North America - September 19, 2020 Category: Gastroenterology Authors: Val érie Heron, Edward V. Loftus Source Type: research

Disability and quality of life before and during the COVID-19 outbreak: A cross-sectional study in inflammatory bowel disease patients
Conclusion: The current study showed that disability and HRQoL appears to be unaffected by the COVID-19 pandemic among our cohort, however further studies with longer follow up and larger sample size is needed. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - September 18, 2020 Category: Gastroenterology Authors: Nahla A Azzam Abdulrahman Aljebreen Arwa Almuhareb Majid A Almadi Source Type: research

A decrease in the tear secretion volume in a mouse model with ulcerative colitis.
Conclusions: These findings suggest that a decrease in the tear volume in UC was associated with a functional decline in the inflamed lacrimal gland. This result therefore provides useful information that could contribute to the development of treatment approaches for dry eye associated with UC. PMID: 32942916 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - September 18, 2020 Category: Toxicology Authors: Sekijima H, Hiramoto K, Kozawa S Tags: Cutan Ocul Toxicol Source Type: research

Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it
AbstractBackgroundPatients with inflammatory bowel disease (IBD) have numerous risk factors for low bone mineral density (BMD). We aimed to study the prevalence of low BMD in IBD and the factors associated with it.MethodsBMD was measured by radial quantitative ultrasound, and clinical and biochemical characteristics were compared in prospectively enrolled patients and healthy age and gender-matched controls. Chi-square test,t test for independent samples, analysis of variance (ANOVA), Mann –WhitneyU test and Kruskal –WallisH tests were used as appropriate for univariate analysis to compare the characteristics b...
Source: Indian Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Source Type: research

Efficacy and Safety of Continued Treatment with Mirikizumab in a Phase 2 Trial of Patients with Ulcerative Colitis
We present results of the open-label extended induction period in patients who did not initially respond to treatment with mirikizumab. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 17, 2020 Category: Gastroenterology Authors: William J. Sandborn, Marc Ferrante, Bal R. Bhandari, Elina Berliba, Toshifumi Hibi, Geert R. D ’Haens, Jay L. Tuttle, Kathryn Krueger, Stuart Friedrich, Michael Durante, Vipin Arora, April N. Naegeli, Jochen Schmitz, Brian G. Feagan Source Type: research

Regulation of microRNAs in Inflammation-Associated Colorectal Cancer: A Mechanistic Approach.
Abstract The development of colorectal cancer (CRC) is a multi-stage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn's disease (CD) is often regarded as the initial trigger for the development of CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and several interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC through differential regulation of microRNAs (miRNAs/miRs). miRNAs can be oncogenic miRNAs (oncomiRs) or anti-oncomiRs/tum...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 17, 2020 Category: Endocrinology Authors: Muthusami S, Ramachandran I, Krishnamoorthy S, Sambandam Y, Ramalingam S, Queimado L, Chaudhuri G, Kumaran RI Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Association of Copper and Zinc Intake with Inflammatory Bowel Disease and Fecal Incontinence Symptoms: Evidence from the National Health and Nutrition Examination Survey.
This study aims to evaluate the associations of zinc and copper intake with the risk of IBD and fecal incontinence symptoms in adults aged ≥ 20 years using data from the 2009-2010 National Health and Nutritional Examination Surveys (NHANES) (N = 5593). The presence of IBD was analyzed from the NHANES data, directly querying the presence or absence of ulcerative colitis (UC) and Crohn's disease (CD). Fecal incontinence symptoms including accidental bowel leakage of gas, mucus, liquid, or solid stool were determined by using the bowel health questionnaire. Multivariable logistic regressions models were performed controlli...
Source: Biological Trace Element Research - September 17, 2020 Category: Biology Authors: Zhang L, Shao F, Li L Tags: Biol Trace Elem Res Source Type: research

Review: Evolution of evidence on PFOA and health following the assessments of the C8 Science Panel.
CONCLUSION: Overall, the epidemiologic evidence remains limited. For a few outcomes there has been some replication of our earlier findings. More longitudinal research is needed in large populations with large exposure contrasts. Additional cross-sectional studies of low exposed populations may be less informative. PMID: 32950793 [PubMed - as supplied by publisher] (Source: Environment International)
Source: Environment International - September 17, 2020 Category: Environmental Health Authors: Steenland K, Fletcher T, Stein CR, Bartell SM, Darrow L, Lopez-Espinosa MJ, Barry Ryan P, Savitz DA Tags: Environ Int Source Type: research

