Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Efficacy of optimised thiopurine therapy in patients with moderate-to-severe ulcerative colitis: retrospective long-term follow-up from two randomised trials
CONCLUSION: Optimised thiopurine therapy demonstrated effective long-term treatment for patients with ulcerative colitis.PMID:38444060 | DOI:10.1080/00365521.2024.2323502 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 5, 2024 Category: Gastroenterology Authors: Anette Mertz Nielsen Klaus Theede Lise Lotte Gluud Marianne Kiszka-Kanowitz Source Type: research

Whole genome sequencing analysis of Limosilactobacillus reuteri from the intestinal tract of mice recovering from ulcerative colitis and preliminary study on anti-inflammatory effects of its derived peptides
Arch Microbiol. 2024 Mar 5;206(4):140. doi: 10.1007/s00203-024-03906-8.ABSTRACTLimosilactobacillus reuteri is an indigenous inhabitant of the animal gut known for its probiotic effects on the host. In our previous study, a large number of L. reuteri strains were isolated from the gastrointestinal tract of mice recovering from ulcerative colitis, from which we randomly selected L. reuteri RE225 for whole genome sequencing to explore its probiotic properties. The results of next-generation sequencing and third-generation single molecule sequencing showed that L. reuteri RE225 contained many genes encoding functional proteins...
Source: Archives of Microbiology - March 5, 2024 Category: Microbiology Authors: Ziyan Wang Zhixuan Zhang Qiuyue Shi Songyi Liu Qiaoli Wu Ze Wang Emilaguli Saiding Jiaojiao Han Jun Zhou Rixin Wang Xiurong Su Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Exposure-efficacy relationship of vedolizumab subcutaneous and intravenous formulations in Crohn's disease and ulcerative colitis
CONCLUSION: Exposure-efficacy relationships for IV and SC vedolizumab administration were comparable, confirming that both are equally effective during maintenance treatment.PMID:38441048 | DOI:10.1080/17512433.2024.2318465 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Geert D'Haens Maria Rosario Daniel Polhamus Nathanael L Dirks Chunlin Chen Krisztina Kisfalvi Christian Agboton S éverine Vermeire Brian G Feagan William J Sandborn Source Type: research

Patient experiences in ulcerative colitis: conceptual model and review of patient-reported outcome measures
ConclusionExisting PRO measures assess concepts relevant to patients with UC, but all PRO measures reviewed require further psychometric evaluation to demonstrate they are fit for purpose. (Source: Quality of Life Research)
Source: Quality of Life Research - March 5, 2024 Category: Health Management Source Type: research

GSE228622 Short Noncoding RNAs as predictive biomarkers for the development from Inflammatory Bowel Disease Unclassified to Crohn ’s Disease or Ulcerative Colitis
Contributors : Jaslin P James ; Lene Buhl Riis ; Mikkel Malham ; Estrid H øgdall ; Ebbe Langholz ; Boye S NielsenSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructTo find predictive biomarkers for the development from inflammatory bowel disease unclassified (IBDU) to Crohn's disease(CD) or ulcerative colitis (UC), we performed short non-coding RNA profiling on IBDU patient samples at the time of diagnostic endoscopy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 4, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research

Activation of free fatty acid receptors, FFAR1 and FFAR4, ameliorates ulcerative colitis by promote fatty acid metabolism and mediate macrophage polarization
CONCLUSION: Activated FFAR1 and FFAR4 ameliorates DSS-induced UC by promoting fatty acid metabolism to reduce lipid accumulation and mediate M2 macrophage polarization.PMID:38432147 | DOI:10.1016/j.intimp.2024.111778 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 3, 2024 Category: Allergy & Immunology Authors: Lin-Sheng Zhang Zhi-Shou Zhang Yu-Zhu Wu Botang Guo Jing Li Xiao-Qi Huang Feng-Min Zhang Min-Yao Li Ping-Chang Yang Xue-Bao Zheng Source Type: research

STEC colitis mimicking acute severe colitis with life-threatening consequences: a case report
We present a patient with a medical history of refractory ulcerative colitis, where making the diagnosis of STEC-HUS was challenging since the initial clinical presentation was difficult to differentiate from a flare of ulcerative colitis. This case illustrates that STEC induced colitis can mimic acute severe ulcerative colitis. This finding is of utmost clinical importance because of the potential life-threatening complications of STEC-HUS. Therefore it should be excluded promptly in patients with acute severe ulcerative colitis by using multiplex-PCR assay on a faecal sample.PMID:38431789 | DOI:10.51821/87.1.11652 (Sourc...
Source: Acta Gastro-Enterologica Belgica - March 3, 2024 Category: Gastroenterology Authors: T Hendrickx M Peetermans A D'Hoore K Claes A Van Hootegem J Sabino Source Type: research