Elucidation of antioxidant activities of intracellular and extracellular polysaccharides from Cordyceps militaris in vitro and their protective effects on ulcerative colitis in vivo
In this study, we extracted the polysaccharides from C. militaris fruiting bodies (CFIPs), mycelial intracellular polysaccharides (CMIPs), and fermentation broth extracellular polysaccharides (CFEPs) to investigate their physicochemical properties, antioxidant capacities, and effects on oxazolone-induced zebrafish ulcerative colitis (UC). Our results revealed differences in monosaccharide composition and surface structure among CFIPs, CMIPs, and CFEPs. The molar ratios of glucose to mannose in CFIPs, glucose to xylose in CMIPs, and xylose to glucose in CFEPs were 7.57: 1.6, 7.26: 1.81, and 5.44: 2.98 respectively. Moreover...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Yangbian Guo Yin Wei Chang Liu Hao Li Xiao Du Junlong Meng Jingyu Liu Qi Li Source Type: research
Elucidation of antioxidant activities of intracellular and extracellular polysaccharides from Cordyceps militaris in vitro and their protective effects on ulcerative colitis in vivo
In this study, we extracted the polysaccharides from C. militaris fruiting bodies (CFIPs), mycelial intracellular polysaccharides (CMIPs), and fermentation broth extracellular polysaccharides (CFEPs) to investigate their physicochemical properties, antioxidant capacities, and effects on oxazolone-induced zebrafish ulcerative colitis (UC). Our results revealed differences in monosaccharide composition and surface structure among CFIPs, CMIPs, and CFEPs. The molar ratios of glucose to mannose in CFIPs, glucose to xylose in CMIPs, and xylose to glucose in CFEPs were 7.57: 1.6, 7.26: 1.81, and 5.44: 2.98 respectively. Moreover...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Yangbian Guo Yin Wei Chang Liu Hao Li Xiao Du Junlong Meng Jingyu Liu Qi Li Source Type: research
Colon Targeting pH ‐Responsive Coacervate Microdroplets for Treatment of Ulcerative Colitis
A biocompatible coacervate microdroplets, which loaded emodin and coated with eudragit S100 (EMO@EU-Coac) can achieve stability in gastric acid after oral administration and targets colon lesions. And EMO@EU-Coac can achieve effective treatment of UC through anti-inflammation, anti-oxidative stress, repair of the intestinal epithelial barrier, and regulation of intestinal microbiota balance. AbstractUlcerative colitis (UC), an immune-mediated chronic inflammatory disease, drastically impacts patients' quality of life and increases their risk of colorectal cancer worldwide. However, effective oral targeted delivery and rete...
Source: Small - April 6, 2024 Category: Nanotechnology Authors: Yinmei Tian,
Qian Hu,
Zhengjun Sun,
Yulin Yu,
Xiaonan Li,
Tianyi Tian,
Xinying Bi,
Yang Li,
Boning Niu,
Zhiping Zhang Tags: Research Article Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis
CONCLUSIONS: The findings demonstrated that PAL improved DSS-induced experimental colitis. This effect was associated with inhibiting FTO expression and regulating m6A methylation.PMID:38579565 | DOI:10.1016/j.intimp.2024.111968 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Wanli Ji Yan Huo Yifan Zhang Xiaojing Qian Yi Ren Cheng Hu Jiaqi Zhang Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis
CONCLUSIONS: The findings demonstrated that PAL improved DSS-induced experimental colitis. This effect was associated with inhibiting FTO expression and regulating m6A methylation.PMID:38579565 | DOI:10.1016/j.intimp.2024.111968 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Wanli Ji Yan Huo Yifan Zhang Xiaojing Qian Yi Ren Cheng Hu Jiaqi Zhang Source Type: research