The Clinical Significance and Risk Factors of Colorectal Stricture in Ulcerative Colitis.
Authors: Park SC, Jeen YT PMID: 32921638 [PubMed - in process] (Source: Gut and Liver)
Source: Gut and Liver - September 16, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

B cell-activating factor (BAFF) in children with inflammatory bowel disease.
CONCLUSION: Faecal BAFF is a promising marker for monitoring the children with IBD, higher levels of BAFF being correlated with high CP. IMPACT: Faecal BAFF is a promising marker in monitoring the children with IBD, higher levels of BAFF being correlated with high faecal calprotectin.To our knowledge, this is the first paediatric study concerning BAFF evaluation in IBD.Faecal BAFF levels could be considered a potential non-invasive marker in monitoring IBD activity in paediatric population with clinically mild or inactive disease.Fig. 1Box plots of faecal BAFF concentration in the whole group with inflammatory bowel d...
Source: Pediatric Research - September 16, 2020 Category: Pediatrics Authors: Fodor I, Serban O, Serban DE, Farcau D, Man SC, Dumitrascu DL Tags: Pediatr Res Source Type: research

The efficacy of Ramak (a traditional herbal medicine preparation) for patients with ulcerative colitis: A pilot randomized, triple-blinded, placebo-controlled clinical trial
Publication date: Available online 15 September 2020Source: European Journal of Integrative MedicineAuthor(s): Fatemeh Rezayat, Mohammad Hashem Hashempur, Hemase Tavahen, Hassan Salmanroghani, Majid Emtiazy (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - September 15, 2020 Category: Complementary Medicine Source Type: research

Use of segmental colorectal lavage cytology during surveillance colonoscopy for detecting dysplastic and cancer cells in patients with ulcerative colitis.
CONCLUSIONS: Segmental CRLC is a less-invasive and effective method in detecting dysplastic and cancer cells in UC patients during surveillance colonoscopy. It could be used as a complementary method for colonoscopy-directed biopsy. PMID: 32922598 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Torii Y, Sano D, Ikeuchi H, Hida N, Hirota S Tags: Int J Clin Exp Pathol Source Type: research

Astragalin Attenuates Dextran Sulfate Sodium (DSS)-Induced Acute Experimental Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting NF- κB Activation in Mice
In this study, we investigated the therapeutic effects of AG on mice with dextran sulfate sodium (DSS)-induced colitis. Our results suggested that AG treatment reduced weight loss and the disease activity index (DAI), prevented colon shortening and alleviated colonic tissue damage. AG treatment reduced the expression of pro-inflammatory cytokines and related mRNAs (such as TNF-α, IL-6, and IL-1β), inhibited colonic infiltration by macrophages and neutrophils, ameliorated metabolic endotoxemia, and improved intestinal mucosal barrier function (increased expression levels of mRNAs such as ZO-1, occludin, and Muc2)...
Source: Frontiers in Immunology - September 15, 2020 Category: Allergy & Immunology Source Type: research

Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.
CONCLUSION: The results of meta-analysis indicate IL12B rs10045431 and rs6887695 polymorphisms significantly associate with IBD in Caucasian population. PMID: 32947150 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - September 15, 2020 Category: Molecular Biology Authors: Wu PB, Wu XM, Qian R, Hong C, Yitian G, Zhang G, Yu YJ Tags: Cytokine Source Type: research

[ASAP] Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c04119 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - September 14, 2020 Category: Food Science Authors: Yi Wu, Yafei Li, Zheng Ruan, Jiaojiao Li, Li Zhang, Hui Lu, and Zhenjiang Xu Source Type: research

A rare case of arteriovenous fistula leading to mesenteric ischemia
A 64-year-old man without cardiovascular risk factors was admitted to our gastroenterology unit for chronic abdominal pain. His medical history only included a subtotal colectomy with ileorectal anastomosis for ulcerative colitis 20 years ago. Over the previous 6 months, the patient had experienced abdominal pain when eating, resulting in a 10% loss of total weight. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 14, 2020 Category: Gastroenterology Authors: Gabriel Marcellier, Mathieu Uzzan, Olivier Corcos Tags: Image of the Month Source Type: research

Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis via the suppression of inflammatory and oxidative responses in ICR mice
Publication date: Available online 11 September 2020Source: Journal of EthnopharmacologyAuthor(s): Nitima Tatiya-aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 13, 2020 Category: Drugs & Pharmacology Source Type: research